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  1. Article ; Online: MACULAR PIGMENT OPTICAL DENSITY IS LOWER IN TYPE 2 DIABETES, COMPARED WITH TYPE 1 DIABETES AND NORMAL CONTROLS.

    Scanlon, Grainne / Connell, Paul / Ratzlaff, Matthew / Foerg, Brittany / McCartney, Daniel / Murphy, Audrey / OʼConnor, Karen / Loughman, James

    Retina (Philadelphia, Pa.)

    2015  Volume 35, Issue 9, Page(s) 1808–1816

    Abstract: ... between the three groups (P < 0.01 for all). Chi-square analysis revealed a statistically significant ... difference in diabetic retinopathy distribution (P < 0.01). None of these variables exhibited a statistically ... significant correlation with macular pigment optical density for any study group (P > 0.05 for all). There was ...

    Abstract Purpose: This study was designed to investigate the optical density of macular pigment in Type 1 and Type 2 diabetes subjects relative to normal controls.
    Methods: One hundred and fifty subjects were recruited to the study and divided into one of the three study groups on the basis of their health status, as follows: Group 1: Healthy controls; Group 2: Type 1 diabetes; Group 3: Type 2 diabetes. Macular Pigment Optical Density, at 0.5° of retinal eccentricity, was measured using customized heterochromatic flicker photometry. Dietary intake of macular carotenoids was quantified using a lutein and zeaxanthin food frequency questionnaire. Diabetes type, duration, medication, smoking habits, glycosylated hemoglobin (HbA1C), and serum lipid levels were recorded, whereas visual acuity, body mass index, and diabetic retinopathy grade were measured for each participant.
    Results: One-way analysis of variance revealed a statistically significant difference in body mass index, age, high-density lipoprotein cholesterol and HbA1C between the three groups (P < 0.01 for all). Chi-square analysis revealed a statistically significant difference in diabetic retinopathy distribution (P < 0.01). None of these variables exhibited a statistically significant correlation with macular pigment optical density for any study group (P > 0.05 for all). There was no difference in dietary carotenoid intake between groups. Macular pigment optical density was lower among Type 2 diabetes subjects (0.33 ± 0.21) compared with Type 1 diabetes (0.49 ± 0.23) and controls (0.48 ± 0.35). General linear model analysis, including age, body mass index, diabetes duration, diabetic retinopathy status, high-density lipoprotein cholesterol, and HbA1C as covariates, revealed a statistically significant effect of diabetes type on macular pigment optical density (F = 2.62; P = 0.04).
    Conclusion: Macular pigment optical density was statistically significantly lower in Type 2 diabetes compared with Type 1 diabetes and normal controls. Although body mass index was higher in the Type 2 diabetes group, the lower macular pigment optical density levels observed among Type 2 diabetes seem not to be attributable to differences in dietary carotenoid intake or to the specific presence of diabetes, diabetic control, duration, or diabetic retinopathy.
    MeSH term(s) Adult ; Aged ; Body Mass Index ; Case-Control Studies ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Diet ; Feeding Behavior ; Female ; Glycated Hemoglobin A/metabolism ; Healthy Volunteers ; Humans ; Lipids/blood ; Lutein/administration & dosage ; Lutein/metabolism ; Macular Pigment/metabolism ; Male ; Middle Aged ; Photometry ; Visual Acuity/physiology ; Zeaxanthins/administration & dosage ; Zeaxanthins/metabolism
    Chemical Substances Glycated Hemoglobin A ; Lipids ; Macular Pigment ; Zeaxanthins ; hemoglobin A1c protein, human ; Lutein (X72A60C9MT)
    Language English
    Publishing date 2015-09
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000000551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1724: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Extracorporeal membrane oxygenation after traumatic injury.

    Ahmad, Sarwat B / Menaker, Jay / Kufera, Joseph / OʼConnor, James / Scalea, Thomas M / Stein, Deborah M

    The journal of trauma and acute care surgery

    2017  Volume 82, Issue 3, Page(s) 587–591

    Abstract: ... Nonsurvivors were more severely injured (median Injury Severity Score, 41 vs. 25; p = 0.03), had a lower ... arterial pH on arrival, and a shorter length of stay (11 vs. 41 days; p = 0.006). Neither mechanism ... of the survivors were anticoagulated with heparin versus 55% of nonsurvivors (p = 0.01). Median ...

    Abstract Background: The use of extracorporeal membrane oxygenation (ECMO) for acute respiratory failure after injury is controversial and poorly described.
    Methods: We reviewed our single-center experience with use of ECMO from January 2006 to November 2015 at a Level 1 primary adult resource center for trauma to determine the association of in-hospital mortality with patient demographics and clinical variables.
    Results: Forty-six patients were treated with ECMO. Patients requiring venoarterial ECMO (n = 7) were excluded. Thirty-nine (85%) were cannulated for venovenous ECMO. Of these, 44% patients survived to discharge. Median age was 28 years. Survivors had a lower BMI and PaCO2 at time of cannulation. Nonsurvivors were more severely injured (median Injury Severity Score, 41 vs. 25; p = 0.03), had a lower arterial pH on arrival, and a shorter length of stay (11 vs. 41 days; p = 0.006). Neither mechanism of injury nor indication for ECMO was associated with mortality. Forty-one percent developed at least one ECMO-related complication, but this was not associated with mortality. Ninety-four percent of the survivors were anticoagulated with heparin versus 55% of nonsurvivors (p = 0.01). Median Injury Severity Score and presence of TBI were not significantly different between survivors and nonsurvivors who were anticoagulated.
    Conclusion: The use of venovenous ECMO for acute lung injury after trauma should be considered in special patient populations. Ability to tolerate systemic anticoagulation was associated with improved survival.
    Level of evidence: Therapeutic study, level V.
    MeSH term(s) Adult ; Extracorporeal Membrane Oxygenation ; Female ; Hospital Mortality ; Humans ; Injury Severity Score ; Length of Stay/statistics & numerical data ; Male ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/mortality ; Respiratory Insufficiency/therapy ; Retrospective Studies ; Survival Rate ; Trauma Centers ; Wounds and Injuries/complications ; Wounds and Injuries/mortality
    Language English
    Publishing date 2017-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000001352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 127: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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