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  1. Article ; Online: Aluminyl derived ethene functionalization with heteroallenes, leading to an intramolecular ligand rearrangement.

    O'Reilly, Andrea / Gardiner, Michael G / McMullin, Claire L / Fulton, J Robin / Coles, Martyn P

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 7, Page(s) 881–884

    Abstract: The aluminacyclopropane K[Al(NON)(η- ... ...

    Abstract The aluminacyclopropane K[Al(NON)(η-C
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc05785b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hair Loss in Patients with Gastroparesis: A Sign of Nutritional Deficiency in Gastroparesis?

    Silver, Paul J / Coles, Michael J / Heath, Candrice R / Parkman, Henry P

    Digestive diseases and sciences

    2023  Volume 68, Issue 4, Page(s) 1397–1402

    Abstract: Introduction: Some patients with gastroparesis (Gp) report hair loss. The aim of this study was to investigate the prevalence of patient-reported hair loss in Gp patients, analyze hair loss association to severity of Gp and nutritional deficiencies, and ...

    Abstract Introduction: Some patients with gastroparesis (Gp) report hair loss. The aim of this study was to investigate the prevalence of patient-reported hair loss in Gp patients, analyze hair loss association to severity of Gp and nutritional deficiencies, and study effects of multivitamin treatment on hair loss.
    Methods: Patients with Gp were questioned about hair characteristics, Gp symptoms, and diet. Patients with hair loss had blood drawn for vitamin levels. Patients with hair loss were treated with daily multivitamin and assessed 8 weeks later.
    Results: Hair loss was reported in 65 of 143 patients with Gp (45.5%), occurring similarly in idiopathic and diabetic Gp. Hair loss was most commonly noticed while washing and/or combing hair. Patients with hair loss had more severe nausea, abdominal pain, stomach fullness, loss of appetite, abdominal discomfort, bloating, retching, stomach distension, vomiting, early satiety, postprandial fullness, and constipation. Hair loss patients lost more weight over prior 6 months. Patients with hair loss had similar gastric retention on gastric emptying scintigraphy. Overall, 29 of 61 (47.5%) patients with hair loss had at least one abnormal bloodwork result. After 8 weeks of treatment with a daily multivitamin, 17 of 41 (41%) patients had improvement in hair loss.
    Conclusion: Hair loss occurred in 46% of patients with Gp, being associated with more severe symptoms, loss of weight, and several vitamin deficiencies, although not a specific one. Treatment with multivitamins improved hair loss in 40% of patients. Presence of hair loss in patients with Gp should prompt nutritional evaluation and supplementation.
    MeSH term(s) Humans ; Gastroparesis/diagnosis ; Gastroparesis/epidemiology ; Gastroparesis/etiology ; Gastric Emptying ; Vomiting/epidemiology ; Nausea ; Malnutrition/complications ; Vitamins/pharmacology
    Chemical Substances Vitamins
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-022-07803-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Advancing Brain Research through Surface-Enhanced Raman Spectroscopy (SERS): Current Applications and Future Prospects.

    Elsheikh, Suzan / Coles, Nathan P / Achadu, Ojodomo J / Filippou, Panagiota S / Khundakar, Ahmad A

    Biosensors

    2024  Volume 14, Issue 1

    Abstract: Surface-enhanced Raman spectroscopy (SERS) has recently emerged as a potent analytical technique with significant potential in the field of brain research. This review explores the applications and innovations of SERS in understanding the ... ...

    Abstract Surface-enhanced Raman spectroscopy (SERS) has recently emerged as a potent analytical technique with significant potential in the field of brain research. This review explores the applications and innovations of SERS in understanding the pathophysiological basis and diagnosis of brain disorders. SERS holds significant advantages over conventional Raman spectroscopy, particularly in terms of sensitivity and stability. The integration of label-free SERS presents promising opportunities for the rapid, reliable, and non-invasive diagnosis of brain-associated diseases, particularly when combined with advanced computational methods such as machine learning. SERS has potential to deepen our understanding of brain diseases, enhancing diagnosis, monitoring, and therapeutic interventions. Such advancements could significantly enhance the accuracy of clinical diagnosis and further our understanding of brain-related processes and diseases. This review assesses the utility of SERS in diagnosing and understanding the pathophysiological basis of brain disorders such as Alzheimer's and Parkinson's diseases, stroke, and brain cancer. Recent technological advances in SERS instrumentation and techniques are discussed, including innovations in nanoparticle design, substrate materials, and imaging technologies. We also explore prospects and emerging trends, offering insights into new technologies, while also addressing various challenges and limitations associated with SERS in brain research.
    MeSH term(s) Humans ; Spectrum Analysis, Raman ; Brain ; Brain Neoplasms ; Stroke ; Machine Learning
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios14010033
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  4. Article ; Online: Advanced crystallisation methods for small organic molecules.

    Metherall, J P / Carroll, R C / Coles, S J / Hall, M J / Probert, M R

    Chemical Society reviews

    2023  Volume 52, Issue 6, Page(s) 1995–2010

    Abstract: Molecular materials based on small organic molecules often require advanced structural analysis, beyond the capability of spectroscopic techniques, to fully characterise them. In such cases, diffraction methods such as single crystal X-ray diffraction ( ... ...

    Abstract Molecular materials based on small organic molecules often require advanced structural analysis, beyond the capability of spectroscopic techniques, to fully characterise them. In such cases, diffraction methods such as single crystal X-ray diffraction (SCXRD), are one of the most powerful tools available to researchers, providing molecular and structural elucidation at atomic level resolution, including absolute stereochemistry. However SCXRD, and related diffraction methods, are heavily dependent on the availability of suitable, high-quality crystals, thus crystallisation often becomes the major bottleneck in preparing samples. Following a summary of classical methods for the crystallisation of small organic molecules, this review will focus on a number of recently developed advanced methods for crystalline material sample preparation for SCXRD. This review will cover two main areas of modern small organic molecule crystallisation, namely the inclusion of molecules within host complexes (
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/d2cs00697a
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  5. Article ; Online: Reductions in sustained prescription opioid use within the US between 2017 and 2021.

    Schoenfeld, Andrew J / Munigala, Satish / Gong, Jonathan / Schoenfeld, Roman J / Banaag, Amanda / Coles, Christian / Koehlmoos, Tracey P

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1432

    Abstract: ... reduction in the odds of sustained prescription opioid use (OR 0.32; 95% CI 0.27, 0.38; p < 0.001) in 2020 ...

    Abstract Over the last decade, various efforts have been made to curtail the opioid crisis. The impact of these efforts, since the onset of the COVID-19 pandemic, has not been well characterized. We sought to develop national estimates of the prevalence of sustained prescription opioid use for a time period spanning the COVID-19 pandemic (2017-2021). We used TRICARE claims data (fiscal year 2017-2021) to identify patients who were prescription opioid non-users prior to receipt of a new opioid medication. We evaluated eligible patients for subsequent sustained prescription opioid use. The prevalence of sustained prescription opioid use during 2020-2021 was compared to 2017-2019. We performed multivariable logistic regression analyses to adjust for confounding. We performed secondary analyses that accounted for interactions between the time period and age, as well as a proxy for socioeconomic status. We determined there was a 68% reduction in the odds of sustained prescription opioid use (OR 0.32; 95% CI 0.27, 0.38; p < 0.001) in 2020-2021 as compared to 2017-2019. Significant reductions were identified across all US census divisions and all patient age groups. In both time periods, the plurality of encounters associated with initial receipt of an opioid that culminated in sustained prescription opioid use were associated with non-specific primary diagnoses. We found significant reductions in sustained prescription opioid use in 2020-2021 as compared to 2017-2019. The persistence of prescribing behaviors that result in issue of opioids for poorly characterized conditions remains an area of concern.
    MeSH term(s) Female ; Humans ; Analgesics, Opioid/therapeutic use ; Pandemics ; Opioid-Related Disorders/epidemiology ; Opioid-Related Disorders/drug therapy ; Drug Prescriptions ; COVID-19/epidemiology ; Practice Patterns, Physicians'
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52032-4
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  6. Article ; Online: Changes in Surgical Volume in Military Medical Treatment Facilities and Military Surgeon Clinical Combat Readiness During the COVID-19 Pandemic.

    Schoenfeld, Andrew J / Ho, Hoa T / Schoenfeld, Roman J / Coles, Christian / Koehlmoos, Tracey P

    Annals of surgery open : perspectives of surgical history, education, and clinical approaches

    2023  Volume 4, Issue 3, Page(s) e308

    Abstract: Mini-abstract In this retrospective study, we evaluated changes in measures of surgeon clinical combat readiness within the military health system during the COVID-19 pandemic. We found a 36% reduction in surgical knowledge and skills as compared to pre- ... ...

    Abstract Mini-abstract In this retrospective study, we evaluated changes in measures of surgeon clinical combat readiness within the military health system during the COVID-19 pandemic. We found a 36% reduction in surgical knowledge and skills as compared to pre-COVID. Sizable reductions were encountered for surgery for colectomy (-50%) and aneurysm repair (-61%).
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article
    ISSN 2691-3593
    ISSN (online) 2691-3593
    DOI 10.1097/AS9.0000000000000308
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  7. Article ; Online: Pinacol Cross-Coupling Promoted by an Aluminyl Anion.

    O'Reilly, Andrea / Evans, Matthew J / McMullin, Claire L / Fulton, J Robin / Coles, Martyn P

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 30, Issue 1, Page(s) e202302999

    Abstract: A simple sequential addition protocol for the reductive coupling of ketones and aldehydes by a potassium aluminyl grants access to unsymmetrical pinacolate derivatives. Isolation of an aluminium ketyl complex presents evidence for the accessibility of ... ...

    Abstract A simple sequential addition protocol for the reductive coupling of ketones and aldehydes by a potassium aluminyl grants access to unsymmetrical pinacolate derivatives. Isolation of an aluminium ketyl complex presents evidence for the accessibility of radical species. Product release from the aluminium centre was achieved using an iodosilane, forming the disilylated 1,2-diol and a neutral aluminium iodide, thereby demonstrating the steps required to generate a closed synthetic cycle for pinacol (cross) coupling at an aluminyl anion.
    Language English
    Publishing date 2023-11-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202302999
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  8. Article ; Online: Extending chain growth beyond C

    Evans, Matthew J / Gardiner, Michael G / Anker, Mathew D / Coles, Martyn P

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 39, Page(s) 5833–5836

    Abstract: ... ...

    Abstract (NON
    Language English
    Publishing date 2022-05-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc01554d
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  9. Article: Controlled reductive C-C coupling of isocyanides promoted by an aluminyl anion.

    Evans, Matthew J / Anker, Mathew D / McMullin, Claire L / Coles, Martyn P

    Chemical science

    2023  Volume 14, Issue 23, Page(s) 6278–6288

    Abstract: We report the reaction of the potassium aluminyl, K[Al(NON)] ([NON] ...

    Abstract We report the reaction of the potassium aluminyl, K[Al(NON)] ([NON]
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc01387a
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  10. Article ; Online: Reductive Coupling of a Diazoalkane Derivative Promoted by a Potassium Aluminyl and Elimination of Dinitrogen to Generate a Reactive Aluminium Ketimide.

    Evans, Matthew J / Anker, Mathew D / McMullin, Claire L / Coles, Martyn P

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 71, Page(s) e202302903

    Abstract: The reaction of 9-diazo-9H-fluorene ( ... ...

    Abstract The reaction of 9-diazo-9H-fluorene (fluN
    Language English
    Publishing date 2023-11-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202302903
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