LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 2629

Search options

  1. Article ; Online: Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism.

    Brooks, David J

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2021  Volume 18, Issue 2, Page(s) 753–771

    Abstract: In this paper, the structural and functional imaging changes associated with sporadic and genetic Parkinson's disease and atypical Parkinsonian variants are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is ... ...

    Abstract In this paper, the structural and functional imaging changes associated with sporadic and genetic Parkinson's disease and atypical Parkinsonian variants are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is discussed, and the potential use and drawbacks of using imaging biomarkers for monitoring disease progression is debated. Imaging changes associated with nonmotor complications of PD are presented. The similarities and differences in imaging findings in Lewy body dementia, Parkinson's disease dementia, and Alzheimer's disease are discussed.
    MeSH term(s) Brain/diagnostic imaging ; Brain/metabolism ; Dopamine/genetics ; Dopamine/metabolism ; Humans ; Magnetic Resonance Imaging/trends ; Molecular Imaging/trends ; Neurodegenerative Diseases/diagnostic imaging ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Neuroimaging/trends ; Parkinsonian Disorders/diagnostic imaging ; Parkinsonian Disorders/genetics ; Parkinsonian Disorders/metabolism ; Positron-Emission Tomography/trends
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2021-01-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-020-00994-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6156: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Future Imaging in Dementia.

    Brooks, David J

    Seminars in nuclear medicine

    2020  Volume 51, Issue 3, Page(s) 303–308

    Abstract: Imaging has made an immense contribution toward supporting the diagnosis of dementias, detecting preclinical and prodromal pathology, and allowing disease progression to be objectively tracked. This has led to consensus guidelines for the use of imaging ... ...

    Abstract Imaging has made an immense contribution toward supporting the diagnosis of dementias, detecting preclinical and prodromal pathology, and allowing disease progression to be objectively tracked. This has led to consensus guidelines for the use of imaging in dementias to be published and a future task will be to validate these guidelines. Additionally, there needs to be standardised approaches over the use of binary thresholds when assigning an abnormality status. Other medical unmet needs include the need for specific imaging markers of (1) linear tau tangles, TDP-43 and alpha synuclein aggregates; (2) microglial phenotypes that throw light on the activity of these inflammatory cells; (3) activity of intracellular processes which normally act to clear misfolded proteins; (4) epigenetic activity which regulates gene expression. Future imaging studies are predicted to be active in all these areas. Finally, as safer and more effective immunotherapy and other protective strategies against the pathologies of dementias are developed and trialed, imaging will play a major future role in determining the efficacy of neuroprotective treatments and their mechanism of action to be examined.
    MeSH term(s) Biomarkers ; Dementia/diagnostic imaging ; Diagnostic Imaging ; Disease Progression ; Humans ; tau Proteins
    Chemical Substances Biomarkers ; tau Proteins
    Language English
    Publishing date 2020-12-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2020.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 763: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Complete genome sequences of

    Pearce, David / Brooks, Elliot / Wright, Charles / Rankin, Daniel / Crombie, Andrew T / Murrell, J Colin

    Microbiology resource announcements

    2024  Volume 13, Issue 2, Page(s) e0067523

    Abstract: Here we report the complete genome sequence of two moderately thermophilic methanotrophs isolated from a landfill methane biofilter, ...

    Abstract Here we report the complete genome sequence of two moderately thermophilic methanotrophs isolated from a landfill methane biofilter,
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00675-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Severe cerebral palsy survival is similar in California, USA and Victoria, Australia.

    Walz, Lucas / Brooks, Jordan C / Strauss, David J / Shavelle, Robert M

    Developmental medicine and child neurology

    2023  Volume 65, Issue 11, Page(s) 1532–1533

    MeSH term(s) Humans ; Victoria ; Cerebral Palsy/epidemiology ; California
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/dmcn.15616
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Exploring the declared and the formal and informal taught curricula at a UK dental school through the lens of pulp management.

    Brooks, Laura / Edwards, David / Field, James / Ellis, Janice

    British dental journal

    2024  Volume 236, Issue 2, Page(s) 117–123

    Abstract: Introduction This paper explores the declared and formal and informal taught endodontic curriculum within an undergraduate dental programme in the UK as part of a wider study, which also investigates the learned curriculum. Management of the dental pulp ... ...

    Abstract Introduction This paper explores the declared and formal and informal taught endodontic curriculum within an undergraduate dental programme in the UK as part of a wider study, which also investigates the learned curriculum. Management of the dental pulp was chosen due to the availability of clear internationally recognised guidelines.Method The declared curriculum was identified through existing course guides and seminar and practical session plans. The formal taught curriculum was identified by cataloguing all lectures, practical teaching sessions, seminars and handouts available to dental students. Questionnaires using clinical vignettes were used to explore the informal taught curriculum.Results Valid responses to the questionnaire were received from 25/40 (62.5%) clinical supervisors. Disparities between national guidelines and the declared and taught curriculum were primarily due to broad learning objectives and disparate information from lectures and supervising clinicians. Although the majority of formal teaching aligned with national guidelines, the main deviation occurred within the informal taught curriculum.Conclusion This study highlights disparities between current evidence-based guidelines and the declared and taught curriculum in relation to pulp management in a UK dental school. Recommendations are that all policies, procedures and protocols are updated and aligned to a contemporaneous evidence base annually, plus engagement with clinical lecturers, to enable more standardised teaching.
    MeSH term(s) Humans ; Schools, Dental ; Curriculum ; Learning ; Students ; Surveys and Questionnaires ; United Kingdom ; Teaching
    Language English
    Publishing date 2024-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-024-6762-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.143: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 447: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Healthcare professionals' experiences of caring for women with false-positive screening test results in the National Health Service Breast Screening Programme.

    Long, Hannah A / Brooks, Joanna M / Maxwell, Anthony J / Peters, Sarah / Harvie, Michelle / French, David P

    Health expectations : an international journal of public participation in health care and health policy

    2024  Volume 27, Issue 2, Page(s) e14023

    Abstract: Background: Understanding healthcare professionals' (HCPs) experiences of caring for women with false-positive screening test results in the National Health Service Breast Screening Programme (NHSBSP) is important for reducing the impact of such results. ...

    Abstract Background: Understanding healthcare professionals' (HCPs) experiences of caring for women with false-positive screening test results in the National Health Service Breast Screening Programme (NHSBSP) is important for reducing the impact of such results.
    Methods: Interviews were undertaken with 12 HCPs from a single NHSBSP unit, including advanced radiographer practitioners, breast radiographers, breast radiologists, clinical nurse specialists (CNSs), and a radiology healthcare assistant. Data were analysed thematically using Template Analysis.
    Results: Two themes were produced: (1) Gauging and navigating women's anxiety during screening assessment was an inevitable and necessary task for all participants. CNSs were perceived as particularly adept at this, while breast radiographers reported a lack of adequate formal training. (2) Controlling the delivery of information to women (including amount, type and timing of information). HCPs reported various communication strategies to facilitate women's information processing and retention during a distressing time.
    Conclusions: Women's anxiety could be reduced through dedicated CNS support, but this should not replace support from other HCPs. Breast radiographers may benefit from more training to emotionally support recalled women. While HCPs emphasised taking a patient-centred communication approach, the use of other strategies (e.g., standardised scripts) and the constraints of the 'one-stop shop' model pose challenges to such an approach.
    Patient and public contribution: During the study design, two Patient and Public Involvement members (women with false-positive-breast screening test results) were consulted to gain an understanding of patient perspectives and experiences of being recalled specifically in the NHSBSP. Their feedback informed the formulations of the research aim, objectives and the direction of the interview guide.
    MeSH term(s) Female ; Humans ; State Medicine ; Mammography/psychology ; Health Personnel ; Allied Health Personnel ; Delivery of Health Care ; Breast Neoplasms/diagnosis ; Qualitative Research
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2119434-8
    ISSN 1369-7625 ; 1369-6513
    ISSN (online) 1369-7625
    ISSN 1369-6513
    DOI 10.1111/hex.14023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5896: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Optical constraints on two-photon voltage imaging.

    Davis, Hunter C / Brooks, F Phil / Wong-Campos, J David / Cohen, Adam E

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Genetically encoded voltage indicators (GEVIs) are a valuable tool for studying neural ... ...

    Abstract Genetically encoded voltage indicators (GEVIs) are a valuable tool for studying neural circuits
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.18.567441
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Treadmill exercise modulates nigral and hippocampal cannabinoid receptor type 1 in the 6-OHDA model of Parkinson's disease.

    Binda, Karina Henrique / Landau, Anne M / Chacur, Marucia / Brooks, David J / Real, Caroline Cristiano

    Brain research

    2023  Volume 1814, Page(s) 148436

    Abstract: Physical exercise benefits Parkinson's disease (PD) patients but the mechanism is unclear. Cannabinoid receptor type 1 (CB1R) is known to be reduced in PD patients and animal models. We test the hypothesis that binding of the CB1R inverse agonist, [ ...

    Abstract Physical exercise benefits Parkinson's disease (PD) patients but the mechanism is unclear. Cannabinoid receptor type 1 (CB1R) is known to be reduced in PD patients and animal models. We test the hypothesis that binding of the CB1R inverse agonist, [
    MeSH term(s) Rats ; Male ; Animals ; Parkinson Disease/metabolism ; Oxidopamine/pharmacology ; Rats, Wistar ; Drug Inverse Agonism ; Rimonabant/metabolism ; Rimonabant/pharmacology ; Substantia Nigra/metabolism ; Corpus Striatum/metabolism ; Hippocampus/metabolism ; Receptors, Cannabinoid/metabolism ; Disease Models, Animal
    Chemical Substances Oxidopamine (8HW4YBZ748) ; Rimonabant (RML78EN3XE) ; Receptors, Cannabinoid
    Language English
    Publishing date 2023-06-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2023.148436
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Dying at home during the pandemic.

    Higginson, Irene J / Brooks, David / Barclay, Stephen

    BMJ (Clinical research ed.)

    2021  Volume 373, Page(s) n1437

    MeSH term(s) COVID-19/mortality ; Cause of Death/trends ; General Practitioners ; Home Care Services/standards ; Home Care Services/statistics & numerical data ; Humans ; Noncommunicable Diseases/classification ; Noncommunicable Diseases/mortality ; Patient Preference ; Physician's Role ; SARS-CoV-2 ; Terminal Care/methods ; Terminal Care/psychology ; Terminal Care/statistics & numerical data ; United Kingdom/epidemiology
    Language English
    Publishing date 2021-06-08
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n1437
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Imaging of genetic and degenerative disorders primarily causing Parkinsonism.

    Brooks, David J

    Handbook of clinical neurology

    2016  Volume 135, Page(s) 493–505

    Abstract: In this chapter the structural and functional imaging changes associated with both genetic causes of Parkinson's disease and the sporadic condition are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is discussed ... ...

    Abstract In this chapter the structural and functional imaging changes associated with both genetic causes of Parkinson's disease and the sporadic condition are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is discussed and the potential use and drawbacks of using imaging biomarkers for monitoring disease progression are debated. Additionally, the use of imaging for differentiating atypical parkinsonian syndromes from Parkinson's disease is presented.
    MeSH term(s) Brain/diagnostic imaging ; Dopamine/metabolism ; Humans ; Image Processing, Computer-Assisted ; Neurodegenerative Diseases/complications ; Neuroimaging ; Parkinsonian Disorders/diagnostic imaging ; Parkinsonian Disorders/etiology ; Parkinsonian Disorders/genetics
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2016-07-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-444-53485-9.00024-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top