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Article ; Online: Impact of parasitic infection on human gut ecology and immune regulations

Ahsan Naveed / Sabahat Abdullah

Translational Medicine Communications, Vol 6, Iss 1, Pp 1-

2021 Volume 9

Abstract: Abstract The human body harbors trillions of microbes collectively known as microbiota. The human gut microbiota is importantly involved in most of the human metabolic and regulatory pathways. The gut microbiota needs to be balanced for the health of the ...

Abstract	Abstract The human body harbors trillions of microbes collectively known as microbiota. The human gut microbiota is importantly involved in most of the human metabolic and regulatory pathways. The gut microbiota needs to be balanced for the health of the host. Several factors are involved in the distribution of microbiota in the human body, in most cases these microbiotas are commensals, but some circumstances lead to serious disorders and the development of infections from microbiota. When parasites colonize the gut, the balance between the host and the gut microbiota can be disturbed. Parasitic invasion in the gut is associated with unhygienic conditions including contaminated food and water. Parasitic invasion in the gut induces the immune response to recognize and eliminate pathogens. The current study highlights the immune system’s response to disruption of normal intestinal microbiota and parasitic infections.
Keywords	Microbiota ; Parasite ; Entamoeba histolytica ; Toxoplasma gondii ; Immune system ; Gut microflora ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Idiotype/anti-idiotype antibodies: as a glorious savior in COVID-19 pandemics.

Naveed, Ahsan / Naz, Deeba / Rahman, Sajjad Ur

Translational medicine communications

2021 Volume 6, Issue 1, Page(s) 18

Abstract: The idiotype network is experimentally modified to provide protective immunity against various microbial pathogens. Both internal and non-internal image-idiotype antibodies can trigger specific immune responses to antigens. The current outbreak of Severe ...

Abstract	The idiotype network is experimentally modified to provide protective immunity against various microbial pathogens. Both internal and non-internal image-idiotype antibodies can trigger specific immune responses to antigens. The current outbreak of Severe Acute Respiratory Syndrome 2 (SARS-2) has provided a great opportunity to take advantage of idiotype / anti-idiotype antibodies as a protective regimen when no approved vaccine is available on earth. The current review identifies successful applications of idiotype/ anti-idiotype antibodies in various viral diseases and highlights their importance in COVID-19 pandemics. In the absence of vaccines and targeted therapies, polyclonal idiotype/ anti-idiotype antibodies against the viral structure may be a potential approach to the prevention and treatment of COVID-19 patients.
Language	English
Publishing date	2021-08-23
Publishing country	England
Document type	Journal Article ; Review
ISSN	2396-832X
ISSN (online)	2396-832X
DOI	10.1186/s41231-021-00097-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rotavirus exploits SREBP pathway for hyper lipid biogenesis during replication.

Naveed, Ahsan / Naveed, Muhammad Ammar / Akram, Lubna / Sharif, Muhammad / Kang, Mun-Il / Park, Sang-Ik

The Journal of general virology

2022 Volume 103, Issue 5

Abstract: Species A rotavirus (RVA) is one of the pathogens causing severe acute gastroenteritis in young children and animals worldwide. RVA replicates and assembles its immature particle within electron dense compartments known as viroplasm. Despite the ... ...

Abstract	Species A rotavirus (RVA) is one of the pathogens causing severe acute gastroenteritis in young children and animals worldwide. RVA replicates and assembles its immature particle within electron dense compartments known as viroplasm. Despite the importance of lipid droplet (LD) formation in the RVA viroplasm, the upstream molecules modulating LD formation have remained elusive. Here, we demonstrate that RVA infection reprogrammes sterol regulatory element binding proteins (SREBPs)-dependent lipogenic pathways in virus-infected cells. Interestingly, silencing of SREBPs significantly reduced RVA protein synthesis, genome replication and progeny virus production. Moreover, knockout of SREBP-1c gene conferred resistance to RVA-induced diarrhoea, reduction of RVA replication, and mitigation of small intestinal pathology in mice. This study identifies SREBPs-mediated lipogenic reprogramming in RVA-infected host cells for facilitating virus replication and SREBPs as a potential target for developing therapeutics against RVA infection.
MeSH term(s)	Animals ; Lipids ; Mice ; Rotavirus/genetics ; Rotavirus Infections ; Sterol Regulatory Element Binding Protein 1 ; Viral Replication Compartments
Chemical Substances	Lipids ; Sterol Regulatory Element Binding Protein 1
Language	English
Publishing date	2022-06-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219316-4
ISSN	1465-2099 ; 0022-1317
ISSN (online)	1465-2099
ISSN	0022-1317
DOI	10.1099/jgv.0.001757
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Article: Association of fetuin-A with dyslipidemia and insulin resistance in type-II Diabetics of Pakistani population.

Fatima, Fasiha / Ahsan, Naveed / Nasim, Aliya / Alam, Faiza

Pakistan journal of medical sciences

2020 Volume 36, Issue 2, Page(s) 64–68

Abstract: Background & objective: Fetuin-A, hepatokine is responsible for instigating insulin resistance by inhibiting tyrosine kinase receptors. Our objective was to investigate the relationship of fetuin-A with dyslipidemia and insulin resistance in type-II ... ...

Abstract	Background & objective: Fetuin-A, hepatokine is responsible for instigating insulin resistance by inhibiting tyrosine kinase receptors. Our objective was to investigate the relationship of fetuin-A with dyslipidemia and insulin resistance in type-II diabetics of Pakistani population. Methods: In this cross sectional study which was conducted at Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi between October 2013 to March 2014, a total of 330 participants were selected and divided into two groups. Group-A (n = 165) normal healthy individual and Group-B (n = 165) Type-II diabetes mellitus mellitus with no comorbidities. Serum fetuin-A and insulin levels were determined by commercially prepared ELISA kits while fasting blood glucose (FBG) and lipid profile were performed by enzymatic kit method. Employing independent t-test, comparison of groups was done and correlation was achieved by using spearman correlation. Results: The results demonstrate a significant difference in mean values of fetuin-A, lipid profile, glucose, insulin and Homoeostasis Model Assessment of Insulin resistance (HOMA-IR) in type-II diabetics when compared to normal healthy individuals (p<0.01). A positive correlation was found between serum fetuin-A levels and FBG(r= 0.495, p< 0.001), insulin(r= 0.227, p< 0.001), HOMA-IR(r= 0.336, p<0.001, triglycerides(r= 0.197, p< 0.001) and LDL-cholesterol(r= 0.170, p= 0.002), while negative correlation with HDL-cholesterol(r= -0.251, p< 0.001). Conclusion: The study concludes that fetuin-A might be accountable for dyslipidemia and insulin resistance in type-II diabetes mellitus mellitus. So the high levels of Fetuin-A responsible for insulin resistance might alters endothelium and causes inflammation, vasoconstriction and thrombosis and ultimately atherosclerosis.
Language	English
Publishing date	2020-01-27
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.36.2.1106
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Article ; Online: Idiotype/anti-idiotype antibodies

Ahsan Naveed / Deeba Naz / Sajjad ur Rahman

Translational Medicine Communications, Vol 6, Iss 1, Pp 1-

as a glorious savior in COVID-19 pandemics

2021 Volume 5

Abstract: Abstract The idiotype network is experimentally modified to provide protective immunity against various microbial pathogens. Both internal and non-internal image-idiotype antibodies can trigger specific immune responses to antigens. The current outbreak ... ...

Abstract	Abstract The idiotype network is experimentally modified to provide protective immunity against various microbial pathogens. Both internal and non-internal image-idiotype antibodies can trigger specific immune responses to antigens. The current outbreak of Severe Acute Respiratory Syndrome 2 (SARS-2) has provided a great opportunity to take advantage of idiotype / anti-idiotype antibodies as a protective regimen when no approved vaccine is available on earth. The current review identifies successful applications of idiotype/ anti-idiotype antibodies in various viral diseases and highlights their importance in COVID-19 pandemics. In the absence of vaccines and targeted therapies, polyclonal idiotype/ anti-idiotype antibodies against the viral structure may be a potential approach to the prevention and treatment of COVID-19 patients.
Keywords	COVID-19 ; SARS-2 ; Idiotype ; Anti-idiotype ; Vaccine ; Medicine ; R
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influenza D virus utilizes both 9-

Uprety, Tirth / Yu, Jieshi / Nogales, Aitor / Naveed, Ahsan / Yu, Hai / Chen, Xi / Liu, Yunpeng / Bowman, Andrew S / Martinez-Sobrido, Luis / Parrish, Colin R / Melikyan, Gregory B / Wang, Dan / Li, Feng

Journal of virology

2024 Volume 98, Issue 3, Page(s) e0004224

Abstract: Influenza D virus (IDV) utilizes bovines as a primary reservoir with periodical spillover to other hosts. We have previously demonstrated that IDV binds both 9- ...

Abstract	Influenza D virus (IDV) utilizes bovines as a primary reservoir with periodical spillover to other hosts. We have previously demonstrated that IDV binds both 9-
MeSH term(s)	Animals ; Cattle ; Cell Membrane/metabolism ; Deltainfluenzavirus ; N-Acetylneuraminic Acid/metabolism ; Neuraminic Acids/metabolism ; Orthomyxoviridae/metabolism ; Receptors, Virus/metabolism ; Sialic Acids/metabolism
Chemical Substances	N-Acetylneuraminic Acid (GZP2782OP0) ; N-glycolylneuraminic acid (1113-83-3) ; Neuraminic Acids ; Receptors, Virus ; Sialic Acids
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00042-24
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Article ; Online: Evaluation of BaCo

Irshad, Muneeb / Khalid, Mehak / Rafique, Muhammad / Ahmad, Naveed / Siraj, Khurram / Raza, Rizwan / Sadiq, Muhammad / Ahsan, Muhammad / Ghaffar, Abdul / Ashfaq, Amina

RSC advances

2021 Volume 11, Issue 24, Page(s) 14475–14483

Abstract: In this research work, ... ...

Abstract	In this research work, BaCo
Language	English
Publishing date	2021-04-16
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra00789k
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Article: Assessment of trends in climatic extremes from observational data in the Kashmir basin, NW Himalaya

Ahsan, Shafkat / Bhat, M. Sultan / Alam, Akhtar / Ahmed, Naveed / Farooq, Hakim / Ahmad, Bashir

Environmental monitoring and assessment. 2021 Oct., v. 193, no. 10

2021

Abstract: The present study aims to assess the recent changes and trends in the extreme climate indices in the Kashmir basin using the observational records from 1980 to 2016. The extreme climate indices were computed using the ClimPACT2 software and a total of 39 ...

Abstract	The present study aims to assess the recent changes and trends in the extreme climate indices in the Kashmir basin using the observational records from 1980 to 2016. The extreme climate indices were computed using the ClimPACT2 software and a total of 39 indices were selected for the analysis having particular utility to various sectors like agriculture, water resources, energy consumption, and human health. Besides adopting the station scale analysis, regional averages were computed for each index. In terms of the mean climatology, an increase has been observed in the annual mean temperature with a magnitude of 0.024 °C/year. Further, differential warming patterns have been observed in the mean maximum and minimum temperatures with mean maximum temperature revealing higher increases than mean minimum temperature. On the other hand, the annual precipitation shows a decrease over most of the region, and the decreases are more pronouncing in the higher altitudes. The trend analysis of the extreme indices reveals that in consonance with the rising temperature there has been an increase in the warm temperatures and decrease in the cold temperatures across the Kashmir basin. Furthermore, our analysis suggests a decrease in the extreme precipitation events. The drought indices viz., Standardised Precipitation Index (SPI), and Standardised Precipitation Evapotranspiration Index (SPEI) manifest decreasing trends with the tendency towards drier regimes implying the need for better water resource management in the region under changing climate.
Keywords	atmospheric precipitation ; basins ; climate ; climatology ; cold ; computer software ; drought ; energy ; evapotranspiration ; human health ; observational studies ; temperature ; water management ; Himalayan region ; India
Language	English
Dates of publication	2021-10
Size	p. 649.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-021-09439-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Assessment of trends in climatic extremes from observational data in the Kashmir basin, NW Himalaya.

Ahsan, Shafkat / Bhat, M Sultan / Alam, Akhtar / Ahmed, Naveed / Farooq, Hakim / Ahmad, Bashir

Environmental monitoring and assessment

2021 Volume 193, Issue 10, Page(s) 649

Abstract	The present study aims to assess the recent changes and trends in the extreme climate indices in the Kashmir basin using the observational records from 1980 to 2016. The extreme climate indices were computed using the ClimPACT2 software and a total of 39 indices were selected for the analysis having particular utility to various sectors like agriculture, water resources, energy consumption, and human health. Besides adopting the station scale analysis, regional averages were computed for each index. In terms of the mean climatology, an increase has been observed in the annual mean temperature with a magnitude of 0.024 °C/year. Further, differential warming patterns have been observed in the mean maximum and minimum temperatures with mean maximum temperature revealing higher increases than mean minimum temperature. On the other hand, the annual precipitation shows a decrease over most of the region, and the decreases are more pronouncing in the higher altitudes. The trend analysis of the extreme indices reveals that in consonance with the rising temperature there has been an increase in the warm temperatures and decrease in the cold temperatures across the Kashmir basin. Furthermore, our analysis suggests a decrease in the extreme precipitation events. The drought indices viz., Standardised Precipitation Index (SPI), and Standardised Precipitation Evapotranspiration Index (SPEI) manifest decreasing trends with the tendency towards drier regimes implying the need for better water resource management in the region under changing climate.
MeSH term(s)	Climate Change ; Droughts ; Environmental Monitoring ; Humans ; Meteorology ; Temperature
Language	English
Publishing date	2021-09-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-021-09439-7
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Article ; Online: Pharmacological support to anti-arthritic prospective of physostigmine: a new approach.

Ahsan, Haseeb / Haider, Ihtisham / Mushtaq, Muhammad Naveed / Qaisar, Muhammad Naeem / Naqvi, Farwa / Asif, Awais

Inflammopharmacology

2021 Volume 29, Issue 4, Page(s) 1119–1129

Abstract: Rheumatoid arthritis (RA) is a slowly progressing inflammatory autoimmune disease. Several features are involved in the RA pathogenesis in addition to environmental and genetic factors. Previously it has been reported that acetyl cholinesterase (AChE) ... ...

Abstract	Rheumatoid arthritis (RA) is a slowly progressing inflammatory autoimmune disease. Several features are involved in the RA pathogenesis in addition to environmental and genetic factors. Previously it has been reported that acetyl cholinesterase (AChE) activity is enhanced in old age and may contribute in the progression of RA. The current experimental work was projected to assess the activity of physostigmine (a cholinesterase inhibitor) for treatment of RA. In vitro and in vivo approaches were used for such evaluation. However, enzyme linked immunosorbent assays (ELISA) was performed to determine the concentrations of Prostaglandins E2 (PGE2) and tumor necrosis factor-α in arthritic rats after treatment with physostigmine. Moreover, anti-oxidant assays were employed to calculate the level of super oxide dismutase (SOD) and catalase peroxidase (CAT) in tissue of treated animals. The results claimed the dose dependent protective and stabilizing effect of physostigmine on denaturation of albumin (egg and bovine serum) protein and human red blood cell membrane, respectively, through in vitro studies. Furthermore, the physostigmine (10 and 20 mg/kg) significantly (p < 0.001) reduced the swelling of paw after induction of arthritis with formaldehyde or complete Freund's adjuvant (CFA) as compared to arthritic control animals. Moreover, significant (p < 0.001) reduction in the levels of inflammatory markers (PGE2 and TNF-α) at doses of 10 and 20 mg/kg of physostigmine has been observed in ELISA test. Likewise, there was a prominent rise in levels of SOD and CAT in animals treated with physostigmine. These findings pharmacologically conclude the anti-arthritic effect of physostigmine.
MeSH term(s)	Animals ; Antirheumatic Agents/pharmacology ; Antirheumatic Agents/therapeutic use ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/metabolism ; Arthritis, Experimental/pathology ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Dose-Response Relationship, Drug ; Erythrocytes/drug effects ; Erythrocytes/metabolism ; Humans ; Male ; Physostigmine/pharmacology ; Physostigmine/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Serum Albumin, Bovine/antagonists & inhibitors ; Serum Albumin, Bovine/metabolism
Chemical Substances	Antirheumatic Agents ; Cholinesterase Inhibitors ; Serum Albumin, Bovine (27432CM55Q) ; Physostigmine (9U1VM840SP)
Language	English
Publishing date	2021-07-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-021-00840-9
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