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Article ; Online: Update to RIFM fragrance ingredient safety assessment, l-carvone, CAS Registry Number 6485-40-1.

Api, A M / Bartlett, A / Belsito, D / Botelho, D / Bruze, M / Bryant-Freidrich, A / Burton, G A / Cancellieri, M A / Chon, H / Dagli, M L / Dekant, W / Deodhar, C / Farrell, K / Fryer, A D / Jones, L / Joshi, K / Lapczynski, A / Lavelle, M / Lee, I /

Moustakas, H / Muldoon, J / Penning, T M / Ritacco, G / Sadekar, N / Schember, I / Schultz, T W / Siddiqi, F / Sipes, I G / Sullivan, G / Thakkar, Y / Tokura, Y

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2024 Volume 183 Suppl 1, Page(s) 114505

MeSH term(s)	Odorants ; Perfume/toxicity ; Cyclohexane Monoterpenes
Chemical Substances	carvone (75GK9XIA8I) ; Perfume ; Cyclohexane Monoterpenes
Language	English
Publishing date	2024-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2024.114505
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Article ; Online: RIFM fragrance ingredient safety assessment, l-lactic acid (2-hydroxy propionic acid), CAS Registry Number 79-33-4.

Api, A M / Belsito, D / Botelho, D / Bruze, M / Burton, G A / Cancellieri, M A / Chon, H / Dagli, M L / Dekant, W / Deodhar, C / Fryer, A D / Jones, L / Joshi, K / Kumar, M / Lapczynski, A / Lavelle, M / Lee, I / Liebler, D C / Moustakas, H /

Muldoon, J / Penning, T M / Ritacco, G / Romine, J / Sadekar, N / Schultz, T W / Selechnik, D / Siddiqi, F / Sipes, I G / Sullivan, G / Thakkar, Y / Tokura, Y

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2023 Volume 182 Suppl 1, Page(s) 114137

Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2023.114137
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Article: D,L-fenfluramine challenge test: experience in nonpatient sample.

Muldoon, M F / Manuck, S B / Jansma, C L / Moore, A L / Perel, J / Mann, J J

Biological psychiatry

1996 Volume 39, Issue 9, Page(s) 761–768

Abstract: The plasma prolactin response to a single-dose fenfluramine challenge is increasingly utilized in psychiatric research as an indirect and noninvasive measure of central serotonergic activity. However, the influences of age, gender, and body weight on ... ...

Abstract	The plasma prolactin response to a single-dose fenfluramine challenge is increasingly utilized in psychiatric research as an indirect and noninvasive measure of central serotonergic activity. However, the influences of age, gender, and body weight on prolactin response and characterization of physical and psychological symptoms evoked by fenfluramine remain poorly studied. In the current study, 83 nonpatient male and female volunteers, 25-60 years old, were administered a standardized fenfluramine challenge test (60 mg). Serial blood samples for plasma drug concentration and plasma prolactin concentration were obtained and side effects reported by participants were recorded. Analyses revealed that both plasma drug concentration and prolactin response were correlated with weight-relative dose (r = 0.43 and r = 0.38, respectively; p < 0.001). No significant relationship was noted between prolactin response and either age or gender. Symptoms during fenfluramine challenge were reported by 90% of subjects, most commonly fatigue, headache, lightheadedness, and difficulty concentrating. Overall side effect severity was related to weight-relative dose (r = 0.26; p < 0.05) and prolactin response (r = 0.42; p < 0.001). We conclude that fenfluramine challenge results should be reported as change in plasma prolactin relative to dose, and that in nonpatient samples the test is associated with frequent side effects.
MeSH term(s)	Adult ; Age Factors ; Female ; Fenfluramine/pharmacokinetics ; Humans ; Male ; Middle Aged ; Personality Assessment ; Prolactin/blood ; Reference Values ; Serotonin Uptake Inhibitors/pharmacokinetics ; Sex Factors
Chemical Substances	Serotonin Uptake Inhibitors ; Fenfluramine (2DS058H2CF) ; Prolactin (9002-62-4)
Language	English
Publishing date	1996-05-01
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/0006-3223(95)00227-8
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Article: Malignant Large Bowel Obstruction.

Muldoon, Roberta L

Clinics in colon and rectal surgery

2021 Volume 34, Issue 4, Page(s) 251–261

Abstract: Large bowel obstruction is a serious and potentially life-threatening surgical emergency which is associated with high morbidity and mortality rate. The most common etiology is colorectal cancer which accounts for over 60% of all large bowel obstructions. ...

Abstract	Large bowel obstruction is a serious and potentially life-threatening surgical emergency which is associated with high morbidity and mortality rate. The most common etiology is colorectal cancer which accounts for over 60% of all large bowel obstructions. Proper assessment, thoughtful decision-making and prompt treatment is necessary to decrease the high morbidity and mortality which is associated with this entity. Knowledge of the key elements regarding the presentation of a patient with a large bowel obstruction will help the surgeon in formulating an appropriate treatment plan for the patient. Comprehensive knowledge and understanding of the various treatment options available is necessary when caring for these patients. This chapter will review the presentation of patients with malignant large bowel obstruction, discuss the various diagnostic modalities available, as well as discuss treatment options and the various clinical scenarios in which they are most appropriately utilized.
Language	English
Publishing date	2021-07-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2048635-2
ISSN	1531-0043
ISSN	1531-0043
DOI	10.1055/s-0041-1729922
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Article: A comparison of d, l-fenfluramine and citalopram challenges in healthy adults.

Flory, Janine D / Manuck, Stephen B / Perel, James M / Muldoon, Matthew F

Psychopharmacology

2004 Volume 174, Issue 3, Page(s) 376–380

Abstract: Dimensional personality characteristics (e.g. impulsivity) and related behaviors and psychiatric disorders are linked to abnormalities of central nervous system (CNS) serotonergic functioning. Although neuroendocrine [e.g. plasma prolactin (PRL)] ... ...

Abstract	Dimensional personality characteristics (e.g. impulsivity) and related behaviors and psychiatric disorders are linked to abnormalities of central nervous system (CNS) serotonergic functioning. Although neuroendocrine [e.g. plasma prolactin (PRL)] responses to the serotonin agonist, fenfluramine, have been used widely to index CNS serotonergic responsivity, safety concerns constrain continued use of fenfluramine. Citalopram, which inhibits serotonin reuptake, may serve as an alternative pre-synaptic neuropharmacologic challenge agent, due to its high selectivity and absence of intrinsic activity at serotonin or other receptor families. Twenty-two healthy adults who had been administered a fenfluramine challenge before May 1996 completed a 5-h oral citalopram challenge 3-6 years later. PRL responsivity to citalopram correlated significantly with PRL response to fenfluramine for baseline-corrected maximal and area-under-the-curve (AUC) indices ( r's > or =0.49, P's< or =0.02). The magnitude of the correlations is notable given the length of time between challenges. The results support the use of citalopram as an alternate neuroendocrine challenge to index CNS serotonergic responsivity.
MeSH term(s)	Adult ; Aged ; Area Under Curve ; Citalopram/pharmacology ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Fenfluramine/pharmacology ; Humans ; Immunoradiometric Assay/methods ; Longitudinal Studies ; Male ; Middle Aged ; Prolactin/blood ; Retrospective Studies ; Serotonin Uptake Inhibitors/pharmacology ; Time Factors
Chemical Substances	Serotonin Uptake Inhibitors ; Citalopram (0DHU5B8D6V) ; Fenfluramine (2DS058H2CF) ; Prolactin (9002-62-4)
Language	English
Publishing date	2004-07
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-003-1763-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Structure of an acidic polysaccharide from a marine bacterium Pseudoalteromonas distincta KMM 638 containing 5-acetamido-3,5,7,9-tetradeoxy-7-formamido-L-glycero-L-manno-nonulosonic acid.

Muldoon, J / Shashkov, A S / Senchenkova, S N / Tomshich, S V / Komandrova, N A / Romanenko, L A / Knirel, Y A / Savage, A V

Carbohydrate research

2001 Volume 330, Issue 2, Page(s) 231–239

Abstract: ... acid (D-GalNAcA) and 5-acetamido-3,5,7,9-tetradeoxy-7-formamido-L-glycero-L-manno-nonulosonic acid ...

Abstract	An acidic polysaccharide was obtained from the lipopolysaccharide of Pseudoalteromonas distincta strain KMM 638, isolated from a marine sponge, and found to contain D-GlcA, D-GalNAc, 2-acetamido-2,6-dideoxy-D-glucose (D-QuiNAc) and two unusual acidic amino sugars: 2-acetamido-2-deoxy-D-galacturonic acid (D-GalNAcA) and 5-acetamido-3,5,7,9-tetradeoxy-7-formamido-L-glycero-L-manno-nonulosonic acid (Pse5Ac7Fo, a derivative of pseudaminic acid). Oligosaccharides were derived from the polysaccharide by partial acid hydrolysis and mild alkaline degradation and characterised by electrospray ionisation (ESI) MS and 1H and 13C NMR spectroscopy. Based on these data and NMR spectroscopic studies of the initial and O-deacetylated polysaccharides, including quaternary carbon detection, 2D COSY, TOCSY, ROESY, H-detected 1H,13C HMQC and HMBC experiments, the following structure of the branched pentasaccharide repeating unit was established: [structure: see text].
MeSH term(s)	Alteromonas/chemistry ; Animals ; Carbohydrate Conformation ; Carbohydrate Sequence ; Lipopolysaccharides/chemistry ; Lipopolysaccharides/isolation & purification ; Marine Biology ; Molecular Sequence Data ; Nuclear Magnetic Resonance, Biomolecular ; O Antigens/chemistry ; O Antigens/isolation & purification ; Porifera/chemistry ; Sialic Acids/chemistry ; Spectrometry, Mass, Electrospray Ionization
Chemical Substances	Lipopolysaccharides ; O Antigens ; Sialic Acids ; 5-N-acetyl-7-N-formylpseudaminic acid (101410-16-6)
Language	English
Publishing date	2001-01-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1435-7
ISSN	1873-426X ; 0008-6215
ISSN (online)	1873-426X
ISSN	0008-6215
DOI	10.1016/s0008-6215(00)00280-9
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Article: Effects of defoliation on flower development in atemoya custard apple (Annona cherimola Mill.×A. squamosa L.) and implications for flower-development modelling

Olesen, Trevor / Muldoon, Steven J

Australian journal of botany. 2012, v. 60, no. 2

2012

Abstract: The effects of different levels of carbon limitation on the flower development of custard apple were studied in two defoliation experiments. The duration of flower development was unaffected by moderate carbon limitation, but increased with severe ... ...

Abstract	The effects of different levels of carbon limitation on the flower development of custard apple were studied in two defoliation experiments. The duration of flower development was unaffected by moderate carbon limitation, but increased with severe limitation. Both moderate and severe limitation caused a decrease in flower dry weight. Some of the data collected were combined with data from an earlier study to develop a model of the dependency of the duration of flower development on temperature. The model was applied to long-term weather records from Alstonville, northern New South Wales, to illustrate the effects of late 20th century warming on the duration of flower development.
Keywords	Annona cherimola ; Annona reticulata ; carbon ; defoliation ; flowering ; flowers ; models ; temperature ; weather ; New South Wales
Language	English
Size	p. 160-164.
Publishing place	CSIRO Publishing
Document type	Article
ISSN	0067-1924
DOI	10.1071/BT11299
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Better Together: A Joined-Up Psychological Approach to Health, Well-Being, and Rehabilitation

Muldoon, Orla M. / Kinsella, Elaine L. / Fortune, Donal G.

2016

Abstract: Health and well-being is best understood in terms of a combination of biological, psychological, and social factors. But how 'social' is the biopsychosocial model when applied to mental health and rehabilitation? Psychology has traditionally viewed ... ...

Abstract	Health and well-being is best understood in terms of a combination of biological, psychological, and social factors. But how 'social' is the biopsychosocial model when applied to mental health and rehabilitation? Psychology has traditionally viewed health as being determined by individual behavior. An integrative psychological approach is required to draw understanding from sociology, social psychology, and politics to consider how wider systemic, structural, and contextual factors impact on health behavior and outcomes. This e-book is dedicated to examining collective and community approaches to well-being and rehabilitation. In particular, the articles contained within this e-book are seeking to understand how social integration, social groups, social identity, and social capital influence health, well-being, and rehabilitation outcomes
Keywords	Science (General) ; Psychology
Size	1 electronic resource (166 p.)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020090661
ISBN	9782889199419 ; 288919941X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Exertional rhabdomyolysis and malignant hyperthermia in a patient with ryanodine receptor type 1 gene, L-type calcium channel alpha-1 subunit gene, and calsequestrin-1 gene polymorphisms.

Capacchione, John F / Sambuughin, Nyamkhishig / Bina, Saiid / Mulligan, Lisa P / Lawson, Tamara D / Muldoon, Sheila M

Anesthesiology

2010 Volume 112, Issue 1, Page(s) 239–244

MeSH term(s)	Adult ; Anesthesia, General ; Biopsy ; Body Temperature/physiology ; Calcium/metabolism ; Calcium Channels/genetics ; Calcium-Binding Proteins/genetics ; Humans ; Male ; Malignant Hyperthermia/genetics ; Malignant Hyperthermia/pathology ; Mitochondrial Proteins/genetics ; Pain/etiology ; Polymorphism, Genetic/genetics ; RNA, Messenger/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Rhabdomyolysis/genetics ; Rhabdomyolysis/pathology ; Rhabdomyolysis/surgery ; Ryanodine Receptor Calcium Release Channel/genetics
Chemical Substances	CACNA1S protein, human ; CASQ1 protein, human ; Calcium Channels ; Calcium-Binding Proteins ; Mitochondrial Proteins ; RNA, Messenger ; Ryanodine Receptor Calcium Release Channel ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2010-01
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0b013e3181c29504
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Article: Malignant Large Bowel Obstruction

Muldoon, Roberta L.

Clinics in Colon and Rectal Surgery

(Bowel Obstructions)

2021 Volume 34, Issue 04, Page(s) 251–261

Series title	Bowel Obstructions
Abstract	Large bowel obstruction is a serious and potentially life-threatening surgical emergency which is associated with high morbidity and mortality rate. The most common etiology is colorectal cancer which accounts for over 60% of all large bowel obstructions. Proper assessment, thoughtful decision-making and prompt treatment is necessary to decrease the high morbidity and mortality which is associated with this entity. Knowledge of the key elements regarding the presentation of a patient with a large bowel obstruction will help the surgeon in formulating an appropriate treatment plan for the patient. Comprehensive knowledge and understanding of the various treatment options available is necessary when caring for these patients. This chapter will review the presentation of patients with malignant large bowel obstruction, discuss the various diagnostic modalities available, as well as discuss treatment options and the various clinical scenarios in which they are most appropriately utilized.
Keywords	malignant bowel obstruction ; colon cancer ; palliative treatment ; anastomosis
Language	English
Publishing date	2021-07-01
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2048635-2
ISSN	1530-9681 ; 1531-0043
ISSN (online)	1530-9681
ISSN	1531-0043
DOI	10.1055/s-0041-1729922
Database	Thieme publisher's database

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