Article ; Online: Identifying the culprit lesion in tumor induced hypophosphatemia, the solution of a clinical enigma.
2016 Volume 54, Issue 3, Page(s) 642–647
Abstract: Tumor-induced osteomalacia is a rare acquired metabolic bone disorder characterized by isolated renal phosphate wasting due to abnormal tumor production of fibroblast growth factor 23. We report the case of a 59 year old woman referred to our department ... ...
| Abstract | Tumor-induced osteomalacia is a rare acquired metabolic bone disorder characterized by isolated renal phosphate wasting due to abnormal tumor production of fibroblast growth factor 23. We report the case of a 59 year old woman referred to our department with a long history of progressive diffuse muscle weakness and pain, generalized bone pains and multiple insufficiency fractures of heels, ankles and hips due to a hypophosphatemic osteomalacia. A fibroblast growth factor 23-producing phosphaturic mesenchymal tumor localized in the left quadriceps femoris muscle was identified 7 years after onset of symptoms. Excision of the tumor resulted in normalization of serum phosphate and fibroblast growth factor 23 levels and in complete resolution of the clinical picture with disappearance of all musculoskeletal symptoms. This case illustrates the diagnostic difficulties in establishing a diagnosis tumor-induced osteomalacia and in identifying the responsible tumor. Our case underscores the clinical need to investigate all patients with persistent musculoskeletal symptoms for hypophosphatemia. A systematic approach is of pivotal importance because early recognition and treatment of the metabolic abnormality can prevent deleterious effects of osteomalacia on the skeleton. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Female ; Fibroblast Growth Factors/secretion ; Humans ; Hypophosphatemia/diagnostic imaging ; Hypophosphatemia/etiology ; Middle Aged ; Muscle Neoplasms/diagnostic imaging ; Muscle Neoplasms/secretion ; Neoplasms, Connective Tissue/diagnostic imaging ; Neoplasms, Connective Tissue/etiology | |||||
| Chemical Substances | fibroblast growth factor 23 ; Fibroblast Growth Factors (62031-54-3) | |||||
| Language | English | |||||
| Publishing date | 2016-12 | |||||
| Publishing country | United States | |||||
| Document type | Case Reports ; Journal Article | |||||
| ZDB-ID | 1194484-5 | |||||
| ISSN | 1559-0100 ; 1355-008X ; 0969-711X | |||||
| ISSN (online) | 1559-0100 | |||||
| ISSN | 1355-008X ; 0969-711X | |||||
| DOI | 10.1007/s12020-016-1092-5 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 3884: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.