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Article ; Online: Editorial: Unravelling the fibres-low dietary fibre may lower risk of developing IBD. Authors' reply.

Dan, Lintao / Wang, Xiaoyan / Chen, Jie

2023 Volume 58, Issue 9, Page(s) 940–941

MeSH term(s)	Humans ; Dietary Fiber ; Inflammatory Bowel Diseases/etiology ; Inflammatory Bowel Diseases/prevention & control ; Risk
Chemical Substances	Dietary Fiber
Language	English
Publishing date	2023-10-13
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17730
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Article: Study on the molecular mechanism of anti-liver cancer effect of Evodiae fructus by network pharmacology and QSAR model.

Chen, Peng-Yu / Han, Lin-Tao

Frontiers in chemistry

2023 Volume 10, Page(s) 1060500

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2022.1060500
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Article: BRCA2 mutation in advanced lung squamous cell carcinoma treated with Olaparib and a PD-1 inhibitor: a case report.

Chen, Zhujun / Wang, Kang / Zhao, Lintao / Gong, Liang

Frontiers in oncology

2023 Volume 13, Page(s) 1190100

Abstract: Background: Mutations in the human breast cancer susceptibility gene 2 (breast cancer 2, BRCA2) increase the risk of breast, ovarian and other cancers. Olaparib, an oral poly[adenosine diphosphate (ADP)-ribose] polymerase (PARP) inhibitor, is usually ... ...

Abstract	Background: Mutations in the human breast cancer susceptibility gene 2 (breast cancer 2, BRCA2) increase the risk of breast, ovarian and other cancers. Olaparib, an oral poly[adenosine diphosphate (ADP)-ribose] polymerase (PARP) inhibitor, is usually prescribed to treat BRCA mutated tumors, especially breast and ovarian cancers. Programmed cell death-1 (PD-1) inhibitors have revolutionized the treatment of lung cancer and many other cancers by destroying the interaction between receptors with ligands in the tumor-immune microenvironment and enabling T cells to recognize and attack cancer cells. Case description: In our study, we report a patient with advanced BRCA2 lung squamous cell carcinoma who received platinum-based chemotherapy combined with paclitaxel. Seven months later, the disease progressed. BRCA2 mutations were detected in peripheral blood by next-generation sequencing. After 2 months of treatment with Olaparib combined with Cindilimab, the patient was in partial remission and the progression-free survival (PFS) lasted for 6 months, but the patient developed immune renal damage. Conclusions: This study adds to the clinical data for the treatment of BRCA2 mutant non-small cell lung cancer by demonstrating that lung squamous cell carcinoma has a good response to PARP inhibitors. It also serves as a reminder that there may still be some negative effects from targeted superimposed immunotherapy.
Language	English
Publishing date	2023-05-16
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1190100
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Article ; Online: Association of serum vitamin C levels with Asthma in adults: results of NHANES 2003-2006 and mendelian randomization study.

Wang, Kang / Zhao, Lintao / Luo, Hu / Deng, Caixia / Gong, Liang / Chen, Zhujun

BMC pulmonary medicine

2024 Volume 24, Issue 1, Page(s) 4

Abstract: Background: The protective effect of vitamin C as an antioxidant against asthma in adults remains controversial. This study used an observational study and Mendelian randomization (MR) analysis to investigate the association between adult asthma and ... ...

Abstract	Background: The protective effect of vitamin C as an antioxidant against asthma in adults remains controversial. This study used an observational study and Mendelian randomization (MR) analysis to investigate the association between adult asthma and serum vitamin C levels. Methods: Using information from the National Health and Nutrition Examination Survey (NHANES) 2003-2006, we carried out an observational study. A multivariate logistic regression model was employed to examine the connection between adult asthma and serum vitamin C levels. We used the inverse-variance weighted (IVW) method of MR analysis as the primary method to analyze the causal effect of serum vitamin C levels on asthma in adults. Results: A total of 8,504 participants were included in the observational study, including 639 in the asthma group and 7,865 in the non-asthma group. Before sample weighting, serum vitamin C was associated with a reduced risk of asthma in adults (OR = 0.798, 95% CI: 0.673-0.945, P = 0.009). After sample weighting, serum vitamin C was not associated with adult asthma risk (OR = 0.829, 95% CI: 0.660 ~ 1.042, P = 0.104). MR analysis showed no causal relationship between serum vitamin C and adult asthma in either the UK Biobank (OR = 0.957, 95% CI: 0.871 ~ 1.053, P = 0.370) or FinnGen (OR = 0.973, 95% CI: 0.824 ~ 1.149, P = 0.750) cohorts. Conclusion: Our study did not support a causal association between serum vitamin C levels and adult asthma risk. The relationship between serum vitamin C and adult asthma requires further research.
MeSH term(s)	Adult ; Humans ; Mendelian Randomization Analysis ; Nutrition Surveys ; Antioxidants ; Ascorbic Acid ; Asthma/epidemiology ; Genome-Wide Association Study
Chemical Substances	Antioxidants ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-023-02821-w
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Article ; Online: A Highway Pavement Crack Identification Method Based on an Improved U-Net Model

Qinge Wu / Zhichao Song / Hu Chen / Yingbo Lu / Lintao Zhou

Applied Sciences, Vol 13, Iss 7227, p

2023 Volume 7227

Abstract: Crack identification plays a vital role in preventive maintenance strategies during highway pavement maintenance. Therefore, accurate identification of cracks in highway pavement images is the key to highway maintenance work. In this paper, an improved U- ...

Abstract	Crack identification plays a vital role in preventive maintenance strategies during highway pavement maintenance. Therefore, accurate identification of cracks in highway pavement images is the key to highway maintenance work. In this paper, an improved U-Net network adopting multi-scale feature prediction fusion and the improved parallel attention module was put forward to better identify concrete cracks. Multiscale feature prediction fusion combines multiple U-Net features generated by intermediate layers for aggregated prediction, thus using global information from different scales. The improved parallel attention module is used to process the U-Net decoded output of multi-scale feature prediction fusion, which can give more weight to the target region in the image and further capture the global contextual information of the image to improve the recognition accuracy. Improving the bottleneck layer is used to improve the robustness of the model and prevent overfitting. Experiments show that the improved U-Net network in this paper has a significant improvement over the original U-Net network. The performance of the proposed method in this paper was investigated on two publicly available datasets (Crack500 and CFD) and compared with competing methods proposed in the literature. Using the Crack500 dataset, the method in this paper achieved the highest score in precision (89.60%), recall (95.83%), mIOU (83.80%), and F1-score (92.61%). Similarly, for the CFD dataset, the method in this paper achieved high values for precision (93.29%), mIOU (82.07%), recall (86.26%), and F1-score (89.64%). Thus, the method has several advantages for identifying cracks in highway pavements and is an ideal tool for practical work. In future work, identifying more crack types and model light-weighting are the key objectives. Meanwhile, this paper provides a new idea for road crack identification.
Keywords	pavement crack ; multi-scale feature prediction fusion ; attention mechanism ; U-Net ; image segmentation ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	006
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Risk of subsequent gastrointestinal disease assessed by skeletal muscle strength and mass in a prospective cohort study.

Dan, Lintao / Qin, Pei / Xie, Siyuan / Sun, Yuhao / Fu, Tian / Ruan, Xixian / Shi, Wenming / Chen, Jie / Cai, Jianting / Li, Xue

iScience

2024 Volume 27, Issue 4, Page(s) 109341

Abstract: Skeletal muscle may mutually interact with gastrointestinal disease through metabolic homeostasis and nutritional status and therefore may be a marker for early risk detection. We conducted a prospective cohort analysis including 393,606 participants ( ... ...

Abstract	Skeletal muscle may mutually interact with gastrointestinal disease through metabolic homeostasis and nutritional status and therefore may be a marker for early risk detection. We conducted a prospective cohort analysis including 393,606 participants (mean age 56.0 years, 53.9% female) from the UK Biobank. The exposures were grip strength and skeletal muscle mass (SMM). The primary outcomes were 24 incident gastrointestinal diseases. During a mean follow-up of 12.1 years, we found that one sex-specific SD increase in grip strength and SMM were associated with reduced risk of 16 and 19 gastrointestinal diseases, respectively. For grip strength, the HRs ranged from 0.94 (for ulcerative colitis) to 0.80 (for liver cancers). For SMM, the HRs ranged from 0.92 (for colorectal cancer) to 0.51 (for non-alcoholic fatty liver disease). Our finding suggested that grip strength and SMM might be significant indicators for gastrointestinal diseases risk screen.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109341
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Article ; Online: T1-Weighted Signal-Intensity Ratio of Renal Hemorrhagic Cysts.

Chen, Lintao / Liang, Wenjie

AJR. American journal of roentgenology

2020 Volume 215, Issue 5, Page(s) W53

MeSH term(s)	Carcinoma, Renal Cell ; Cysts ; Humans ; Kidney Neoplasms ; Magnetic Resonance Imaging ; Retrospective Studies
Language	English
Publishing date	2020-10-21
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.20.22944
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Article ; Online: Effect of KI Concentration in Correcting Tank on Optical Properties of PVA Polarizing Film.

Yang, Yang / Zheng, Ziyuan / Lin, Jun / Zhou, Lintao / Chen, Guohua

Polymers

2022 Volume 14, Issue 7

Abstract: Polarizer is a key component of the liquid crystal display panel, and the optical properties mainly include transmittance, degree of polarization and chromaticity. Polarizer is made of a multilayer optical film, in which the PVA polarizing film is the ... ...

Abstract	Polarizer is a key component of the liquid crystal display panel, and the optical properties mainly include transmittance, degree of polarization and chromaticity. Polarizer is made of a multilayer optical film, in which the PVA polarizing film is the core structure for realizing the polarization of the whole polarizer. PVA polarizing film is commonly manufactured through a multi-step craft, including rinsing, dyeing, stretching and correcting. The correction process has a significant impact on the final apparent color and optical properties of the polarizer. In this study, the KI concentration in the correcting tank, ranging from 1% to 3%, was systematically investigated. With the increase in KI concentration, the Raman vibration peak at 160 cm
Language	English
Publishing date	2022-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14071413
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Article ; Online: Deciphering the chemical profile and pharmacological mechanism of Jinlingzi powder against bile reflux gastritis using ultra-high performance liquid chromatography coupled with Q exactive focus mass spectrometry, network pharmacology, and molecular docking.

Hui, Ren / Lintao, Zhao / Kai, Gao / Yuanyuan, Yang / Xiaomin, Cui / Jing, H U / Zhiyong, Chen / Ye, L I

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2023 Volume 43, Issue 6, Page(s) 1209–1218

Abstract: Objective: To elucidate the chemical profile and the pharmacological mechanism by which Jinlingzi powder (, JLZP) treats bile reflux gastritis (BRG).: Methods: A BRG model was established in rats by oral administration of the model solution. JLZP was ...

Abstract	Objective: To elucidate the chemical profile and the pharmacological mechanism by which Jinlingzi powder (, JLZP) treats bile reflux gastritis (BRG). Methods: A BRG model was established in rats by oral administration of the model solution. JLZP was orally administered for 35 d. Residual gastric rate and tumor necrosis factor (TNF)-α, interleukin (IL)-6, and gastrin levels in the serum were measured, and stomach tissues were collected for histopathological analysis. We used ultra-high performance liquid chromatography coupled with Q Exactive Focus mass spectrometry to identify the chemical ingredients in JLZP. Then, protein-protein interaction and herb-compound-target networks were constructed to screen potential bioactive compounds and targets. Kyoto Encyclopedia of Genes and Genomes pathway analysis was then performed to elucidate the pathway involved in the JLZP-mediated treatment of BRG. After constructing the core compound-target-pathway interaction network, molecular docking was performed to study the binding free energy of core bioactive compounds and two candidate targets [RAC-alpha serine/threonine-protein kinase (AKT1) and phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)]. Results: JLZP extracts significantly promoted gastric emptying, regulating the release of cytokines (TNF-α and IL-6) and improving gastrin secretion and mucosal repair. Fifty-six compounds were tentatively characterized in JLZP. Moreover, the network pharmacology and molecular docking results showed that alkaloids and flavonoids might be the bioactive compounds in JLZP that treat BRG. JLZP might improve mucosal repair during BRG progression by modulating the phosphatidylinositol-4,5-bisphosphate 3-kinase-protein kinase B, hypoxia inducible factor-1, mitogen-activated protein kinase, forkhead box O, TNF, and IL-17 signaling pathways. Conclusions: We elucidated the chemical constituents and the pharmacological mechanism of JLZP in treating BRG and provided a basis for clinical application.
MeSH term(s)	Animals ; Rats ; Gastrins ; Chromatography, High Pressure Liquid ; Molecular Docking Simulation ; Network Pharmacology ; Powders ; Bile Reflux ; Gastritis/drug therapy ; Tumor Necrosis Factor-alpha ; Phosphatidylinositols ; Drugs, Chinese Herbal
Chemical Substances	Gastrins ; Powders ; Tumor Necrosis Factor-alpha ; Phosphatidylinositols ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-09-30
Publishing country	China
Document type	Journal Article
ZDB-ID	603186-9
ISSN	2589-451X ; 0254-6272 ; 0255-2922
ISSN (online)	2589-451X ; 0254-6272
ISSN	0255-2922
DOI	10.19852/j.cnki.jtcm.20230908.002
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Article ; Online: Risk Assessment for Gastrointestinal Diseases via Clinical Dimension and Genome-Wide Polygenic Risk Scores of Type 2 Diabetes: A Population-Based Cohort Study.

Fu, Tian / Sun, Yuhao / Lu, Shiyuan / Zhao, Jianhui / Dan, Lintao / Shi, Wenming / Chen, Jie / Chen, Yan / Li, Xue

Diabetes care

2024 Volume 47, Issue 3, Page(s) 418–426

Abstract: Objective: We aimed to evaluate whether individuals with type 2 diabetes (T2D) were at higher risk of developing a wide range of gastrointestinal diseases based on a population-based cohort study.: Research design and methods: This study included 374, ...

Abstract	Objective: We aimed to evaluate whether individuals with type 2 diabetes (T2D) were at higher risk of developing a wide range of gastrointestinal diseases based on a population-based cohort study. Research design and methods: This study included 374,125 participants free of gastrointestinal disorders at baseline; of them, 19,719 (5.27%) with T2D were followed-up by linking to multiple medical records to record gastrointestinal disease diagnoses. Multivariable Cox models were used to estimate the hazard ratios (HRs) and CIs. Logistic models were used to examine the associations between polygenic risk scores (PRS) and clinical gastrointestinal phenotypes. Results: During a median follow-up of 12.0 years, we observed the new onset of 15 gastrointestinal diseases. Compared with nondiabetes, participants with T2D had an increased risk of gastritis and duodenitis (HR 1.58, 95% CI 1.51-1.65), peptic ulcer (HR 1.56, 95% CI 1.43-1.71), diverticular disease (HR 1.19, 95% CI 1.14-1.24), pancreatitis (HR 1.45, 95% CI 1.24-1.71), nonalcoholic fatty liver disease (HR 2.46, 95% CI 2.25-2.69), liver cirrhosis (HR 2.92, 95% CI 2.58-3.30), biliary disease (HR 1.18, 95% CI 1.10-1.26), gastrointestinal tract cancers (HR 1.28, 95% CI 1.17-1.40), and hepatobiliary and pancreatic cancer (HR 2.32, 95% CI 2.01-2.67). Positive associations of PRS of T2D with gastritis, duodenitis, and nonalcoholic fatty liver disease were also observed. Conclusions: In this large cohort study, we found that T2D was associated with increased risks of a wide range of gastrointestinal outcomes. We suggest the importance of early detection and prevention of gastrointestinal disorders among patients with T2D.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/genetics ; Cohort Studies ; Genetic Risk Score ; Non-alcoholic Fatty Liver Disease/complications ; Duodenitis/complications ; Prospective Studies ; Risk Assessment ; Gastritis/complications ; Risk Factors
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc23-0978
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