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  1. Article ; Online: Synthesis of Five-Membered

    Ruer, Paul C / Nassar, Youssef / Polák, Peter / Cossy, Janine

    The Journal of organic chemistry

    2023  Volume 88, Issue 11, Page(s) 7228–7232

    Abstract: ... Five- ... ...

    Abstract Five-membered
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c00464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4473: Show issues Location:
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  2. Article ; Online: Incorporation of a cyclobutyl substituent in molecules by transition metal-catalyzed cross-coupling reactions.

    Cossy, Janine / Polàk, Peter / Ruer, Paul C

    Organic & biomolecular chemistry

    2022  Volume 20, Issue 38, Page(s) 7529–7553

    Abstract: In this review, the incorporation of a cyclobutyl substituent in molecules, by transition metal-catalyzed cross-coupling, is described by only considering the formation of C-C bonds. Three main strategies are used to introduce a cyclobutyl substituent in ...

    Abstract In this review, the incorporation of a cyclobutyl substituent in molecules, by transition metal-catalyzed cross-coupling, is described by only considering the formation of C-C bonds. Three main strategies are used to introduce a cyclobutyl substituent in molecules by involving either electrophilic or nucleophilic cyclobutane derivatives.
    Language English
    Publishing date 2022-10-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob01045c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Regenwasser im Garten nachhaltig nutzen

    Polak, Paula

    naturnah planen, bauen und gestalten

    2011  

    Author's details Paula Polak. Ill. von Lisa Apfelbacher
    Keywords Garten ; Regenwasser ; Nutzung ; Naturnahe Gestaltung
    Subject Naturnaher Ausbau ; Naturnahe Umgestaltung ; Gärten
    Subject code 635
    Language German
    Size 195 S. : Ill., graph. Darst.
    Publisher Pala-Verl
    Publishing place Darmstadt
    Publishing country Germany
    Document type Book
    HBZ-ID HT016846438
    ISBN 978-3-89566-285-0 ; 3-89566-285-2
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    118/1002 available for loan (reading room) Freihandmagazin (U1)

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  4. Article ; Online: An approach to evaluation of the point-spread function for

    Polak, Paul / Schulte, Rolf F / Noseworthy, Michael D

    NMR in biomedicine

    2021  Volume 35, Issue 2, Page(s) e4627

    Abstract: Despite the technical challenges that require lengthy acquisitions to overcome poor signal-to-noise ratio (SNR), sodium ( ...

    Abstract Despite the technical challenges that require lengthy acquisitions to overcome poor signal-to-noise ratio (SNR), sodium (
    MeSH term(s) Computer Simulation ; Humans ; Magnetic Resonance Imaging/methods ; Phantoms, Imaging ; Signal-To-Noise Ratio ; Sodium Isotopes
    Chemical Substances Sodium Isotopes
    Language English
    Publishing date 2021-10-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.4627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2869: Show issues Location:
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  5. Article ; Online: Understanding the tuberculosis granuloma: the matrix revolutions.

    Elkington, Paul / Polak, Marta E / Reichmann, Michaela T / Leslie, Alasdair

    Trends in molecular medicine

    2021  Volume 28, Issue 2, Page(s) 143–154

    Abstract: Mycobacterium tuberculosis (Mtb) causes the human disease tuberculosis (TB) and remains the top global infectious pandemic after coronavirus disease 2019 (COVID-19). Furthermore, TB has killed many more humans than any other pathogen, after prolonged ... ...

    Abstract Mycobacterium tuberculosis (Mtb) causes the human disease tuberculosis (TB) and remains the top global infectious pandemic after coronavirus disease 2019 (COVID-19). Furthermore, TB has killed many more humans than any other pathogen, after prolonged coevolution to optimise its pathogenic strategies. Full understanding of fundamental disease processes in humans is necessary to successfully combat this highly successful pathogen. While the importance of immunodeficiency has been long recognised, biologic therapies and unbiased approaches are providing unprecedented insights into the intricacy of the host-pathogen interaction. The nature of a protective response is more complex than previously hypothesised. Here, we integrate recent evidence from human studies and unbiased approaches to consider how Mtb causes human TB and highlight the recurring theme of extracellular matrix (ECM) turnover.
    MeSH term(s) COVID-19 ; Granuloma ; Host-Pathogen Interactions ; Humans ; Mycobacterium tuberculosis ; SARS-CoV-2 ; Tuberculosis
    Language English
    Publishing date 2021-12-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2021.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: ALSUntangled #62: vitamin C.

    Bedlack, Richard / Barkhaus, Paul / Carter, Greg / Crayle, Jesse / Mcdermott, Christopher / Pattee, Gary / Polak, Meraida / Salmon, Kristiana / Wicks, Paul

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2021  Volume 23, Issue 5-6, Page(s) 476–479

    Abstract: Vitamin C is one of the most common supplements taken by people with ALS. As an antioxidant, it has a plausible mechanism for slowing disease progression and there are some flawed pre-clinical studies and case reports suggesting benefit. However, a small ...

    Abstract Vitamin C is one of the most common supplements taken by people with ALS. As an antioxidant, it has a plausible mechanism for slowing disease progression and there are some flawed pre-clinical studies and case reports suggesting benefit. However, a small human trial showed no benefit. Given this negative trial, we do not currently advise vitamin C as an ALS treatment.
    MeSH term(s) Amyotrophic Lateral Sclerosis/drug therapy ; Ascorbic Acid/therapeutic use ; Clinical Trials as Topic ; Dietary Supplements ; Humans ; Treatment Outcome ; Vitamins/therapeutic use
    Chemical Substances Vitamins ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2021-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2021.1946088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5874: Show issues Location:
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  7. Article ; Online: Morphological changes induced by β-lactam antibiotics observed on Gram staining.

    Bitterman, R / Paul, M / Polak, D / Geffen, Y

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2017  Volume 23, Issue 1, Page(s) 26

    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; Bacteremia ; Gentian Violet ; Humans ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/cytology ; Klebsiella pneumoniae/drug effects ; Male ; Osteomyelitis/drug therapy ; Osteomyelitis/microbiology ; Phenazines ; beta-Lactams/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Gram's stain ; Phenazines ; beta-Lactams ; ertapenem (G32F6EID2H) ; Gentian Violet (J4Z741D6O5)
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2016.09.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 284: Show issues

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  8. Article: The big potential of small farms.

    Polak, Paul

    Scientific American

    2005  Volume 293, Issue 3, Page(s) 84–91

    MeSH term(s) Agriculture/economics ; Agriculture/instrumentation ; Agriculture/methods ; Developing Countries ; Food Supply ; Income ; Poverty ; Rural Population ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2005-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 246-x
    ISSN 1946-7087 ; 0036-8733
    ISSN (online) 1946-7087
    ISSN 0036-8733
    DOI 10.1038/scientificamerican0905-84
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    Zs.A 1209: Show issues Location:
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  9. Article ; Online: ALSUntangled #66: antimycobacterial antibiotics.

    Pierce, Ellen S / Barkhaus, Paul / Beauchamp, Morgan / Bromberg, Mark / Carter, Gregory T / Goslinga, Jill / Greeley, David / Kihuwa-Mani, Sky / Levitsky, Gleb / Lund, Isaac / McDermott, Christopher / Pattee, Gary / Pierce, Kaitlyn / Polak, Meraida / Ratner, Dylan / Wicks, Paul / Bedlack, Richard

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2022  Volume 24, Issue 5-6, Page(s) 539–543

    Abstract: Several infections have been associated with motor neuron diseases resembling ALS, including species of viruses, bacteria, and parasites. ...

    Abstract Several infections have been associated with motor neuron diseases resembling ALS, including species of viruses, bacteria, and parasites.
    MeSH term(s) Animals ; Humans ; Anti-Bacterial Agents/therapeutic use ; Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/complications ; Crohn Disease/etiology ; Crohn Disease/microbiology ; Mycobacterium avium subsp. paratuberculosis ; Motor Neuron Disease/complications
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-08-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2022.2104650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Gene Expression Signatures in Tuberculosis Have Greater Overlap with Autoimmune Diseases Than with Infectious Diseases.

    Clayton, Kalum / Polak, Marta E / Woelk, Christopher H / Elkington, Paul

    American journal of respiratory and critical care medicine

    2017  Volume 196, Issue 5, Page(s) 655–656

    Language English
    Publishing date 2017-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201706-1248LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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