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Article: LASH in Severely Enlarged Uterine Leiomyoma: Removal of a Uterus of 4065 g.

Tchartchian, Garri / Krentel, Harald / Bojahr, Bernd / De Wilde, Rudy L

2018 Volume 2018, Page(s) 2078923

Abstract: ... removal of the largest uterus ever reported (4065 g) by means of laparoscopy-assisted supracervical ...

Abstract	Today, even though minimally invasive approaches have become standard worldwide, large uteri are still mainly removed by means of open abdominal approaches. The present case describes the successful removal of the largest uterus ever reported (4065 g) by means of laparoscopy-assisted supracervical hysterectomy (LASH). We combined LASH with the changeover technique which allows a better access and view. We further explain how this approach allows for the safe minimally invasive removal of uteri of any size.
Language	English
Publishing date	2018-06-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2502642-2
ISSN	1687-9635 ; 1687-9627
ISSN (online)	1687-9635
ISSN	1687-9627
DOI	10.1155/2018/2078923
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Article ; Online: Transcriptomic analysis of hookworm Ancylostoma ceylanicum life cycle stages reveals changes in G-protein coupled receptor diversity associated with the onset of parasitism.

Bernot, James P / Rudy, Gabriella / Erickson, Patti T / Ratnappan, Ramesh / Haile, Meseret / Rosa, Bruce A / Mitreva, Makedonka / O'Halloran, Damien M / Hawdon, John M

International journal for parasitology

2020 Volume 50, Issue 8, Page(s) 603–610

Abstract: ... of environmental stages in the nematode life cycle and an increasing number of G-protein coupled receptors (GPCRs ...

Abstract	Free-living nematodes respond to variable and unpredictable environmental stimuli whereas parasitic nematodes exist in a more stable host environment. A positive correlation between the presence of environmental stages in the nematode life cycle and an increasing number of G-protein coupled receptors (GPCRs) reflects this difference in free-living and parasitic lifestyles. As hookworm larvae move from the external environment into a host, they detect uncharacterized host components, initiating a signalling cascade that results in the resumption of development and eventual maturation. Previous studies suggest this process is mediated by GPCRs in amphidial neurons. Here we set out to uncover candidate GPCRs required by a hookworm to recognise its host. First, we identified all potential Ancylostoma ceylanicum GPCRs encoded in the genome. We then used life cycle stage-specific RNA-seq data to identify differentially expressed GPCRs between the free-living infective L3 (iL3) and subsequent parasitic stages to identify receptors involved in the transition to parasitism. We reasoned that GPCRs involved in host recognition and developmental activation would be expressed at higher levels in the environmental iL3 stage than in subsequent stages. Our results support the model that a decrease in GPCR diversity occurs as the larvae develop from the free-living iL3 stage to the parasitic L3 (pL3) in the host over 24-72 h. We find that overall GPCR expression and diversity is highest in the iL3 compared with subsequent parasitic stages. By 72 h, there was an approximately 50% decrease in GPCR richness associated with the moult from the pL3 to the L4. Taken together, our data uncover a negative correlation between GPCR diversity and parasitic development in hookworm. Finally, we demonstrate proof of principal that Caenorhabditis elegans can be used as a heterologous system to examine the expression pattern of candidate host signal chemoreceptors (CRs) from hookworm. We observe expression of candidate host signal CRs in C. elegans, demonstrating that C. elegans can be effectively used as a surrogate to identify expressed hookworm genes. We present several preliminary examples of this strategy and confirm a candidate CR as neuronally expressed.
MeSH term(s)	Ancylostoma/genetics ; Animals ; Caenorhabditis elegans ; Helminth Proteins/genetics ; Life Cycle Stages ; Receptors, G-Protein-Coupled/genetics ; Transcriptome
Chemical Substances	Helminth Proteins ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2020-06-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	120518-3
ISSN	1879-0135 ; 0020-7519
ISSN (online)	1879-0135
ISSN	0020-7519
DOI	10.1016/j.ijpara.2020.05.003
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Article ; Online: Polymorphism g.-371T>A Promoter of the Myostatin Gene in Indonesian Beef Cattle

Sutikno / Rudy Priyanto / Cece Sumantri / Jakaria Jakaria

Jurnal Ilmu Pertanian Indonesia, Vol 25, Iss 2, Pp 238-

2020 Volume 243

Abstract: ... was to identify polymorphism of g.-371T>A in promoter region of MSTN gene in Indonesian beef cattle ... and direct sequencing methods. Results of genotyping g-371T>A were polymorphic (TT, TA, and AA ... that mutations transversion was occurred in T to A at g.-371. It was concluded that g.-371T>A of MSTN gene was ...

Abstract	Myostatin (MSTN) gene acts as a negative regulator of muscle growth. The aim of the present study was to identify polymorphism of g.-371T>A in promoter region of MSTN gene in Indonesian beef cattle. Blood samples were collected from 191 cattle, including Bali (BL) (42), Madura (MD) (20), Pesisir (PI) (17), Katingan (KT) (16), Ongole grade (PO) (22), Pasundan (PD) (14), Sumba ongole (SO) (10), Brahman (BH) (17), Simmental (SM) (15), and Limousin (LM) (18). Polymorphism of MSTN gene was analyzed using PCR-RFLP (DraI) and direct sequencing methods. Results of genotyping g-371T>A were polymorphic (TT, TA, and AA genotypes) in Simmental, SO, and Katingan. The frequencies of alleles T and A were 0.83; 0.90; 0.97 and 0.17; 0.10; 0.03 respectively. The values of Ho and He were 0.06–0.20 and 0.06–0.28, respectively. The results of this study are in Hardy-Weinberg equilibrium (P> 0.05). Whereas in PD, MD, PI, PO, BH, LM, and BL were monomorphic (TT genotype). The result of sequencing the promoter region of MSTN gene found that mutations transversion was occurred in T to A at g.-371. It was concluded that g.-371T>A of MSTN gene was polymorphic which was potential to be used as genetic markers of muscle growth in SM, SO, and KT cattle.
Keywords	snp g.-371t>a of mstn gene ; sumba ongole cattle ; katingan cattle ; simmental cattle ; Agriculture ; S ; Agriculture (General) ; S1-972
Subject code	572
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Bogor Agricultural University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Polymorphism g.-371T>A Promoter of the Myostatin Gene in Indonesian Beef Cattle

Sutikno / Rudy Priyanto / Cece Sumantri / Jakaria Jakaria

Jurnal Ilmu Pertanian Indonesia. 2020 Apr., v. 25, no. 2

2020

Abstract	Myostatin (MSTN) gene acts as a negative regulator of muscle growth. The aim of the present study was to identify polymorphism of g.-371T>A in promoter region of MSTN gene in Indonesian beef cattle. Blood samples were collected from 191 cattle, including Bali (BL) (42), Madura (MD) (20), Pesisir (PI) (17), Katingan (KT) (16), Ongole grade (PO) (22), Pasundan (PD) (14), Sumba ongole (SO) (10), Brahman (BH) (17), Simmental (SM) (15), and Limousin (LM) (18). Polymorphism of MSTN gene was analyzed using PCR-RFLP (DraI) and direct sequencing methods. Results of genotyping g-371T>A were polymorphic (TT, TA, and AA genotypes) in Simmental, SO, and Katingan. The frequencies of alleles T and A were 0.83; 0.90; 0.97 and 0.17; 0.10; 0.03 respectively. The values of Ho and He were 0.06–0.20 and 0.06–0.28, respectively. The results of this study are in Hardy-Weinberg equilibrium (P> 0.05). Whereas in PD, MD, PI, PO, BH, LM, and BL were monomorphic (TT genotype). The result of sequencing the promoter region of MSTN gene found that mutations transversion was occurred in T to A at g.-371. It was concluded that g.-371T>A of MSTN gene was polymorphic which was potential to be used as genetic markers of muscle growth in SM, SO, and KT cattle.
Keywords	Brahman ; Ongole ; Simmental ; beef cattle ; blood ; genotype ; genotyping ; muscles ; myostatin ; promoter regions ; Indonesia
Language	English
Dates of publication	2020-04
Size	p. 238-243.
Publishing place	Bogor Agricultural University
Document type	Article
ISSN	2443-3462
DOI	10.18343/jipi.25.2.239
Database	NAL-Catalogue (AGRICOLA)

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Article: Analysis of the impact of determinants of kosherness on the content of macro‐ and microelements in beef

Rudy, Mariusz

Food Science & Nutrition, 7(11):3463-3470

2019

Abstract: ... significant impact of the interaction effects between the analyzed factors (S × G, S × M, G × M, and S × G × M ...

Abstract	There are no studies in the literature that comprehensively present the impact of factors related only to kosher slaughter on the content of minerals in beef. Therefore, learning the impact of such kosher determinants of beef as follows: no stunning during slaughter, cattle category, muscle, or the so‐called kosher treatment for mineral content in beef has an original character. In this connection, the aim of the research was a comprehensive analysis of the impact of kosher determinants (slaughter type, muscle, cattle category, and technological treatment) on the content of selected macro‐ and microelements in beef. On the content of minerals in muscles obtained from beef carcasses, the statistically significant (p < .05) impact was found in the case of slaughter type for such elements as: K, P, and Na. Higher content of phosphorus, potassium, and sodium was found in muscles of heifers and bulls from standard slaughter, compared with the amount of these elements determined in muscles of cattle from kosher slaughter. In turn, statistically significant (p < .05) impact of cattle sex was confirmed only in the case of iron and molybdenum content in beef. Higher amounts of these elements were determined in muscle from heifer carcasses (excluding the molybdenum content in MLT muscle of heifer carcasses from kosher slaughter). The process of koshering (soaking in brine) causes approximately 10‐fold increase in the amount of sodium in beef, regardless of the muscle or gender of cattle. The statistically significant impact of muscle was confirmed only in the case of zinc content. In the authors’ own research, there was found no statistically significant impact of the interaction effects between the analyzed factors (S × G, S × M, G × M, and S × G × M) on the content of particular mineral components.
Keywords	ICP‐OES ; beef ; bulls ; heifers ; minerals ; ritual slaughter
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article: Transcriptomic analysis of hookworm Ancylostoma ceylanicum life cycle stages reveals changes in G-protein coupled receptor diversity associated with the onset of parasitism

Bernot, James P / Rudy, Gabriella / Erickson, Patti T / Ratnappan, Ramesh / Haile, Meseret / Rosa, Bruce A / Mitreva, Makedonka / O'Halloran, Damien M / Hawdon, John M

Australian Society for Parasitology International journal for parasitology. 2020 July, v. 50, no. 8

2020

Abstract: ... of environmental stages in the nematode life cycle and an increasing number of G-protein coupled receptors (GPCRs ...

Abstract	Free-living nematodes respond to variable and unpredictable environmental stimuli whereas parasitic nematodes exist in a more stable host environment. A positive correlation between the presence of environmental stages in the nematode life cycle and an increasing number of G-protein coupled receptors (GPCRs) reflects this difference in free-living and parasitic lifestyles. As hookworm larvae move from the external environment into a host, they detect uncharacterized host components, initiating a signalling cascade that results in the resumption of development and eventual maturation. Previous studies suggest this process is mediated by GPCRs in amphidial neurons. Here we set out to uncover candidate GPCRs required by a hookworm to recognise its host. First, we identified all potential Ancylostoma ceylanicum GPCRs encoded in the genome. We then used life cycle stage-specific RNA-seq data to identify differentially expressed GPCRs between the free-living infective L3 (iL3) and subsequent parasitic stages to identify receptors involved in the transition to parasitism. We reasoned that GPCRs involved in host recognition and developmental activation would be expressed at higher levels in the environmental iL3 stage than in subsequent stages. Our results support the model that a decrease in GPCR diversity occurs as the larvae develop from the free-living iL3 stage to the parasitic L3 (pL3) in the host over 24–72 h. We find that overall GPCR expression and diversity is highest in the iL3 compared with subsequent parasitic stages. By 72 h, there was an approximately 50% decrease in GPCR richness associated with the moult from the pL3 to the L4. Taken together, our data uncover a negative correlation between GPCR diversity and parasitic development in hookworm. Finally, we demonstrate proof of principal that Caenorhabditis elegans can be used as a heterologous system to examine the expression pattern of candidate host signal chemoreceptors (CRs) from hookworm. We observe expression of candidate host signal CRs in C. elegans, demonstrating that C. elegans can be effectively used as a surrogate to identify expressed hookworm genes. We present several preliminary examples of this strategy and confirm a candidate CR as neuronally expressed.
Keywords	Ancylostoma ceylanicum ; Caenorhabditis elegans ; G-protein coupled receptors ; G-proteins ; chemoreceptors ; free-living nematodes ; hookworms ; models ; molting ; parasitism ; parasitology ; sequence analysis ; transcriptomics
Language	English
Dates of publication	2020-07
Size	p. 603-610.
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	120518-3
ISSN	1879-0135 ; 0020-7519
ISSN (online)	1879-0135
ISSN	0020-7519
DOI	10.1016/j.ijpara.2020.05.003
Database	NAL-Catalogue (AGRICOLA)

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Book ; Thesis: Einfluss des 25(OH)D3-Spiegels auf Stoffwechsel und Immunparameter bei Patienten mit diabetischer Polyneuropathie und einem diabetischem Fußsyndrom

Rudy, Margret Heike

2019

Institution	Goethe-Universität Frankfurt am Main
Author's details	vorgelegt von Margret Heike Rudy
Language	German
Size	105 Seiten, Diagramme, 21 cm
Publishing place	Frankfurt am Main
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2019
Note	Zusammenfassung auf Deutsch und Englisch ; Im Titel ist "3" tiefgestellt
HBZ-ID	HT020396947
Database	Catalogue ZB MED Medicine, Health

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2020 D 263	order for loan	Magazin

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Article ; Online: Should women with diabetic nephropathy considering pregnancy continue ACE inhibitor or angiotensin II receptor blocker therapy until pregnancy is confirmed? Reply to Lewis G and Maxwell AP [letter].

Tennant, Peter W G / Glinianaia, Svetlana V / Bilous, Rudy W / Rankin, Judith / Bell, Ruth

Diabetologia

2014 Volume 57, Issue 5, Page(s) 1084–1085

MeSH term(s)	Congenital Abnormalities/epidemiology ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 2/complications ; Female ; Fetal Death/epidemiology ; Humans ; Preconception Care/methods ; Pregnancy ; Pregnancy in Diabetics ; Stillbirth/epidemiology
Language	English
Publishing date	2014-02-15
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-014-3191-2
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Article ; Online: Extremely high mutation load of the mitochondrial 8993 T>G mutation in a newborn: implications for prognosis and family planning decisions.

De Praeter, Claudine / Vanlander, Arnaud / Vanhaesebrouck, Piet / Smet, Joél / Seneca, Sara / De Sutter, Petra / Van Coster, Rudy

European journal of pediatrics

2014 Volume 174, Issue 2, Page(s) 267–270

Abstract: ... novo pathogenic mutation (m.8993 T>G) in the gene encoding subunit 6 of the mitochondrial ATP synthase ... on a neonate with the m.8993 T>G mutation and emphasize implications of mtDNA disorders on family planning ...

Abstract	Unlabelled: The propositus presented with hypotonia, respiratory failure, and seizures in the newborn period and was found to have severe hyperlactacidemia and a hypertrophic heart. He carried a de novo pathogenic mutation (m.8993 T>G) in the gene encoding subunit 6 of the mitochondrial ATP synthase (MTATP6). Although the lactate concentration in serum normalized and the proband recovered after a short period at the neonatal intensive care unit, his ultimate motor and cognitive development was poor. Brain MRI at the age of 6 months showed bilaterally signal abnormalities in the caudate nucleus, putamen, thalamus, and mesencephalon. He died at the age of 9 months. The difficulty in genetic counseling in families with a maternal mitochondrial mutation disorder is emphasized. Conclusion: Here, we report on a neonate with the m.8993 T>G mutation and emphasize implications of mtDNA disorders on family planning decisions.
MeSH term(s)	Acidosis, Lactic/genetics ; DNA, Mitochondrial/genetics ; Fatal Outcome ; Genetic Counseling ; Humans ; Infant, Newborn ; Leigh Disease/genetics ; Magnetic Resonance Imaging ; Male ; Mitochondria/genetics ; Mitochondrial Proton-Translocating ATPases/genetics ; Point Mutation/genetics
Chemical Substances	DNA, Mitochondrial ; MT-ATP6 protein, human ; Mitochondrial Proton-Translocating ATPases (EC 3.6.3.-)
Language	English
Publishing date	2014-07-10
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-014-2370-y
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Article ; Online: Poor correlation between polar bodies and blastomere mutation load in a patient with m.3243A>G tRNALeu(UUR) point mutation.

Vandewoestyne, Mado / Heindryckx, Björn / De Gheselle, Stefanie / Lepez, Trees / Neupane, Jitesh / Gerris, Jan / Van Coster, Rudy / De Sutter, Petra / Deforce, Dieter

Mitochondrion

2012 Volume 12, Issue 4, Page(s) 477–479

MeSH term(s)	Blastomeres/cytology ; DNA, Mitochondrial/genetics ; Humans ; Point Mutation ; Polar Bodies/cytology ; RNA, Transfer, Leu/genetics
Chemical Substances	DNA, Mitochondrial ; RNA, Transfer, Leu
Language	English
Publishing date	2012-07
Publishing country	Netherlands
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2056923-3
ISSN	1872-8278 ; 1567-7249
ISSN (online)	1872-8278
ISSN	1567-7249
DOI	10.1016/j.mito.2012.04.002
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