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Article ; Online: In Vivo Monitoring of Polycythemia Vera Development Reveals Carbonic Anhydrase 1 as a Potent Therapeutic Target.

Murakami, Shohei / Barroca, Vilma / Perié, Leïla / Bravard, Anne / Bernardino-Sgherri, Jacqueline / Tisserand, Amandine / Devanand, Caroline / Edmond, Valérie / Magniez, Aurélie / Tenreira Bento, Sabrina / Torres, Claire / Pasquier, Florence / Plo, Isabelle / Vainchenker, William / Villeval, Jean-Luc / Roméo, Paul-Henri / Lewandowski, Daniel

publication RETRACTED

Blood cancer discovery

2022 Volume 3, Issue 4, Page(s) 285–297

Abstract: ... in JAK2V617F hematopoietic cells into a single irradiated leg, we show development of polycythemia vera (PV ...

Abstract	Current murine models of myeloproliferative neoplasms (MPNs) cannot examine how MPNs progress from a single bone marrow source to the entire hematopoietic system. Thus, using transplantation of knock-in JAK2V617F hematopoietic cells into a single irradiated leg, we show development of polycythemia vera (PV) from a single anatomic site in immunocompetent mice. Barcode experiments reveal that grafted JAK2V617F stem/progenitor cells migrate from the irradiated leg to nonirradiated organs such as the contralateral leg and spleen, which is strictly required for development of PV. Mutant cells colonizing the nonirradiated leg efficiently induce PV in nonconditioned recipient mice and contain JAK2V617F hematopoietic stem/progenitor cells that express high levels of carbonic anhydrase 1 (CA1), a peculiar feature also found in CD34+ cells from patients with PV. Finally, genetic and pharmacologic inhibition of CA1 efficiently suppresses PV development and progression in mice and decreases PV patients' erythroid progenitors, strengthening CA1 as a potent therapeutic target for PV. Significance: Follow-up of hematopoietic malignancies from their initiating anatomic site is crucial for understanding their development and discovering new therapeutic avenues. We developed such an approach, used it to characterize PV progression, and identified CA1 as a promising therapeutic target of PV. This article is highlighted in the In This Issue feature, p. 265.
MeSH term(s)	Animals ; Carbonic Anhydrases ; Hematologic Neoplasms/pathology ; Hematopoietic Stem Cells ; Janus Kinase 2/genetics ; Mice ; Polycythemia Vera/drug therapy
Chemical Substances	Janus Kinase 2 (EC 2.7.10.2) ; Carbonic Anhydrases (EC 4.2.1.1)
Language	English
Publishing date	2022-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
ZDB-ID	3028898-8
ISSN	2643-3249 ; 2643-3230
ISSN (online)	2643-3249
ISSN	2643-3230
DOI	10.1158/2643-3230.BCD-21-0039
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Article ; Online: O uso do aloe vera como coadjuvante no tratamento periodontal

Adriano Flores da Silva / Erika Thaís Cruz da Silva / Suellen Rabelo Rocha da Costa / Priscila Lima Bezerra / Aretha Helen Aragão Lourenço / Ítalo de Macedo Bernardino

Research, Society and Development, Vol 10, Iss 1, Pp e7110111511-e

2021 Volume 7110111511

Abstract: Objetivo: Revisar os estudos mais atuais na literatura sobre a eficácia da Aloe Vera ... escolhidos mediante consulta nos Descritores de Ciências da Saúde – DECs da BIREME. Resultados: A Aloe Vera ... clínicos das doenças periodontais. Conclusão: A Aloe Vera é um medicamento fitoterápico com propriedades ...

Abstract	Objetivo: Revisar os estudos mais atuais na literatura sobre a eficácia da Aloe Vera como coadjuvante no tratamento periodontal. Material e Métodos: Foram selecionados artigos científicos publicados entre os anos de 2013 e 2019, através dos bancos de dados PubMed e Google Scholar com os seguintes descritores em português e inglês respectivamente, “Gengivite (Gengivitis)”, “Periodontite (Periodontitis)”, “Aloe (Aloe)”, “Medicamentos Fitoterápicos (Phytotherapeutic Drugs)”, “Periodontia (Periodontics)” e “Odontologia (Dentistry), escolhidos mediante consulta nos Descritores de Ciências da Saúde – DECs da BIREME. Resultados: A Aloe Vera é uma planta medicinal com ações semelhantes ao da Clorexidina e superior a outros fitoterápicos na diminuição dos sinais clínicos das doenças periodontais. Conclusão: A Aloe Vera é um medicamento fitoterápico com propriedades antibacterianas e anti-inflamatórias, comprovado através de testes clínicos e laboratoriais, capaz de agir com segurança na diminuição dos patógenos periodontais e, por isto, é eficaz como coadjuvante no tratamento periodontal.
Keywords	gengivite ; periodontite ; medicamentos fitoterápicos ; aloe ; ; Special aspects of education ; LC8-6691 ; Science (General) ; Q1-390 ; Social Sciences ; H
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Orazione quarta. Tenuta il 6 novembre 1702. La vera teoria e la prassi delle febbri devono essere annoverate fra i desiderata.

Ramazzini, Bernardino

La Medicina del lavoro

2010 Volume 101 Suppl 3, Page(s) 44–53

Title translation	4th lecture. Held on 6 November 1702. The true theory and praxis for fevers ought to be counted among the desirable things.
MeSH term(s)	Antipyretics/history ; Antipyretics/therapeutic use ; Fever/drug therapy ; Fever/etiology ; Fever/history ; Fever/physiopathology ; Fever/therapy ; History, 18th Century ; Humans ; Italy ; Models, Biological ; Occupational Medicine/history ; Plant Preparations/history ; Plant Preparations/therapeutic use
Chemical Substances	Antipyretics ; Plant Preparations
Language	Italian
Publishing date	2010
Publishing country	Italy
Document type	Biography ; Classical Article ; Historical Article ; Journal Article
ZDB-ID	123678-7
ISSN	0025-7818
ISSN	0025-7818
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Article ; Online: Estudo da viabilidade econômica do cultivo da babosa (aloe vera L.) Study of economic viability of the Aloe vera L. culture

Dionizio Bernardino Bach / Marcos Aurélio Lopes

Ciência e Agrotecnologia, Vol 31, Iss 4, Pp 1136-

2007 Volume 1144

Abstract: ... the economic viability of Aloe vera L. and verify if the culture of this plant is or not an alternative economically ... in Paulo Lopes, SC. In the determination of the production cost of one Aloe vera L hectare, all the phases ...

Abstract	Conduziu-se este este trabalho, com o objetivo de estudar a viabilidade econômica da babosa e verificar se o cultivo desta planta é ou não, uma alternativa economicamente viável ao produtor rural. Os dados relativos ao custo de produção, utilizados neste trabalho, foram obtidos junto às áreas de produção e instalações industriais da NATURAMA - Indústria e Comércio de Produtos Agropecuários Ltda, estabelecida no município de Paulo Lopes, SC. Na determinação do custo de produção de um hectare de babosa, em cultivo orgânico, foram consideradas todas as etapas, desde a obtenção das mudas até a conclusão do processamento, quando o produto final encontra-se apto ao consumo, e neste caso, é uma bebida em forma de suco. O processamento dos dados foi realizado utilizando uma planilha eletrônica desenvolvida especificamente para esse fim, a qual estimou os custos utilizando as metodologias do custo total (custos fixos e variáveis) e do custo operacional total (custo operacional efetivo e depreciações). Pela análise da rentabilidade, conclui-se que a atividade é economicamente viável. The aim of this work is to study the economic viability of Aloe vera L. and verify if the culture of this plant is or not an alternative economically viable for the farmer. The data of production cost used in this work were gotten in the areas of production and industrial installations of NATURAMA- Industry and Trade of Farming Products LTDA, settled in Paulo Lopes, SC. In the determination of the production cost of one Aloe vera L hectare, all the phases were taken into consideration, from the getting of molts up to the conclusion of the processing, when the final product is ready to the consumption, and in this case, it's a beverage in a way of juice. The processing data was made by using an electronic spread sheet developed specifically for this reason, which estimated the costs using the methodologies of the total cost (steady and variable costs) and of the total operational cost (effective operational cost and depreciations). By ...
Keywords	Cultivo orgânico ; custo de produção ; rentabilidade ; Aloe vera ; Organic culture ; production cost ; profitability ; Agriculture (General) ; S1-972
Language	English
Publishing date	2007-08-01T00:00:00Z
Publisher	Universidade Federal de Lavras
Document type	Article ; Online
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Article: Non-bacterial Thrombotic Endocarditis as a Rare Manifestation of Early Stage Gastric Cancer.

Fernandes, Jorge R / Rodrigues, Ana C / Bernardino, Vera R / Panarra, António

Cureus

2022 Volume 14, Issue 5, Page(s) e25213

Abstract: Endocarditis is an inflammation of the endocardium and is characterized by the presence of vegetation, which may occur in the context of infectious or non-infectious diseases. Despite the higher rate of infective endocarditis diagnosis, it may also surge ...

Abstract	Endocarditis is an inflammation of the endocardium and is characterized by the presence of vegetation, which may occur in the context of infectious or non-infectious diseases. Despite the higher rate of infective endocarditis diagnosis, it may also surge in other non-infectious conditions such as cancer or chronic inflammatory syndromes. Cancer defines a hypercoagulable state, and cancer-associated thrombophilia can have a diverse clinical presentation, most commonly venous thromboembolism and rarely non-bacterial thrombotic endocarditis (NBTE). The diagnosis of NBTE is difficult and requires a high level of suspicion. The treatment relies on anticoagulant therapy, control of underlying disease, and valve replacement when applied. Independently of the etiology, without treatment, endocarditis may lead to valve dysfunction and to the worst prognosis. In this paper, we describe a case of a patient with persistent fever and NBTE of the tricuspid valve, disclosing a rare presentation of gastric cancer.
Language	English
Publishing date	2022-05-22
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.25213
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Article: Case Report: Artifactual Hypoglycemia: A Condition That Should Not Be Forgotten.

Amaral, Sara / Palha, Ana / Bernardino, Vera / Silva-Nunes, José

Frontiers in endocrinology

2022 Volume 13, Page(s) 951377

Abstract: Background: Hypoglycemia is uncommon in people who are not being treated for diabetes mellitus and, when present, the differential diagnosis is broad. Artifactual hypoglycemia describes discrepancy between low capillary and normal plasma glucose levels ... ...

Abstract	Background: Hypoglycemia is uncommon in people who are not being treated for diabetes mellitus and, when present, the differential diagnosis is broad. Artifactual hypoglycemia describes discrepancy between low capillary and normal plasma glucose levels regardless of symptoms and should be considered in patients with Raynaud's phenomenon. Case presentation: A 46-year-old female patient with a history of a sleeve gastrectomy started complaining about episodes of lipothymias preceded by sweating, nausea, and dizziness. During one of these episodes, a capillary blood glucose was obtained with a value of 24 mg/dl. She had multiple emergency admissions with low-capillary glycemia. An exhaustive investigation for possible causes of hypoglycemia was made for 18 months. The 72h fasting test was negative for hypoglycemia. A Raynaud's phenomenon was identified during one appointment. Conclusion: Artifactual hypoglycemia has been described in various conditions including Raynaud's phenomenon, peripheral arterial disease, Eisenmenger syndrome, acrocyanosis, or hypothermia. With this case report, we want to reinforce the importance of being aware of this diagnosis to prevent anxiety, unnecessary treatment, and diagnostic tests.
MeSH term(s)	Awareness ; Blood Glucose ; Diabetes Mellitus ; Female ; Humans ; Hypoglycemia/diagnosis ; Hypoglycemia/etiology ; Memory Disorders ; Middle Aged
Chemical Substances	Blood Glucose
Language	English
Publishing date	2022-07-28
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.951377
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Article ; Online: Raynaud's phenomenon and inflammatory bowel disease: The possible role of microcirculation.

Bernardino, Vera R / Rodrigues, Ana Catarina / Panarra, António

European journal of internal medicine

2019 Volume 62, Page(s) e16

MeSH term(s)	Adult ; Capillaries/pathology ; Female ; Humans ; Inflammatory Bowel Diseases/complications ; Male ; Microcirculation ; Middle Aged ; Nails/blood supply ; Raynaud Disease/diagnosis ; Raynaud Disease/pathology
Language	English
Publishing date	2019-02-06
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2019.02.001
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Article ; Online: The Prevalence of COVID-19 Fog and the Impact on Quality of Life After SARS-CoV-2 Infection (QoL-COVID): A Cross Sectional Study.

Rego de Figueiredo, Inês / Branco Ferrão, Joana / Dias, Sara / Drummond Borges, Diogo / Fernandes, Jorge / Bernardino, Vera / Gruner, Heidi / Panarra, António

Acta medica portuguesa

2023 Volume 36, Issue 10, Page(s) 631–638

Abstract: Introduction: Coronavirus has an impact on both the physical and mental health of individuals. The literature regarding the patient's health status post-SARS-CoV-2 is still scarce with limited data on the prevalence of residual symptoms and quality of ... ...

Abstract	Introduction: Coronavirus has an impact on both the physical and mental health of individuals. The literature regarding the patient's health status post-SARS-CoV-2 is still scarce with limited data on the prevalence of residual symptoms and quality of life (QoL) after the infection. The aim of this study was to understand the impact of SARS-CoV-2 on patient QoL, and remaining symptoms. Material and methods: Single center cross-sectional study of patients who had been admitted to our COVID-19 ward between March 2020 and March 2021. By applying a QoL questionnaire (EQ-5D-5L) we assessed the overall sample, at three time points and in different groups of patients: those admitted to the intensive care unit (ICU) and the elderly. Results: A total of 125 participants were included in our study. Most patients who were admitted had a severe course of disease (51%), with 22% of admissions to the ICU, with 8% requiring prone ventilation, 10% experiencing thrombotic complications and 18% of nosocomial infections throughout the admission. As for persistent symptoms related with COVID-19 fog, the most frequent were fatigue (57%), memory loss (52%) and insomnia (50%). Regarding QoL, the average decrease was 0.08 ± 0.2 in the index and 8.7 ± 19 in the Visual Analogue Scale (VAS). The QoL index decrease correlated with age, chronic obstructive pulmonary disease, asthma and heart failure, and all persistent symptoms, significantly. QoL VAS correlated significantly with fatigue, mood changes, difficulty concentrating and memory loss. The decrease in QoL and the persistent symptoms remained overall stable over the three time points. The ICU group showed no statistically significant difference in QoL, but the most frequently persistent symptoms were mood changes and attention disturbances. However, the elderly experienced a worsening in QoL expressed by index (0.69 ± 0.3 vs 0.8 ± 0.2, p-value = 0.01). Conclusion: A decrease in QoL was observed following SARS-CoV-2 infection, correlating with both chronic conditions and persistent symptoms. The lack of difference through time points of both QoL and persistent symptoms suggests a long-standing effect.
MeSH term(s)	Humans ; Aged ; COVID-19 ; Cross-Sectional Studies ; SARS-CoV-2 ; Quality of Life ; Prevalence ; Memory Disorders ; Fatigue
Language	English
Publishing date	2023-02-15
Publishing country	Portugal
Document type	Journal Article
ZDB-ID	603078-6
ISSN	1646-0758 ; 0870-399X
ISSN (online)	1646-0758
ISSN	0870-399X
DOI	10.20344/amp.18784
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Article ; Online: Monitoring free digoxin serum concentrations after injection of digoxin-specific antibody fragments in a man with chronic digoxin poisoning.

Socias Crespí, Lorenzo / Gomila Muñiz, Isabel / Socias Mir, Antonia / Ripoll-Vera, Tomás / Elorza Guerrero, Miguel Ángel / Barceló Martín, Bernardino

Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias

2022 Volume 34, Issue 3, Page(s) 238–239

Title translation	Monitorización de digoxina libre tras la administración de anticuerpos antidigoxina en un caso de intoxicación digitálica crónica.
MeSH term(s)	Chronic Disease ; Digoxin ; Disease Progression ; Humans ; Male
Chemical Substances	Digoxin (73K4184T59)
Language	Spanish
Publishing date	2022-06-23
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2127173-2
ISSN	2386-5857 ; 2386-5857
ISSN (online)	2386-5857
ISSN	2386-5857
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Article: A Very Rare Case of Mass-Like Mesenteric Fat Necrosis in a Patient with Antiphospholipid Syndrome.

Lourenço, Ana Luísa / Lopes Dias, João / Marques, Joana / Bernardino, Vera

GE Portuguese journal of gastroenterology

2020 Volume 28, Issue 2, Page(s) 139–143

Abstract: Introduction: Intra-abdominal fat is a metabolically active tissue that can undergo necrosis due to torsion, infarction, or trauma. Despite being asymptomatic in most cases, fat necrosis or steatonecrosis can cause abdominal pain. : Presentation: ... ...

Abstract	Introduction: Intra-abdominal fat is a metabolically active tissue that can undergo necrosis due to torsion, infarction, or trauma. Despite being asymptomatic in most cases, fat necrosis or steatonecrosis can cause abdominal pain. Presentation: This article describes the case of a male patient admitted to the emergency department with diffuse abdominal pain for the past month. The patient had a past medical history of antiphospholipid syndrome with multiple venous thromboembolic events and one episode of lower limb vasculitis, currently under anticoagulation treatment. Imaging studies with computed tomography and magnetic resonance revealed a mesenteric mass-like lesion adjacent to the ileal bowel loops. The patient underwent surgical resection, and the microscopic analysis revealed extensive organizing fat necrosis with reactive panniculitis and hemorrhage. Discussion and conclusion: This article describes a rare case of a mesenteric mass-like encapsulated fat necrosis in a patient with antiphospholipid syndrome, with very atypical location and imaging features.
Language	English
Publishing date	2020-06-11
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2835774-7
ISSN	2387-1954 ; 2341-4545
ISSN (online)	2387-1954
ISSN	2341-4545
DOI	10.1159/000507939
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