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  1. Article ; Online: Commotio Cordis and One Medicine.

    Meyerholz, David K

    Veterinary pathology

    2023  Volume 60, Issue 3, Page(s) 291–293

    MeSH term(s) Animals ; Commotio Cordis/veterinary ; Death, Sudden, Cardiac/veterinary ; Wounds, Nonpenetrating/veterinary ; Thoracic Injuries/veterinary
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188012-3
    ISSN 1544-2217 ; 0300-9858
    ISSN (online) 1544-2217
    ISSN 0300-9858
    DOI 10.1177/03009858231162223
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  2. Article ; Online: Rigid respiration: fulminant pulmonary fibrosis after COVID-19.

    Meyerholz, David K

    EBioMedicine

    2022  Volume 87, Page(s) 104428

    MeSH term(s) Humans ; Pulmonary Fibrosis/diagnosis ; Pulmonary Fibrosis/etiology ; Pulmonary Fibrosis/pathology ; COVID-19/pathology ; Lung/diagnostic imaging ; Lung/pathology ; Respiration
    Language English
    Publishing date 2022-12-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.104428
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  3. Article ; Online: Cells that survive acute murine SARS-CoV-2 infection are detected nearly exclusively in the respiratory tract.

    Pan, Ruangang / Meyerholz, David K / Perlman, Stanley

    The Journal of clinical investigation

    2023  Volume 133, Issue 22

    MeSH term(s) Animals ; Mice ; COVID-19 ; SARS-CoV-2 ; Respiratory System ; Virus Replication
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI172659
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  4. Article ; Online: Concerns about pathology expertise and data quality.

    McInnes, Elizabeth F / Meyerholz, David K / Arends, Mark J

    The Journal of pathology

    2023  Volume 259, Issue 4, Page(s) 468

    MeSH term(s) Data Accuracy ; Pathology
    Language English
    Publishing date 2023-02-24
    Publishing country England
    Document type Letter
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.6058
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  5. Article ; Online: Influence of SARS-CoV-2 on airway mucus production: A review and proposed model.

    Meyerholz, David K / Reznikov, Leah R

    Veterinary pathology

    2021  Volume 59, Issue 4, Page(s) 578–585

    Abstract: Coronavirus disease 2019 (COVID-19) is a worldwide pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has affected millions of lives. Individuals who survive severe COVID-19 can experience sustained respiratory symptoms ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is a worldwide pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has affected millions of lives. Individuals who survive severe COVID-19 can experience sustained respiratory symptoms that persist for months after initial infection. In other airway diseases, abnormal airway mucus contributes to sustained airway symptoms. However, the impact of SARS-CoV-2 on airway mucus has received limited attention. In the current review, we assess literature describing the impact of SARS-CoV-2 on airway pathophysiology with specific emphasis on mucus production. Accumulating evidence suggests that the 2 major secreted airway mucin glycoproteins, MUC5AC and MUC5B, are abnormal in some patients with COVID-19. Aberrations in MUC5AC or MUC5B in response to SARS-CoV-2 infection are likely due to inflammation, though the responsible mechanisms have yet to be determined. Thus, we also provide a proposed model highlighting mechanisms that can contribute to acute and sustained mucus abnormalities in SARS-CoV-2, with an emphasis on inflammatory cells and mediators, including mast cells and histamine. Last, we bring to light the challenges of studying abnormal mucus production in SARS-CoV-2 infections and discuss the strengths and limitations of model systems commonly used to study COVID-19. The evidence to date suggests that ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
    MeSH term(s) Animals ; COVID-19/veterinary ; Ferrets ; Mucus ; Pandemics/veterinary ; SARS-CoV-2
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 188012-3
    ISSN 1544-2217 ; 0300-9858
    ISSN (online) 1544-2217
    ISSN 0300-9858
    DOI 10.1177/03009858211058837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Swine models in translational research and medicine.

    Meyerholz, David K / Burrough, Eric R / Kirchhof, Nicole / Anderson, Douglas J / Helke, Kristi L

    Veterinary pathology

    2024  , Page(s) 3009858231222235

    Abstract: Swine are increasingly studied as animal models of human disease. The anatomy, size, longevity, physiology, immune system, and metabolism of swine are more like humans than traditional rodent models. In addition, the size of swine is preferred for ... ...

    Abstract Swine are increasingly studied as animal models of human disease. The anatomy, size, longevity, physiology, immune system, and metabolism of swine are more like humans than traditional rodent models. In addition, the size of swine is preferred for surgical placement and testing of medical devices destined for humans. These features make swine useful for biomedical, pharmacological, and toxicological research. With recent advances in gene-editing technologies, genetic modifications can readily and efficiently be made in swine to study genetic disorders. In addition, gene-edited swine tissues are necessary for studies testing and validating xenotransplantation into humans to meet the critical shortfall of viable organs versus need. Underlying all of these biomedical applications, the knowledge of husbandry, background diseases and lesions, and biosecurity needs are important for productive, efficient, and reproducible research when using swine as a human disease model for basic research, preclinical testing, and translational studies.
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 188012-3
    ISSN 1544-2217 ; 0300-9858
    ISSN (online) 1544-2217
    ISSN 0300-9858
    DOI 10.1177/03009858231222235
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  7. Article: Influence of SARS-CoV-2 on airway mucus production: A review and proposed model

    Meyerholz, David K. / Reznikov, Leah R.

    Veterinary pathology. 2022 July, v. 59, no. 4

    2022  

    Abstract: Coronavirus disease 2019 (COVID-19) is a worldwide pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has affected millions of lives. Individuals who survive severe COVID-19 can experience sustained respiratory symptoms ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is a worldwide pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has affected millions of lives. Individuals who survive severe COVID-19 can experience sustained respiratory symptoms that persist for months after initial infection. In other airway diseases, abnormal airway mucus contributes to sustained airway symptoms. However, the impact of SARS-CoV-2 on airway mucus has received limited attention. In the current review, we assess literature describing the impact of SARS-CoV-2 on airway pathophysiology with specific emphasis on mucus production. Accumulating evidence suggests that the 2 major secreted airway mucin glycoproteins, MUC5AC and MUC5B, are abnormal in some patients with COVID-19. Aberrations in MUC5AC or MUC5B in response to SARS-CoV-2 infection are likely due to inflammation, though the responsible mechanisms have yet to be determined. Thus, we also provide a proposed model highlighting mechanisms that can contribute to acute and sustained mucus abnormalities in SARS-CoV-2, with an emphasis on inflammatory cells and mediators, including mast cells and histamine. Last, we bring to light the challenges of studying abnormal mucus production in SARS-CoV-2 infections and discuss the strengths and limitations of model systems commonly used to study COVID-19. The evidence to date suggests that ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; animal pathology ; histamine ; inflammation ; models ; mucins ; mucus ; pandemic ; pathophysiology
    Language English
    Dates of publication 2022-07
    Size p. 578-585.
    Publishing place SAGE Publications
    Document type Article
    ZDB-ID 188012-3
    ISSN 1544-2217 ; 0300-9858
    ISSN (online) 1544-2217
    ISSN 0300-9858
    DOI 10.1177/03009858211058837
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  8. Article ; Online: Evolving challenges to model human diseases for translational research.

    Beck, Amanda P / Meyerholz, David K

    Cell and tissue research

    2020  Volume 380, Issue 2, Page(s) 305–311

    Abstract: Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have been significant ...

    Abstract Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have been significant changes in the landscape of animal modeling. For example, newer techniques have greatly expanded the use and successful application of large animal models such as pigs for translational studies. The evolving types and species of animal models can influence the research landscape in terms of facilities, expertise, reproducibility and funding streams, which creates new challenges for research studies. It is also important that investigators are prepared to address the necessity of their animal model research and capable to educate the public regarding its value.
    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Translational Research, Biomedical/methods
    Language English
    Publishing date 2020-03-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-019-03134-3
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  9. Article ; Online: Early intrahepatic duct defects in a cystic fibrosis porcine model.

    Zarei, Keyan / Meyerholz, David K / Stoltz, David A

    Physiological reports

    2021  Volume 9, Issue 14, Page(s) e14978

    Abstract: Hepatobiliary disease causes significant morbidity and mortality in people with cystic fibrosis (CF), yet this problem remains understudied. Previous studies in the newborn CF pig demonstrated decreased bile flow into the small intestine and a ... ...

    Abstract Hepatobiliary disease causes significant morbidity and mortality in people with cystic fibrosis (CF), yet this problem remains understudied. Previous studies in the newborn CF pig demonstrated decreased bile flow into the small intestine and a microgallbladder with increased luminal mucus and fluid secretion defects. In this study, we examined the intrahepatic bile ducts of the newborn CF pig. We assessed whether our findings from the gallbladder are present elsewhere in the porcine biliary tract and if CF pig cholangiocytes have fluid secretion defects. Immunohistochemistry demonstrated apical CFTR expression in non-CF pig intrahepatic bile ducts of a variety of sizes; CF pig intrahepatic bile ducts lacked CFTR expression. Assessment of serum markers did not reveal significant signs of hepatobiliary disease except for an elevation in direct bilirubin. Quantitative histology demonstrated that CF pigs had smaller bile ducts that more frequently contained luminal mucus. CF intrahepatic cholangiocyte organoids were smaller and lacked cAMP-mediated fluid secretion. Together these data suggest that cholangiocyte fluid secretion is decreased in the CF pig, contributing to structural changes in bile ducts and decreased biliary flow.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Animals, Newborn ; Bile Ducts, Intrahepatic/metabolism ; Bile Ducts, Intrahepatic/pathology ; Cystic Fibrosis/genetics ; Cystic Fibrosis/metabolism ; Cystic Fibrosis/pathology ; Cystic Fibrosis Transmembrane Conductance Regulator/deficiency ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Disease Models, Animal ; Swine
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2021-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.14978
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  10. Article ; Online: Does common cold coronavirus infection protect against severe SARS-CoV-2 disease?

    Meyerholz, David K / Perlman, Stanley

    The Journal of clinical investigation

    2020  Volume 131, Issue 1

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic continues to cause morbidity and mortality. Since SARS coronavirus 2 (SARS-CoV-2) was identified as the cause for COVID-19, some have questioned whether exposure to seasonal common cold coronaviruses (CCCs) ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic continues to cause morbidity and mortality. Since SARS coronavirus 2 (SARS-CoV-2) was identified as the cause for COVID-19, some have questioned whether exposure to seasonal common cold coronaviruses (CCCs) could provide tangible protection against SARS-CoV-2 infection or disease. In this issue of the JCI, Sagar et al. examined SARS-CoV-2 infections and outcomes of patients who had previously tested positive or negative for CCC infection (CCC+ or CCC-) by a comprehensive respiratory panel using PCR. No differences were seen between groups in terms of susceptibility to SARS-CoV-2 infection. However, hospitalized patients with a documented history of CCC infection had lower rates of intensive care unit (ICU) admissions and higher rates of survival than hospitalized CCC- patients. While these findings are associative and not causative, they highlight evidence suggesting that previous CCC infection may influence the disease course of SARS-CoV-2 infection.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/prevention & control ; Common Cold/epidemiology ; Common Cold/immunology ; Humans ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2/immunology
    Language English
    Publishing date 2020-11-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI144807
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