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Article ; Online: The Potential of the HeartLogic

Feijen, Michelle / Egorova, Anastasia D / Tops, Laurens F / Palmen, Meindert / Jukema, J Wouter / Schalij, Martin J / Beeres, Saskia L M A

Journal of cardiovascular development and disease

2024 Volume 11, Issue 2

Abstract: Background: Survival and quality-of-life of left ventricular assist device (LVAD) recipients improved significantly because of growing experience and technological advances. However, LVAD-related complication rates, including recurrent episodes of ... ...

Abstract	Background: Survival and quality-of-life of left ventricular assist device (LVAD) recipients improved significantly because of growing experience and technological advances. However, LVAD-related complication rates, including recurrent episodes of congestion, remain high. Early detection of fluid retention to provide a time-window for medical intervention is the pillar in preventing hospitalizations. The multisensory HeartLogic Methods: Consecutive LVAD destination therapy patients were followed-up according the structured HeartLogic Results: Data from 7 patients were included: the median age was 67 years [IQR 61-71], 71% were male and 71% had a non-ischemic aetiology. Total follow-up entailed 12 patient-years. All patients experienced at least one alert. In total, 33 alerts were observed. Majority of alerts (70%, Conclusions: HeartLogic
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd11020051
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Article ; Online: Time Trends in Patient Characteristics, Anticoagulation Treatment, and Prognosis of Incident Nonvalvular Atrial Fibrillation in the Netherlands.

Chen, Qingui / Toorop, Myrthe M A / Tops, Laurens F / Lijfering, Willem M / Cannegieter, Suzanne C

JAMA network open

2023 Volume 6, Issue 4, Page(s) e239973

Abstract: Importance: The temporal trend in adverse events regarding stroke prevention for nonvalvular atrial fibrillation (NVAF) in the direct oral anticoagulant (DOAC) era was rarely investigated comprehensively, especially taking into account potential changes ...

Abstract	Importance: The temporal trend in adverse events regarding stroke prevention for nonvalvular atrial fibrillation (NVAF) in the direct oral anticoagulant (DOAC) era was rarely investigated comprehensively, especially taking into account potential changes in patient characteristics and anticoagulation treatment. Objective: To investigate time trends in patient characteristics, anticoagulation treatment, and prognosis of patients with incident NVAF in the Netherlands. Design, setting, and participants: This retrospective cohort study assessed patients with incident NVAF initially recognized within a hospitalization between 2014 and 2018, using data from Statistics Netherlands. Participants were followed-up for 1 year from the hospital admission at which the incident NVAF diagnosis was made or until death, whichever occurred first. Data were analyzed from January 15, 2021, to March 8, 2023. Exposure: Calendar year of the incident NVAF diagnosis, according to which the participants were categorized into 5 cohorts. Main outcomes and measures: Outcomes of interest were baseline patient characteristics, anticoagulation treatment, and occurrence of ischemic stroke or major bleeding within the 1-year follow-up after incident NVAF. Results: Between 2014 and 2018, 301 301 patients (mean [SD] age, 74.2 [11.9] years; 169 748 [56.3%] male patients) experienced incident NVAF in the Netherlands, each of whom was categorized into 1 of 5 cohorts by calendar year. Baseline patient characteristics were broadly the same between cohorts with a mean (SD) CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years [doubled], diabetes, stroke [doubled], vascular disease, age 65 to 74 years, and sex category [female]) score of 2.9 (1.7). The median (IQR) proportion of days covered by OACs (ie, vitamin K antagonists or DOACs) within the 1-year follow-up increased from 56.99% (0%-86.30%) to 75.62% (0%-94.52%), and DOACs increased from 5102 patients (13.5%) to 32 314 patients (72.0%) among those who received OACs, gradually replacing VKAs as the first choice of OACs. Over the course of the study, there were statistically significant decreases in the 1-year cumulative incidence of ischemic stroke (from 1.63% [95% CI, 1.52%-1.73%] to 1.39% [95% CI, 1.30%-1.48%) and major bleeding (from 2.50% [95% CI, 2.37%-2.63%] to 2.07% [95% CI, 1.96%-2.19%]), and the association was consistent after adjusting for baseline patient characteristics and excluding those with preexisting chronic anticoagulation. Conclusions and relevance: This cohort study of patients with incident NVAF diagnosed between 2014 and 2018 in the Netherlands found similar baseline characteristics, increased OAC use with DOACs being favored over time, and improved 1-year prognosis. Comorbidity burden, potential underuse of anticoagulation medications, and specific subgroups of patients with NVAF remain directions for future investigations and further improvement.
MeSH term(s)	Humans ; Male ; Female ; Aged ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Retrospective Studies ; Cohort Studies ; Netherlands/epidemiology ; Anticoagulants/adverse effects ; Stroke/epidemiology ; Stroke/prevention & control ; Stroke/etiology ; Prognosis ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Ischemic Stroke/drug therapy
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.9973
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Article ; Online: The ever-changing field of mechanical circulatory support: new challenges at the advent of the 'single device era'.

Tops, Laurens F / Coats, Andrew J S / Ben Gal, Tuvia

European journal of heart failure

2021 Volume 23, Issue 9, Page(s) 1428–1431

MeSH term(s)	Heart Failure/therapy ; Heart Transplantation ; Heart-Assist Devices ; Humans
Language	English
Publishing date	2021-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.2314
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Zs.A 5299: Show issues

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Article: Prognostic Value of Natriuretic Peptides for All-Cause Mortality, Right Ventricular Failure, Major Adverse Events, and Myocardial Recovery in Advanced Heart Failure Patients Receiving a Left Ventricular Assist Device: A Systematic Review.

Janssen, Eva / Jukema, J Wouter / Beeres, Saskia L M A / Schalij, Martin J / Tops, Laurens F

Frontiers in cardiovascular medicine

2021 Volume 8, Page(s) 699492

Abstract: Aims: ...

Abstract	Aims:
Language	English
Publishing date	2021-07-07
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.699492
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Article ; Online: Fusion cardiac resynchronization therapy in an left ventricular assist device patient from two devices and crossing leads: a case report.

Egorova, Anastasia D / van Erven, Lieselot / Beeres, Saskia L M A / Tops, Laurens F

European heart journal. Case reports

2021 Volume 5, Issue 9, Page(s) ytab335

Abstract: Background: Cardiac implanted electronic devices (CIED) have significantly improved the survival and quality of life in heart failure patients. Although implantable cardioverter-defibrillators (ICD) and cardiac resynchronization therapy (CRT) have a ... ...

Abstract	Background: Cardiac implanted electronic devices (CIED) have significantly improved the survival and quality of life in heart failure patients. Although implantable cardioverter-defibrillators (ICD) and cardiac resynchronization therapy (CRT) have a major role in patients with moderate to severe heart failure symptoms, the role of these devices in patients with a left ventricular assist device (LVAD) is not yet well defined. The burden of CIED-related procedures in patients with an LVAD is high. The price of lead malfunctions and pocket complications requires creative approaches to tackle CIED-related issues in this patient population. Case summary: Here, we describe the clinical course of a 67-year-old ventricular pacing dependent LVAD patient with an ICD indication based on recurrent monomorphic ventricular tachycardias and a CRT indication due to previous deterioration of (right-sided) heart failure in the absence of biventricular pacing. We were confronted with impending right ventricular lead failure and bilateral venous access problems due to chronic subclavian vein occlusion in a patient with a total of five transvenous leads, therapeutic anticoagulation, and pronounced thoracic collaterals. We sought for a creative solution to be able to deliver effective biventricular fusion pacing with the existing leads from two contralateral pulse generators resulting in biventricular fusion pacing. This provided the solution to deliver effective CRT. Discussion: This case illustrates the complexity of care and CIED-related decision-making in pacing dependent LVAD patients, in particularly those with an ICD and CRT indication.
Language	English
Publishing date	2021-08-17
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytab335
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Article: Systemic thrombolysis in the management of pump thrombosis in patients with left ventricular assist devices.

Kortekaas, Kirsten A / den Exter, Paul L / Beeres, Saskia L M A / Palmen, Meindert / Jukema, J Wouter / Huisman, Menno V / Tops, Laurens F

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 969766

Abstract: Left ventricular assist device (LVAD) implantation as destination therapy (DT) is a valuable treatment option in patients with end-stage heart failure ineligible for heart transplant. However, this therapy can be complicated by life-threatening pump ... ...

Abstract	Left ventricular assist device (LVAD) implantation as destination therapy (DT) is a valuable treatment option in patients with end-stage heart failure ineligible for heart transplant. However, this therapy can be complicated by life-threatening pump thrombosis (PT). This case series reports our single-center experience with a structured systemic thrombolysis protocol in case of PT. Consecutive patients undergoing DT LVAD (HVAD, Medtronic, Framingham, MA) implantation between 2010 and April 2021 at our institution were reviewed and those with PT identified. Clinical, laboratory and LVAD specific data were collected and analyzed retrospectively. All patients with PT were treated with systemic thrombolysis according to a structured bedside protocol. Treatment was defined successful if a patient was alive at 30 days follow-up and free of recurrent PT, stroke or device exchange. Fourteen out of 94 patients experienced a PT after LVAD implantation (11%). Systemic thrombolysis was successful in 10 of 14 patients (71%) at 30 days. Two patients died within 30 days due to a hemothorax and multi-organ failure. In three patients treatment was complicated by a major bleeding; twice a hemothorax (one fatal) and one right calf bleeding. No intracerebral hemorrhage was observed. Three patients experienced a thrombotic complication within 30 days; all recurrent PT. Eleven of the 14 DT patients were discharged home after a limited hospital stay after thrombolysis (average of 11 days). In conclusion, systemic thrombolysis may be a reasonable option for life-threatening PT in this vulnerable DT group in whom device exchange is often impossible due to comorbidity.
Language	English
Publishing date	2022-10-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.969766
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Article ; Online: The first experience with sodium-glucose cotransporter 2 inhibitor for the treatment of systemic right ventricular failure.

Egorova, Anastasia D / Nederend, Marieke / Tops, Laurens F / Vliegen, Hubert W / Jongbloed, Monique R M / Kiès, Philippine

ESC heart failure

2022 Volume 9, Issue 3, Page(s) 2007–2012

Abstract: In congenitally corrected transposition of the great arteries, the morphological right ventricle supports the systemic circulation. This chronic exposure to pressure overload ultimately leads to systemic right ventricular (sRV) dysfunction and heart ... ...

Abstract	In congenitally corrected transposition of the great arteries, the morphological right ventricle supports the systemic circulation. This chronic exposure to pressure overload ultimately leads to systemic right ventricular (sRV) dysfunction and heart failure. Pharmacological options for the treatment of sRV failure are poorly defined and no solid recommendations are made in the most recent guidelines. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are a new class of antihyperglycaemic drugs that have been demonstrated to significantly reduce the risk of worsening heart failure and death from cardiovascular causes in patients with chronic heart failure with reduced left ventricular ejection fraction, yet no data are available in sRV patients. We report on the treatment and clinical follow-up of a patient with advanced heart failure and poor sRV function in the context of congenitally corrected transposition of the great arteries, who did not tolerate sacubitril/valsartan and had a high burden of heart-failure-related hospitalizations. Treatment with dapagliflozin was well tolerated and resulted in (small) subjective and objective functional and echocardiographic improvement and a reduction in heart-failure-related hospitalizations.
MeSH term(s)	Aminobutyrates ; Biphenyl Compounds ; Congenitally Corrected Transposition of the Great Arteries ; Glucose ; Heart Failure ; Humans ; Sodium ; Stroke Volume ; Transposition of Great Vessels/complications ; Ventricular Dysfunction, Right ; Ventricular Function, Left
Chemical Substances	Aminobutyrates ; Biphenyl Compounds ; sacubitril (17ERJ0MKGI) ; Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-03-30
Publishing country	England
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.13871
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Article ; Online: Left ventricular assist device and pump thrombosis: the importance of the inflow cannula position.

Kortekaas, Kirsten A / de Graaf, Michiel A / Palmen, Meindert / Braun, Jerry / Mertens, Bart J A / Tops, Laurens F / Beeres, Saskia L M A

The international journal of cardiovascular imaging

2022 Volume 38, Issue 12, Page(s) 2771–2779

Abstract: Pump thrombosis is a devastating complication after left ventricular assist device implantation. This study aims to elucidate the relation between left ventricular assist device implantation angle and risk of pump thrombosis. Between November 2010 and ... ...

Abstract	Pump thrombosis is a devastating complication after left ventricular assist device implantation. This study aims to elucidate the relation between left ventricular assist device implantation angle and risk of pump thrombosis. Between November 2010 and March 2020, 53 left ventricular assist device-patients underwent a computed tomography scan. Using a 3-dimensional multiplanar reformation the left ventricular axis was reconstructed to measure the implantation angle of the inflow cannula. All patients were retrospectively analyzed for the occurrence of pump thrombosis. In 10 (91%) patients with a pump thrombosis, the implantation angle was towards the lateral wall of the left ventricle. In only 20 patients (49%) of the patients without a pump thrombosis the inflow cannula pointed towards the lateral wall of the left ventricle. The mean angle in patients with a pump thrombosis was 10.1 ± 11.9 degrees towards the lateral wall of the left ventricle compared to 4.1 ± 19.9 degrees towards the septum in non-pump thrombosis patients (P = 0.005). There was a trend towards a significant difference in time to first pump thrombosis between patients with a lateral or septal deviated left ventricular assist device (hazard ratio of 0.15, P = 0.07). This study demonstrates that left ventricular assist device implantation angle is associated with pump thrombosis. Almost all patients in whom a pump thrombosis occurred during follow-up had a left ventricular assist device implanted with the inflow-cannula pointing towards the lateral wall of the left ventricle.
MeSH term(s)	Humans ; Heart-Assist Devices/adverse effects ; Cannula ; Retrospective Studies ; Predictive Value of Tests ; Thrombosis/diagnostic imaging ; Thrombosis/etiology
Language	English
Publishing date	2022-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2055311-0
ISSN	1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
ISSN (online)	1875-8312 ; 1573-0743
ISSN	1569-5794 ; 0167-9899
DOI	10.1007/s10554-022-02683-z
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Article ; Online: Left atrial fibrosis and recurrent arrhythmia.

Tops, Laurens F / Schalij, Martin J

JAMA

2014 Volume 311, Issue 22, Page(s) 2335

MeSH term(s)	Atrial Fibrillation/pathology ; Atrial Fibrillation/therapy ; Female ; Heart Atria/pathology ; Humans ; Male
Language	English
Publishing date	2014-06-11
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2014.5184
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Article ; Online: Successfully meeting analytical expectations for the fast 0/1-h algorithm for NSTEMI by internal control procedures for cardiac troponin T.

Endlich, Wendy / Mensink, Willemina J / den Elzen, Wendy P J / Tops, Laurens F / Cobbaert, Christa M

Clinical chemistry and laboratory medicine

2020 Volume 59, Issue 1, Page(s) e13–e17

MeSH term(s)	Algorithms ; Biomarkers/blood ; Blood Chemical Analysis/standards ; Blood Chemical Analysis/statistics & numerical data ; Humans ; Non-ST Elevated Myocardial Infarction/blood ; Non-ST Elevated Myocardial Infarction/diagnosis ; Troponin T/blood
Chemical Substances	Biomarkers ; Troponin T
Language	English
Publishing date	2020-09-18
Publishing country	Germany
Document type	Letter
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2020-0055
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