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Article ; Online: Fulminant intracranial hypertension as a result of otological surgery: case report and discussion of management.

Morris, A / Higgins, J N / Axon, P R

2021 Volume 135, Issue 6, Page(s) 551–554

Abstract: Background: Dural venous sinus injury is a rare complication of otological surgery that can lead to life-threatening sequelae, the management of which is complex and poorly described.: Case report: This paper describes the case of a 40-year-old ... ...

Abstract	Background: Dural venous sinus injury is a rare complication of otological surgery that can lead to life-threatening sequelae, the management of which is complex and poorly described. Case report: This paper describes the case of a 40-year-old female who underwent routine right myringoplasty complicated by sigmoid sinus laceration. The patient subsequently developed right-sided lateral sinus thrombosis leading to fulminant intracranial hypertension. The patient underwent successful emergency management by surgical reconstruction of the sigmoid sinus, followed by endovascular thrombolysis, catheter balloon angioplasty and endovascular stenting. Conclusion: Torrential haemorrhage following otological procedures is uncommon and rarely requires packing of a bleeding venous sinus. This case highlights that injury to a highly dominant venous sinus can lead to venous outflow obstruction and life-threatening intracranial hypertension. To our knowledge, the development of this complication following otological surgery and its management has not been reported previously.
MeSH term(s)	Adult ; Female ; Humans ; Intracranial Hypertension/diagnostic imaging ; Intracranial Hypertension/etiology ; Intracranial Hypertension/therapy ; Myringoplasty/adverse effects ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Severity of Illness Index
Language	English
Publishing date	2021-06-01
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215121001262
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Article ; Online: Post-trial access to implantable neural devices: an exploratory international survey.

Higgins, Nathan / Gardner, John / Wexler, Anna / Kellmeyer, Philipp / O'Brien, Kerry / Carter, Adrian

BMJ surgery, interventions, & health technologies

2024 Volume 6, Issue 1, Page(s) e000262

Abstract: ... groups.: Design setting and participants: Trial investigators (n=66) completed a survey on post-trial ...

Abstract	Objectives: Clinical trials of innovative neural implants are rapidly increasing and diversifying, but little is known about participants' post-trial access to the device and ongoing clinical care. This exploratory study examines common practices in the planning and coordination of post-trial access to neurosurgical devices. We also explore the perspectives of trial investigators on the barriers to post-trial access and ongoing care, as well as ethical questions related to the responsibilities of key stakeholder groups. Design setting and participants: Trial investigators (n=66) completed a survey on post-trial access in the most recent investigational trial of a surgically implanted neural device they had conducted. Survey respondents predominantly specialized in neurosurgery, neurology and psychiatry, with a mean of 14.8 years of experience working with implantable neural devices. Main outcome measures: Outcomes of interest included rates of device explantation during or at the conclusion of the trial (pre-follow-up) and whether plans for post-trial access were described in the study protocol. Outcomes also included investigators' greatest 'barrier' and 'facilitator' to providing research participants with post-trial access to functional implants and perspectives on current arrangements for the sharing of post-trial responsibilities among key stakeholders. Results: Trial investigators reported either 'all' (64%) or 'most' (33%) trial participants had remained implanted after the end of the trial, with 'infection' and 'non-response' the most common reasons for explantation. When asked to describe the main barriers to facilitating post-trial access, investigators described limited funding, scarcity of expertise and specialist clinical infrastructure and difficulties maintaining stakeholder relationships. Notwithstanding these barriers, investigators overwhelmingly (95%) agreed there is an ethical obligation to provide post-trial access when participants individually benefit during the trial. Conclusions: On occasions when devices were explanted during or at the end of the trial, this was done out of concern for the safety and well-being of participants. Further research into common practices in the post-trial phase is needed and essential to ethical and pragmatic discussions regarding stakeholder responsibilities.
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ISSN	2631-4940
ISSN (online)	2631-4940
DOI	10.1136/bmjsit-2024-000262
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Article ; Online: Hydrothermal Alkaline Treatment (HALT) of Foam Fractionation Concentrate Derived from PFAS-Contaminated Groundwater.

Hao, Shilai / Reardon, Patrick N / Choi, Youn Jeong / Zhang, Chuhui / Sanchez, Juan Moises / Higgins, Christopher P / Strathmann, Timothy J

Environmental science & technology

2023 Volume 57, Issue 44, Page(s) 17154–17165

Abstract: While foam fractionation (FF) process has emerged as a promising technology for removal of per- and polyfluoroalkyl substances (PFASs) from contaminated groundwater, management of the resulting foam concentrates with elevated concentrations of PFASs (e.g. ...

Abstract	While foam fractionation (FF) process has emerged as a promising technology for removal of per- and polyfluoroalkyl substances (PFASs) from contaminated groundwater, management of the resulting foam concentrates with elevated concentrations of PFASs (e.g., >1 g/L) remains a challenge. Here, we applied hydrothermal alkaline treatment (HALT) to two foam concentrates derived from FF field demonstration projects that treated aqueous film-forming foam (AFFF)-impacted groundwater. Results showed >90% degradation and defluorination within 90 min of treatment (350 °C, 1 M NaOH) of all 62 PFASs (including cations, anions, and zwitterions) identified in foam concentrates. Observed rate constants for degradation of individual perfluoroalkyl sulfonates (PFSAs, C
MeSH term(s)	Water Pollutants, Chemical/analysis ; Fluorocarbons/analysis ; Groundwater/chemistry ; Water ; Chlorides/analysis
Chemical Substances	Water Pollutants, Chemical ; Fluorocarbons ; Water (059QF0KO0R) ; Chlorides
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c05140
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Article ; Online: Synergistic Fire Resistance of Nanobrick Wall Coated 3D Printed Photopolymer Lattices.

Kolibaba, Thomas J / Iverson, Ethan T / Legendre, Hudson / Higgins, Callie I / Buck, Zachary N / Weeks, Timothy S / Grunlan, Jaime C / Killgore, Jason P

ACS applied materials & interfaces

2023 Volume 15, Issue 12, Page(s) 16046–16054

Abstract: Photopolymer additive manufacturing has become the subject of widespread interest in recent years due to its capacity to enable fabrication of difficult geometries that are impossible to build with traditional manufacturing methods. The flammability of ... ...

Abstract	Photopolymer additive manufacturing has become the subject of widespread interest in recent years due to its capacity to enable fabrication of difficult geometries that are impossible to build with traditional manufacturing methods. The flammability of photopolymer resin materials and the lattice structures enabled by 3D printing is a barrier to widespread adoption that has not yet been adequately addressed. Here, a water-based nanobrick wall coating is deposited on 3D printed parts with simple (i.e., dense solid) or complex (i.e., lattice) geometries. When subject to flammability testing, the printed parts exhibit no melt dripping and a propensity toward failure at the print layer interfaces. Moving from a simple solid geometry to a latticed geometry leads to reduced time to failure during flammability testing. For nonlatticed parts, the coating provides negligible improvement in fire resistance, but coating of the latticed structures significantly increases time to failure by up to ≈340% compared to the uncoated lattice. The synergistic effect of coating and latticing is attributed to the lattice structures' increased surface area to volume ratio, allowing for an increased coating:photopolymer ratio and the ability of the lattice to better accommodate thermal expansion strains. Overall, nanobrick wall coated lattices can serve as metamaterials to increase applications of polymer additive manufacturing in extreme environments.
Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c00177
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Article ; Online: Hepatic infarction, hematoma, and rupture in HELLP syndrome: support for a vasospastic hypothesis.

McCormick, P A / Higgins, M / McCormick, C A / Nolan, N / Docherty, J R

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2021 Volume 35, Issue 25, Page(s) 7942–7947

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Humans ; Female ; Pregnancy ; HELLP Syndrome/epidemiology ; Hepatic Infarction ; Posterior Leukoencephalopathy Syndrome/complications ; Placenta ; Liver Diseases/complications ; Hematoma/complications ; Hemorrhage ; Ischemia
Language	English
Publishing date	2021-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2021.1939299
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Zs.A 3510: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Discrepancies in Non-Mohs Micrographic Surgery for Non-melanoma Skin Cancer Between Lighter-Skinned and Darker-Skinned Patients.

Borda, Luis J / Encarnacion, Iain Noel M / Saal, Ryan C / Higgins Ii, H William / Pariser, Robert J

Cureus

2024 Volume 16, Issue 2, Page(s) e54027

Abstract: ... was found in LSP (n=9; 50.0% female; p=0.23). Time-to-diagnosis was significantly longer in DSP ... used to determine the association between continuous variables. P-values <0.05 were considered ... were DSP. Patients of darker skin were predominantly female (n=7; 77.8%), while no gender predilection ...

Abstract	Background: Non-melanoma skin cancer (NMSC) is highly prevalent in the United States, with darker-skinned patients (DSP) exhibiting lower incidence but increased morbidity and mortality. The purpose of this study is to elucidate NMSC disparities between DSP (Fitzpatrick skin phototype IV or more) and lighter-skinned patients (LSP, Fitzpatrick skin phototype III or less), focusing on surgical features of non-Mohs micrographic surgery-treated NMSC. Methods: This retrospective cohort study included LSP and DSP diagnosed with either basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) in an academic dermatology setting. Variables collected included age, gender, type of NMSC, location, staging, time-to-diagnosis (TTD), pre-operative lesion size, and post-operative defect size. Categorical variables were reported as counts and percentages, while the association between categorical variables was assessed using a two-tailed Fisher's test. A paired t-test was used to determine the association between continuous variables. P-values <0.05 were considered statistically significant. Results: A total of 27 patients with NMSC were identified, of which 9 (33.3%) were DSP. Patients of darker skin were predominantly female (n=7; 77.8%), while no gender predilection was found in LSP (n=9; 50.0% female; p=0.23). Time-to-diagnosis was significantly longer in DSP than in LSP (61.3 weeks vs 25.1 weeks, respectively; p = 0.02). Despite this, there was no statistical difference in terms of staging, pre-operative lesion size (11.89 mm in DSP vs 10.76 mm in LSP, p=0.75), and post-operative defect size (45.56 ± 29.21 mm in DSP vs 31.22 ± 19.60 mm in LSP; p=0.33). Conclusions: Darker-skinned patients had a longer TTD without staging differences. Our study confirms the need for reducing TTDs for NMSC in DSP. Action initiatives include continued educational efforts to increase awareness of NMSC risk in DSP and more rigorous routine skin cancer screening.
Language	English
Publishing date	2024-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.54027
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Article ; Online: Quantification of long-chain, short-chain, and ultrashort-chain liquid chromatography-amenable PFASs in water: Evaluation of approaches and tradeoffs for AFFF-impacted water.

Zhang, Chuhui / Hao, Shilai / Gonda, Nicholas / Zhi, Yue / Strathmann, Timothy J / Schaefer, Charles E / Higgins, Christopher P

Journal of hazardous materials

2024 Volume 466, Page(s) 133591

Abstract: The widespread use of aqueous film-forming foam (AFFF) for firefighting and firefighter training has led to extensive per- and polyfluoroalkyl substance (PFAS) contamination in the environment. Challenges remain in the analytical determination of PFASs ... ...

Abstract	The widespread use of aqueous film-forming foam (AFFF) for firefighting and firefighter training has led to extensive per- and polyfluoroalkyl substance (PFAS) contamination in the environment. Challenges remain in the analytical determination of PFASs via liquid chromatography-mass spectrometry (LC-MS), particularly when attempting to include ultrashort-chain perfluoroalkyl acids (PFAAs) and longer-chain anionic and zwitterionic PFASs in a single direct injection. In this study, we assessed the performance of three analytical LC columns (C18, JJ, and Acclaim columns) to separate targeted and suspect PFASs in AFFF-impacted water samples collected from five sites. The C18 column failed to retain ultrashort-chain PFAAs while the JJ and Acclaim columns were not suitable for hydrophobic PFASs. Ultrashort-chain PFAAs were detected at three sites and comprised 1.6-18% of the total perfluoroalkyl carboxylic and sulfonic acids. Semi-quantified concentrations of suspect PFASs comprised 0.70-13% of the total PFASs. When attempting to capture the entirety of the PFAS mass in a water sample, the C18 column captured the broadest suite of suspect PFASs, while the JJ column quantified the most total PFAS mass. Results of this study highlight the importance and tradeoffs of LC column choice to comprehensively determine the composition of PFASs and their concentrations in AFFF-impacted water samples.
Language	English
Publishing date	2024-01-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.133591
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Article ; Online: Robotic Repair: An Alternative Technique for Rectus Diastasis and Abdominal Bulge Following DIEP Flap Breast Reconstruction.

Herold, Kaila / Stoddard, Timothy / Rodriguez-Unda, Nelson / LoGiudice, John / Hettinger, Patrick / Higgins, Rana M / Doren, Erin L

Aesthetic surgery journal

2024

Abstract: Background: The Deep Inferior Epigastric Artery Perforator (DIEP) flap is the gold standard in autologous breast reconstruction. Despite advances in perforator dissection, abdominal morbidity still occurs. Traditional rectus diastasis (RD), abdominal ... ...

Abstract	Background: The Deep Inferior Epigastric Artery Perforator (DIEP) flap is the gold standard in autologous breast reconstruction. Despite advances in perforator dissection, abdominal morbidity still occurs. Traditional rectus diastasis (RD), abdominal bulge, and hernia repair with open techniques are associated with higher complication rates and recurrence. Objectives: We present a novel case series of robotic repair of symptomatic RD and/or abdominal bulge with concurrent hernia following DIEP flap surgery. Methods: A single-center, retrospective review was conducted on 10 patients who underwent bilateral DIEP flap breast reconstruction and subsequent robotic repair of RD and/or abdominal bulge and hernia. Pre-operative demographics and post-operative clinical outcomes were reviewed. RD up to 5 cm, abdominal bulge, and any concurrent ventral/umbilical hernias were repaired robotically via retrorectus plication and macroporus mesh reinforcement. Results: The average age and BMI were 49 years (range 41-63) and 31 kg/m2 (range 26-44), respectively. The average number of perforators harvested per flap was 2.5 (range 1-4). Average RD and hernia size were 3.95 cm (range 2-5) and 5.8 cm2 (1-15), respectively. Eight patients stayed one night in the hospital, two went home the same day as the robotic repair. No patients converted to open technique and none experienced complications within 30 days. Conclusions: For the patients who experience donor site morbidity following DIEP flap breast reconstruction, minimally invasive robotic repair of RD and/or abdominal bulge with hernia can be performed with mesh reinforcement. This technique is effective with low complication rates and should be considered over open repair.
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjae059
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Zs.A 5721: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 570: Show issues

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Article ; Online: Impact of time to surgical treatment in Merkel cell carcinoma: Surveillance, Epidemiology, and End Results-based population study.

Lin, Stephanie K / Deitermann, Annika M / Haynes, Dylan / Ricciardelli, Kaley / Etzkorn, Jeremy R / Miller, Christopher J / Higgins, H William / Giordano, Cerrene N / McMurray, Stacy L / Walker, Joanna L / Zhang, Junqian / Nguyen, Harrison P / Sobanko, Joseph F

Journal of the American Academy of Dermatology

2023 Volume 90, Issue 1, Page(s) 208–210

MeSH term(s)	Humans ; Carcinoma, Merkel Cell/epidemiology ; Carcinoma, Merkel Cell/surgery ; Carcinoma, Merkel Cell/pathology ; Skin Neoplasms/epidemiology ; Skin Neoplasms/surgery ; Skin Neoplasms/pathology ; Neoplasm Staging ; SEER Program
Language	English
Publishing date	2023-09-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.09.058
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Zs.A 1540: Show issues

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Article ; Online: Perianal and anal skin cancers treated with Mohs micrographic surgery and interdisciplinary care: Local recurrence rates and patient-reported outcomes.

Nugent, Shannon T / Raj, Leela K / Aarons, Cary B / Saur, Nicole M / Kovach, Stephen J / Fischer, John P / Etzkorn, Jeremy R / Shin, Thuzar M / Giordano, Cerrene N / Higgins, H William / Walker, Joanna L / Miller, Christopher J

Journal of the American Academy of Dermatology

2023 Volume 89, Issue 6, Page(s) 1283–1285

MeSH term(s)	Humans ; Mohs Surgery ; Skin Neoplasms/surgery ; Skin ; Anus Neoplasms/surgery ; Patient Reported Outcome Measures ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/surgery ; Retrospective Studies
Language	English
Publishing date	2023-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.07.1034
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