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  1. Article: Cases Illustrative of the Sedative Powers of the Datura Stramonium.

    Begbie, James

    Transactions. Medico-Chirurgical Society of Edinburgh

    2018  Volume 1, Page(s) 285–295

    Language English
    Publishing date 2018-03-19
    Publishing country Scotland
    Document type Journal Article
    ISSN 0267-2790
    ISSN 0267-2790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Illustrations of Gout and the Gouty Diathesis.

    Begbie, James

    Edinburgh medical and surgical journal

    2018  Volume 81, Issue 199, Page(s) 209–230

    Language English
    Publishing date 2018-10-17
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2793596-6
    ISSN 0963-4932
    ISSN 0963-4932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Illustrations of Gout and the Gouty Diathesis.

    Begbie, James

    Edinburgh medical and surgical journal

    2018  Volume 81, Issue 198, Page(s) 1–21

    Language English
    Publishing date 2018-10-17
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2793596-6
    ISSN 0963-4932
    ISSN 0963-4932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Notice of Some of the Therapeutic Effects of the Bromide of Potassium.

    Begbie, James

    Edinburgh medical journal

    2018  Volume 12, Issue 6, Page(s) 481–492

    Language English
    Publishing date 2018-04-03
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 414086-2
    ISSN 0367-1038
    ISSN 0367-1038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Memoir of the life and writings of the late Richard James Mackenzie, M. D

    Begbie, James Warburton / Struthers, John

    1855  

    Language English
    Size 44 p., 1 port
    Publisher Sutherland & Knox
    Publishing place Edinburgh
    Document type Book
    Note Repr. from: Edinb. M. & S. J., 1855.
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Article: Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): association with venous thromboembolism.

    Shovlin, Claire L / Sulaiman, N Laila / Govani, Fatima S / Jackson, James E / Begbie, Megan E

    Thrombosis and haemostasis

    2007  Volume 98, Issue 5, Page(s) 1031–1039

    Abstract: Hereditary haemorrhagic telangiectasia (HHT) causes chronic nasal and gastrointestinal haemorrhage. Prothrombotic agents are commonly used for severe haemorrhage. Thrombotic risks have not been defined. In order to identify prothrombotic variables in HHT ...

    Abstract Hereditary haemorrhagic telangiectasia (HHT) causes chronic nasal and gastrointestinal haemorrhage. Prothrombotic agents are commonly used for severe haemorrhage. Thrombotic risks have not been defined. In order to identify prothrombotic variables in HHT patients, and assess their potential functional significance, a pilot ELISA-based study comparing plasma proteins in healthy individuals with HHT to age/sex-matched non-HHT controls was validated in a full study of 309 consecutive HHT-affected individuals. In the pilot study, factor VIII (FVIII) and von Willebrand factor antigen concentrations were elevated in the HHT group compared to non-HHT controls (p<0.0013, Mann-Whitney). Service laboratory measurements confirmed high FVIII:Ag in 125 HHT-affected individuals with no recent ill-health, intervention or venous thromboemboli. FVIII:Ag levels increased with age. Logistic regression also suggested an age-independent association with HHT-associated pulmonary arteriovenous malformations (AVMs). No association was demonstrated between FVIII:Ag and acute phase response, disseminated intravascular coagulation, ABO group, pulmonary artery pressure, or markers of HHT haemorrhage. Elevated FVIII:Ag were associated with shortened activated partial thromboplastin times (APTTs), and VTE:VTE affected 20/309 (6.5%) HHT-affected individuals, at median age 61(36-71) years. Four VTE occurred in factorV Leiden heterozygotes in the months following PAVM-associated brain abscess. The strongest association with VTE was with log-transformed FVIII:Ag measured 10-132 months from VTE (odds ratio 2.41, 95% confidence intervals 1.254, 4.612, p=0.008). Age made no additional contribution to VTE risk once adjusted for FVIII:Ag. In conclusion, HHT-related elevation of FVIII:Ag levels may influence thrombotic risk in HHT. Individualised risk-benefit considerations may be helpful in HHT management.
    MeSH term(s) Adult ; Aged ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Factor VIII/analysis ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; Regression Analysis ; Risk Factors ; Telangiectasia, Hereditary Hemorrhagic/blood ; Telangiectasia, Hereditary Hemorrhagic/complications ; Up-Regulation ; Venous Thromboembolism/etiology ; von Willebrand Factor/analysis
    Chemical Substances von Willebrand Factor ; Factor VIII (9001-27-8)
    Language English
    Publishing date 2007-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 433: Show issues

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  7. Article ; Online: Phase I, Open-Label, Dose-Escalation/Dose-Expansion Study of Lifirafenib (BGB-283), an RAF Family Kinase Inhibitor, in Patients With Solid Tumors.

    Desai, Jayesh / Gan, Hui / Barrow, Catherine / Jameson, Michael / Atkinson, Victoria / Haydon, Andrew / Millward, Michael / Begbie, Stephen / Brown, Michael / Markman, Ben / Patterson, William / Hill, Andrew / Horvath, Lisa / Nagrial, Adnan / Richardson, Gary / Jackson, Christopher / Friedlander, Michael / Parente, Phillip / Tran, Ben /
    Wang, Lai / Chen, Yunxin / Tang, Zhiyu / Huang, Wendy / Wu, John / Zeng, Dewan / Luo, Lusong / Solomon, Benjamin

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2020  Volume 38, Issue 19, Page(s) 2140–2150

    Abstract: Purpose: Lifirafenib is an investigational, reversible inhibitor of B-RAF: Methods: During dose escalation, adult patients with histologically/cytologically confirmed advanced solid tumors received escalating doses of lifirafenib. Primary end points ... ...

    Abstract Purpose: Lifirafenib is an investigational, reversible inhibitor of B-RAF
    Methods: During dose escalation, adult patients with histologically/cytologically confirmed advanced solid tumors received escalating doses of lifirafenib. Primary end points were safety/tolerability during dose escalation and objective response rate in preselected patients with
    Results: The maximum tolerated dose was established as 40 mg/d; dose-limiting toxicities included reversible thrombocytopenia and nonhematologic toxicity. Across the entire study, the most common grade ≥ 3 treatment-emergent adverse events were hypertension (n = 23; 17.6%) and fatigue (n = 13; 9.9%). One patient with
    Conclusion: Lifirafenib is a novel inhibitor of key RAF family kinases and EGFR, with an acceptable risk-benefit profile and antitumor activity in patients with
    MeSH term(s) Adult ; Aged ; Benzimidazoles/pharmacology ; Benzimidazoles/therapeutic use ; Female ; Humans ; Male ; Maximum Tolerated Dose ; Middle Aged ; Naphthyridines/pharmacology ; Naphthyridines/therapeutic use ; Neoplasms/drug therapy ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances BGB-283 ; Benzimidazoles ; Naphthyridines ; Protein Kinase Inhibitors
    Language English
    Publishing date 2020-03-17
    Publishing country United States
    Document type Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.19.02654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  8. Article: Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): Association with venous thromboembolism

    Shovlin, Claire L. / Sulaiman, Laila N. / Govani, Fatima S. / Jackson, James E. / Begbie, Megan E.

    Thrombosis and Haemostasis

    2007  Volume 97, Issue 11, Page(s) 1031–1039

    Abstract: Hereditary haemorrhagic telangiectasia (HHT) causes chronic nasal and gastrointestinal haemorrhage. Prothrombotic agents are commonly used for severe haemorrhage. Thrombotic risks have not been defined. In order to identify prothrombotic variables in HHT ...

    Abstract Hereditary haemorrhagic telangiectasia (HHT) causes chronic nasal and gastrointestinal haemorrhage. Prothrombotic agents are commonly used for severe haemorrhage. Thrombotic risks have not been defined. In order to identify prothrombotic variables in HHT patients, and assess their potential functional significance, a pilot ELISA-based study comparing plasma proteins in healthy individuals with HHT to age/sex-matched non-HHT controls was validated in a full study of 309 consecutive HHTaffected individuals. In the pilot study, factor VIII (FVIII) and von Willebrand factor antigen concentrations were elevated in the HHT group compared to non-HHT controls (p<0.0013, Mann- Whitney). Service laboratory measurements confirmed high FVIII:Ag in 125 HHT-affected individuals with no recent illhealth, intervention or venous thromboemboli. FVIII:Ag levels increased with age. Logistic regression also suggested an age-independent association with HHT-associated pulmonary arteriovenous malformations (AVMs). No association was demonstrated between FVIII:Ag and acute phase response, disseminated intravascular coagulation, ABO group, pulmonary artery pressure, or markers of HHT haemorrhage. Elevated FVIII:Ag were associated with shortened activated partial thromboplastin times (APTTs), andVTE:VTE affected 20/309 (6.5%) HHT-affected individuals, at median age 61(36–71) years. Four VTE occurred in factorV Leiden heterozygotes in the months following PAVM-associated brain abscess. The strongest association with VTE was with log-transformed FVIII:Ag measured 10–132 months from VTE (odds ratio 2.41, 95% confidence intervals 1.254, 4.612, p=0.008). Age made no additional contribution to VTE risk once adjusted for FVIII:Ag. In conclusion, HHT-related elevation of FVIII:Ag levels may influence thrombotic risk in HHT. Individualised risk-benefit considerations may be helpful in HHT management.
    Keywords Brain abscess ; DIC ; pulmonary AVMs ; tranexamic acid ; VWF
    Language English
    Publishing date 2007-01-01
    Publisher Schattauer GmbH
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1160/TH07-01-0064
    Database Thieme publisher's database

    Full text online

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  9. Book: The Malayan peninsula

    Begbie, Peter James / Banerjee, Diptendra M

    (Oxford in Asia historical reprints)

    1967  

    Author's details by P. J. Begbie. with an introd. by Diptendra M. Banerjee
    Series title Oxford in Asia historical reprints
    Keywords Malay Peninsula
    Language English
    Dates of publication 1967-1834
    Size 523, XIX S
    Publisher Oxford Univ. Press
    Publishing place Kuala Lumpur
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  10. Book: The Malayan peninsula

    Begbie, Peter James / Banerjee, Diptendra M

    (Oxford in Asia historical reprints)

    1967  

    Author's details by P. J. Begbie. with an introd. by Diptendra M. Banerjee
    Series title Oxford in Asia historical reprints
    Keywords Malay Peninsula ; Malaya ; Wirtschaftsgeschichte ; Reisebeschreibungen
    Language English
    Dates of publication 1967-1834
    Size 523, XIX S
    Edition [Reprint]
    Document type Book
    Database ECONomics Information System

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