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  1. Article: Next-generation endoscopic probe for detection of esophageal dysplasia using combined OCT and angle-resolved low-coherence interferometry.

    Jelly, Evan T / Steelman, Zachary A / Zhang, Haoran / Chu, Kengyeh K / Cotton, Cary C / Eluri, Swathi / Shaheen, Nicholas J / Wax, Adam

    Biomedical optics express

    2024  Volume 15, Issue 3, Page(s) 1943–1958

    Abstract: Angle-resolved low-coherence interferometry (a/LCI) is an optical technique that enables depth-specific measurements of nuclear morphology, with applications to detecting epithelial cancers in various organs. Previous a/LCI setups have been limited by ... ...

    Abstract Angle-resolved low-coherence interferometry (a/LCI) is an optical technique that enables depth-specific measurements of nuclear morphology, with applications to detecting epithelial cancers in various organs. Previous a/LCI setups have been limited by costly fiber-optic components and large footprints. Here, we present a novel a/LCI instrument incorporating a channel for optical coherence tomography (OCT) to provide real-time image guidance. We showcase the system's capabilities by acquiring imaging data from
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.515469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Light scattering methods for tissue diagnosis.

    Steelman, Zachary A / Ho, Derek S / Chu, Kengyeh K / Wax, Adam

    Optica

    2020  Volume 6, Issue 4, Page(s) 479–489

    Abstract: Light scattering has become a common biomedical research tool, enabling diagnostic sensitivity to myriad tissue alterations associated with disease. Light-tissue interactions are particularly attractive for diagnostics due to the variety of contrast ... ...

    Abstract Light scattering has become a common biomedical research tool, enabling diagnostic sensitivity to myriad tissue alterations associated with disease. Light-tissue interactions are particularly attractive for diagnostics due to the variety of contrast mechanisms that can be used, including spectral, angle-resolved, and Fourier-domain detection. Photonic diagnostic tools offer further benefit in that they are non-ionizing, non-invasive, and give real-time feedback. In this review, we summarize recent innovations in light scattering technologies, with a focus on clinical achievements over the previous ten years.
    Language English
    Publishing date 2020-01-13
    Publishing country United States
    Document type Journal Article
    ISSN 2334-2536
    ISSN 2334-2536
    DOI 10.1364/optica.6.000479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A review of low-cost and portable optical coherence tomography.

    Song, Ge / Jelly, Evan T / Chu, Kengyeh K / Kendall, Wesley Y / Wax, Adam

    Progress in biomedical engineering (Bristol, England)

    2021  Volume 3, Issue 3

    Abstract: Optical coherence tomography (OCT) is a powerful optical imaging technique capable of visualizing the internal structure of biological tissues at near cellular resolution. For years, OCT has been regarded as the standard of care in ophthalmology, acting ... ...

    Abstract Optical coherence tomography (OCT) is a powerful optical imaging technique capable of visualizing the internal structure of biological tissues at near cellular resolution. For years, OCT has been regarded as the standard of care in ophthalmology, acting as an invaluable tool for the assessment of retinal pathology. However, the costly nature of most current commercial OCT systems has limited its general accessibility, especially in low-resource environments. It is therefore timely to review the development of low-cost OCT systems as a route for applying this technology to population-scale disease screening. Low-cost, portable and easy to use OCT systems will be essential to facilitate widespread use at point of care settings while ensuring that they offer the necessary imaging performances needed for clinical detection of retinal pathology. The development of low-cost OCT also offers the potential to enable application in fields outside ophthalmology by lowering the barrier to entry. In this paper, we review the current development and applications of low-cost, portable and handheld OCT in both translational and research settings. Design and cost-reduction techniques are described for general low-cost OCT systems, including considerations regarding spectrometer-based detection, scanning optics, system control, signal processing, and the role of 3D printing technology. Lastly, a review of clinical applications enabled by low-cost OCT is presented, along with a detailed discussion of current limitations and outlook.
    Language English
    Publishing date 2021-05-24
    Publishing country England
    Document type Journal Article
    ISSN 2516-1091
    ISSN (online) 2516-1091
    DOI 10.1088/2516-1091/abfeb7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Origin of improved depth penetration in dual-axis optical coherence tomography: a Monte Carlo study.

    Zhao, Yang / Chu, Kengyeh K / Jelly, Evan T / Wax, Adam

    Journal of biophotonics

    2019  Volume 12, Issue 6, Page(s) e201800383

    Abstract: Recent studies have demonstrated that extended imaging depth can be achieved using dual-axis optical coherence tomography (DA-OCT). By illuminating and collecting at an oblique angle, multiple forward scattered photons from large probing depths are ... ...

    Abstract Recent studies have demonstrated that extended imaging depth can be achieved using dual-axis optical coherence tomography (DA-OCT). By illuminating and collecting at an oblique angle, multiple forward scattered photons from large probing depths are preferentially detected. However, the mechanism behind the enhancement of imaging depth needs further illumination. Here, the signal of a DA-OCT system is studied using a Monte Carlo simulation. We modeled light transport in tissue and recorded the spatial and angular distribution of photons exiting the tissue surface. Results indicate that the spatial separation and offset angle created by the non-telecentric scanning configuration promote the collection of more deeply propagating photons than conventional on-axis OCT.
    MeSH term(s) Anisotropy ; Contrast Media ; Monte Carlo Method ; Photons ; Tomography, Optical Coherence
    Chemical Substances Contrast Media
    Language English
    Publishing date 2019-03-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.201800383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6723: Show issues Location:
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  5. Article ; Online: Reconstruction of angle-resolved backscattering through a multimode fiber for cell nuclei and particle size determination.

    Zhang, Haoran / Steelman, Zachary A / Ceballos, Silvia / Chu, Kengyeh K / Wax, Adam

    APL photonics

    2020  Volume 5, Issue 7

    Abstract: We demonstrate reconstruction of angle-resolved optical backscattering after transmission through a multimode fiber. Angle-resolved backscattering is an important tool for particle sizing, and has been developed as a diagnostic modality for detecting ... ...

    Abstract We demonstrate reconstruction of angle-resolved optical backscattering after transmission through a multimode fiber. Angle-resolved backscattering is an important tool for particle sizing, and has been developed as a diagnostic modality for detecting epithelial precancer. In this work, we fully characterized the transfer function of a multimode fiber using a plane-wave illumination basis across two dimensions. Once characterized, angle-resolved scattering information which has been scrambled by multimodal propagation can be easily and accurately reconstructed. Our technique was validated using a Mie theory-based inverse light scattering analysis (ILSA) algorithm on polystyrene microsphere phantoms of known sizes. To demonstrate the clinical potential of this approach, nuclear morphology was determined from the reconstructed angular backscattering from MCF-10A human mammary epithelial cell samples and validated against quantitative image analysis (QIA) of fluorescence microscopy images.
    Language English
    Publishing date 2020-07-09
    Publishing country United States
    Document type Journal Article
    ISSN 2378-0967
    ISSN (online) 2378-0967
    DOI 10.1063/5.0011500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Connectivity-based deep learning approach for segmentation of the epithelium in

    Yang, Ziyun / Soltanian-Zadeh, Somayyeh / Chu, Kengyeh K / Zhang, Haoran / Moussa, Lama / Watts, Ariel E / Shaheen, Nicholas J / Wax, Adam / Farsiu, Sina

    Biomedical optics express

    2021  Volume 12, Issue 10, Page(s) 6326–6340

    Abstract: Optical coherence tomography (OCT) is used for diagnosis of esophageal diseases such as Barrett's esophagus. Given the large volume of OCT data acquired, automated analysis is needed. Here we propose a bilateral connectivity-based neural network ... ...

    Abstract Optical coherence tomography (OCT) is used for diagnosis of esophageal diseases such as Barrett's esophagus. Given the large volume of OCT data acquired, automated analysis is needed. Here we propose a bilateral connectivity-based neural network for
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.434775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Deep imaging with 1.3 µm dual-axis optical coherence tomography and an enhanced depth of focus.

    Jelly, Evan T / Zhao, Yang / Chu, Kengyeh K / Price, Hillel / Crose, Michael / Steelman, Zachary A / Wax, Adam

    Biomedical optics express

    2021  Volume 12, Issue 12, Page(s) 7689–7702

    Abstract: For many clinical applications, such as dermatology, optical coherence tomography (OCT) suffers from limited penetration depth due primarily to the highly scattering nature of biological tissues. Here, we present a novel implementation of dual-axis ... ...

    Abstract For many clinical applications, such as dermatology, optical coherence tomography (OCT) suffers from limited penetration depth due primarily to the highly scattering nature of biological tissues. Here, we present a novel implementation of dual-axis optical coherence tomography (DA-OCT) that offers improved depth penetration in skin imaging at 1.3 µm compared to conventional OCT. Several unique aspects of DA-OCT are examined here, including the requirements for scattering properties to realize the improvement and the limited depth of focus (DOF) inherent to the technique. To overcome this limitation, our approach uses a tunable lens to coordinate focal plane selection with image acquisition to create an enhanced DOF for DA-OCT. This improvement in penetration depth is quantified experimentally against conventional on-axis OCT using tissue phantoms and mouse skin. The results presented here suggest the potential use of DA-OCT in situations where a high degree of scattering limits depth penetration in OCT imaging.
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.438621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Scanning system for angle-resolved low-coherence interferometry.

    Steelman, Zachary A / Ho, Derek / Chu, Kengyeh K / Wax, Adam

    Optics letters

    2017  Volume 42, Issue 22, Page(s) 4581–4584

    Abstract: Angle-resolved low-coherence interferometry (a/LCI) detects precancer by enabling depth-resolved measurements of nuclear morphology in vivo. A significant limitation of a/LCI is the point-probe nature of the method, sampling <0.5 ... ...

    Abstract Angle-resolved low-coherence interferometry (a/LCI) detects precancer by enabling depth-resolved measurements of nuclear morphology in vivo. A significant limitation of a/LCI is the point-probe nature of the method, sampling <0.5  mm
    Language English
    Publishing date 2017-11-15
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.42.004581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Esophageal OCT Imaging Using a Paddle Probe Externally Attached to Endoscope.

    Chu, Kengyeh K / Zhao, Yang / Jelly, Evan T / Steelman, Zachary A / Crose, Michael / Cox, Brian / Ofori-Marfoh, Yaa / Moussa, Lama / Cirri, Holly / Watts, Ariel / Shaheen, Nicholas / Wax, Adam

    Digestive diseases and sciences

    2022  Volume 67, Issue 10, Page(s) 4805–4812

    Abstract: Background and aims: Endoscopic surveillance of Barrett's esophagus (BE) by white light examination is insufficient to diagnose dysplastic change. In this work, we describe an optical imaging method to obtain high-resolution cross-sectional imaging ... ...

    Abstract Background and aims: Endoscopic surveillance of Barrett's esophagus (BE) by white light examination is insufficient to diagnose dysplastic change. In this work, we describe an optical imaging method to obtain high-resolution cross-sectional imaging using a paddle-shaped probe affixed to the endoscope tip.
    Methods: We integrated Optical Coherence Tomography (OCT), an optical imaging method that produces cross-sectional images, into a paddle probe attached to video endoscope. We acquired images of esophageal epithelium from patients undergoing routine upper GI endoscopy. Images were classified by a reviewer blinded to patient identity and condition, and these results were compared with clinical diagnosis.
    Results: We successfully captured epithelial OCT images from 30 patients and identified features consistent with both squamous epithelium and Barrett's esophagus. Our blinded image reviewer classified BE versus non-BE with 91.5% accuracy (65/71 image regions), including sensitivity of 84.6% for BE (11/13) and a specificity of 93.1% (54/58). However, in 16 patients, intubation of the probe into the esophagus could not be achieved.
    Conclusions: A paddle probe is a feasible imaging format for acquiring cross-sectional OCT images from the esophagus and can provide a structural assessment of BE and non-BE tissue. Probe form factor is the current limiting obstacle, but could be addressed by further miniaturization.
    MeSH term(s) Barrett Esophagus/diagnostic imaging ; Endoscopes ; Endoscopy, Digestive System ; Esophageal Neoplasms ; Esophagoscopy/methods ; Humans ; Tomography, Optical Coherence/methods
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-021-07372-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.35: Show issues Location:
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  10. Article ; Online: Comparison of imaging fiber bundles for coherence-domain imaging.

    Steelman, Zachary A / Kim, Sanghoon / Jelly, Evan T / Crose, Michael / Chu, Kengyeh K / Wax, Adam

    Applied optics

    2018  Volume 57, Issue 6, Page(s) 1455–1462

    Abstract: Use of imaging fiber bundles for coherence-domain imaging has remained limited to date. In this work, we provide characterization of commercially available imaging bundles for coherence-domain imaging, by evaluating their modal structure for ... ...

    Abstract Use of imaging fiber bundles for coherence-domain imaging has remained limited to date. In this work, we provide characterization of commercially available imaging bundles for coherence-domain imaging, by evaluating their modal structure for applicability to interferometric imaging. We further examine custom fabricated bundles developed in collaboration with a corporate partner for their ability to reduce interelement optical path length variability and cross talk between elements. The results presented here will serve as a useful guide for comparing fiber bundles for coherence imaging while also offering an improved understanding of the functionality and limitations of imaging bundles for advancing coherent imaging technologies.
    Language English
    Publishing date 2018-02-19
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.57.001455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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