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Article ; Online: Identifying causal role of COVID-19 in immunopsychiatry models.

Horn, Sarah R / Weston, Sara J / Fisher, Philip A

2020 Volume 88, Page(s) 6–8

MeSH term(s)	Allergy and Immunology ; Betacoronavirus ; Biomedical Research ; COVID-19 ; Causality ; Computer Simulation ; Confounding Factors, Epidemiologic ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/psychology ; Humans ; Models, Immunological ; Models, Psychological ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/psychology ; Psychiatry ; Regression Analysis ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-29
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2020.05.066
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Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 327: Show issues

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Article: Replacing Fertilizer with Dried Distillers' Grains in Stocker Cattle Systems on Southern Great Plains Old World Bluestem, USA.

Wallis, Brody D / Gunter, Phillip A / Horn, Gerald W / Reuter, Ryan / Arnall, Brian / Warren, Jason / Lancaster, Sarah R / Lancaster, Phillip A

Animals : an open access journal from MDPI

2023 Volume 13, Issue 18

Abstract: ... of treatment, year, and treatment × year (R software). Nitrogen use efficiency (retained/inputs) was affected ...

Abstract	The objective was to examine the effects of dried distillers' grains supplementation and fertilization strategies on the cattle performance and resource use efficiency of stocker cattle grazing on Plains Old World bluestem. Over 4 consecutive years, heifers and steers (average n = 239) were randomly assigned to 1 of 4 treatments: (1) low input, low stocking density, and no fertilizer or distillers grains supplementation (LOW); (2) high stocking density and no fertilizer with distillers grains supplementation (DDGS); (3) high stocking density and 90 kg of nitrogen/ha with no distillers grains supplementation (NFERT); (4) high stocking density, 90 kg of nitrogen/ha, and 39 kg of phosphorus/ha with no distillers grains supplementation (NPFERT). Cattle grazed in the pastures from mid-May to mid-September each year, except for 2011, when the experiment ended in July due to lack of forage. Data were analyzed using a linear model with fixed effects of treatment, year, and treatment × year (R software). Nitrogen use efficiency (retained/inputs) was affected by a treatment × year interaction, where LOW had the greatest efficiency in all years and DDGS was greater than NFERT and NPFERT in all years except 2012, with NFERT and NPFERT being not different in all years. The estimated total carbon equivalent emissions were greater for DDGS, NFERT, and NPFERT than LOW, but the carbon footprint (kg CO
Language	English
Publishing date	2023-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13182904
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Article ; Online: The Effectiveness of KEEP for Families of Children with Developmental Delays: Integrating FIND Video Coaching into Parent Management Training-Oregon Model: a Randomized Trial.

Salisbury, Marlee R / Roos, Leslie E / Horn, Sarah R / Peake, Shannon J / Fisher, Philip A

Prevention science : the official journal of the Society for Prevention Research

2022 Volume 23, Issue 6, Page(s) 1029–1040

Abstract: Children with developmental delays or disabilities (DD) are at risk for self-regulation difficulties and behaviour problems compared to typically developing children. Intervening early is crucial to prevent long-term adjustment challenges across home and ...

Abstract	Children with developmental delays or disabilities (DD) are at risk for self-regulation difficulties and behaviour problems compared to typically developing children. Intervening early is crucial to prevent long-term adjustment challenges across home and school contexts. Parenting has been identified as a malleable target of intervention for improving children's adaptive functioning across behavioural, emotional and cognitive domains. Although parent management training (PMT) is an identified best-practice, key questions remain about the critical components of interventions and how novel approaches like video feedback may offer additional benefits. Using a pre-test-post-test one group and superiority design, we evaluated the efficacy of two models of the Keeping Parents Trained and Supported (KEEP) preschool program with parent-only components among 175 families with children diagnosed or at-risk for DD. KEEP-P included core PMT (Oregon Model) methods and KEEP-V integrated KEEP with Filming Interactions to Nurture Development video coaching methods for enhancing developmentally supportive interactions. Intervention outcomes on children's behaviour problems and executive functioning, parenting stress and parent-child relationship quality were compared between groups. Both groups demonstrated significant reductions over time in child behavioural problems, developmental problems and parenting stress. Significant improvements were observed in children's executive functioning, parents' sense of competence and mindfulness in parenting. Group differences were observed in parent's sense of competence, with individuals receiving KEEP-P displaying greater increases over time. Higher intervention dosage predicted a greater reduction in stressful child behaviours and greater improvements in children's inhibitory control.
MeSH term(s)	Child, Preschool ; Humans ; Mentoring ; Parent-Child Relations ; Parenting/psychology ; Parents/education ; Problem Behavior
Language	English
Publishing date	2022-02-02
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2251270-6
ISSN	1573-6695 ; 1389-4986
ISSN (online)	1573-6695
ISSN	1389-4986
DOI	10.1007/s11121-022-01344-w
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Zs.A 6466: Show issues

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Article ; Online: Understanding Resilience and Preventing and Treating PTSD.

Horn, Sarah R / Feder, Adriana

Harvard review of psychiatry

2018 Volume 26, Issue 3, Page(s) 158–174

Abstract: Resilience is defined as the dynamic ability to adapt successfully in the face of adversity, trauma, or significant threat. Some of the key early studies of resilience were observational studies in children. They were followed by research in adults, ... ...

Abstract	Resilience is defined as the dynamic ability to adapt successfully in the face of adversity, trauma, or significant threat. Some of the key early studies of resilience were observational studies in children. They were followed by research in adults, studies testing interventions to promote resilience in different populations, and a recent upsurge of studies on the underlying genomic and neurobiological mechanisms. Neural and molecular studies in preclinical models of resilience are also increasingly identifying active stress adaptations in resilient animals. Knowledge gained from animal and human studies of resilience can be harnessed to develop new preventive interventions to enhance resilience in at-risk populations. Further, treatment interventions focused on enhancing potentially modifiable protective factors that are consistently linked to psychological resilience can enrich currently available treatment interventions for individuals with posttraumatic stress disorder (PTSD). Translating our expanding knowledge of the neurobiology of resilience additionally promises to yield novel therapeutic strategies for treating this disabling condition. This review summarizes the vast field of resilience research spanning genomic, psychosocial, and neurobiological levels, and discusses how findings have led and can lead to new preventive and treatment interventions for PTSD.
MeSH term(s)	Adaptation, Psychological/physiology ; Adult ; Child ; Humans ; Psychotherapy/methods ; Resilience, Psychological ; Stress Disorders, Post-Traumatic/drug therapy ; Stress Disorders, Post-Traumatic/physiopathology ; Stress Disorders, Post-Traumatic/prevention & control ; Stress Disorders, Post-Traumatic/therapy
Language	English
Publishing date	2018-05-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1174775-4
ISSN	1465-7309 ; 1067-3229
ISSN (online)	1465-7309
ISSN	1067-3229
DOI	10.1097/HRP.0000000000000194
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Zs.A 3888: Show issues

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Article ; Online: Survival and risk assessment in revision arthroplasty of the ankle.

Hintermann, Beat / Peterhans, Ursina-Sarah / Susdorf, Roman / Horn Lang, Tamara / Ruiz, Roxa / Kvarda, Peter

The bone & joint journal

2024 Volume 106-B, Issue 1, Page(s) 46–52

Abstract: Aims: Implant failure has become more common as the number of primary total ankle arthroplasties (TAAs) performed has increased. Although revision arthroplasty has gained attention for functional preservation, the long-term results remain unclear. This ... ...

Abstract	Aims: Implant failure has become more common as the number of primary total ankle arthroplasties (TAAs) performed has increased. Although revision arthroplasty has gained attention for functional preservation, the long-term results remain unclear. This study aimed to assess the long-term outcomes of revision TAA using a mobile-bearing prosthesis in a considerably large cohort; the risk factors for failure were also determined. Methods: This single-centre retrospective cohort study included 116 patients (117 ankles) who underwent revision TAA for failed primary TAA between July 2000 and March 2010. Survival analysis and risk factor assessment were performed, and clinical performance and patient satisfaction were evaluated preoperatively and at last follow-up. Results: The mean duration from initial revision TAA to last follow-up was 15.0 years (SD 3.0; 11.2 to 20.5). The cumulative survival rates of the revised ankles were 81% (95% confidence interval (CI) 74% to 88%), 74% (65% to 82%), and 70% (61% to 79%) at five, ten, and 15 years, respectively. Comorbidities prior to primary TAA, aseptic loosening, instability, or grafting of cysts were found to be the most common risk factors for secondary revision. The median value for preoperative pain, as assessed using the visual analogue scale, declined from 6 (interquartile range (IQR) 5 to 8) to 2 (IQR 0 to 5) (p < 0.001) and the mean American Orthopaedic Foot and Ankle Society ankle-hindfoot score improved from 43 (SD 17) preoperatively to 70 (SD 20) (p < 0.001) at last follow-up. Conclusion: Revision TAA offers acceptable survival rates after 15 years; it therefore offers a valuable option for treatment of implant failure in carefully selected cases. Although patient-reported outcomes improve substantially, the degree of improvement reported following primary TAA is not achieved.
MeSH term(s)	Humans ; Ankle ; Retrospective Studies ; Osteoarthritis/surgery ; Prosthesis Failure ; Ankle Joint/surgery ; Arthroplasty, Replacement, Ankle/adverse effects ; Arthroplasty, Replacement, Ankle/methods ; Risk Assessment ; Reoperation ; Treatment Outcome
Language	English
Publishing date	2024-01-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.106B1.BJJ-2023-0716.R2
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Zs.A 6989: Show issues

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Article: Identifying causal role of COVID-19 in immunopsychiatry models

Horn, Sarah R / Weston, Sara J / Fisher, Philip A

Brain Behav Immun

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #436897
Database	COVID19

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Article ; Online: Association of Caregiver Depression Risk With Patient Outcomes in Parkinson Disease.

Rashid, Rudmila / Aamodt, Whitley W / Horn, Sarah / Dahodwala, Nabila

JAMA network open

2023 Volume 6, Issue 8, Page(s) e2327485

Abstract: Importance: Caregivers are integral to Parkinson disease (PD) care, but little information exists regarding how caregivers impact patient outcomes.: Objective: To assess the association between caregivers reporting depression symptoms and patient ... ...

Abstract	Importance: Caregivers are integral to Parkinson disease (PD) care, but little information exists regarding how caregivers impact patient outcomes. Objective: To assess the association between caregivers reporting depression symptoms and patient quality of life (QOL), emergency department (ED) visits, and hospitalizations. Design, setting, and participants: This retrospective cohort study was conducted at 15 Parkinson's Foundation Centers of Excellence within the US. The Parkinson's Foundation Parkinson Outcomes Project registry was used to collect baseline data from January 1, 2016, to December 31, 2018, with subsequent annual study visits through July 31, 2020. Data were analyzed from August 5, 2020, to June 9, 2023. A convenience sample of 454 patients with PD and their caregivers was recruited during routine clinical visits with movement disorder specialists. Patients with a physician diagnosis of idiopathic PD who lived at home and had 1 or more follow-up study visits were included. Exposure: Caregiver depression symptoms using the Center for Epidemiologic Studies Depression Scale. Main outcomes and measures: Patient health-related QOL (measured by the 39-item Parkinson Disease Questionnaire), number of annual ED visits, and number of annual hospitalizations were measured. The independent association between caregivers reporting depression symptoms and patient outcomes was assessed using linear mixed-effects and Poisson regression models. The a priori hypotheses were that a greater number of depression symptoms reported via the Center for Epidemiologic Studies Depression Scale would be associated with worse patient QOL and a greater number of ED visits and hospitalizations. Results: Among 454 patient-caregiver dyads (patients: mean [SD] age, 67.3 [8.4] years; 320 men [70.5%]; caregivers: mean [SD] age, 65.9 [8.7] years; 326 women [71.8%]), the mean (SD) follow-up was 2.0 (1.4) study visits. Greater depression symptoms among caregivers were associated with worse patient QOL as measured by the Parkinson Disease Questionnaire (mean [SD] score, 33.78 [17.71], on a scale of 0-100, with higher scores indicating worse QOL, among patients with caregivers who had depression symptoms vs 24.50 [14.19] among patients with caregivers who did not have depression symptoms; β = 0.43; 95% CI, 0.28-0.58; P < .001) and more annual ED visits (β = 0.02; 95% CI, 0 to 0.04; P = .03) but not more hospitalizations (β = 0.02; 95% CI, -0.01 to 0.03; P = .10). Conclusions and relevance: In this cohort study, patients with PD who had caregivers at higher risk of depression were more likely to have worse QOL and higher ED use than patients who had caregivers not at higher risk of depression. Additional caregiving resources and interventions to reduce caregiver depression symptoms could potentially improve patient outcomes.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Quality of Life ; Parkinson Disease/complications ; Parkinson Disease/epidemiology ; Caregivers ; Cohort Studies ; Retrospective Studies ; Depression/epidemiology ; Depression/etiology ; Follow-Up Studies
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.27485
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Article ; Online: Parkinson's disease cerebrovascular reactivity pattern: A feasibility study.

van der Horn, Harm Jan / Vakhtin, Andrei A / Julio, Kayla / Nitschke, Stephanie / Shaff, Nicholas / Dodd, Andrew B / Erhardt, Erik / Phillips, John P / Pirio Richardson, Sarah / Deligtisch, Amanda / Stewart, Melanie / Suarez Cedeno, Gerson / Meles, Sanne K / Mayer, Andrew R / Ryman, Sephira G

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

2024 , Page(s) 271678X241241895

Abstract: A mounting body of research points to cerebrovascular dysfunction as a fundamental element in the pathophysiology of Parkinson's disease (PD). In the current feasibility study, blood-oxygen-level-dependent (BOLD) MRI was used to measure cerebrovascular ... ...

Abstract	A mounting body of research points to cerebrovascular dysfunction as a fundamental element in the pathophysiology of Parkinson's disease (PD). In the current feasibility study, blood-oxygen-level-dependent (BOLD) MRI was used to measure cerebrovascular reactivity (CVR) in response to hypercapnia in 26 PD patients and 16 healthy controls (HC), and aimed to find a multivariate pattern specific to PD. Whole-brain maps of CVR amplitude (i.e., magnitude of response to CO
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	604628-9
ISSN	1559-7016 ; 0271-678X
ISSN (online)	1559-7016
ISSN	0271-678X
DOI	10.1177/0271678X241241895
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Zs.A 1663: Show issues

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Article ; Online: Identifying causal role of COVID-19 in immunopsychiatry models

Horn, Sarah R. / Weston, Sara J. / Fisher, Philip A.

Brain, Behavior, and Immunity

2020 Volume 88, Page(s) 6–8

Keywords	Immunology ; Behavioral Neuroscience ; Endocrine and Autonomic Systems ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	639219-2
ISSN	0889-1591
ISSN	0889-1591
DOI	10.1016/j.bbi.2020.05.066
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 327: Show issues

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Article ; Online: Tractography-Based Modeling Explains Treatment Outcomes in Patients Undergoing Deep Brain Stimulation for Obsessive-Compulsive Disorder.

Gadot, Ron / Li, Ningfei / Shofty, Ben / Avendano-Ortega, Michelle / McKay, Sarah / Bijanki, Kelly R / Robinson, Meghan E / Banks, Garrett / Provenza, Nicole / Storch, Eric A / Goodman, Wayne K / Horn, Andreas / Sheth, Sameer A

Biological psychiatry

2023

Abstract: ... significantly correlated with actual Y-BOCS improvement ranks at the 6-month follow-up (r = 0.75, p = .013 ... Predicted score improvements correlated with actual Y-BOCS score improvements (r = 0.72, p = .018 ...

Abstract	Background: Deep brain stimulation (DBS) is an established and expanding therapy for treatment-refractory obsessive-compulsive disorder. Previous work has suggested that a white matter circuit providing hyperdirect input from the dorsal cingulate and ventrolateral prefrontal regions to the subthalamic nucleus could be an effective neuromodulatory target. Methods: We tested this concept by attempting to retrospectively explain through predictive modeling the ranks of clinical improvement as measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) in 10 patients with obsessive-compulsive disorder who underwent DBS to the ventral anterior limb of internal capsule with subsequent programming uninformed by the putative target tract. Results: Rank predictions were carried out using the tract model by a team that was completely uninvolved in DBS planning and programming. Predicted Y-BOCS improvement ranks significantly correlated with actual Y-BOCS improvement ranks at the 6-month follow-up (r = 0.75, p = .013). Predicted score improvements correlated with actual Y-BOCS score improvements (r = 0.72, p = .018). Conclusions: Here, we provide data in a first-of-its-kind report suggesting that normative tractography-based modeling can blindly predict treatment response in DBS for obsessive-compulsive disorder.
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2023.01.017
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