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Article: CT-Based Radiomics to Predict

Porto-Álvarez, Jacobo / Cernadas, Eva / Aldaz Martínez, Rebeca / Fernández-Delgado, Manuel / Huelga Zapico, Emilio / González-Castro, Víctor / Baleato-González, Sandra / García-Figueiras, Roberto / Antúnez-López, J Ramon / Souto-Bayarri, Miguel

Biomedicines

2023 Volume 11, Issue 8

Abstract: Colorectal cancer (CRC) is one of the most common types of cancer worldwide. ... ...

Abstract	Colorectal cancer (CRC) is one of the most common types of cancer worldwide. The
Language	English
Publishing date	2023-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11082144
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Article ; Online: Radiomics in CT and MR imaging of the liver and pancreas: tools with potential for clinical application.

Berbís, M Álvaro / Godino, Félix Paulano / Rodríguez-Comas, Júlia / Nava, Enrique / García-Figueiras, Roberto / Baleato-González, Sandra / Luna, Antonio

Abdominal radiology (New York)

2023 Volume 49, Issue 1, Page(s) 322–340

Abstract: Radiomics allows the extraction of quantitative imaging features from clinical magnetic resonance imaging (MRI) and computerized tomography (CT) studies. The advantages of radiomics have primarily been exploited in oncological applications, including ... ...

Abstract	Radiomics allows the extraction of quantitative imaging features from clinical magnetic resonance imaging (MRI) and computerized tomography (CT) studies. The advantages of radiomics have primarily been exploited in oncological applications, including better characterization and staging of oncological lesions and prediction of patient outcomes and treatment response. The potential introduction of radiomics in the clinical setting requires the establishment of a standardized radiomics pipeline and a quality assurance program. Radiomics and texture analysis of the liver have improved the differentiation of hypervascular lesions such as adenomas, focal nodular hyperplasia, and hepatocellular carcinoma (HCC) during the arterial phase, and in the pretreatment determination of HCC prognostic factors (e.g., tumor grade, microvascular invasion, Ki-67 proliferation index). Radiomics of pancreatic CT and MR images has enhanced pancreatic ductal adenocarcinoma detection and its differentiation from pancreatic neuroendocrine tumors, mass-forming chronic pancreatitis, or autoimmune pancreatitis. Radiomics can further help to better characterize incidental pancreatic cystic lesions, accurately discriminating benign from malignant intrapancreatic mucinous neoplasms. Nonetheless, despite their encouraging results and exciting potential, these tools have yet to be implemented in the clinical setting. This non-systematic review will describe the essential steps in the implementation of the radiomics and feature extraction workflow from liver and pancreas CT and MRI studies for their potential clinical application. A succinct overview of reported radiomics applications in the liver and pancreas and the challenges and limitations of their implementation in the clinical setting is also discussed, concluding with a brief exploration of the future perspectives of radiomics in the gastroenterology field.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular ; Liver Neoplasms/diagnostic imaging ; Radiomics ; Pancreas/diagnostic imaging ; Pancreas/pathology ; Tomography, X-Ray Computed/methods ; Pancreatic Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Retrospective Studies
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-023-04071-0
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Article ; Online: Testicular Evaluation Using Shear Wave Elastography (SWE) in Patients with Varicocele.

Baleato-Gonzalez, Sandra / Osorio-Vazquez, Iria / Flores-Ríos, Enrique / Santiago-Pérez, María Isolina / Laguna-Reyes, Juan Pablo / Garcia-Figueiras, Roberto

Journal of imaging

2023 Volume 9, Issue 9

Abstract: Purpose: To assess the possible influence of the presence of varicocele on the quantification of testicular stiffness.: Methods: Ultrasound with shear wave elastography (SWE) was performed on 48 consecutive patients (96 testicles) referred following ... ...

Abstract	Purpose: To assess the possible influence of the presence of varicocele on the quantification of testicular stiffness. Methods: Ultrasound with shear wave elastography (SWE) was performed on 48 consecutive patients (96 testicles) referred following urology consultation for different reasons. A total of 94 testes were studied and distributed in three groups: testes with varicocele (group A, n = 19), contralateral normal testes (group B; n = 13) and control group (group C, n = 62). Age, testicular volume and testicular parenchymal tissue stiffness values of the three groups were compared using the Kruskal-Wallis test. Results: The mean age of the patients was 42.1 ± 11.1 years. The main reason for consultation was infertility (64.6%). The mean SWE value was 4 ± 0.4 kPa (kilopascal) in group A, 4 ± 0.5 kPa in group B and 4.2 ± 0.7 kPa in group C or control. The testicular volume was 15.8 ± 3.8 mL in group A, 16 ± 4.3 mL in group B and 16.4 ± 5.9 mL in group C. No statistically significant differences were found between the three groups in terms of age, testicular volume and tissue stiffness values. Conclusion: Tissue stiffness values were higher in our control group (healthy testicles) than in patients with varicocele.
Language	English
Publishing date	2023-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2824270-1
ISSN	2313-433X ; 2313-433X
ISSN (online)	2313-433X
ISSN	2313-433X
DOI	10.3390/jimaging9090166
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Article ; Online: How Imaging Advances Are Defining the Future of Precision Radiation Therapy.

García-Figueiras, Roberto / Baleato-González, Sandra / Luna, Antonio / Padhani, Anwar R / Vilanova, Joan C / Carballo-Castro, Ana M / Oleaga-Zufiria, Laura / Vallejo-Casas, Juan Antonio / Marhuenda, Ana / Gómez-Caamaño, Antonio

Radiographics : a review publication of the Radiological Society of North America, Inc

2023 Volume 44, Issue 2, Page(s) e230152

Abstract: Radiation therapy is fundamental in the treatment of cancer. Imaging has always played a central role in radiation oncology. Integrating imaging technology into irradiation devices has increased the precision and accuracy of dose delivery and decreased ... ...

Abstract	Radiation therapy is fundamental in the treatment of cancer. Imaging has always played a central role in radiation oncology. Integrating imaging technology into irradiation devices has increased the precision and accuracy of dose delivery and decreased the toxic effects of the treatment. Although CT has become the standard imaging modality in radiation therapy, the development of recently introduced next-generation imaging techniques has improved diagnostic and therapeutic decision making in radiation oncology. Functional and molecular imaging techniques, as well as other advanced imaging modalities such as SPECT, yield information about the anatomic and biologic characteristics of tumors for the radiation therapy workflow. In clinical practice, they can be useful for characterizing tumor phenotypes, delineating volumes, planning treatment, determining patients' prognoses, predicting toxic effects, assessing responses to therapy, and detecting tumor relapse. Next-generation imaging can enable personalization of radiation therapy based on a greater understanding of tumor biologic factors. It can be used to map tumor characteristics, such as metabolic pathways, vascularity, cellular proliferation, and hypoxia, that are known to define tumor phenotype. It can also be used to consider tumor heterogeneity by highlighting areas at risk for radiation resistance for focused biologic dose escalation, which can impact the radiation planning process and patient outcomes. The authors review the possible contributions of next-generation imaging to the treatment of patients undergoing radiation therapy. In addition, the possible roles of radio(geno)mics in radiation therapy, the limitations of these techniques, and hurdles in introducing them into clinical practice are discussed.
MeSH term(s)	Humans ; Diagnostic Imaging ; Neoplasms/diagnostic imaging ; Neoplasms/radiotherapy ; Radiotherapy Planning, Computer-Assisted/methods ; Radiation Oncology ; Biological Products
Chemical Substances	Biological Products
Language	English
Publishing date	2023-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.230152
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Article ; Online: Current and Advanced Applications of Gadoxetic Acid-enhanced MRI in Hepatobiliary Disorders.

Baleato-González, Sandra / Vilanova, Joan C / Luna, Antonio / Menéndez de Llano, Rafael / Laguna-Reyes, Juan Pablo / Machado-Pereira, Diogo M / Bermúdez-Naveira, Anaberta / Osorio-Vázquez, Iria / Alcalá-Mata, Lidia / García-Figueiras, Roberto

Radiographics : a review publication of the Radiological Society of North America, Inc

2023 Volume 43, Issue 4, Page(s) e220087

Abstract: Gadoxetic acid is an MRI contrast agent that has specific applications in the study of hepatobiliary disease. After being distributed in the vascular and extravascular spaces during the dynamic phase, gadoxetic acid is progressively taken up by ... ...

Abstract	Gadoxetic acid is an MRI contrast agent that has specific applications in the study of hepatobiliary disease. After being distributed in the vascular and extravascular spaces during the dynamic phase, gadoxetic acid is progressively taken up by hepatocytes and excreted to the bile ducts during the hepatobiliary phase. The information derived from the enhancement characteristics during dynamic and hepatobiliary phases is particularly relevant in the detection and characterization of focal liver lesions and in the evaluation of the structure and function of the liver and biliary system. The use of new MRI sequences and advanced imaging techniques (eg, relaxometry, multiparametric imaging, and analysis of heterogeneity), the introduction of artificial intelligence, and the development of biomarkers and radiomic and radiogenomic tools based on gadoxetic acid-enhanced MRI findings will play an important role in the future in assessing liver function, chronic liver disease, and focal liver lesions; in studying biliary pathologic conditions; and in predicting treatment responses and prognosis. © RSNA, 2023
MeSH term(s)	Humans ; Artificial Intelligence ; Carcinoma, Hepatocellular ; Contrast Media/administration & dosage ; Gadolinium DTPA/administration & dosage ; Gallbladder Diseases ; Liver Neoplasms ; Magnetic Resonance Imaging/methods ; Retrospective Studies ; Sensitivity and Specificity ; Digestive System Diseases/diagnostic imaging ; Diagnostic Techniques, Digestive System
Chemical Substances	Contrast Media ; Gadolinium DTPA (K2I13DR72L) ; gadolinium ethoxybenzyl DTPA
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.220087
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Article ; Online: Usefulness of balanced SSFP sequence in robot-assisted MRI-guided prostate biopsy: Beyond scouting.

Vilanova, Joan C / Pérez de Tudela, Anna / Thio-Henestrosa, Santiago / Barceló, Joaquim / Boada, Maria / Planas, Montse / Sala, Sònia / Artazkoz, Juanjo / García-Figueiras, Roberto / Baleato-González, Sandra / Vilanova, Cristina / Puig, Josep

European journal of radiology

2023 Volume 160, Page(s) 110707

Abstract: Objectives: To determine whether bSSFP images are useful for visualizing prostatic lesionsin MRI-guided in-bore transrectal biopsy.: Methods: This retrospective studyincluded 67 men witha single suspected cancer on MRI (PI-RADS 2.1 category ≥ 3) who ... ...

Abstract	Objectives: To determine whether bSSFP images are useful for visualizing prostatic lesionsin MRI-guided in-bore transrectal biopsy. Methods: This retrospective studyincluded 67 men witha single suspected cancer on MRI (PI-RADS 2.1 category ≥ 3) who underwent in-bore transrectal MRI-guided biopsy. Two uroradiologists independently rated lesion conspicuity on a 3-point scale (1:non-visible, 2:slightly visible, 3:clearly visible) on T2WI, DWI, and balanced SSFP.We used measures of frequency to compare lesion conspicuity in 3 sequences. We used Cohen's kappa to assess inter-rater reliability. Results: Lesions were rated (1) non-visible in 18 % (12/67) of T2WI, 5 % (3/67) of DWI, and 10 % (7/67) of balanced SSFP images, (2) slightly visible in 56 % (37/67) on T2WI, 13 % (9/67) on DWI, and 48 % (32/67) on bSSFP, and (3) clearly visible in 27 %(18/67) on T2WI, 82 % (55/67) on DWI, and 42 % (28/67) on bSSFP. Lesions classified as prostate cancer at histology were slightly-clearly visible in 85 % (41/48) on T2WI, 100 % (48/48) on DWI, and 94 % (45/48) on bSSFP. Lesions classified as PI-RADS ≥ 4 were visible in 87 % (47/54) of T2WI, 100 % (54/54) of DWI, and 93 % (50/54) of bSSFP. Gleason ≥ 3 + 4 lesions were visible in 85 % (37/43) of T2WI, 100 % (43/43) of DWI, and 95 % (41/43) of bSSFP. Inter-rater agreement was excellent for T2WI (k = 0.97) and bSSFP (k = 0.94), and good for DWI (k = 0.75). Conclusion: Balanced SSFP is useful for visualizing prostatic lesions. Replacing T2WI with balanced SSFP can reduce the duration of in-bore transrectal MRI-guided biopsy.
MeSH term(s)	Male ; Humans ; Prostate/diagnostic imaging ; Prostate/pathology ; Magnetic Resonance Imaging/methods ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Retrospective Studies ; Reproducibility of Results ; Robotics ; Image-Guided Biopsy/methods
Language	English
Publishing date	2023-01-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2023.110707
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Article ; Online: "Rectal cancer survival: A retrospective analysis of MRI features and their association with prognosis".

Junquera-Olay, Sonsoles / Baleato-González, Sandra / Canedo-Antelo, María / Capeans-González, Lucia / Santiago-Pérez, María Isolina / Garcia-Figueiras, Roberto

Current problems in diagnostic radiology

2021 Volume 51, Issue 1, Page(s) 30–37

Abstract: Purpose: To assess rectal cancer aggressiveness using magnetic resonance (MR) imaging features and to investigate their relationship with patient prognosis.: Materials and methods: Clinical information and Pelvic MR scans of 106 consecutive patients ... ...

Abstract	Purpose: To assess rectal cancer aggressiveness using magnetic resonance (MR) imaging features and to investigate their relationship with patient prognosis. Materials and methods: Clinical information and Pelvic MR scans of 106 consecutive patients with primary rectal cancer (RC) were analyzed. Clinical symptoms, age, sex, tumor location, and patient´s survival were recorded. The variables investigated by MR were: depth or mural/extramural tumor involvement, distance to mesorectal margin, lymph node involvement, vascular, peritoneal or sphincter complex infiltration. The association between imaging features and disease-free survival (DFS) was also assessed using a Kaplan-Meier model. Differences between survival curves were tested for significance using the Mantel-Cox LogRank test. Results: The final study population was 106 patients (65 males, 41 females). The median age was 69.5 years (range, 39-92 years). No significant differences were found between death risk and sex, age or tumor location (p>0,05). However, the relative risk (RR) of tumor mortality increased significantly with the presence of the variables: vascular infiltration (×5), T4 tumors (× 4.57), N2 lymph node involvement (more than 3 affected nodes × 4.11) and mesorectal fascia involvement (× 3,77). Conclusion: Tumor extension, number of pathological lymph nodes, mesorectal fascia involvement and vascular infiltration values obtained on initial MR imaging staging showed a significant difference for disease-free survival in RC at six years of control.
MeSH term(s)	Aged ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Neoplasm Staging ; Prognosis ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/pathology ; Retrospective Studies
Language	English
Publishing date	2021-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	198954-6
ISSN	1535-6302 ; 0363-0188
ISSN (online)	1535-6302
ISSN	0363-0188
DOI	10.1067/j.cpradiol.2020.12.005
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Article: The morphological and functional diagnosis of a rare entity: lipomatous pseudohypertrophy of the pancreas.

Baleato-González, Sandra / Vieira Leite, Cecilia / García-Figueiras, Roberto

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2018 Volume 110, Issue 3, Page(s) 207

Abstract: Lipomatous pseudohypertrophy of the pancreas is a rare entity characterized by a replacement, focal or diffuse, of the normal pancreatic tissue by mature fatty tissue. Its definitive diagnosis is made based on histopathologic analysis. Nevertheless, ... ...

Abstract	Lipomatous pseudohypertrophy of the pancreas is a rare entity characterized by a replacement, focal or diffuse, of the normal pancreatic tissue by mature fatty tissue. Its definitive diagnosis is made based on histopathologic analysis. Nevertheless, typical imaging findings can allow a non-invasive diagnosis and help its clinical approach.
MeSH term(s)	Abdominal Pain/etiology ; Aged ; Female ; Humans ; Hypertrophy ; Lipomatosis/diagnosis ; Lipomatosis/pathology ; Magnetic Resonance Imaging ; Pancreatic Diseases/diagnosis ; Pancreatic Diseases/pathology ; Tomography, X-Ray Computed
Language	English
Publishing date	2018-01-13
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2018.5367/2017
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Article ; Online: Usefulness of Computed Tomography Angiography in the Preoperative Workup of Patients With Colorectal Cancer.

Canedo-Antelo, María / García-Figueiras, Roberto / Quintero-Rivera, Juan Carlos / Huelga-Zapico, Emilio / Junquera-Olay, Sonsoles / Fernández-López, Fernando / Baleato-González, Sandra

Journal of computer assisted tomography

2022 Volume 46, Issue 3, Page(s) 349–354

Abstract: Objectives: The objective of this study is to analyze the main patterns of branching of the inferior mesenteric artery (IMA) and to determine if your knowledge changes the surgical strategy in the colorectal cancer.: Methods: This retrospective study ...

Abstract	Objectives: The objective of this study is to analyze the main patterns of branching of the inferior mesenteric artery (IMA) and to determine if your knowledge changes the surgical strategy in the colorectal cancer. Methods: This retrospective study included 63 patients with cancer of the sigmoid or rectum. We assessed the patterns of IMA in 3 subtypes: type A (independent left colic artery [LCA]), type B (LCA and sigmoid artery arising in a common trunk) and type C (LCA, sigmoid artery, and superior rectal artery with a common origin). Colorectal surgeons evaluated how the vascular map changed the type of IMA ligation. Results: Inferior mesenteric artery branching was classified as type A in 55.6% patients, type B in 23.8%, and type C in 20.6%. Knowledge of the vascular map changed the type of ligation from high to low in 20 of the 50 patients who were candidates for surgery. The change was possible in tumors located in the sigmoid colon and the rectosigmoid junction with the type A or B branching. Conclusions: Preoperative Multidetector Computed Tomography angiography can define the pattern of IMA branching. Based on this information, a low ligation can be performed in tumors located in sigmoid colon and rectosigmoid junction with IMA branching types A and B.
MeSH term(s)	Angiography ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/surgery ; Computed Tomography Angiography ; Humans ; Laparoscopy ; Mesenteric Artery, Inferior/diagnostic imaging ; Mesenteric Artery, Inferior/surgery ; Multidetector Computed Tomography ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/surgery ; Retrospective Studies
Language	English
Publishing date	2022-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	80392-3
ISSN	1532-3145 ; 0363-8715
ISSN (online)	1532-3145
ISSN	0363-8715
DOI	10.1097/RCT.0000000000001288
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Article ; Online: Cortical blindness secondary to posterior reversible encephalopathy syndrome, recovered by successful blood pressure management.

Abalo-Lojo, José Manuel / Baleato-González, Sandra / Gonzalez, Francisco

Arquivos brasileiros de oftalmologia

2017 Volume 80, Issue 5, Page(s) 324–326

Abstract: We report a case of cortical blindness secondary to posterior leukoencephalopathy syndrome, which was successfully treated by blood pressure management. A 66-year-old white man presented at the emergency room complaining of severe frontal headache, ... ...

Abstract	We report a case of cortical blindness secondary to posterior leukoencephalopathy syndrome, which was successfully treated by blood pressure management. A 66-year-old white man presented at the emergency room complaining of severe frontal headache, disorientation, and progressive blurred vision. The initial physical examination disclosed a blood pressure of 200/176 mmHg. One hour later the patient exhibited mental confusion and bilateral blindness. Computed tomography and magnetic resonance imaging were performed, and a systemic workup was conducted, resulting in a diagnosis of posterior leukoencephalopathy syndrome. This syndrome is a rare manifestation of systemic hypertension that requires proper diagnosis and management to avoid irreversible brain damage. Early recognition of this condition and prompt control of the patient's blood pressure are essential because they may bring about a reversal of the syndrome, which may otherwise result in permanent brain damage.
Language	English
Publishing date	2017-09
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	603915-7
ISSN	1678-2925 ; 0004-2749
ISSN (online)	1678-2925
ISSN	0004-2749
DOI	10.5935/0004-2749.20170079
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