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Article ; Online: Identity Narratives in China and the EU’s Economic Diplomacy: Comparing the BRI and the EU Connectivity Strategy for Asia

Holzer, Constantin

Chinese National Identity in the Age of Globalisation

Abstract: The Belt and Road Initiative (BRI) and the EU Connectivity Strategy for Asia represent China and the EU’s respective flagship initiatives of economic diplomacy in the twenty-first century and offer two separate blueprints for shaping the future of shared ...

Abstract	The Belt and Road Initiative (BRI) and the EU Connectivity Strategy for Asia represent China and the EU’s respective flagship initiatives of economic diplomacy in the twenty-first century and offer two separate blueprints for shaping the future of shared economic prosperity on the Eurasian continent. The basic understanding of external economic engagement in China and the EU is heavily marked by the respective actors’ identity narratives—that is, ‘ national rejuvenation’ and national interest in the case of China, and ‘reconciliation’ and the support for rules-based multilateralism in the case of the European Union. While China and the EU pursue similar objectives, it is more the political questions of how to guarantee a ‘level playing field’ and ‘shared benefits’ that cause uncertainty and tension between them.
Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1007/978-981-15-4538-2_8
Database	COVID19

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Article ; Online: Differences in Automated External Defibrillator Types in Out-of-Hospital Cardiac Arrest Treated by Police First Responders.

Krammel, Mario / Eichelter, Jakob / Gatterer, Constantin / Lobmeyr, Elisabeth / Neymayer, Marco / Grassmann, Daniel / Holzer, Michael / Sulzgruber, Patrick / Schnaubelt, Sebastian

Journal of cardiovascular development and disease

2023 Volume 10, Issue 5

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd10050196
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparison of microfluidic platforms for the enrichment of circulating tumor cells in breast cancer patients.

Sajdik, Constantin / Schuster, Eva / Holzer, Barbara / Krainer, Michael / Deutschmann, Christine / Peter, Stefan / Marhold, Maximilian / Zeillinger, Robert / Obermayr, Eva

Breast cancer research and treatment

2022 Volume 196, Issue 1, Page(s) 75–85

Abstract: Purpose: Circulating tumor cells (CTCs) hold promise to be a non-invasive measurable biomarker in all cancer stages. Because the analysis of CTCs is still a technical challenge, we compared different types of microfluidic enrichment protocols to isolate ...

Abstract	Purpose: Circulating tumor cells (CTCs) hold promise to be a non-invasive measurable biomarker in all cancer stages. Because the analysis of CTCs is still a technical challenge, we compared different types of microfluidic enrichment protocols to isolate these rare cells from the blood. Methods: Blood samples from patients with early and metastatic breast cancer (BC) were processed using the microfluidic Parsortix® technology employing (i) a single-step cell separation using the standard GEN3D6.5 microfluidic cassette, (ii) a two-step separation with an upfront pre-enrichment, and (iii) a two-step separation with a different type of cassette. In the enriched cells, the gene expression levels of CTC-related transcripts were assessed using quantitative real-time PCR (qPCR) by Taqman® and Lightcycler (LC) technology. Results: 23/60 (38.3%) BC samples were assigned as positive due to the presence of at least one gene marker beyond the threshold level. The prevalence of epithelial markers was significantly higher in metastatic compared to early BC (EpCAM: 31.3% vs. 7.3%; CK19: 21.1% vs. 2.4%). A high level of concordance was observed between CK19 assessed by Taqman® and LC technology, and for detection of the BC-specific gene SCGB2A2. An upfront pre-enrichment resulted in lower leukocyte contamination, at the cost of fewer tumor cells captured. Conclusion: The Parsortix® system offers both reasonable recovery of tumor cells and depletion of contaminating leukocytes when the single-step separation using the GEN3D6.5 cassette is employed. Careful selection of suitable markers and cut-off thresholds is an essential point for the subsequent molecular analysis of the enriched cells.
MeSH term(s)	Biomarkers, Tumor/metabolism ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Epithelial Cell Adhesion Molecule/genetics ; Female ; Humans ; Microfluidics ; Neoplastic Cells, Circulating/pathology
Chemical Substances	Biomarkers, Tumor ; Epithelial Cell Adhesion Molecule
Language	English
Publishing date	2022-09-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-022-06717-x
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Article ; Online: Short-Term Hypocalcemia Prophylaxis With Calcitriol Before Thyroidectomy.

Sonnenberg, Stefanie / Scheunchen, Mandy / Smaxwil, Constantin Aurel / Weih, Heimo / Vorländer, Christian / Langer, Peter / Ostermann, Aaltje / Holzer, Katharina / Zielke, Andreas

Deutsches Arzteblatt international

2021 Volume 118, Issue 47, Page(s) 799–805

Abstract: Background: Total thyroidectomy is the most common surgical treatment of thyroid diseases, and postoperative hypocalcemia is its most common complication. Hypocalcemia prolongs the patient's hospital stay and impairs his or her quality of life. Although ...

Abstract	Background: Total thyroidectomy is the most common surgical treatment of thyroid diseases, and postoperative hypocalcemia is its most common complication. Hypocalcemia prolongs the patient's hospital stay and impairs his or her quality of life. Although a low vitamin D level is a recognized risk factor, the utility of preoperative vitamin D administration to prevent postoperative hypocalcemia is unclear. In this trial, therefore, we studied the effect of giving vitamin D before total thyroidectomy. Methods: In a multicenter, randomized, minimally interventional trial (registration number: DRKS 00005615), patients about to undergo total thyroidectomy were randomized either to an intervention group that received 0.5 μg of calcitriol per os twice daily for three days up to the day immediately before surgery, or to a control group that did not (no placebo was given). The primary endpoint was the absence of hypocalcemia (serum calcium <2.1 mmol/L) in the postoperative course. Results: Of the 287 patients recruited in six hospitals over the period 23 July 2014 to 20 March 2017, 246 were included in the final analysis. The intervention and control groups did not differ significantly with respect to the rate of postoperative hypocalcemia (29.2% and 33.6%, respectively; p = 0.546, power 8.8%). The duration of postoperative hypocalcemia was, however, shorter in the intervention group (3.5 vs. 7 days; p = 0.016, power 68%). The rates of hypocalcemia in the individual trial locations varied widely, ranging from 13.9% to 71.4%. Conclusion: Short-term administration of calcitriol did not affect the rate of occurrence of hypocalcemia after thyroidectomy, but did shorten its duration. The rate of postoperative hypocalcemia varied widely across hospitals, probably because of differences in surgical technique.
MeSH term(s)	Calcitriol/therapeutic use ; Calcium/therapeutic use ; Female ; Humans ; Hypocalcemia/epidemiology ; Hypocalcemia/prevention & control ; Male ; Postoperative Complications/epidemiology ; Quality of Life ; Thyroidectomy/adverse effects
Chemical Substances	Calcitriol (FXC9231JVH) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-10-24
Publishing country	Germany
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2406159-1
ISSN	1866-0452 ; 1866-0452
ISSN (online)	1866-0452
ISSN	1866-0452
DOI	10.3238/arztebl.m2021.0351
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Article: The potentials and limits of China-EU cooperation on climate change and energy security

Holzer, Constantin / Zhang, Haibin

Asia Europe journal : intercultural studies in the social sciences and humanities Vol. 6, No. 2 , p. 217-227

2008 Volume 6, Issue 2, Page(s) 217–227

Author's details	Constantin Holzer; Haibin Zhang
Keywords	Klimawandel ; Energieversorgung ; Internationale Wirtschaftsbeziehungen ; China ; EU-Staaten
Language	English
Publisher	Springer
Publishing place	Berlin
Document type	Article
ZDB-ID	2116984-6
Database	ECONomics Information System

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Article ; Online: Prolonged Activated Partial Thromboplastin Time after Successful Resuscitation from Cardiac Arrest is Associated with Unfavorable Neurologic Outcome.

Schriefl, Christoph / Schoergenhofer, Christian / Grafeneder, Juergen / Poppe, Michael / Clodi, Christian / Mueller, Matthias / Ettl, Florian / Jilma, Bernd / Wallmueller, Pia / Buchtele, Nina / Weikert, Constantin / Losert, Heidrun / Holzer, Michael / Sterz, Fritz / Schwameis, Michael

Thrombosis and haemostasis

2020 Volume 121, Issue 4, Page(s) 477–483

Abstract: Coagulation abnormalities after successful resuscitation from cardiac arrest may be associated with unfavorable neurologic outcome. We investigated a potential association of activated partial thromboplastin time (aPTT) with neurologic outcome in adult ... ...

Abstract	Coagulation abnormalities after successful resuscitation from cardiac arrest may be associated with unfavorable neurologic outcome. We investigated a potential association of activated partial thromboplastin time (aPTT) with neurologic outcome in adult cardiac arrest survivors. Therefore, we included all adults ≥18 years of age who suffered a nontraumatic cardiac arrest and had achieved return of spontaneous circulation between January 2013 and December 2018. Patients receiving anticoagulants or thrombolytic therapy and those subjected to extracorporeal membrane oxygenation support were excluded. Routine blood sampling was performed on admission as soon as a vascular access was available. The primary outcome was 30-day neurologic function, assessed by the Cerebral Performance Category scale (3-5 = unfavorable neurologic function). Multivariable regression was used to assess associations between normal (≤41 seconds) and prolonged (>41 seconds) aPTT on admission (exposure) and the primary outcome. Results are given as odds ratio (OR) with 95% confidence intervals (95% CIs). Out of 1,591 cardiac arrest patients treated between 2013 and 2018, 360 patients (32% female; median age: 60 years [interquartile range: 48-70]) were eligible for analysis. A total of 263 patients (73%) had unfavorable neurologic function at day 30. aPTT prolongation >41 seconds was associated with a 190% increase in crude OR of unfavorable neurologic function (crude OR: 2.89; 95% CI: 1.78-4.68,
MeSH term(s)	Adult ; Aged ; Blood Coagulation ; Blood Coagulation Disorders/blood ; Blood Coagulation Disorders/diagnosis ; Brain/physiopathology ; Female ; Heart Arrest/blood ; Heart Arrest/diagnosis ; Heart Arrest/physiopathology ; Heart Arrest/therapy ; Humans ; Male ; Middle Aged ; Neurologic Examination ; Partial Thromboplastin Time ; Patient Admission ; Predictive Value of Tests ; Recovery of Function ; Registries ; Resuscitation/adverse effects ; Return of Spontaneous Circulation ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2020-11-13
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/s-0040-1719029
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Article ; Online: Immune Response in Moderate to Critical Breakthrough COVID-19 Infection After mRNA Vaccination.

Frontiers in immunology

2022 Volume 13, Page(s) 816220

Abstract: SARS-CoV-2 variants of concern (VOCs) can trigger severe endemic waves and vaccine breakthrough infections (VBI). We analyzed the cellular and humoral immune response in 8 patients infected with the alpha variant, resulting in moderate to fatal COVID-19 ... ...

Abstract	SARS-CoV-2 variants of concern (VOCs) can trigger severe endemic waves and vaccine breakthrough infections (VBI). We analyzed the cellular and humoral immune response in 8 patients infected with the alpha variant, resulting in moderate to fatal COVID-19 disease manifestation, after double mRNA-based anti-SARS-CoV-2 vaccination. In contrast to the uninfected vaccinated control cohort, the diseased individuals had no detectable high-avidity spike (S)-reactive CD4+ and CD8+ T cells against the alpha variant and wild type (WT) at disease onset, whereas a robust CD4+ T-cell response against the N- and M-proteins was generated. Furthermore, a delayed alpha S-reactive high-avidity CD4+ T-cell response was mounted during disease progression. Compared to the vaccinated control donors, these patients also had lower neutralizing antibody titers against the alpha variant at disease onset. The delayed development of alpha S-specific cellular and humoral immunity upon VBI indicates reduced immunogenicity against the S-protein of the alpha VOC, while there was a higher and earlier N- and M-reactive T-cell response. Our findings do not undermine the current vaccination strategies but underline a potential need for the inclusion of VBI patients in alternative vaccination strategies and additional antigenic targets in next-generation SARS-CoV-2 vaccines.
MeSH term(s)	2019-nCoV Vaccine mRNA-1273/immunology ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Antibody Affinity/immunology ; BNT162 Vaccine/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; COVID-19/immunology ; COVID-19/mortality ; COVID-19 Vaccines/immunology ; Coronavirus M Proteins/immunology ; Coronavirus Nucleocapsid Proteins/immunology ; Female ; Humans ; Male ; Middle Aged ; Phosphoproteins/immunology ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Vaccination
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Coronavirus M Proteins ; Coronavirus Nucleocapsid Proteins ; Phosphoproteins ; Spike Glycoprotein, Coronavirus ; membrane protein, SARS-CoV-2 ; nucleocapsid phosphoprotein, SARS-CoV-2 ; spike protein, SARS-CoV-2 ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-01-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.816220
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Article ; Online: The SARS-COV-2 T-Cell Immunity is Directed Against the Spike, Membrane, and Nucleocapsid Protein and Associated with COVID 19 Severity

Thieme, Constantin / Anft, Moritz / Paniskaki, Krystallenia / Blázquez Navarro, Arturo / Doevelaar, Adrian / Seibert, Felix S. / Hölzer, Bodo / Konik, Margarethe Justine / Brenner, Thorsten / Tempfer, Clemens / Watzl, Carsten / Dolff, Sebastian / Dittmer, Ulf / Witzke, Oliver / Westhoff, Timm H. / Stervbo, Ulrik / Roch, Toralf / Babel, Nina

SSRN Electronic Journal ; ISSN 1556-5068

2020

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.2139/ssrn.3606763
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Prolonged Activated Partial Thromboplastin Time after Successful Resuscitation from Cardiac Arrest is Associated with Unfavorable Neurologic Outcome

Thrombosis and Haemostasis

2020 Volume 121, Issue 04, Page(s) 477–483

Abstract	Coagulation abnormalities after successful resuscitation from cardiac arrest may be associated with unfavorable neurologic outcome. We investigated a potential association of activated partial thromboplastin time (aPTT) with neurologic outcome in adult cardiac arrest survivors. Therefore, we included all adults ≥18 years of age who suffered a nontraumatic cardiac arrest and had achieved return of spontaneous circulation between January 2013 and December 2018. Patients receiving anticoagulants or thrombolytic therapy and those subjected to extracorporeal membrane oxygenation support were excluded. Routine blood sampling was performed on admission as soon as a vascular access was available. The primary outcome was 30-day neurologic function, assessed by the Cerebral Performance Category scale (3–5 = unfavorable neurologic function). Multivariable regression was used to assess associations between normal (≤41 seconds) and prolonged (>41 seconds) aPTT on admission (exposure) and the primary outcome. Results are given as odds ratio (OR) with 95% confidence intervals (95% CIs). Out of 1,591 cardiac arrest patients treated between 2013 and 2018, 360 patients (32% female; median age: 60 years [interquartile range: 48–70]) were eligible for analysis. A total of 263 patients (73%) had unfavorable neurologic function at day 30. aPTT prolongation >41 seconds was associated with a 190% increase in crude OR of unfavorable neurologic function (crude OR: 2.89; 95% CI: 1.78–4.68, p < 0.001) and with more than double the odds after adjustment for traditional risk factors (adjusted OR: 2.01; 95% CI: 1.13–3.60, p = 0.018). In conclusion, aPTT prolongation on admission is associated with unfavorable neurologic outcome after successful resuscitation from cardiac arrest.
Keywords	cardiac arrest ; survival ; activated partial thromboplastin time
Language	English
Publishing date	2020-11-13
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/s-0040-1719029
Database	Thieme publisher's database

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Uh III Zs.192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11a

Anft, Moritz / Paniskaki, Krystallenia / Blazquez-Navarro, Arturo / Doevelaar, Adrian / Seibert, Felix S / Hölzer, Bodo / Skrzypczyk, Sarah / Kohut, Eva / Kurek, Julia / Zapka, Jan / Wehler, Patrizia / Kaliszczyk, Sviatlana / Bajda, Sharon / Thieme, Constantin J / Roch, Toralf / Konik, Margarethe Justine / Berger, Marc Moritz / Brenner, Thorsten / Kölsch, Uwe /

Meister, Toni L / Pfaender, Stephanie / Steinmann, Eike / Tempfer, Clemens / Watzl, Carsten / Dolff, Sebastian / Dittmer, Ulf / Abou-El-Enein, Mohamed / Westhoff, Timm H / Witzke, Oliver / Stervbo, Ulrik / Babel, Nina

Molecular therapy : the journal of the American Society of Gene Therapy

2020 Volume 28, Issue 12, Page(s) 2691–2702

Abstract: Preventing the progression to acute respiratory distress syndrome (ARDS) in COVID-19 is an unsolved challenge. The involvement of T cell immunity in this exacerbation remains unclear. To identify predictive markers of COVID-19 progress and outcome, we ... ...

Abstract	Preventing the progression to acute respiratory distress syndrome (ARDS) in COVID-19 is an unsolved challenge. The involvement of T cell immunity in this exacerbation remains unclear. To identify predictive markers of COVID-19 progress and outcome, we analyzed peripheral blood of 10 COVID-19-associated ARDS patients and 35 mild/moderate COVID-19 patients, not requiring intensive care. Using multi-parametric flow cytometry, we compared quantitative, phenotypic, and functional characteristics of circulating bulk immune cells, as well as SARS-CoV-2 S-protein-reactive T cells between the two groups. ARDS patients demonstrated significantly higher S-protein-reactive CD4
MeSH term(s)	Adult ; Aged ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; COVID-19/immunology ; COVID-19/virology ; Female ; Humans ; Immunologic Memory/immunology ; Male ; Membrane Glycoproteins/immunology ; Middle Aged ; Pandemics ; Respiratory Distress Syndrome/immunology ; Respiratory Distress Syndrome/pathology ; Respiratory Distress Syndrome/virology ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; T-Lymphocyte Subsets/immunology ; Vitronectin
Chemical Substances	Membrane Glycoproteins
Keywords	covid19
Language	English
Publishing date	2020-10-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1016/j.ymthe.2020.10.001
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