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Article ; Online: Current management of neonatal abstinence syndrome: a survey of practice in the UK and Ireland.

Dempsey, Sharon / O' Grady, Michael J

Archives of disease in childhood. Fetal and neonatal edition

2024 Volume 109, Issue 3, Page(s) 261–264

Abstract: Objective: To study the current management practices of neonatal abstinence syndrome (NAS) throughout the UK and Ireland and identify changes in practice from the most recent survey in 2008.: Design: Postal questionnaire to a consultant paediatrician ...

Abstract	Objective: To study the current management practices of neonatal abstinence syndrome (NAS) throughout the UK and Ireland and identify changes in practice from the most recent survey in 2008. Design: Postal questionnaire to a consultant paediatrician or neonatologist in all 215 neonatal units in the UK and Ireland in January 2020. Results: Response rate was 62%. An objective scoring tool was used in 97% of units and the Finnegan score was favoured by 70%. Morphine sulfate use as first line for the treatment of opiate withdrawal was almost universal and 70% used a dose of 40 µg/kg every 4 hours (240 µg/kg/day). Phenobarbitone administration as a second-line agent for opiate withdrawal increased to 61% of units with significant reductions in chloral hydrate and chlorpromazine use compared with the previous survey. Morphine sulfate and phenobarbitone remain the preferred first-line and second-line agents, respectively, for polysubstance withdrawal. There was a significant increase in chlorpromazine use as first line for polydrug withdrawal (1.5-14.2%). The practice of units discharging infants' home on medication increased to 46% from 29%. All units now permit breastfeeding in mothers taking methadone, compared with 81% previously. Conclusion and relevance: Compared with the previous survey, improvements in evidence-based practices were noted, highlighting the benefits of this type of research. Nonetheless, significant variation still exists in some aspects of the management of NAS. Post-discharge follow-up varies widely, with particular deficits in ophthalmology follow-up.
MeSH term(s)	Female ; Infant, Newborn ; Humans ; Morphine/therapeutic use ; Neonatal Abstinence Syndrome/drug therapy ; Ireland/epidemiology ; Chlorpromazine/therapeutic use ; Aftercare ; Patient Discharge ; Phenobarbital/therapeutic use ; Methadone/therapeutic use ; Surveys and Questionnaires ; United Kingdom ; Opioid-Related Disorders/drug therapy
Chemical Substances	Morphine (76I7G6D29C) ; Chlorpromazine (U42B7VYA4P) ; Phenobarbital (YQE403BP4D) ; Methadone (UC6VBE7V1Z)
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2007331-8
ISSN	1468-2052 ; 1359-2998
ISSN (online)	1468-2052
ISSN	1359-2998
DOI	10.1136/archdischild-2023-326204
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Um IV Zs.106 -F.N.Ed.-: Show issues

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Article ; Online: Electronic cigarettes: a brief update.

Mathur, A / Dempsey, O J

The journal of the Royal College of Physicians of Edinburgh

2018 Volume 48, Issue 4, Page(s) 346–351

Abstract: More people are using electronic cigarettes (e-cigarettes) and fewer people are smoking conventional tobacco cigarettes. A wide variety of e-cigarettes are available and there is emerging evidence that they may help with smoking cessation. This evidence- ... ...

Abstract	More people are using electronic cigarettes (e-cigarettes) and fewer people are smoking conventional tobacco cigarettes. A wide variety of e-cigarettes are available and there is emerging evidence that they may help with smoking cessation. This evidence-based clinical review summarises the latest evidence regarding use of e-cigarettes as smoking cessation aids. The ongoing debate surrounding the safety and regulation of e-cigarettes is also discussed.
MeSH term(s)	Electronic Nicotine Delivery Systems ; European Union ; Humans ; Nicotine/pharmacology ; Smoking Cessation/methods ; Smoking Cessation Agents/adverse effects ; Smoking Cessation Agents/therapeutic use ; United Kingdom ; Vaping/adverse effects ; Vaping/legislation & jurisprudence
Chemical Substances	Smoking Cessation Agents ; Nicotine (6M3C89ZY6R)
Language	English
Publishing date	2018-11-29
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	2866363-9
ISSN	2042-8189 ; 0953-0932
ISSN (online)	2042-8189
ISSN	0953-0932
DOI	10.4997/JRCPE.2018.415
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Zs.A 3088 -Suppl.-: Show issues

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Article ; Online: Electrical Cardiometry during transition and short-term outcome in very preterm infants: a prospective observational study.

Schwarz, C E / O'Toole, J M / Healy, D B / Panaviene, J / Livingstone, V / Dempsey, E M

European journal of pediatrics

2024 Volume 183, Issue 4, Page(s) 1629–1636

Abstract: The purpose of this study is to evaluate the association of Electrical Cardiometry (EC)-derived cardiac output indexed to weight (CO) and its changes during the first 48 h in relation to adverse short-term outcome in very preterm infants. In this ... ...

Abstract	The purpose of this study is to evaluate the association of Electrical Cardiometry (EC)-derived cardiac output indexed to weight (CO) and its changes during the first 48 h in relation to adverse short-term outcome in very preterm infants. In this prospective observational study of preterm infants < 32 weeks gestational age (GA), the combined adverse outcome was defined as mortality or abnormal cranial ultrasound (any grade intracranial hemorrhage (ICH) or periventricular leukomalacia) within the first 2 weeks postnatally. Logistic regression models were used to investigate the association between median CO and outcome and mixed-effects models for the time trajectory of CO. In the absence of device-specific thresholds for low or high CO, no thresholds were used in our analysis. Fifty-three infants (median (IQR) GA 29.0 (25.4-30.6) weeks, birthweight 1020 (745-1505) g) were included in the analysis. Median CO was 241 (197-275) mL/kg/min for the adverse outcome and 198 (175-227) mL/kg/min for normal outcome (odds ratio (OR) (95% confidence interval (95% CI)), 1.01 (1.00 to 1.03); p = 0.028). After adjustment for GA, the difference was not significant (adjusted OR (95% CI), 1.01 (0.99 to 1.02); p = 0.373). CO trajectory did not differ by outcome (p = 0.352). A post hoc analysis revealed an association between CO time trajectory and ICH ≥ grade 2. Conclusions: EC-derived CO estimates within 48 h postnatally were not independently associated with brain injury (any grade) or mortality in the first 14 days of life. CO time trajectory was found to be associated with ICH ≥ grade 2. What is Known: • Bioreactance-derived cardiac output indexed to bodyweight (CO) in the transitional period has been associated with adverse short-term outcome in preterm infants. What is New: • Electrical Cardiometry (EC)-derived CO measurements in very preterm infants during the transitional period are not independently associated with adverse outcome (death or ultrasound detected brain damage) within 2 weeks postnatally. • In the first 48 h EC-derived CO increases over time and is higher in extremely preterm infants compared to very preterm and differs from previously reported bioreactance-derived CO values.
MeSH term(s)	Female ; Humans ; Infant, Newborn ; Birth Weight ; Fetal Growth Retardation ; Gestational Age ; Infant, Extremely Premature ; Infant, Premature, Diseases/diagnosis ; Infant, Very Low Birth Weight ; Intracranial Hemorrhages
Language	English
Publishing date	2024-01-08
Publishing country	Germany
Document type	Observational Study ; Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-023-05387-1
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Article: Ureteroinguinal herniation complicated by obstructive uropathy and pyelonephritis.

O'Herlihy, Fergus / Dempsey, Philip J / Gorman, Dora / McDermott, Edward / Kavanagh, Eoin C

Radiology case reports

2023 Volume 19, Issue 1, Page(s) 111–113

Abstract: Herniation of the ureters into the inguinal canal is a rare but recognized phenomenon. It may be noted incidentally on cross-sectional imaging, or when it presents with complications such as obstruction or infection. It is important to highlight the ... ...

Abstract	Herniation of the ureters into the inguinal canal is a rare but recognized phenomenon. It may be noted incidentally on cross-sectional imaging, or when it presents with complications such as obstruction or infection. It is important to highlight the finding when present, as surgical intervention will be required in the majority of cases. We present a case of a 91-year-old man who developed obstructive uropathy and pyelonephritis due to inguinal herniation of the ureter.
Language	English
Publishing date	2023-10-28
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2023.09.089
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Article ; Online: Quantitative content analysis of Freedom of Information requests examining the extent and variations of tools and training for conducting suicide risk assessments in NHS Trusts across England.

Fedorowicz, Sophia / Dempsey, Robert C / Ellis, Naomi J / Mulvey, Olivia / Gidlow, Christopher J

BMJ open

2023 Volume 13, Issue 10, Page(s) e072004

Abstract: Objectives: Determining the risk for suicide is a difficult endeavour. Clinical guidance in the UK explicitly advises against using risk assessment tools and scales to determine suicide risk. Based on Freedom of Information (FoI) requests made to NHS ... ...

Abstract	Objectives: Determining the risk for suicide is a difficult endeavour. Clinical guidance in the UK explicitly advises against using risk assessment tools and scales to determine suicide risk. Based on Freedom of Information (FoI) requests made to NHS Trusts in England, this study provides an overview of suicide risk assessment tools in use, training provided in how to use such assessments, and explores implementation of suicide risk assessment guidance in practice in English NHS Trusts. Design: A cross-sectional survey of suicide risk assessment tools and training gathered via FoI requests and subjected to a content analysis. Setting: FoI requests were submitted to NHS Trusts across England. Results: A wide variety of suicide risk assessments tools were identified as being used in practice, with several trusts reported using more than one tool to determine suicide risk. Forty-one trusts reported using locally developed, unvalidated, tools to assess risk of suicide and 18 stated they do not use a tool. Ten trusts stated they do not train their staff in suicide risk assessment while 13 reported use of specific suicide risk assessment training. Sixty-two trusts stated they do not centrally record the number of assessments conducted or how many individuals are identified as at risk. Content analysis indicated the frequent wider assessment of risk not restricted to suicide risk. Conclusions: There is wide variation in suicide risk assessment tools being used in practice and some lack of specific training for healthcare staff in determining suicide risk. Few trusts routinely record the number of assessments being conducted or the number of individuals identified at high risk. Implementation of specific training is necessary for the suicide risk assessment process to identify patient needs and develop therapeutic engagement. Routinely recording how many assessments are conducted is a crucial step in improving suicide prevention.
MeSH term(s)	Humans ; Cross-Sectional Studies ; England/epidemiology ; Risk Assessment ; State Medicine ; Suicide
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-072004
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Article ; Online: Correction: Breathing a low-density gas reduces respiratory muscle force development and marginally improves exercise performance in master athletes.

Haddad, Toni / Mons, Valentin / Meste, Olivier / Dempsey, Jerome A / Abbiss, Chris R / Brisswalter, Jeanick / Blain, Gregory M

European journal of applied physiology

2024 Volume 124, Issue 2, Page(s) 667–668

Language	English
Publishing date	2024-01-29
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-023-05383-1
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Article ; Online: Blood flow restricted walking alters gait kinematics.

Walden, Thomas P / Fairchild, Timothy / Girard, Olivier / Peiffer, Jeremiah J / Jonson, Andrew M / Dempsey, Alasdair R

European journal of sport science

2023 Volume 23, Issue 8, Page(s) 1528–1537

Abstract: This study investigated the impact of blood flow restriction (BFR) during treadmill walking on gait kinematics. Twenty-one participants completed one familiarisation and four experimental sessions, including two walking speeds (moderate [5.0 ± 0.3km· ... ...

Abstract	This study investigated the impact of blood flow restriction (BFR) during treadmill walking on gait kinematics. Twenty-one participants completed one familiarisation and four experimental sessions, including two walking speeds (moderate [5.0 ± 0.3km·h
MeSH term(s)	Humans ; Biomechanical Phenomena ; Walking/physiology ; Gait ; Hemodynamics ; Regional Blood Flow/physiology ; Lactates ; Muscle, Skeletal/blood supply
Chemical Substances	Lactates
Language	English
Publishing date	2023-04-04
Publishing country	England
Document type	Journal Article
ISSN	1536-7290
ISSN (online)	1536-7290
DOI	10.1080/17461391.2023.2194274
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Article ; Online: Delayed photoacidity produced through the triplet-triplet annihilation of a neutral pyranine derivative.

Lennox, J Christian / Danilov, Evgeny O / Dempsey, Jillian L

Physical chemistry chemical physics : PCCP

2019 Volume 21, Issue 29, Page(s) 16353–16358

Abstract: A novel pyranine derivative, EtHPTA-OH, was synthesized via the substitution of the anionic sulfonate groups with neutral diethylsulfonamide groups. The photophysical and photochemical properties of EtHPTA-OH were studied using photoluminescence ... ...

Abstract	A novel pyranine derivative, EtHPTA-OH, was synthesized via the substitution of the anionic sulfonate groups with neutral diethylsulfonamide groups. The photophysical and photochemical properties of EtHPTA-OH were studied using photoluminescence quenching and transient absorption spectroscopy. The singlet state of EtHPTA-OH was found to be highly photoacidic (pKa* = 8.74 in acetonitrile). A series of aniline and pyridine bases were used to investigate excited-state proton transfer (ESPT) from singlet EtHPTA-OH, and rate constants for singlet quenching via ESPT were determined (kq = 5.18 × 109 to 1.05 × 1010 M-1 s-1). EtHPTA-OH was also found to exhibit a long-lived triplet state which reacts through a triplet-triplet annihilation (TTA) process to reform singlet EtHPTA-OH on timescales of up to 80 μs. Detection of ESPT photoproducts on timescales comparable to that of TTA singlet regeneration provides strong evidence for photoacidic behavior stemming from the regenerated singlet EtHPTA-OH.
Language	English
Publishing date	2019-07-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/c9cp02929j
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Article: Solitary late metastasis of primary renal cell carcinoid tumor to the extraocular muscles imaged with indium-111 octreotide.

Dempsey, Philip Jude / O'Connell, Martin J / Bolster, Ferdia

World journal of nuclear medicine

2020 Volume 20, Issue 1, Page(s) 99–101

Abstract: A 75-year-old male presented with right eye pain and proptosis. His history was significant for renal cell carcinoma treated with left nephrectomy 2 years previously. Computed tomography (CT) imaging demonstrated a 1.6-cm enhancing lesion in the right ... ...

Abstract	A 75-year-old male presented with right eye pain and proptosis. His history was significant for renal cell carcinoma treated with left nephrectomy 2 years previously. Computed tomography (CT) imaging demonstrated a 1.6-cm enhancing lesion in the right retrobulbar space. Surgical biopsy revealed a low-grade metastatic carcinoid tumor. At retrospective review, the primary renal lesion from 2 years prior was rediagnosed as consistent with a renal carcinoid tumor. Indium-111 octreotide single photon emission CT/CT imaging demonstrated a solitary metastasis within the right extraocular muscles. The patient subsequently developed additional metastases within the remaining right kidney and lung.
Language	English
Publishing date	2020-07-22
Publishing country	Austria
Document type	Case Reports
ZDB-ID	2911903-0
ISSN	1607-3312 ; 1450-1147
ISSN (online)	1607-3312
ISSN	1450-1147
DOI	10.4103/wjnm.WJNM_28_20
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Article ; Online: Nonstationary coupling between heart rate and perfusion index in extremely preterm infants in the first day of life.

O'Toole, J M / Dempsey, E M / Van Laere, D

Physiological measurement

2021 Volume 42, Issue 3

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Cohort Studies ; Gestational Age ; Heart Rate ; Humans ; Infant ; Infant, Extremely Premature ; Infant, Newborn ; Perfusion Index
Language	English
Publishing date	2021-04-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1149545-5
ISSN	1361-6579 ; 0967-3334
ISSN (online)	1361-6579
ISSN	0967-3334
DOI	10.1088/1361-6579/abe3de
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