Article ; Online: Progress in the Treatment of Pulmonary Hypertension Associated with Interstitial Lung Disease.
American journal of respiratory and critical care medicine
2023 Volume 208, Issue 3, Page(s) 238–246
Abstract: Pulmonary hypertension, frequently complicating the course of patients with fibrotic interstitial lung disease, is associated with significantly increased morbidity and mortality. The availability of multiple medications to treat pulmonary arterial ... ...
| Abstract | Pulmonary hypertension, frequently complicating the course of patients with fibrotic interstitial lung disease, is associated with significantly increased morbidity and mortality. The availability of multiple medications to treat pulmonary arterial hypertension has resulted in these agents being used beyond their original indication, including in patients with interstitial lung disease. Whether pulmonary hypertension in the context of interstitial lung disease is an adaptive response not to be treated or a maladaptive phenomenon amenable to therapy has been uncertain. Although some studies have suggested a benefit of treatment, there have been others demonstrating harm. This concise clinical review provides an overview of prior studies and the issues that have plagued drug development for a patient population in dire need of treatment options. More recently, there has been a paradigm shift, with the largest study to date demonstrating benefit, resulting in the first approved therapy in the United States for patients with interstitial lung disease complicated by pulmonary hypertension. A pragmatic management algorithm in the context of changing definitions, comorbid contributors, and an available treatment option is provided, as are considerations for future clinical trials. |
|---|---|
| MeSH term(s) | Humans ; Familial Primary Pulmonary Hypertension/complications ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/etiology ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/drug therapy ; Pulmonary Arterial Hypertension/complications |
| Language | English |
| Publishing date | 2023-05-07 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 1180953-x |
| ISSN | 1535-4970 ; 0003-0805 ; 1073-449X |
| ISSN (online) | 1535-4970 |
| ISSN | 0003-0805 ; 1073-449X |
| DOI | 10.1164/rccm.202212-2342CI |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Uh II Zs.80: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.