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  1. Article: Fabrication of folic acid-modified bovine serum albumin cloaked dual-drug loaded hollow mesoporous silica nanoparticles for pH-responsive and targeted delivery of gastric cancer therapy.

    Zhang, Yuanwei / Liang, Yuanxiao

    Heliyon

    2024  Volume 10, Issue 8, Page(s) e29274

    Abstract: Combination therapy is a highly successful way to address the limitations of using a single treatment method and improve therapy's overall efficacy. In this study, we developed a unique hollow mesoporous silica nanoparticle (HMSN) coated with folic acid ( ...

    Abstract Combination therapy is a highly successful way to address the limitations of using a single treatment method and improve therapy's overall efficacy. In this study, we developed a unique hollow mesoporous silica nanoparticle (HMSN) coated with folic acid (FA)-modified bovine serum albumin (FA-BSA). This nanoparticle, referred to as HFB, was designed to target cancer cells and release dual therapeutic drugs, Indocyanine green (ICG) and Paclitaxel (PTX), in response to specific stimuli termed as HFB@IP. The BSA protein acts as a "gatekeeper" to prevent early drug releases and cargo leakage by detaching from BSA in reaction to GSH. The FA facilitates the targeted transport of the drug into cancer cells that express folate receptors (FR), enhancing the effectiveness of chemo-photodynamic treatment (PDT). The drug nanocarrier demonstrated in vitro pH/redox-triggered drug release from HFB@IP due to breaking the imine bonds between aldehyde-functionalized HMSN (CHO-HMSN) and FA-BSA with the disulfide bond inside BSA. In addition, various biological assessments, including cell uptake experiments, demonstrated that HFB@IP effectively targets SGC-7901 cells and induces apoptosis in vitro. Further, it exhibits remarkable efficiency in synergistically killing cancer cells through chemo-photodynamic therapy, as indicated by a combination index (CI) of 0.328. The results showed that combining HMSN with biodegradable stimuli-responsive BSA molecules could offer a promising approach for precise chemo-photodynamic therapy in treating gastric cancer, allowing for the controlled release of drugs as necessary.
    Language English
    Publishing date 2024-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29274
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  2. Article ; Online: Generation of Cerebral Cortical Neurons from Human Pluripotent Stem Cells in 3D Culture.

    Yan, Yuanwei / Zhang, Su-Chun

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2683, Page(s) 1–11

    Abstract: Human forebrain cortical neurons are essential for fundamental functions like memory and consciousness. Generation of cortical neurons from human pluripotent stem cells provides a great source for creating models specific to cortical neuron diseases and ... ...

    Abstract Human forebrain cortical neurons are essential for fundamental functions like memory and consciousness. Generation of cortical neurons from human pluripotent stem cells provides a great source for creating models specific to cortical neuron diseases and for developing therapeutics. This chapter describes a detailed and robust method for generating human mature cortical neurons from stem cells in 3D suspension culture.
    MeSH term(s) Humans ; Neurons ; Pluripotent Stem Cells ; Prosencephalon ; Cerebral Cortex ; Cell Differentiation ; Induced Pluripotent Stem Cells
    Language English
    Publishing date 2023-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3287-1_1
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  3. Article ; Online: pH-Sensitive and Lysosome Targetable Photosensitizers Based on BODIPYs.

    Liu, Xiangshan / Yu, Shupei / Zhang, Yuanwei

    Journal of fluorescence

    2024  

    Abstract: Photodynamic therapy (PDT) is an effective and U.S. Food and Drug Administration (FDA) approved treatment for cancer and other diseases. Photosensitizer is one of the three key components that harvest the energy of light at a certain wavelength. Compared ...

    Abstract Photodynamic therapy (PDT) is an effective and U.S. Food and Drug Administration (FDA) approved treatment for cancer and other diseases. Photosensitizer is one of the three key components that harvest the energy of light at a certain wavelength. Compared to the conventional fluorophores used as photosensitizers, boron dipyrromethene (BODIPY) derivatives have grown fast in recent years due to their low dark toxicity, versatile tunable sites, and easiness of being paired with other treatments. In this paper, two pH-sensitive BODIPY-based photosensitizers (BDC and BDBrC) were synthesized by adding carbazole moieties onto the BODIPY cores (BD and BDBr) through condensation reactions. BDBrC has two Br atoms at the BODIPY core that promote singlet oxygen generation and further red-shift the absorption maximum peak. Both compounds showed sensitivity toward pH change and generated more singlet oxygen under acidic conditions. The cellular uptake and cell imaging experiments showed that BDBrC can selectively target the lysosome organelle. The further dark cell viability and light cytotoxicity indicate the light triggered PDT treatment can be accomplished with BDBrC.
    Language English
    Publishing date 2024-01-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2016892-5
    ISSN 1573-4994 ; 1053-0509
    ISSN (online) 1573-4994
    ISSN 1053-0509
    DOI 10.1007/s10895-023-03562-z
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  4. Article ; Online: A facile and scalable method to synthesize PEGylated PDMAEMA for gene delivery.

    Dou, Jie / Yu, Shupei / Zhang, Yuanwei

    Biopolymers

    2024  , Page(s) e23584

    Abstract: In recent years, cationic polymer vectors have been viewed as a promising method for delivering nucleic acids. With the advancement of synthetic polymer chemistry, we can control chemical structures and properties to enhance the efficacy of gene delivery. ...

    Abstract In recent years, cationic polymer vectors have been viewed as a promising method for delivering nucleic acids. With the advancement of synthetic polymer chemistry, we can control chemical structures and properties to enhance the efficacy of gene delivery. Herein, a facile, cost-effective, and scalable method was developed to synthesize PEGylated PDMAEMA polymers (PEO-PDMAEMA-PEO), where PEGylation could enable prolonged polyplexes circulation time in the blood stream. Two polymers of different molecular weights were synthesized, and polymer/eGFP polyplexes were prepared and characterized. The correlation between polymers' molecular weight and physicochemical properties (size and zeta potential) of polyplexes was investigated. Lipofectamine 2000, a commercial non-viral transfection reagent, was used as a standard control. PEO-PDMAEMA-PEO with higher molecular weight exhibited slightly better transfection efficiency than Lipofectamine 2000, and the cytotoxicity study proved that it could function as a safe gene vector. We believe that PEO-PDMAEMA-PEO could serve as a model to investigate more potential in the gene delivery area.
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1123-x
    ISSN 1097-0282 ; 0006-3525
    ISSN (online) 1097-0282
    ISSN 0006-3525
    DOI 10.1002/bip.23584
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    Zs.A 77: Show issues Location:
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  5. Article ; Online: A rare case of small intestine torsion in pregnancy.

    Zhang, Yuanwei / Chi, Shenglin

    Asian journal of surgery

    2023  Volume 46, Issue 10, Page(s) 4685–4686

    Abstract: Article's main point: This article retrospectively analyzed the clinical data of a patient with small bowel torsion during pregnancy to provide ideas for diagnosing and treating small bowel torsion during pregnancy. This case of pregnancy with small ... ...

    Abstract Article's main point: This article retrospectively analyzed the clinical data of a patient with small bowel torsion during pregnancy to provide ideas for diagnosing and treating small bowel torsion during pregnancy. This case of pregnancy with small intestinal volvulus gives us the following tips in the diagnosis and treatment: 1) During pregnancy, the abdominal signs of pregnant women are usually atypical, especially in the middle and late stages of pregnancy. Diagnosing intestinal torsion is often tricky and can easily be confused with obstetric emergencies such as threatened abortion, preterm labor pain, placental abruption, and uterine rupture. It is also difficult to distinguish from surgical emergencies such as acute pancreatitis, acute appendicitis, and gastrointestinal perforation. When pregnant women experience nausea, vomiting, and abdominal pain, intestinal torsion should be considered in the differential diagnosis. 2) Abdominal CT, X-ray, and other radiological examinations may cause fetal tissue damage and dysfunction. In addition, ultrasound diagnosis is also limited by the enlarged uterus, patient conditions, and scanning scope, which has a certain risk of missed diagnosis and misdiagnosis. MRI has become an important diagnostic tool for acute abdomen in pregnancy because of its non-radiation and high resolution. 3) Intestinal torsion during pregnancy is often difficult to self-reposition and can lead to intestinal necrosis in a short time. In such cases, surgical treatment is usually the first choice. For pregnant women with acute abdomen, we should adhere to the principles of diagnosis and treatment of the acute surgical abdomen, master the indications of surgical exploration such as peritonitis, and perform surgical treatment in time to avoid further deterioration of the condition and reduce the risk of fetal loss.
    MeSH term(s) Infant, Newborn ; Pregnancy ; Female ; Humans ; Intestinal Volvulus/complications ; Abdomen, Acute/etiology ; Abdomen, Acute/surgery ; Acute Disease ; Emergencies ; Retrospective Studies ; Pancreatitis ; Placenta ; Abdominal Pain/etiology ; Intestine, Small/diagnostic imaging ; Intestine, Small/surgery
    Language English
    Publishing date 2023-06-02
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.05.082
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    Zs.B 2831: Show issues Location:
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  6. Article: Editorial: Complexity of tumor microenvironment: A major culprit in cancer development, volume II.

    Bukhari, Ihtisham / Zhang, Yuanwei / Thorne, Rick Francis / Mi, Yang

    Frontiers in endocrinology

    2023  Volume 13, Page(s) 1126778

    MeSH term(s) Humans ; Neoplasms ; Prognosis
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.1126778
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  7. Article ; Online: Molecular basis and mechanism of action of

    Huang, Bishan / Wu, Yingyao / Li, Chan / Tang, Qingfa / Zhang, Yuanwei

    Chinese herbal medicines

    2023  Volume 15, Issue 2, Page(s) 201–213

    Abstract: ... Albizzia ... ...

    Abstract Albizzia julibrissin
    Language English
    Publishing date 2023-03-15
    Publishing country Singapore
    Document type Journal Article ; Review
    ISSN 2589-3610
    ISSN (online) 2589-3610
    DOI 10.1016/j.chmed.2022.10.004
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  8. Article ; Online: Correlation between Pain and Anal Defecation Function in Postoperative Patients with Colorectal Cancer and Related Factors Affecting Patients' Prognosis.

    Zhang, Yuanwei / Xiang, Chengjiang / Liang, Jinhao

    Annali italiani di chirurgia

    2024  Volume 95, Issue 2, Page(s) 136–143

    Abstract: Background: The degree of postoperative pain and defecation function in colorectal cancer will affect patients' prognosis. Therefore, exploring the correlation between postoperative pain and defecation function, and analyzing the related factors, will ... ...

    Abstract Background: The degree of postoperative pain and defecation function in colorectal cancer will affect patients' prognosis. Therefore, exploring the correlation between postoperative pain and defecation function, and analyzing the related factors, will help to improve the quality of patients' prognosis.
    Methods: A total of 94 patients with colorectal cancer admitted to our hospital from March 2022 to June 2023 were retrospectively selected for study. The visual analog scale (VAS) was used to evaluate the pain level of the patients. The low anterior resection syndrome (LARS) scale was used to evaluate bowel function of the patients, and the incidence of LARS was recorded. The patients were grouped according to whether or not they had the complications of LARS, and they were divided into the groups of concurrent LARS and non-concurrent LARS. The patients' anorectal pressure was measured, and the measurements included maximum tolerated volume (MTV), anorectal resting pressure (ARP), and maximum squeeze pressure (MSP). Pearson's correlation coefficient was used to test associations between anal defecation function and postoperative pain and anorectal manometry. Logistic regression was used to test predictors of concurrent LARS, and the value of each of the indices for prediction of LARS was examined using the receiver operating characteristic (ROC).
    Results: Patients' VAS scores were positively correlated with LARS scores (p < 0.05). A total of 22 patients with VAS score ≥20 points were found to have a LARS incidence of 23.40% based on the LARS score. The VAS score was higher in the concurrent LARS group than in the non-concurrent LARS group (p < 0.05). The concurrent LARS group had a higher percentage of patients with age ≥60 years, body mass index ≥24 kg/m2, anastomotic position <5 cm from the anal verge, preoperative radiotherapy, and anastomotic fistula than the non-current LARS group (p < 0.05). The levels of MTV, ARP, and MSP were lower in patients in the concurrent LARS group than in the non-current LARS group (p < 0.05). Patients' LARS scores were negatively correlated with MTV (r = -0.420), ARP (r = -0.300) and MSP (r = -0.220) levels (p < 0.05). Logistic regression analysis showed that anastomotic position <5 cm from the anal verge, preoperative radiotherapy, anastomotic fistula, high VAS level, and low MTV level were all significant predictors of concurrent LARS. Anastomotic position, whether or not radiotherapy was administered preoperatively, anastomotic fistula, VAS score, and MSP level all had high sensitivity and specificity for prediction of concurrent LARS, and the combined area under the curve (AUC) of each index was 0.921, sensitivity was 0.818, and specificity was 0.944.
    Conclusion: LARS is strongly associated with the patient's pain level, and factors such as anastomotic position <5 cm from the anal verge, preoperative radiotherapy, anastomotic fistula, high VAS level, and low MTV level will increase the risk of concurrent LARS in patients.
    MeSH term(s) Humans ; Defecation ; Male ; Female ; Retrospective Studies ; Prognosis ; Middle Aged ; Colorectal Neoplasms/surgery ; Colorectal Neoplasms/complications ; Pain, Postoperative/etiology ; Pain, Postoperative/physiopathology ; Aged ; Anal Canal/physiopathology ; Pain Measurement ; Manometry ; Adult
    Language English
    Publishing date 2024-04-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 418927-9
    ISSN 2239-253X ; 0003-469X
    ISSN (online) 2239-253X
    ISSN 0003-469X
    DOI 10.62713/aic.3173
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    Zs.B 50: Show issues Location:
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  9. Article: Optically computed phase microscopy to assess cellular uptake of lipid nanoparticles.

    Liu, Xuan / Wan, Zhaoxiong / Zhang, Yuanwei / Liu, Yuwei

    Conference on Lasers and Electro-optics : (CLEO). Conference on Lasers and Electro-optics

    2023  Volume 2022

    Abstract: We developed a novel optically computed phase microscopy (OCPM) system, for depth-resolved phase imaging. We used OCPM to assess cellular uptake of lipid nanoparticles (LNPs), for the optimization of drug delivery systems based on LNPs. ...

    Abstract We developed a novel optically computed phase microscopy (OCPM) system, for depth-resolved phase imaging. We used OCPM to assess cellular uptake of lipid nanoparticles (LNPs), for the optimization of drug delivery systems based on LNPs.
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article
    DOI 10.1364/cleo_at.2022.atu5i.6
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  10. Article ; Online: Subunit C of V-ATPase-VmaC Is Required for Hyphal Growth and Conidiation in

    Sun, Congcong / Li, Xingyue / Zhang, Yuanwei / Lu, Ling

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 11

    Abstract: Aspergillus ... ...

    Abstract Aspergillus fumigatus
    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8111219
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