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  1. Article: A directionally selective collision-sensing visual neural network based on fractional-order differential operator.

    Wang, Yusi / Li, Haiyang / Zheng, Yi / Peng, Jigen

    Frontiers in neurorobotics

    2023  Volume 17, Page(s) 1149675

    Abstract: In this paper, we propose a directionally selective fractional-order lobular giant motion detector (LGMD) visual neural network. Unlike most collision-sensing network models based on LGMDs, our model can not only sense collision threats but also obtain ... ...

    Abstract In this paper, we propose a directionally selective fractional-order lobular giant motion detector (LGMD) visual neural network. Unlike most collision-sensing network models based on LGMDs, our model can not only sense collision threats but also obtain the motion direction of the collision object. Firstly, this paper simulates the membrane potential response of neurons using the fractional-order differential operator to generate reliable collision response spikes. Then, a new correlation mechanism is proposed to obtain the motion direction of objects. Specifically, this paper performs correlation operation on the signals extracted from two pixels, utilizing the temporal delay of the signals to obtain their position relationship. In this way, the response characteristics of direction-selective neurons can be characterized. Finally, ON/OFF visual channels are introduced to encode increases and decreases in brightness, respectively, thereby modeling the bipolar response of special neurons. Extensive experimental results show that the proposed visual neural system conforms to the response characteristics of biological LGMD and direction-selective neurons, and that the performance of the system is stable and reliable.
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2453002-5
    ISSN 1662-5218
    ISSN 1662-5218
    DOI 10.3389/fnbot.2023.1149675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Design of MXene-Based Multiporous Nanosheet Stacking Structures Integrating Multiple Synergistic SERS Enhancements for Ultrasensitive Detection of Chloramphenicol.

    Peng, Yusi / Yang, Lili / Li, Yanyan / Zhang, Weida / Xu, Meimei / Lin, Chenglong / Liu, Jianjun / Huang, Zhengren / Yang, Yong

    JACS Au

    2024  Volume 4, Issue 2, Page(s) 730–743

    Abstract: Motivated by the desire for more sensitivity and stable surface-enhanced Raman scattering (SERS) substrates to trace detect chloramphenicol due to its high toxicity and ubiquity, MXene has attracted increasing attention and is encountering the high- ... ...

    Abstract Motivated by the desire for more sensitivity and stable surface-enhanced Raman scattering (SERS) substrates to trace detect chloramphenicol due to its high toxicity and ubiquity, MXene has attracted increasing attention and is encountering the high-priority task of further observably improving detection sensitivity. Herein, a universal SERS optimization strategy that incorporates NH
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2691-3704
    ISSN (online) 2691-3704
    DOI 10.1021/jacsau.3c00758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dual-Mode Lateral Flow Immunoassay Based on "Pompon Mum"-Like Fe

    Xu, Meimei / Zhao, Shuai / Lin, Chenglong / Li, Yanyan / Zhang, Weida / Peng, Yusi / Xiao, Rui / Huang, Zhengren / Yang, Yong

    ACS applied materials & interfaces

    2024  Volume 16, Issue 9, Page(s) 11172–11184

    Abstract: Lateral flow immunoassay (LFIA) has been widely used for the early diagnosis of diseases. However, conventional colorimetric LFIA possesses limited sensitivity, and the single-mode readout signal is easily affected by the external environment, leading to ...

    Abstract Lateral flow immunoassay (LFIA) has been widely used for the early diagnosis of diseases. However, conventional colorimetric LFIA possesses limited sensitivity, and the single-mode readout signal is easily affected by the external environment, leading to insufficient accuracy. Herein, multifunctional Fe
    MeSH term(s) Influenza A Virus, H1N1 Subtype ; Molybdenum ; Catalysis ; Colorimetry ; Immunoassay ; Metal Nanoparticles ; Gold
    Chemical Substances Molybdenum (81AH48963U) ; Gold (7440-57-5)
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c15851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effectiveness of metagenomic next-generation sequencing in the diagnosis of infectious diseases: A systematic review and meta-analysis.

    Liu, Yusi / Qin, Sibei / Lan, Chunhai / Huang, Qinmiao / Zhang, Peng / Cao, Weiling

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  Volume 142, Page(s) 106996

    Abstract: Objectives: Early diagnosis of infectious diseases remains a challenge. This study assessed the diagnostic value of mNGS in infections and explored the effect of various factors on the accuracy of mNGS.: Methods: An electronic article search of ... ...

    Abstract Objectives: Early diagnosis of infectious diseases remains a challenge. This study assessed the diagnostic value of mNGS in infections and explored the effect of various factors on the accuracy of mNGS.
    Methods: An electronic article search of PubMed, Cochrane Library, and Embase was performed. A total of 85 papers were eligible for inclusion and analysis. Stata 12.0 was used for statistical calculation to evaluate the efficacy of mNGS for the diagnosis of infectious diseases.
    Results: The AUC of 85 studies was 0.88 (95%CI, 0.85-0.90). The AUC of the clinical comprehensive diagnosis and conventional test groups was 0.92 (95%CI, 0.89-0.94) and 0.82 (95%CI, 0.78-0.85), respectively. The results of subgroup analysis indicated that the PLR and NLR were 12.67 (95%CI, 6.01-26.70) and 0.05 (95%CI, 0.03-0.10), respectively, in arthrosis infections. The PLR was 24.41 (95%CI, 5.70-104.58) in central system infections and the NLR of immunocompromised patients was 0.08 (95%CI, 0.01-0.62).
    Conclusion: mNGS demonstrated satisfactory diagnostic performance for infections, especially for bone and joint infections and central system infections. Moreover, mNGS also has a high value in the exclusion of infection in immunocompromised patients.
    MeSH term(s) Humans ; High-Throughput Nucleotide Sequencing ; Arthritis, Infectious ; Immunocompromised Host ; Metagenome ; Metagenomics ; Sepsis ; Communicable Diseases/diagnosis ; Sensitivity and Specificity
    Language English
    Publishing date 2024-03-07
    Publishing country Canada
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.106996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Enhancing LGMD-based model for collision prediction via binocular structure.

    Zheng, Yi / Wang, Yusi / Wu, Guangrong / Li, Haiyang / Peng, Jigen

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1247227

    Abstract: Introduction: Lobular giant motion detector (LGMD) neurons, renowned for their distinctive response to looming stimuli, inspire the development of visual neural network models for collision prediction. However, the existing LGMD-based models could not ... ...

    Abstract Introduction: Lobular giant motion detector (LGMD) neurons, renowned for their distinctive response to looming stimuli, inspire the development of visual neural network models for collision prediction. However, the existing LGMD-based models could not yet incorporate the invaluable feature of depth distance and still suffer from the following two primary drawbacks. Firstly, they struggle to effectively distinguish the three fundamental motion patterns of approaching, receding, and translating, in contrast to the natural abilities of LGMD neurons. Secondly, due to their reliance on a general determination process employing an activation function and fixed threshold for output, these models exhibit dramatic fluctuations in prediction effectiveness across different scenarios.
    Methods: To address these issues, we propose a novel LGMD-based model with a binocular structure (Bi-LGMD). The depth distance of the moving object is extracted by calculating the binocular disparity facilitating a clear differentiation of the motion patterns, after obtaining the moving object's contour through the basic components of the LGMD network. In addition, we introduce a self-adaptive warning depth-distance, enhancing the model's robustness in various motion scenarios.
    Results: The effectiveness of the proposed model is verified using computer-simulated and real-world videos.
    Discussion: Furthermore, the experimental results demonstrate that the proposed model is robust to contrast and noise.
    Language English
    Publishing date 2023-09-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1247227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: High-sensitivity and point-of-care detection of SARS-CoV-2 from nasal and throat swabs by magnetic SERS biosensor.

    Li, Yanyan / Lin, Chenglong / Peng, Yusi / He, Jun / Yang, Yong

    Sensors and actuators. B, Chemical

    2022  Volume 365, Page(s) 131974

    Abstract: The outbreak of COVID-19 caused by SARS-CoV-2 urges the development of rapidly and accurately diagnostic methods. Here, one high-sensitivity and point-of-care detection method based on magnetic SERS biosensor composed of ... ...

    Abstract The outbreak of COVID-19 caused by SARS-CoV-2 urges the development of rapidly and accurately diagnostic methods. Here, one high-sensitivity and point-of-care detection method based on magnetic SERS biosensor composed of Fe
    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1021505-0
    ISSN 0925-4005
    ISSN 0925-4005
    DOI 10.1016/j.snb.2022.131974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Adaptively Integrative Association between Multivariate Phenotypes and Transcriptomic Data for Complex Diseases.

    Li, Yujia / Fang, Yusi / Chang, Hung-Ching / Gorczyca, Michael / Liu, Peng / Tseng, George C

    Genes

    2023  Volume 14, Issue 4

    Abstract: Phenotype-gene association studies can uncover disease mechanisms for translational research. Association with multiple phenotypes or clinical variables in complex diseases has the advantage of increasing statistical power and offering a holistic view. ... ...

    Abstract Phenotype-gene association studies can uncover disease mechanisms for translational research. Association with multiple phenotypes or clinical variables in complex diseases has the advantage of increasing statistical power and offering a holistic view. Existing multi-variate association methods mostly focus on SNP-based genetic associations. In this paper, we extend and evaluate two adaptive Fisher's methods, namely AFp and AFz, from the
    MeSH term(s) Transcriptome/genetics ; alpha-Fetoproteins ; Phenotype ; Gene Expression Profiling ; Genetic Association Studies
    Chemical Substances alpha-Fetoproteins
    Language English
    Publishing date 2023-03-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14040798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Alterations in hippocampus-centered morphological features and function of the progression from normal cognition to mild cognitive impairment.

    Wang, Xiuxiu / Peng, Lixin / Zhan, Shiqi / Yin, Xiaolong / Huang, Li / Huang, Jiayang / Yang, Junchao / Zhang, Yusi / Zeng, Yi / Liang, Shengxiang

    Asian journal of psychiatry

    2024  Volume 93, Page(s) 103921

    Abstract: Mild cognitive impairment (MCI) is a significant precursor to dementia, highlighting the critical need for early identification of individuals at high risk of MCI to prevent cognitive decline. The study aimed to investigate the changes in brain structure ...

    Abstract Mild cognitive impairment (MCI) is a significant precursor to dementia, highlighting the critical need for early identification of individuals at high risk of MCI to prevent cognitive decline. The study aimed to investigate the changes in brain structure and function before the onset of MCI. This study enrolled 19 older adults with progressive normal cognition (pNC) to MCI and 19 older adults with stable normal cognition (sNC). The gray matter (GM) volume and functional connectivity (FC) were estimated via magnetic resonance imaging during their normal cognition state 3 years prior. Additionally, spatial associations between FC maps and neurochemical profiles were examined using JuSpace. Compared to the sNC group, the pNC group showed decreased volume in the left hippocampus and left amygdala. The significantly positive correlation was observed between the GM volume of the left hippocampus and the MMSE scores after 3 years in pNC group. Besides, it showed that the pNC group had increased FC between the left hippocampus and the anterior-posterior cingulate gyrus, which was significantly correlated with the spatial distribution of dopamine D2 and noradrenaline transporter. Taken together, the study identified the abnormal brain characteristics before the onset of MCI, which might provide insight into clinical research.
    MeSH term(s) Humans ; Aged ; Cognitive Dysfunction ; Cognition ; Brain ; Hippocampus/diagnostic imaging ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2024-01-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2024.103921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Transcriptional responses of Crassostrea hongkongensis under high and low salinity stress.

    Li, Wei / Zhang, Xingzhi / He, Pingping / Jiang, Linyuan / Zhang, Li / Guan, Junliang / Chen, Yongxian / Zheng, Yusi / Wei, Pinyuan / Peng, Jinxia

    Comparative biochemistry and physiology. Part D, Genomics & proteomics

    2024  Volume 49, Page(s) 101188

    Abstract: Salinity, a key limiting factor, affects the distribution and survival of marine species. The Hong Kong oyster (Crassostrea hongkongensis), a euryhaline species found along the coast of the South China Sea, has become a major aquaculture bivalve species. ...

    Abstract Salinity, a key limiting factor, affects the distribution and survival of marine species. The Hong Kong oyster (Crassostrea hongkongensis), a euryhaline species found along the coast of the South China Sea, has become a major aquaculture bivalve species. To determine the molecular mechanism by which oysters respond to coastal waters with varying salinity levels, we used RNA-seq to sequence the gill samples of oysters exposed to normal (25 ‰, S25), low (5 ‰, S5) and high (35 ‰, S35) salinity conditions for one month. The results revealed different expression transcriptome levels among oysters living under low and high salinity conditions. Using high-throughput sequencing, we identified 811 up-regulated genes and 769 down-regulated genes. As determined by KEGG pathway mapping, the differentially expressed genes (DEGs) were significantly enriched in the prion diseases, histidine metabolism, arginine and proline metabolism, and beta-alanine metabolism pathways in both the S5 vs. S25 and S35 vs. S25 group comparison. Several DEGs including heat shock 70 kDa protein 12B-like, poly (ADP-ribose) polymerase (PARP), and tripartite motif-containing protein 2 (TRIM2), and low-density lipoprotein receptor-like, as well as KEGG pathways, including arginine and proline metabolism, apoptosis, PPAR signaling pathway, the thyroid hormone signaling pathway, were concerning response to salinity stress. Additionally, eight DEGs involved in salinity adaptation were selected for RT-qPCR validation, and the results confirmed the credibility of the transcriptome sequencing data. Overall, we designed a one-month, medium-term experiment to examine the responses of C. hongkongensis exposed to different levels of salinity stress and performed transcriptome analysis using high-throughput sequencing. Our results enhance current understanding of the molecular mechanisms of salinity stress responses in C. hongkongensis and provided insights into the osmotic biology of oysters.
    MeSH term(s) Animals ; Crassostrea/metabolism ; Transcriptome ; Salt Stress ; Arginine/genetics ; Arginine/metabolism ; Proline/genetics ; Proline/metabolism ; Salinity
    Chemical Substances Arginine (94ZLA3W45F) ; Proline (9DLQ4CIU6V)
    Language English
    Publishing date 2024-01-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2212119-5
    ISSN 1878-0407 ; 1744-117X
    ISSN (online) 1878-0407
    ISSN 1744-117X
    DOI 10.1016/j.cbd.2024.101188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Automatic brain extraction for rat magnetic resonance imaging data using U

    Liang, Shengxiang / Yin, Xiaolong / Huang, Li / Huang, Jiayang / Yang, Junchao / Wang, Xiuxiu / Peng, Lixin / Zhang, Yusi / Li, Zuanfang / Nie, Binbin / Tao, Jing

    Physics in medicine and biology

    2023  Volume 68, Issue 20

    Abstract: Objective. ...

    Abstract Objective.
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/acf641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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