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  1. Article: Historical perspective. David Ferrier (1843-1928).

    Horwitz, N H

    Neurosurgery

    1994  Volume 35, Issue 4, Page(s) 793–795

    MeSH term(s) History, 19th Century ; History, 20th Century ; Neurosurgery/history ; Scotland
    Language English
    Publishing date 1994-10
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/00006123-199410000-00042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424: Show issues Location:
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    Zs.MO 539: Show issues

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  2. Article: F. A. Hayek and the modern economy, economic organization and activity, ed. by Sandra J. Peart and David M. Levy : 1. ed., Basingstoke, Hampshire [u.a.], Palgrave Macmillan, 2013 / [rezensiert von:] Steven Horwitz

    Horwitz, Steven / Peart, Sandra J

    Journal of economic literature Bd. LII.2014, 4 (Dec.), S. 1165-1167

    2014  

    Language English
    Publisher Assoc
    Publishing place Nashville, Tenn
    Document type Article
    ZDB-ID 3076-4 ; 2010159-4
    ISSN 0022-0515
    ISSN 0022-0515
    Database ECONomics Information System

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  3. Article ; Online: Management of suicidal risk in the emergency department: A clinical pathway using the computerized adaptive screen for suicidal youth.

    Grupp-Phelan, Jacqueline / Horwitz, Adam / Brent, David / Chernick, Lauren / Shenoi, Rohit / Casper, Charlie / Webb, Michael / King, Cheryl

    Journal of the American College of Emergency Physicians open

    2024  Volume 5, Issue 2, Page(s) e13132

    Abstract: Objective: Given the critical need for efficient and tailored suicide screening for youth presenting in the emergency department (ED), this study establishes validated screening score thresholds for the Computerized Adaptive Screen for Suicidal Youth ( ... ...

    Abstract Objective: Given the critical need for efficient and tailored suicide screening for youth presenting in the emergency department (ED), this study establishes validated screening score thresholds for the Computerized Adaptive Screen for Suicidal Youth (CASSY) and presents an example of a suicide risk classification pathway.
    Methods: Participants were primarily from the Study One derivation cohort of the Emergency Department Screen for Teens at Risk for Suicide (ED-STARS) enrolled in collaboration with Pediatric Emergency Care Applied Research Networks (PECARN). CASSY scores corresponded to the predicted probabilities of a suicide attempt in the next 3 months and risk thresholds were classified as minimal (<1%), low (1%-5%), moderate (5%-10%), and high (>10%). CASSY scores were compared to risk thresholds derived from clinical consensus and ED complaints and dispositions. CASSY risk thresholds were also examined as predictors of future suicide attempts in the Study Two validation cohort of ED-STARS.
    Results: A total of 1452 teens were enrolled with a median age of 15.2 years, 59.5% were female, 55.6% were White, 22% were Black, 22.3% were Latinx, and 42.8% received public assistance. The clinical consensus suicide risk groups were strongly associated with the CASSY-predicted risk thresholds. Suicide attempts in the Study Two cohort occurred at a frequency consistent with the CASSY-predicted thresholds.
    Conclusions: The CASSY can be a valuable tool in providing patient-specific risk probabilities for a suicide attempt at 3 months and tailor the threshold cutoffs based on the availability of local mental health resources. We give an example of a clinical risk pathway, which should include segmentation of the ED population by medical versus psychiatric chief complaint.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ISSN 2688-1152
    ISSN (online) 2688-1152
    DOI 10.1002/emp2.13132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Strategies to Use Nanoparticles to Generate CD4 and CD8 Regulatory T Cells for the Treatment of SLE and Other Autoimmune Diseases.

    Horwitz, David A / Bickerton, Sean / La Cava, Antonio

    Frontiers in immunology

    2021  Volume 12, Page(s) 681062

    Abstract: Autoimmune diseases are disorders of immune regulation where the mechanisms responsible for self-tolerance break down and pathologic T cells overcome the protective effects of T regulatory cells (Tregs) that normally control them. The result can be the ... ...

    Abstract Autoimmune diseases are disorders of immune regulation where the mechanisms responsible for self-tolerance break down and pathologic T cells overcome the protective effects of T regulatory cells (Tregs) that normally control them. The result can be the initiation of chronic inflammatory diseases. Systemic lupus erythematosus (SLE) and other autoimmune diseases are generally treated with pharmacologic or biological agents that have broad suppressive effects. These agents can halt disease progression, yet rarely cure while carrying serious adverse side effects. Recently, nanoparticles have been engineered to correct homeostatic regulatory defects and regenerate therapeutic antigen-specific Tregs. Some approaches have used nanoparticles targeted to antigen presenting cells to switch their support from pathogenic T cells to protective Tregs. Others have used nanoparticles targeted directly to T cells for the induction and expansion of CD4+ and CD8+ Tregs. Some of these T cell targeted nanoparticles have been formulated to act as tolerogenic artificial antigen presenting cells. This article discusses the properties of these various nanoparticle formulations and the strategies to use them in the treatment of autoimmune diseases. The restoration and maintenance of Treg predominance over effector cells should promote long-term autoimmune disease remission and ultimately prevent them in susceptible individuals.
    MeSH term(s) Animals ; Antigen-Presenting Cells/immunology ; Antigen-Presenting Cells/metabolism ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Biomarkers ; Clinical Decision-Making ; Cytokines/metabolism ; Disease Management ; Humans ; Immune Tolerance ; Immunomodulation ; Immunotherapy/methods ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/therapy ; Nanoparticles ; Signal Transduction ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Treatment Outcome
    Chemical Substances Biomarkers ; Cytokines
    Language English
    Publishing date 2021-06-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.681062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: DO STANDARDS OF CARE MATTER? AND WHY AREN'T THEY BEING MET?.

    Horwitz, David L

    Physician leadership journal

    2019  Volume 3, Issue 6, Page(s) 18–21

    Abstract: Quality metrics have become a fact of life in medical care. In general, these metrics are based either on published standards of care or on "best practice" statistics. Some controversy surrounds the basis for metrics. ...

    Abstract Quality metrics have become a fact of life in medical care. In general, these metrics are based either on published standards of care or on "best practice" statistics. Some controversy surrounds the basis for metrics.
    MeSH term(s) Evidence-Based Medicine ; Guideline Adherence ; Humans ; Standard of Care ; United States
    Language English
    Publishing date 2019-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2815740-0
    ISSN 2374-4030
    ISSN 2374-4030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Editorial: Generating and Sustaining Stable Autoantigen-Specific CD4 and CD8 Regulatory T Cells in Lupus.

    Datta, Syamal K / Horwitz, David A / Piccirillo, Ciriaco A / La Cava, Antonio

    Frontiers in immunology

    2022  Volume 13, Page(s) 838604

    MeSH term(s) Autoantigens ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Lupus Erythematosus, Systemic/immunology ; T-Lymphocytes, Regulatory
    Chemical Substances Autoantigens
    Language English
    Publishing date 2022-03-07
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.838604
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  7. Article ; Online: Nanoparticle-mediated Delivery of IL-2 To T Follicular Helper Cells Protects BDF1 Mice from Lupus-like Disease.

    Ferretti, Concetta / Horwitz, David A / Bickerton, Sean / La Cava, Antonio

    Rheumatology and immunology research

    2021  Volume 2, Issue 3, Page(s) 185–193

    Abstract: We recently reported that poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) loaded with interleukin (IL)-2 and targeted to T cells inhibited the development of lupus-like disease in BDF1 mice by inducing functional T regulatory cells (Tregs). Here ... ...

    Abstract We recently reported that poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) loaded with interleukin (IL)-2 and targeted to T cells inhibited the development of lupus-like disease in BDF1 mice by inducing functional T regulatory cells (Tregs). Here we show that the protection from disease and the extended survival of BDF1 mice provided by IL-2-loaded NPs targeted to T cells is not only due to an induction of Tregs but also contributed by an inhibition of T follicular helper (T
    Language English
    Publishing date 2021-12-15
    Publishing country Germany
    Document type Journal Article
    ISSN 2719-4523
    ISSN (online) 2719-4523
    DOI 10.2478/rir-2021-0024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Nanoparticles Engineered as Artificial Antigen-Presenting Cells Induce Human CD4

    Giang, Sophia / Horwitz, David A / Bickerton, Sean / La Cava, Antonio

    Frontiers in immunology

    2021  Volume 12, Page(s) 628059

    Abstract: Artificial antigen-presenting cells (aAPCs) are synthetic versions of naturally occurring antigen-presenting cells (APCs) that, similar to natural APCs, promote efficient T effector cell ... ...

    Abstract Artificial antigen-presenting cells (aAPCs) are synthetic versions of naturally occurring antigen-presenting cells (APCs) that, similar to natural APCs, promote efficient T effector cell responses
    MeSH term(s) Animals ; Antigen-Presenting Cells/immunology ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Disease Models, Animal ; Forkhead Transcription Factors/metabolism ; Graft vs Host Disease/genetics ; Graft vs Host Disease/immunology ; Graft vs Host Disease/metabolism ; Graft vs Host Disease/prevention & control ; Humans ; Interleukin-2/chemistry ; Interleukin-2/pharmacology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/transplantation ; Mice, Inbred NOD ; Mice, SCID ; Nanoparticles ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Proof of Concept Study ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/chemistry ; Transforming Growth Factor beta/pharmacology ; Mice
    Chemical Substances FOXP3 protein, human ; Forkhead Transcription Factors ; Interleukin-2 ; Transforming Growth Factor beta ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS)
    Language English
    Publishing date 2021-05-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.628059
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  9. Article ; Online: Somatic mutations in FAS pathway increase hemophagocytic lymphohistiocytosis risk in T- and/or NK-cell lymphoma patients.

    Liu, Ying / Sardana, Rohan / Nemirovsky, David / Frosina, Denise / Jungbluth, Achim / Johnson, William T / Vardhana, Santosha A / Arcila, Maria E / Horwitz, Steven M / Derkach, Andriy / Dogan, Ahmet / Xiao, Wenbin

    Blood advances

    2024  

    Abstract: While significant progress has been made in understanding the genetic basis of primary hemophagocytic lymphohistiocytosis (HLH), the pathogenesis of secondary HLH, the more prevalent form, remains unclear. Among the various conditions giving rise to ... ...

    Abstract While significant progress has been made in understanding the genetic basis of primary hemophagocytic lymphohistiocytosis (HLH), the pathogenesis of secondary HLH, the more prevalent form, remains unclear. Among the various conditions giving rise to secondary HLH, HLH in lymphoma patients (HLH-L) accounts for a substantial proportion. In this study, we investigated the role of somatic mutations in the pathogenesis of HLH-L in a cohort of patients with T- and/or NK-cell lymphoma. We identified a 3-time higher frequency of mutations in FAS pathway in patients with HLH-L. Patients harbouring these mutations had a 5-time increased HLH-L risk. These mutations were independently associated with inferior outcome. Hence, our study demonstrates the association between somatic mutations in FAS pathway and HLH-L. Further studies are warranted on the mechanistic role of these mutations in HLH-L.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023011733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The effect of postpartum lifestyle interventions on blood pressure: a systematic literature review.

    Murray Horwitz, Mara E / Tabani, Alaina / Brédy, G Saradjha / Flynn, David B / Edwards, Camille V / Curran, Nadia J / Parikh, Nisha I

    Journal of hypertension

    2023  Volume 41, Issue 8, Page(s) 1231–1238

    Abstract: Postpartum lifestyle modification is recommended to hypertension risk. We conducted a systematic literature review to assess the evidence for postpartum lifestyle interventions to reduce blood pressure. We searched for relevant publications from 2010 ... ...

    Abstract Postpartum lifestyle modification is recommended to hypertension risk. We conducted a systematic literature review to assess the evidence for postpartum lifestyle interventions to reduce blood pressure. We searched for relevant publications from 2010 through November 2022. Two authors independently conducted article screening and data extraction; a third resolved discrepancies. Ultimately, nine studies met inclusion criteria. Most were randomized controlled trials and had sample sizes <100. In all but one of the eight studies reporting race data, nearly all participants identified as White. None of the studies reported a significant intervention effect on blood pressure. However, most interventions were associated with improvements in other outcomes, such as physical activity. Overall, the evidence for postpartum lifestyle interventions to reduce blood pressure is limited to a handful of studies characterized by small sample sizes and a lack of racial diversity. Additional research with larger samples, more diverse populations, and intermediate outcomes is warranted.
    MeSH term(s) Female ; Humans ; Blood Pressure ; Postpartum Period ; Life Style ; Exercise
    Language English
    Publishing date 2023-06-02
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003477
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    Zs.MO 614: Show issues

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