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  1. Article ; Online: Affinity-independent plasma cell differentiation in germinal centers.

    Tachó-Piñot, Roser / Vinuesa, Carola G

    Trends in immunology

    2024  Volume 45, Issue 4, Page(s) 234–236

    Abstract: The role of antibody affinity in plasma cell (PC) differentiation from germinal centers (GCs) remains contested. Parallel studies by Sprumont et al. and Sutton and Gao et al. show that PCs emerging from GCs produce antibodies with a diverse range of ... ...

    Abstract The role of antibody affinity in plasma cell (PC) differentiation from germinal centers (GCs) remains contested. Parallel studies by Sprumont et al. and Sutton and Gao et al. show that PCs emerging from GCs produce antibodies with a diverse range of affinities and lack signatures of affinity-based selection. Therefore, commitment to the PC lineage is affinity independent.
    MeSH term(s) Humans ; B-Lymphocytes ; Germinal Center ; Lymphocyte Activation ; Cell Lineage ; Cell Differentiation ; Plasma Cells
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2024.03.002
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  2. Article ; Online: Monogenic lupus: insights into disease pathogenesis and therapeutic opportunities.

    Qin, Yuting / Ma, Jianyang / Vinuesa, Carola G

    Current opinion in rheumatology

    2024  Volume 36, Issue 3, Page(s) 191–200

    Abstract: Purpose of review: This review aims to provide an overview of the genes and molecular pathways involved in monogenic lupus, the implications for genome diagnosis, and the potential therapies targeting these molecular mechanisms.: Recent findings: To ... ...

    Abstract Purpose of review: This review aims to provide an overview of the genes and molecular pathways involved in monogenic lupus, the implications for genome diagnosis, and the potential therapies targeting these molecular mechanisms.
    Recent findings: To date, more than 30 genes have been identified as contributors to monogenic lupus. These genes are primarily related to complement deficiency, activation of the type I interferon (IFN) pathway, disruption of B-cell and T-cell tolerance and metabolic pathways, which reveal the multifaceted nature of systemic lupus erythematosus (SLE) pathogenesis.
    Summary: In-depth study of the causes of monogenic lupus can provide valuable insights into of pathogenic mechanisms of SLE, facilitate the identification of effective biomarkers, and aid in developing therapeutic strategies.
    MeSH term(s) Humans ; Lupus Erythematosus, Systemic/therapy ; Lupus Erythematosus, Systemic/drug therapy ; Complement System Proteins ; Interferon Type I/metabolism ; Biomarkers
    Chemical Substances Complement System Proteins (9007-36-7) ; Interferon Type I ; Biomarkers
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000001008
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  3. Article ; Online: Monocytes asphyxiate germinal centers.

    He, Yuke / Vinuesa, Carola G

    Immunity

    2022  Volume 55, Issue 3, Page(s) 385–387

    Abstract: Some bacteria and parasites, such as Salmonella, actively disrupt germinal centers and elicit only low affinity antibodies, but the mechanisms by which microbes alter these responses is poorly understood. In this issue of Immunity, Biram et al. (2022) ... ...

    Abstract Some bacteria and parasites, such as Salmonella, actively disrupt germinal centers and elicit only low affinity antibodies, but the mechanisms by which microbes alter these responses is poorly understood. In this issue of Immunity, Biram et al. (2022) uncover a mechanism by which Salmonella recruits Sca-1
    MeSH term(s) Bacterial Infections ; Germinal Center/immunology ; Humans ; Monocytes ; Salmonella
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.02.007
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  4. Article ; Online: Innate virus-sensing pathways in B cell systemic autoimmunity.

    Vinuesa, Carola G / Grenov, Amalie / Kassiotis, George

    Science (New York, N.Y.)

    2023  Volume 380, Issue 6644, Page(s) 478–484

    Abstract: Although all multicellular organisms have germ line-encoded innate receptors to sense pathogen-associated molecular patterns, vertebrates also evolved adaptive immunity based on somatically generated antigen receptors on B and T cells. Because randomly ... ...

    Abstract Although all multicellular organisms have germ line-encoded innate receptors to sense pathogen-associated molecular patterns, vertebrates also evolved adaptive immunity based on somatically generated antigen receptors on B and T cells. Because randomly generated antigen receptors may also react with self-antigens, tolerance checkpoints operate to limit but not completely prevent autoimmunity. These two systems are intricately linked, with innate immunity playing an instrumental role in the induction of adaptive antiviral immunity. In this work, we review how inborn errors of innate immunity can instigate B cell autoimmunity. Increased nucleic acid sensing, often resulting from defects in metabolizing pathways or retroelement control, can break B cell tolerance and converge into TLR7-, cGAS-STING-, or MAVS-dominant signaling pathways. The resulting syndromes span a spectrum that ranges from chilblain and systemic lupus to severe interferonopathies.
    MeSH term(s) Animals ; Adaptive Immunity ; Autoimmunity/genetics ; B-Lymphocytes/immunology ; Host-Pathogen Interactions/immunology ; Immunity, Innate/genetics ; Signal Transduction ; Virus Diseases/immunology ; Viruses/immunology ; Humans
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adg6427
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  5. Article ; Online: Genetics of SLE: mechanistic insights from monogenic disease and disease-associated variants.

    Vinuesa, Carola G / Shen, Nan / Ware, Thuvaraka

    Nature reviews. Nephrology

    2023  Volume 19, Issue 9, Page(s) 558–572

    Abstract: The past few years have provided important insights into the genetic architecture of systemic autoimmunity through aggregation of findings from genome-wide association studies (GWAS) and whole-exome or whole-genome sequencing studies. In the prototypic ... ...

    Abstract The past few years have provided important insights into the genetic architecture of systemic autoimmunity through aggregation of findings from genome-wide association studies (GWAS) and whole-exome or whole-genome sequencing studies. In the prototypic systemic autoimmune disease systemic lupus erythematosus (SLE), monogenic disease accounts for a small fraction of cases but has been instrumental in the elucidation of disease mechanisms. Defects in the clearance or digestion of extracellular or intracellular DNA or RNA lead to increased sensing of nucleic acids, which can break B cell tolerance and induce the production of type I interferons leading to tissue damage. Current data suggest that multiple GWAS SLE risk alleles act in concert with rare functional variants to promote SLE development. Moreover, introduction of orthologous variant alleles into mice has revealed that pathogenic X-linked dominant and recessive SLE can be caused by novel variants in TLR7 and SAT1, respectively. Such bespoke models of disease help to unravel pathogenic pathways and can be used to test targeted therapies. Cell type-specific expression data revealed that most GWAS SLE risk genes are highly expressed in age-associated B cells (ABCs), which supports the view that ABCs produce lupus autoantibodies and contribute to end-organ damage by persisting in inflamed tissues, including the kidneys. ABCs have thus emerged as key targets of promising precision therapeutics.
    MeSH term(s) Animals ; Mice ; Genome-Wide Association Study ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/pathology ; Autoimmunity ; Autoantibodies ; DNA ; Genetic Predisposition to Disease
    Chemical Substances Autoantibodies ; DNA (9007-49-2)
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-023-00732-x
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  6. Article ; Online: COVID-19 Makes B Cells Forget, but T Cells Remember.

    Cañete, Pablo F / Vinuesa, Carola G

    Cell

    2020  Volume 183, Issue 1, Page(s) 13–15

    Abstract: Understanding which arms of the immune response are responsible for protection against SARS-CoV-2 infection is key to predicting long-term immunity and to inform vaccine design. Two studies in this issue of Cell collectively suggest that, although SARS- ... ...

    Abstract Understanding which arms of the immune response are responsible for protection against SARS-CoV-2 infection is key to predicting long-term immunity and to inform vaccine design. Two studies in this issue of Cell collectively suggest that, although SARS-CoV-2 infection may blunt long-lived antibody responses, immune memory might still be achieved through virus-specific memory T cells.
    MeSH term(s) B-Lymphocytes ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; T-Lymphocytes
    Keywords covid19
    Language English
    Publishing date 2020-09-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.09.013
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    Zs.A 1167: Show issues Location:
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  7. Article ; Online: Ataxia telangiectasia and juvenile idiopathic arthritis: A coincidence or a relationship?

    Arsov, Todor / Sestan, Mario / Kifer, Nastasia / Gagro, Alenka / Cook, Matthew / Vinuesa, Carola G / Jelusic, Marija

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 9, Page(s) e14017

    MeSH term(s) Humans ; Arthritis, Juvenile/complications ; Arthritis, Juvenile/diagnosis ; Ataxia Telangiectasia/complications ; Ataxia Telangiectasia/diagnosis
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.14017
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  8. Article ; Online: COVID-19 Makes B Cells Forget, but T Cells Remember

    Cañete, Pablo F. / Vinuesa, Carola G.

    Cell

    2020  Volume 183, Issue 1, Page(s) 13–15

    Keywords General Biochemistry, Genetics and Molecular Biology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.09.013
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  9. Article ; Online: Synaptic Interactions in Germinal Centers.

    Papa, Ilenia / Vinuesa, Carola G

    Frontiers in immunology

    2018  Volume 9, Page(s) 1858

    Abstract: The germinal center (GC) is a complex, highly dynamic microanatomical niche that allows the generation of high-affinity antibody-producing plasma cells and memory B cells. These cells constitute the basis of long-lived highly protective antibody ... ...

    Abstract The germinal center (GC) is a complex, highly dynamic microanatomical niche that allows the generation of high-affinity antibody-producing plasma cells and memory B cells. These cells constitute the basis of long-lived highly protective antibody responses. For affinity maturation to occur, B cells undergo multiple rounds of proliferation and mutation of the genes that encode the immunoglobulin V region followed by selection by specialized T cells called follicular helper T (T
    MeSH term(s) Animals ; Antibody Affinity ; Autoantigens/immunology ; Autoimmunity ; B-Lymphocytes/immunology ; Cell Communication ; Cytokines/metabolism ; Electrical Synapses/physiology ; Epitopes ; Germinal Center/immunology ; Humans ; Immunological Synapses/physiology ; Neurotransmitter Agents/metabolism ; Signal Transduction ; T-Lymphocytes, Helper-Inducer/immunology
    Chemical Substances Autoantigens ; Cytokines ; Epitopes ; Neurotransmitter Agents
    Language English
    Publishing date 2018-08-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.01858
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  10. Article ; Online: Rare genetic variants in systemic autoimmunity.

    Jiang, Simon H / Stanley, Maurice / Vinuesa, Carola G

    Immunology and cell biology

    2020  Volume 98, Issue 6, Page(s) 490–499

    Abstract: Autoimmune disease is a substantial cause of morbidity and is strongly influenced by genetic risk. Extensive efforts have characterized the overall genetic basis of many autoimmune diseases, typically by investigation of common variants. While these ... ...

    Abstract Autoimmune disease is a substantial cause of morbidity and is strongly influenced by genetic risk. Extensive efforts have characterized the overall genetic basis of many autoimmune diseases, typically by investigation of common variants. While these common variants have modest effects and may cumulatively predispose to disease, it is also increasingly apparent that rare variants have significantly greater effect on phenotype and are likely to contribute to autoimmune disease. Recent advances have illustrated the next fundamental step in elucidating the genetic basis of autoimmunity, moving beyond association to demonstrate the functional consequences of these variants.
    MeSH term(s) Autoimmune Diseases/genetics ; Autoimmunity ; Genetic Predisposition to Disease ; Humans ; Phenotype
    Language English
    Publishing date 2020-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1111/imcb.12339
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