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Article ; Online: Investigation on the application of digital guide templates guided dental implantation in China.

Chen, Yunli / Su, Baohui

2023 Volume 23, Issue 1, Page(s) 36

Abstract: Background: The aim of this survey is to investigate the application of digital guide templates (DGTs) across China, and the views and attitudes of oral health professionals toward them.: Methods: This survey was prepared, distributed, and collected ... ...

Abstract	Background: The aim of this survey is to investigate the application of digital guide templates (DGTs) across China, and the views and attitudes of oral health professionals toward them. Methods: This survey was prepared, distributed, and collected by WJX. Chinese oral health professionals were invited to participate in it. The basic information of respondents, the application of DGTs, and the views and attitudes toward their status quo and development were statistically described. Chi-square test was used to evaluate the correlation between the basic information of respondents and the application of DGTs as well as the views and attitudes toward them. Results: A total of 276 questionnaires were collected, of which 273 were identified as valid. 269 (98.5%) respondents were dental clinical workers, 204 (74.7%) were dental clinical implant workers, and 152 (55.7%) had been engaged in the implant industry for more than five years. The chi-square test showed that working years were significantly correlated with the half-guided, tooth-supported, and mucosa-supported DGTs (P < 0.05); and professional backgrounds and working years presented significant differences in the views and attitudes toward the status quo and development of DGTs (P < 0.05). The questionnaires also made a preliminary investigation and evaluation on the factors influencing accuracy, indications, doctors' recommendations and relevant training. Conclusion: Most respondents held a positive attitude toward the accuracy and development of DGTs. This survey can point out the direction for the improvement of DGTs, and provide a reference for the study of factors affecting implant accuracy, the establishment of a training system, and the understanding of clinicians' current views on DGTs. Trial registration This survey was approved by the Ethics Review Committee of Chenghuaxinguanghua Dental Clinic (Approval NO. CDCIRB-D-2021-201).
MeSH term(s)	Humans ; Dental Implants ; Dental Implantation, Endosseous ; Surveys and Questionnaires ; Attitude of Health Personnel ; China
Chemical Substances	Dental Implants
Language	English
Publishing date	2023-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-023-02750-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Nutrient-mediated modulation of flowering time.

Zhang, Yuhang / Liu, Baohui / Kong, Fanjiang / Chen, Liyu

Frontiers in plant science

2023 Volume 14, Page(s) 1101611

Abstract: Nutrition affects plant growth and development, including flowering. Flowering represents the transition from the vegetative period to the reproduction period and requires the consumption of nutrients. Moreover, nutrients (e.g., nitrate) act as signals ... ...

Abstract	Nutrition affects plant growth and development, including flowering. Flowering represents the transition from the vegetative period to the reproduction period and requires the consumption of nutrients. Moreover, nutrients (e.g., nitrate) act as signals that affect flowering. Regulation of flowering time is therefore intimately associated with both nutrient-use efficiency and crop yield. Here, we review current knowledge of the relationships between nutrients (primarily nitrogen, phosphorus, and potassium) and flowering, with the goal of deepening our understanding of how plant nutrition affects flowering.
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1101611
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Article ; Online: Development and validation of a nomogram for predicting immune-related pneumonitis after sintilimab treatment.

Hong, Baohui / Chen, Rong / Zheng, Caiyun / Liu, Maobai / Yang, Jing

Cancer medicine

2024 Volume 13, Issue 3, Page(s) e6708

Abstract: Background: Immune-related pneumonitis is a rare and potentially fatal adverse event associated with sintilimab. We aimed to develop and validate a nomogram for predicting the risk of immune-related pneumonitis in patients treated with sintilimab.: ... ...

Abstract	Background: Immune-related pneumonitis is a rare and potentially fatal adverse event associated with sintilimab. We aimed to develop and validate a nomogram for predicting the risk of immune-related pneumonitis in patients treated with sintilimab. Methods: The least absolute shrinkage and selection operator (LASSO) regression was used to determine risk factors. Multivariable logistic regression was used to establish a prediction model. Its clinical validity was evaluated using calibration, discrimination, decision, and clinical impact curves. Internal validation was performed against the validation set and complete dataset. Results: The study included 632 patients; 59 were diagnosed with immune-related pneumonitis. LASSO regression analysis identified that the risk factors for immune-related pneumonitis were pulmonary metastases (odds ratio [OR], 4.015; 95% confidence interval [CI]: 1.725-9.340) and metastases at >3 sites (OR, 2.687; 95% CI: 1.151-6.269). The use of combined antibiotics (OR, 0.247; 95% CI: 0.083-0.738) and proton pump inhibitors (OR, 0.420; 95% CI: 0.211-0.837) were protective factors. The decision and clinical impact curves showed that the nomogram had clinical value for patients treated with sintilimab. Conclusions: We have developed and validated a practical nomogram model of sintilimab-associated immune-related pneumonitis, which provides clinical value for determining the risk of immune-related pneumonitis and facilitating the safe administration of sintilimab therapy.
MeSH term(s)	Humans ; Nomograms ; Pneumonia/chemically induced ; Pneumonia/diagnosis ; Anti-Bacterial Agents ; Antibodies, Monoclonal, Humanized/adverse effects
Chemical Substances	sintilimab (8FU7FQ8UPK) ; Anti-Bacterial Agents ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6708
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Article ; Online: Competitive Swarm Optimized SVD Clutter Filtering for Ultrafast Power Doppler Imaging.

Chen, Yinran / Fang, Baohui / Meng, Fengling / Luo, Jianwen / Luo, Xiongbiao

IEEE transactions on ultrasonics, ferroelectrics, and frequency control

2024 Volume 71, Issue 4, Page(s) 459–473

Abstract: Ultrafast power Doppler imaging (uPDI) can significantly increase the sensitivity of resolving small vascular paths in ultrasound. While clutter filtering is a fundamental and essential method to realize uPDI, it commonly uses singular value ... ...

Abstract	Ultrafast power Doppler imaging (uPDI) can significantly increase the sensitivity of resolving small vascular paths in ultrasound. While clutter filtering is a fundamental and essential method to realize uPDI, it commonly uses singular value decomposition (SVD) to suppress clutter signals and noise. However, current SVD-based clutter filters using two cutoffs cannot ensure sufficient separation of tissue, blood, and noise in uPDI. This article proposes a new competitive swarm-optimized SVD clutter filter to improve the quality of uPDI. Specifically, without using two cutoffs, such a new filter introduces competitive swarm optimization (CSO) to search for the counterparts of blood signals in each singular value. We validate the CSO-SVD clutter filter on public in vivo datasets. The experimental results demonstrate that our method can achieve higher contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), and blood-to-clutter ratio (BCR) than the state-of-the-art SVD-based clutter filters, showing a better balance between suppressing clutter signals and preserving blood signals. Particularly, our CSO-SVD clutter filter improves CNR by 0.99 ± 0.08 dB, SNR by 0.79 ± 0.08 dB, and BCR by 1.95 ± 0.03 dB when comparing a spatial-similarity-based SVD clutter filter in the in vivo dataset of rat brain bolus.
MeSH term(s)	Rats ; Animals ; Phantoms, Imaging ; Blood Flow Velocity ; Signal Processing, Computer-Assisted ; Ultrasonography, Doppler/methods ; Ultrasonography/methods
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ISSN	1525-8955
ISSN (online)	1525-8955
DOI	10.1109/TUFFC.2024.3362967
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Article ; Online: Prognostic value of pretreatment procalcitonin and neutrophil-lymphocyte ratio in extensive-stage small-cell lung cancer.

Chen, Dongfang / Xu, Jianlin / Zhao, Yizhuo / Han, Baohui / Zhong, Runbo

Cancer biology & therapy

2024 Volume 25, Issue 1, Page(s) 2331273

Abstract: Background: To investigate the influence of pretreatment neutrophil-to-lymphocyte ratio (NLR) and procalcitonin (PCT) on progression-free survival (PFS) in extensive-stage small-cell lung cancer (SCLC) patients.: Method: A total of 100 extensive- ... ...

Abstract	Background: To investigate the influence of pretreatment neutrophil-to-lymphocyte ratio (NLR) and procalcitonin (PCT) on progression-free survival (PFS) in extensive-stage small-cell lung cancer (SCLC) patients. Method: A total of 100 extensive-stage SCLC patients were enrolled in our study. Patients were stratified according to the median values of pretreatment NLR and PCT levels: low NLR group (NLR ≤3.17), high NLR group (NLR＞3.17), low PCT group (PCT ≤0.06; ng/ml), high PCT group (PCT＞0.06; ng/ml). The Kaplan-Meier method and multivariable Cox regression model were used to reveal the prognostic effects of pretreatment NLR and PCT on PFS. Results: The median PFS of the total extensive-stage SCLC patients was 6.0 months. The median PFS of low pretreatment NLR group (NLR ≤3.17) was not significantly different from that of high pretreatment NLR group (6.2 months vs 5.8 months; Conclusion: Pretreatment PCT is an independent factor associated with PFS in extensive-stage SCLC patients treated with first-line chemotherapy, but pretreatment NLR reflects no significant prognostic value in our study.
MeSH term(s)	Humans ; Lung Neoplasms/drug therapy ; Prognosis ; Neutrophils ; Procalcitonin/therapeutic use ; Lymphocyte Count ; Retrospective Studies ; Small Cell Lung Carcinoma/drug therapy ; Lymphocytes
Chemical Substances	Procalcitonin
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2146305-0
ISSN	1555-8576 ; 1538-4047
ISSN (online)	1555-8576
ISSN	1538-4047
DOI	10.1080/15384047.2024.2331273
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Article: [Accuracy of computer-guided oral implant placement and influencing factors].

Chen, Yunli / Su, Baohui

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi

2022 Volume 39, Issue 4, Page(s) 841–847

Abstract: With the development of computer and digital technology, the application of computer-aided technology has become a new trend in the field of oral implant. Computer-guided oral implant surgery has the advantages of being safer and more accurate than ... ...

Abstract	With the development of computer and digital technology, the application of computer-aided technology has become a new trend in the field of oral implant. Computer-guided oral implant surgery has the advantages of being safer and more accurate than traditional implant surgery, and it can truly realize the concept of restoration-oriented implant. However, computer-guided oral implant surgery has various steps which cause deviations accumulation, so that some clinicians remain sceptical about the accuracy of the technology. Currently, due to the lack of a quantitative system for evaluating the accuracy of computer-guided oral implantation, the implant deviation in each step is still inconclusively in the stage of research and debate. The purpose of this paper is to summarize the advantages and disadvantages, research progress, accuracy and influencing factors of computer-guided oral implantation, aiming to provide a reference for improving implant accuracy and guiding clinical design and surgery.
MeSH term(s)	Computer-Aided Design ; Computers ; Cone-Beam Computed Tomography ; Dental Implants ; Imaging, Three-Dimensional ; Patient Care Planning ; Surgery, Computer-Assisted
Chemical Substances	Dental Implants
Language	Chinese
Publishing date	2022-08-24
Publishing country	China
Document type	Journal Article
ZDB-ID	2576847-5
ISSN	1001-5515
ISSN	1001-5515
DOI	10.7507/1001-5515.202110070
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Article ; Online: Ni Single-Atom Bual Catalytic Electrodes for Long Life and High Energy Efficiency Zinc-Iodine Batteries.

Qu, Wentao / Zhu, Jian / Cao, Guozhong / Chen, Shulin / Tan, Yongwen / Chen, Baohui / Zhang, Ming

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2310475

Abstract: Zinc-iodine batteries (Zn-I2) are extremely attractive as the safe and cost-effective scalable energy storage system in the stationary applications. However, the inefficient redox kinetics and "shuttling effect" of iodine species result in unsatisfactory ...

Abstract	Zinc-iodine batteries (Zn-I2) are extremely attractive as the safe and cost-effective scalable energy storage system in the stationary applications. However, the inefficient redox kinetics and "shuttling effect" of iodine species result in unsatisfactory energy efficiency and short cycle life, hindering their commercialization. In this work, Ni single atoms highly dispersed on carbon fibers is designed and synthesized as iodine anchoring sites and dual catalysts for Zn-I2 batteries, and successfully inhibit the iodine species shuttling and boost dual reaction kinetics. Theoretical calculations indicate that the reinforced d-p orbital hybridization and charge interaction between Ni single-atoms and iodine species effectively enhance the confinement of iodine species. Ni single-atoms also accelerate the iodine conversion reactions with tailored bonding structure of I─I bonds and reduced energy barrier for the dual conversion of iodine species. Consequently, the high-rate performance (180 mAh g
Language	English
Publishing date	2024-01-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202310475
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Article: Transcriptome Analysis Reveals Differentially Expressed Genes Involved in Aluminum, Copper and Cadmium Accumulation in Tea 'Qianmei 419' and 'Qianfu 4'.

Yao, Xinzhuan / Chen, Hufang / Zhang, Baohui / Lu, Litang

Plants (Basel, Switzerland)

2023 Volume 12, Issue 13

Abstract: Tea, as a global nonalcoholic beverage, is widely consumed due to its economic, health and cultural importance. Polyploids have the ability to solve the problems of low yield, cold resistance and insect resistance in tea tree varieties. However, the ... ...

Abstract	Tea, as a global nonalcoholic beverage, is widely consumed due to its economic, health and cultural importance. Polyploids have the ability to solve the problems of low yield, cold resistance and insect resistance in tea tree varieties. However, the response mechanism to aluminum and heavy metal remains unclear. In this study, the content of Al, Cu and Cd were measured in the leaves and roots of 'Qianmei 419' and 'Qianfu 4', respectively. The content of Al, Cd and Cu in the roots of the 'Qianmei 419' tea variety were significantly higher than in 'Qianfu 4' roots. Only the content of Cu in the leaves of the 'Qianmei 419' tea variety was significantly higher than that in the roots of the 'Qianfu 4' tea variety. Moreover, we found that the content of Al, Cu and Cd in the soil around the root of 'Qianfu 4' were higher than in the soil around the root of 'Qianmei 419'. RNA-seq was performed to identify the DEGs involved in the accumulation of Al, Cu and Cd between 'Qianmei 419' and 'Qianfu 4'. A total of 23,813 DEGs were identified in the triploid tea variety, including 16,459 upregulated DEGs and 7354 downregulated DEGs. Among them, by analyzing the expression levels of some metal transporter genes, it was found that most of the metal transporter genes were downregulated in the triploid tea plants. In short, through the analysis of transcriptome data and metal content, it was found that changes in metal transporter gene expression affect the accumulation of metals in tea plants. These results provide candidate genes to enhance multi-metal tolerance through genetic engineering technology.
Language	English
Publishing date	2023-07-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12132580
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Article ; Online: Formulating compatible non-flammable electrolyte for lithium-ion batteries with ethoxy (pentafluoro) cyclotriphosphazene.

Liu, Yutao / Lu, Jiazheng / Gong, Xuanlin / Liu, Jingju / Chen, Baohui / Wu, Chuanping / Fang, Zhen

RSC advances

2024 Volume 14, Issue 16, Page(s) 11533–11540

Abstract: Lithium (Li) ion batteries have played a great role in modern society as being extensively used in commercial electronic products, electric vehicles, and energy storage systems. However, battery safety issues have gained growing concerns as there might ... ...

Abstract	Lithium (Li) ion batteries have played a great role in modern society as being extensively used in commercial electronic products, electric vehicles, and energy storage systems. However, battery safety issues have gained growing concerns as there might be thermal runaway, fire or even explosion under external abuse. To tackle these safety issues, developing non-flammable electrolytes is a promising strategy. However, the balance between the flame-retarding effect and the electrochemical performance of electrolytes remains a great challenge. Herein, we evaluate the function of ethoxy (pentafluoro) cyclotriphosphazene (PFPN) as an effective flame-retarding additive for lithium-ion batteries. The flammability of electrolytes is greatly suppressed with the introduction of a small amount of PFPN. Moreover, PFPN exhibited excellent compatibility with LiFePO
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d4ra02095b
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Article ; Online: Comparison of immune checkpoint inhibitors related to pulmonary adverse events: a retrospective analysis of clinical studies and network meta-analysis.

Hong, Baohui / Du, Bin / Chen, Rong / Zheng, Caiyun / Ni, Ruping / Liu, Maobai / Yang, Jing

BMC medicine

2024 Volume 22, Issue 1, Page(s) 75

Abstract: Background: Immune checkpoint inhibitors (ICIs) have transformed tumor treatment. However, the risk of pulmonary adverse events (PAEs) associated with ICI combination therapy is still unclear. We aimed to provide a PAE overview and risk ordering of ICIs ...

Abstract	Background: Immune checkpoint inhibitors (ICIs) have transformed tumor treatment. However, the risk of pulmonary adverse events (PAEs) associated with ICI combination therapy is still unclear. We aimed to provide a PAE overview and risk ordering of ICIs used in tumor treatment. Methods: We searched the databases of PubMed, PsycINFO, Embase, Cochrane Library, CINAHL, Web of Science, Scopus, and clinical trial websites during January 2011-April 2023 to identify phase II and III randomized clinical trials (RCTs) and single-arm clinical trials wherein at least one treatment arm received ICIs (e.g., ICI monotherapy, a combination of two ICIs, or ICIs in combination with conventional cancer therapy). We reported the results of PAEs. Additionally, we compared risks of PAEs between different drug classes using a Bayesian network meta-analysis. Results: Among 143 RCTs and 24 single-arm trials, the incidence of all-grade and grade 3-4 PAEs were highest with programmed death L1 (PD-L1) plus cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and plus chemotherapy and anti-PD1 plus anti-CTLA4, the lowest with targeted therapy drug plus chemotherapy and anti-PD1 plus anti-PDL1. Anti-PD1 plus anti-CTLA4 and plus chemotherapy was the intervention with the highest risk for all-grade and 3-4 grade PAEs, and the intervention with the lowest risk was chemotherapy and anti-PD1 plus anti-PDL1. In terms of all-grade PAEs, chemotherapy was safer than ICI monotherapy. Except for the anti-PD1 plus anti-PDL1 regimen, no significant difference in the risk of grade 3-4 PAEs was detected between dual-ICIs and single-ICIs. Furthermore, the risk of PAEs associated with nivolumab, pembrolizumab, and atezolizumab may be dose dependent. Conclusions: In the single-drug regimen, anti-PD1 caused the greatest incidence of PAEs. The risk of PAEs was higher with all single-ICIs than with chemotherapy. However, no significant difference in the risk of PAEs was detected between single-ICIs. In the combined regimen, anti-PD1 plus anti-CTLA4 and plus chemotherapy showed the greatest risk of PAEs, but there were no significant differences in risk between dual-ICIs and single-ICIs.
MeSH term(s)	Humans ; Antineoplastic Agents, Immunological/adverse effects ; Immune Checkpoint Inhibitors/adverse effects ; Incidence ; Neoplasms/epidemiology ; Network Meta-Analysis ; Clinical Trials as Topic
Chemical Substances	Antineoplastic Agents, Immunological ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-024-03285-3
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