Result 1 - 10 of total 455
Postdigital Science and Education
| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #155124 |
| Database | COVID19 |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Postdigital Science and Education ; ISSN 2524-485X 2524-4868
2020
| Keywords | covid19 |
|---|---|
| Language | English |
| Publisher | Springer Science and Business Media LLC |
| Publishing country | us |
| Document type | Article ; Online |
| DOI | 10.1007/s42438-020-00115-6 |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Postdigital Science and Education
Abstract: This text starts with the premise that ‘normative democracy’ has rendered our societies vulnerable and burdened with unaddressed social inequalities I highlight three central arguments: (1) Social media, and, consequently, citizen engagement are becoming ...
| Abstract | This text starts with the premise that ‘normative democracy’ has rendered our societies vulnerable and burdened with unaddressed social inequalities I highlight three central arguments: (1) Social media, and, consequently, citizen engagement are becoming a significant filter that can potentially re-imagine the political, economic, and social worlds, which increasingly bleed over to how we might develop and engage with ‘democracy’;to this end, I introduce a brief case study on the nefarious interpretation of the killing of Jamal Khashoggi in 2018 to underscore the tension points in normative democracy;(2) Capitalism, or neoliberalism, needs to be more fully exposed, interrogated, and confronted if ‘normative, representative, hegemonic, electoral democracy’ is to be re-considered, re-imagined, and re-invented;the perpetuation of social inequalities lays bare the frailty of normative democratic institutions;(3) Covid-19 has exposed the fault lines and fissures of normative democracy, illustrating here the ‘common sense’ ways that power imbalances are sustained, which leaves little room for social solidarity;I present herein the case of the economic/labor dynamic in Quebec during the coronavirus Ultimately, I believe the quest to re-imagine a more meaningful, critically engaged democracy, especially during a context that is imbued with a political, economic, and public health crisis, cannot be delayed much longer |
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| Keywords | covid19 |
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #592066 |
| Database | COVID19 |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Nature plants
2022 Volume 8, Issue 6, Page(s) 670–681
Abstract: S-acylation is the addition of a fatty acid to a cysteine residue of a protein. While this modification may profoundly alter protein behaviour, its effects on the function of plant proteins remains poorly characterized, largely as a result of the lack of ...
| Abstract | S-acylation is the addition of a fatty acid to a cysteine residue of a protein. While this modification may profoundly alter protein behaviour, its effects on the function of plant proteins remains poorly characterized, largely as a result of the lack of basic information regarding which proteins are S-acylated and where in the proteins the modification occurs. To address this gap in our knowledge, we used an optimized acyl-resin-assisted capture assay to perform a comprehensive analysis of plant protein S-acylation from six separate tissues. In our high- and medium-confidence groups, we identified 1,849 cysteines modified by S-acylation, which were located in 1,640 unique peptides from 1,094 different proteins. This represents around 6% of the detectable Arabidopsis proteome and suggests an important role for S-acylation in many essential cellular functions including trafficking, signalling and metabolism. To illustrate the potential of this dataset, we focus on cellulose synthesis and confirm the S-acylation of a number of proteins known to be involved in cellulose synthesis and trafficking of the cellulose synthase complex. In the secondary cell walls, cellulose synthesis requires three different catalytic subunits (CESA4, CESA7 and CESA8) that all exhibit striking sequence similarity and are all predicted to possess a RING-type zinc finger at their amino terminus composed of eight cysteines. For CESA8, we find evidence for S-acylation of these cysteines that is incompatible with any role in coordinating metal ions. We show that while CESA7 may possess a RING-type domain, the same region of CESA8 appears to have evolved a very different structure. Together, the data suggest that this study represents an atlas of S-acylation in Arabidopsis that will facilitate the broader study of this elusive post-translational modification in plants as well as demonstrating the importance of further work in this area. |
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| MeSH term(s) | Acylation ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis Proteins/metabolism ; Cellulose/metabolism ; Cysteine/metabolism ; Glucosyltransferases/metabolism ; Plant Cells/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plants/metabolism |
| Chemical Substances | Arabidopsis Proteins ; Plant Proteins ; Cellulose (9004-34-6) ; CESA8 protein, Arabidopsis (EC 2.4.1.-) ; Glucosyltransferases (EC 2.4.1.-) ; Cysteine (K848JZ4886) |
| Language | English |
| Publishing date | 2022-06-09 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 2055-0278 |
| ISSN (online) | 2055-0278 |
| DOI | 10.1038/s41477-022-01164-4 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
British journal of hospital medicine (London, England : 2005)
2023 Volume 84, Issue 12, Page(s) 1–8
Abstract: Simulation is ubiquitous in the training of hospital-based doctors worldwide, often focusing on an individual level in traditional 'skills and drills'-based training. However, there has been an expansion in the use of simulation in healthcare practice ... ...
| Abstract | Simulation is ubiquitous in the training of hospital-based doctors worldwide, often focusing on an individual level in traditional 'skills and drills'-based training. However, there has been an expansion in the use of simulation in healthcare practice and training. Simulation is being adopted into many disciplines that traditionally have not used this form of experiential learning. Moreover, simulation is increasingly being harnessed to enhance team and organisational learning in hospital-based practice. This article shares some insights into simulation-based education and makes the 'familiar unfamiliar' about this important method of learning. The aim is to broaden readers' outlook about what simulation has to offer beyond the classic notion of skills and drills-based training. |
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| MeSH term(s) | Humans ; Learning ; Problem-Based Learning ; Physicians ; Delivery of Health Care ; Computer Simulation ; Clinical Competence ; Simulation Training |
| Language | English |
| Publishing date | 2023-12-20 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 1750-8460 |
| ISSN | 1750-8460 |
| DOI | 10.12968/hmed.2023.0353 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
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2023 Volume 14, Page(s) 1170880
Abstract: The successful enzymatic degradation of polyester substrates has fueled worldwide investigation into the treatment of plastic waste using bio-based processes. Within this realm, marine-associated microorganisms have emerged as a promising source of ... ...
| Abstract | The successful enzymatic degradation of polyester substrates has fueled worldwide investigation into the treatment of plastic waste using bio-based processes. Within this realm, marine-associated microorganisms have emerged as a promising source of polyester-degrading enzymes. In this work, we describe the hydrolysis of the synthetic polymer PET by SM14est, a polyesterase which was previously identified from |
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| Language | English |
| Publishing date | 2023-05-12 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2587354-4 |
| ISSN | 1664-302X |
| ISSN | 1664-302X |
| DOI | 10.3389/fmicb.2023.1170880 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Chemistry (Weinheim an der Bergstrasse, Germany)
2022 Volume 28, Issue 32, Page(s) e202200855
Abstract: This work describes a homometallic spin- ...
| Abstract | This work describes a homometallic spin- |
|---|---|
| Language | English |
| Publishing date | 2022-04-27 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 1478547-X |
| ISSN | 1521-3765 ; 0947-6539 |
| ISSN (online) | 1521-3765 |
| ISSN | 0947-6539 |
| DOI | 10.1002/chem.202200855 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Journal of affective disorders
2023 Volume 346, Page(s) 221–222
| MeSH term(s) | Humans ; Ketamine/therapeutic use ; Depressive Disorder, Major/drug therapy ; Depression ; Infusions, Intravenous ; Depressive Disorder, Treatment-Resistant/drug therapy ; Insurance Coverage |
|---|---|
| Chemical Substances | Ketamine (690G0D6V8H) |
| Language | English |
| Publishing date | 2023-11-06 |
| Publishing country | Netherlands |
| Document type | Letter ; Research Support, N.I.H., Extramural |
| ZDB-ID | 135449-8 |
| ISSN | 1573-2517 ; 0165-0327 |
| ISSN (online) | 1573-2517 |
| ISSN | 0165-0327 |
| DOI | 10.1016/j.jad.2023.11.008 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1485: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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2024 Volume 171, Page(s) 105654
Abstract: Background: The advent of lateral flow devices (LFDs) for SARS-CoV-2 detection enabled widespread use of rapid self-tests during the pandemic. While self-testing using LFDs is now common, whether self-testing provides comparable performance to ... ...
| Abstract | Background: The advent of lateral flow devices (LFDs) for SARS-CoV-2 detection enabled widespread use of rapid self-tests during the pandemic. While self-testing using LFDs is now common, whether self-testing provides comparable performance to professional testing was a key question that remained important for pandemic planning. Methods: Three prospective multi-centre studies were conducted to compare the performance of self- and professional testing using LFDs. Participants tested themselves or were tested by trained (professional) testers at community testing sites in the UK. Corresponding qRT-PCR test results served as reference standard. The performance of Innova, Orient Gene and SureScreen LFDs by users (self) and professional testers was assessed in terms of sensitivity, specificity, and kit failure (void) rates. Impact of age, sex and symptom status was analysed using logistic regression modelling. Results: 16,617 participants provided paired tests, of which 15,418 were included in the analysis. Self-testing with Innova, Orient Gene or SureScreen LFDs achieved sensitivities of 50 %, 53 % or 72 %, respectively, compared to qRT-PCR. Self and professional LFD testing showed no statistically different sensitivity with respect to corresponding qRT-PCR testing. Specificity was consistently equal to or higher than 99 %. Sex and age had no or only marginal impact on LFD performance while sensitivity was significantly higher for symptomatic individuals. Sensitivity of LFDs increased strongly to up to 90 % with higher levels of viral RNA measured by qRT-PCR. Conclusions: Our results support SARS-CoV-2 self-testing with LFDs, especially for the detection of individuals whose qRT-PCR tests showed high viral concentrations. |
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| MeSH term(s) | Humans ; COVID-19/diagnosis ; Prospective Studies ; SARS-CoV-2 ; Immunologic Tests ; United Kingdom ; Sensitivity and Specificity |
| Language | English |
| Publishing date | 2024-02-15 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1446080-4 |
| ISSN | 1873-5967 ; 1386-6532 |
| ISSN (online) | 1873-5967 |
| ISSN | 1386-6532 |
| DOI | 10.1016/j.jcv.2024.105654 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3790: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2024
Abstract: Diagnoses of military-relevant sleep disorders have increased substantially since the terrorist attacks of 9-11. The cause of this increase appears to be complicated and multifactorial, with military and civilian populations clearly differing with ... ...
| Abstract | Diagnoses of military-relevant sleep disorders have increased substantially since the terrorist attacks of 9-11. The cause of this increase appears to be complicated and multifactorial, with military and civilian populations clearly differing with respect to both the nature and distribution of sleep disorders diagnoses. In part, these differences may be attributable to the fact that a majority of service members (SMs) are chronically sleep restricted - an unavoidable consequence of continuous and sustained military operations that 'set the stage' for development of specific sleep disorders. The purpose of this narrative review is to describe the military relevance of several common sleep disorders, assess the extent to which these disorders currently constitute a burden on the military healthcare system, and suggest strategies to alleviate that burden. The military healthcare system does not have enough sleep providers to address the immediate and long-term consequences of sleep disorders in military personnel. Digital technologies and education packages can be leveraged to improve access to care. |
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| Language | English |
| Publishing date | 2024-02-29 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2397213-0 |
| ISSN | 1550-9397 ; 1550-9389 |
| ISSN (online) | 1550-9397 |
| ISSN | 1550-9389 |
| DOI | 10.5664/jcsm.11088 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6590: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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