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  1. Article ; Online: The 4-min mile and supplemental oxygen in IPF.

    Swigris, Jeffrey J

    Respirology (Carlton, Vic.)

    2020  Volume 25, Issue 11, Page(s) 1114–1115

    MeSH term(s) Exercise Tolerance ; Humans ; Hypertension, Pulmonary ; Idiopathic Pulmonary Fibrosis/therapy ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2020-06-22
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13890
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    Zs.A 4957: Show issues Location:
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  2. Article ; Online: Digital outcome measures in pulmonary clinical trials.

    Farrand, Erica / Swigris, Jeffrey J

    Current opinion in pulmonary medicine

    2023  Volume 29, Issue 4, Page(s) 322–327

    Abstract: Purpose of review: We highlight recent advances in the development and use of digital outcome measures in clinical trials, focusing on how to select the appropriate technology, use digital data to define trial endpoints, and glean important lessons from ...

    Abstract Purpose of review: We highlight recent advances in the development and use of digital outcome measures in clinical trials, focusing on how to select the appropriate technology, use digital data to define trial endpoints, and glean important lessons from current experiences with digital outcome measures in pulmonary medicine.
    Recent findings: A review of emerging literature demonstrates that the use of digital health technologies, particularly pulse oximeters, remote spirometers, accelerometers, and Electronic Patient-Reported Outcomes, has surged in both pulmonary practice and clinical trials. Lessons learned from their use can help researchers to design the next generation of clinical trials leveraging digital outcomes to improve health.
    Summary: In pulmonary diseases, digital health technologies provide validated, reliable, and usable data on patients in real-world environments. More broadly, digital endpoints have accelerated innovation in clinical trial design, improved clinical trial efficiency, and centered patients. As investigators adopt digital health technologies, it is important to follow a framework informed by both the opportunities and challenges of digitization. Successful use of digital health technologies will transform clinical trials by improving accessibility, efficiency, patient-centricity, and expanding opportunities for personalized medicine.
    MeSH term(s) Humans ; Telemedicine ; Outcome Assessment, Health Care
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000972
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    Zs.A 4900: Show issues Location:
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  3. Article ; Online: A first look at the reliability, validity and responsiveness of L-PF-35 dyspnea domain scores in fibrotic hypersensitivity pneumonitis.

    Swigris, Jeffrey J / Aronson, Kerri / R Fernández Pérez, Evans

    BMC pulmonary medicine

    2024  Volume 24, Issue 1, Page(s) 188

    Abstract: Background: Dyspnea impairs quality of life (QOL) in patients with fibrotic hypersensitivity pneumonitis (FHP). The Living with Pulmonary Fibrosis questionnaire (L-PF) assesses symptoms, their impacts and PF-related QOL in patients with any form of PF. ... ...

    Abstract Background: Dyspnea impairs quality of life (QOL) in patients with fibrotic hypersensitivity pneumonitis (FHP). The Living with Pulmonary Fibrosis questionnaire (L-PF) assesses symptoms, their impacts and PF-related QOL in patients with any form of PF. Its scores have not undergone validation analyses in an FHP cohort.
    Methods: We used data from the Pirfenidone in FHP trial to examine reliability, validity and responsiveness of the L-PF-35 Dyspnea domain score (Dyspnea) and to estimate its meaningful within-patient change (MWPC) threshold for worsening. Lack of suitable anchors precluded conducting analyses for other L-PF-35 scores.
    Results: At baseline, Dyspnea's internal consistency (Cronbach's coefficient alpha) was 0.85; there were significant correlations with all four anchors (University of California San Diego Shortness of Breath Questionnaire scores r = 0.81, St. George's Activity domain score r = 0.82, percent predicted forced vital capacity r = 0.37, and percent predicted diffusing capacity of the lung for carbon monoxide r = 0.37). Dyspnea was significantly different between anchor subgroups (e.g., lowest percent predicted forced vital capacity (FVC%) vs. highest, 33.5 ± 18.5 vs. 11.1 ± 9.8, p = 0.01). There were significant correlations between changes in Dyspnea and changes in anchor scores at all trial time points. Longitudinal models further confirmed responsiveness. The MWPC threshold estimate for worsening was 6.6 points (range 5-8).
    Conclusion: The L-PF-35 Dyspnea domain appears to possess acceptable psychometric properties for assessing dyspnea in patients with FHP. Because instrument validation is never accomplished with one study, additional research is needed to build on the foundation these analyses provide.
    Trial registration: The data for the analyses presented in this manuscript were generated in a trial registered on ClinicalTrials.gov; the identifier was NCT02958917.
    MeSH term(s) Humans ; Quality of Life ; Reproducibility of Results ; Lung ; Dyspnea/etiology ; Dyspnea/diagnosis ; Surveys and Questionnaires ; Alveolitis, Extrinsic Allergic/complications ; Alveolitis, Extrinsic Allergic/drug therapy
    Language English
    Publishing date 2024-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-024-02991-1
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  4. Article ; Online: How Do We Define a Meaningful Change in Quality of Life for Patients with Sarcoidosis?

    Aronson, Kerri I / Swigris, Jeffrey J

    Annals of the American Thoracic Society

    2021  Volume 18, Issue 3, Page(s) 417–418

    MeSH term(s) Humans ; Minimal Clinically Important Difference ; Prospective Studies ; Quality of Life ; Sarcoidosis/diagnosis ; Surveys and Questionnaires
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202010-1241ED
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  5. Article ; Online: Towards a refined definition of combined pulmonary fibrosis and emphysema.

    Swigris, Jeffrey J

    Respirology (Carlton, Vic.)

    2018  Volume 24, Issue 1, Page(s) 9–10

    MeSH term(s) Emphysema ; Humans ; Idiopathic Pulmonary Fibrosis ; Prognosis ; Pulmonary Emphysema
    Language English
    Publishing date 2018-10-15
    Publishing country Australia
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4957: Show issues Location:
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  6. Article: Transitions and touchpoints in idiopathic pulmonary fibrosis.

    Swigris, Jeffrey J

    BMJ open respiratory research

    2018  Volume 5, Issue 1, Page(s) e000317

    Abstract: Patients with idiopathic pulmonary fibrosis (IPF) face a poor prognosis and endure intrusive symptoms that impair quality of life. Many patients with IPF will require supplemental oxygen ( ... ...

    Abstract Patients with idiopathic pulmonary fibrosis (IPF) face a poor prognosis and endure intrusive symptoms that impair quality of life. Many patients with IPF will require supplemental oxygen (O
    Language English
    Publishing date 2018-06-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2736454-9
    ISSN 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2018-000317
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  7. Article ; Online: A New Tool to Capture Patients' Perceptions of the Effects of Lung Transplantation.

    Swigris, Jeffrey J

    American journal of respiratory and critical care medicine

    2018  Volume 199, Issue 8, Page(s) 941–943

    MeSH term(s) Humans ; Lung Transplantation ; Perception ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2018-11-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201810-2001ED
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  8. Article ; Online: A Patient-Centered Approach to Care and Research in Chronic Disease.

    Swigris, Jeffrey J

    The American journal of the medical sciences

    2018  Volume 357, Issue 2, Page(s) 85–86

    MeSH term(s) Biomedical Research/methods ; Biomedical Research/standards ; Chronic Disease/therapy ; Humans ; Patient-Centered Care/methods ; Patient-Centered Care/standards
    Language English
    Publishing date 2018-08-21
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2018.08.008
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  9. Article ; Online: Is it time to include oxygen needs as an endpoint in clinical trials in patients with fibrosing interstitial lung disease? If so, how?

    Aronson, Kerri / Jacobs, Susan S / Repola, Dawn / Swigris, Jeffrey J

    BMJ open respiratory research

    2023  Volume 10, Issue 1

    Abstract: Many patients with fibrosing interstitial lung disease (fILD) will need to use supplemental oxygen ( ... ...

    Abstract Many patients with fibrosing interstitial lung disease (fILD) will need to use supplemental oxygen (O
    MeSH term(s) Humans ; Oxygen ; Quality of Life ; Lung Diseases, Interstitial/diagnosis ; Fibrosis ; Hypertension, Pulmonary
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2022-001546
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  10. Article ; Online: Supplemental Oxygen for Patients with Interstitial Lung Disease: Managing Expectations.

    Swigris, Jeffrey J

    Annals of the American Thoracic Society

    2017  Volume 14, Issue 6, Page(s) 831–832

    MeSH term(s) Humans ; Lung Diseases, Interstitial ; Motivation ; Oxygen ; Oxygen Inhalation Therapy
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2017-05-31
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201703-236ED
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