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Article: Purpura.

Charrot, S C / Sellar, R S / Manson, J J

British journal of hospital medicine (London, England : 2005)

2017 Volume 78, Issue 10, Page(s) C147–C151

MeSH term(s)	Diagnosis, Differential ; Drug Hypersensitivity/complications ; Drug Hypersensitivity/diagnosis ; Hematologic Diseases/complications ; Hematologic Diseases/diagnosis ; Humans ; Purpura/diagnosis ; Purpura/etiology ; Skin/pathology ; Vascular Diseases/complications ; Vascular Diseases/diagnosis
Language	English
Publishing date	2017-10-11
Publishing country	England
Document type	Journal Article ; Review
ISSN	1750-8460
ISSN	1750-8460
DOI	10.12968/hmed.2017.78.10.C147
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Article ; Online: Best evidence: comments on meta-analysis of coiling versus clipping.

Sellar, R J / White, P

AJNR. American journal of neuroradiology

2013 Volume 34, Issue 7, Page(s) 1385–1386

MeSH term(s)	Aneurysm, Ruptured/surgery ; Aneurysm, Ruptured/therapy ; Embolization, Therapeutic/instrumentation ; Endovascular Procedures ; Evidence-Based Practice ; Humans ; Intracranial Aneurysm/surgery ; Intracranial Aneurysm/therapy ; Medical Audit ; Meta-Analysis as Topic ; Neurosurgical Procedures ; Postoperative Complications ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Vascular Surgical Procedures/methods
Language	English
Publishing date	2013-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A3404
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Article ; Online: Reporting of sex and gender in human studies published in anaesthesia journals.

Leslie, K / Edgley, C / Lee, A C-Y / Sellar, A / Sgroi, J / Toh, R

British journal of anaesthesia

2018 Volume 120, Issue 5, Page(s) 1128–1130

MeSH term(s)	Anesthesiology ; Classification ; Female ; Gender Identity ; Humans ; Male ; Periodicals as Topic ; Research Design ; Sex
Language	English
Publishing date	2018-02-01
Publishing country	England
Document type	Letter
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2017.11.097
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Article: Beam statistics and diffraction from materials in the critical state.

Sellar, J R

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

2004 Volume 10, Issue 1, Page(s) 112–115

Abstract: It is shown that room-temperature diffraction pattern spots and diffuse scatter can appear to change their size and appearance relative to reciprocal-space sublattice reflections when the scattering material corresponds in structure to a critical phase. ... ...

Abstract	It is shown that room-temperature diffraction pattern spots and diffuse scatter can appear to change their size and appearance relative to reciprocal-space sublattice reflections when the scattering material corresponds in structure to a critical phase. Under such a condition, the material is considered to be continually on the verge of a phase transition and the diffraction spot will have no definite width, its apparent size in reciprocal space dependent on the strength of the scattering into the diffracted beam. It is thought that the materials described in the experiments--niobia-zirconia ceramic alloys--are capable of entering such a critical phase because of their recently suggested planar XY spin character. After first describing how the seemingly crystalline ceramic alloy can display XY-like behavior, we analyze the intensity dependence of the critical scattering from the alloys oxygen superlattice using information-theoretic methods.
MeSH term(s)	Alloys/chemistry ; Ceramics/chemistry ; Hot Temperature ; Microscopy, Electron/instrumentation ; Microscopy, Electron/methods ; Models, Theoretical ; Niobium/chemistry ; Scattering, Radiation ; Zirconium/chemistry
Chemical Substances	Alloys ; Niobium (05175J654G) ; Zirconium (C6V6S92N3C)
Language	English
Publishing date	2004-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1385710-1
ISSN	1435-8115 ; 1431-9276
ISSN (online)	1435-8115
ISSN	1431-9276
DOI	10.1017/S1431927604040206
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Article ; Online: Coupling cognitive and brainstem dysfunction in multiple sclerosis-related chronic neuropathic limb pain.

Foley, Peter / Kong, Yazhuo / Dirvanskiene, Ramune / Valdes-Hernandez, Maria / Bastiani, Matteo / Murnane, Jonathan / Sellar, Robin / Roberts, Neil / Pernet, Cyril / Weir, Christopher / Bak, Thomas / Colvin, Lesley / Chandran, Siddharthan / Fallon, Marie / Tracey, Irene

Brain communications

2022 Volume 4, Issue 3, Page(s) fcac124

Abstract: Chronic pain in multiple sclerosis is common and difficult to treat. Its mechanisms remain incompletely understood. Dysfunction of the descending pain modulatory system is known to contribute to human chronic pain conditions. However, it is not clear how ...

Abstract	Chronic pain in multiple sclerosis is common and difficult to treat. Its mechanisms remain incompletely understood. Dysfunction of the descending pain modulatory system is known to contribute to human chronic pain conditions. However, it is not clear how alterations in executive function influence this network, despite healthy volunteer studies linking function of the descending pain modulatory system, to cognition. In adults with multiple sclerosis-associated chronic neuropathic limb pain, compared to those without pain, we hypothesized altered functional connectivity of the descending pain modulatory system, coupled to executive dysfunction. Specifically we hypothesized reduced mental flexibility, because of potential importance in stimulus reappraisal. To investigate these hypotheses, we conducted a case-control cross-sectional study of 47 adults with relapsing remitting multiple sclerosis (31 with chronic neuropathic limb pain, 16 without pain), employing clinical, neuropsychological, structural, and functional MRI measures. We measured brain lesions and atrophy affecting descending pain modulatory system structures. Both cognitive and affective dysfunctions were confirmed in the chronic neuropathic limb pain group, including reduced mental flexibility (Delis Kaplan Executive Function System card sorting tests
Language	English
Publishing date	2022-05-17
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcac124
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Article ; Online: Environmental & load data: 1:15 Scale tidal turbine subject to a variety of regular wave conditions.

Draycott, S / Payne, G S / Steynor, J / Nambiar, A / Sellar, B / Davey, T / Noble, D R / Venugopal, V

Data in brief

2019 Volume 23, Page(s) 103732

Abstract: Experimental data was obtained in order to investigate the effect of waves on the loads and performance of tidal turbines. An instrumented 1:15 scale tidal turbine was installed in the FloWave Ocean Energy Research Facility, and a wide range of regular ... ...

Abstract	Experimental data was obtained in order to investigate the effect of waves on the loads and performance of tidal turbines. An instrumented 1:15 scale tidal turbine was installed in the FloWave Ocean Energy Research Facility, and a wide range of regular wave conditions were generated; systematically varying both wave frequency and height. Waves were generated both following and opposing a fixed mean current velocity of 0.81 m/s. Data are made available of the measured turbine loads and environmental conditions obtained for five repeats of 24 wave conditions via https://doi.org/10.7488/ds/2472. A description of the data collection process, data processing, file structure and naming conventions are provided in this article. The analysis and presentation of the described dataset can be found in Ref. [1].
Language	English
Publishing date	2019-03-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2019.103732
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Article ; Online: Long-term follow-up of a patient with JAG1-associated retinopathy.

Cheema, Muhammad R / Stone, Lydia G / Sellar, Peter W / Quinn, Stephanie / Clark, Stephen C / Martin, Richard J / O'Brien, Jill M / Warriner, Clare / Browning, Andrew C

Documenta ophthalmologica. Advances in ophthalmology

2021 Volume 143, Issue 2, Page(s) 237–247

Abstract: Purpose: To report the long-term structural and functional changes in the posterior segments of an adult with an unusual retinal dystrophy caused by a novel mutation in JAG1.: Methods: A 33-year-old female underwent comprehensive ophthalmic ... ...

Abstract	Purpose: To report the long-term structural and functional changes in the posterior segments of an adult with an unusual retinal dystrophy caused by a novel mutation in JAG1. Methods: A 33-year-old female underwent comprehensive ophthalmic examination, including best corrected visual acuity (BCVA) measurement, dilated fundus imaging (wide-angle fundus colour and short wavelength autofluorescence imaging), macular and peripheral spectral-domain optical coherence tomography (SD-OCT) and electroretinography (ERG) at baseline and 10 years later at the age of 43. The patient also underwent systemic review with detailed cardiac, brain and renal investigations. During follow-up, genetic analysis using whole-exome sequencing was performed on the patient and her parents to identify disease-causing variants. Results: The patient's main complaint was of a recent onset of bilateral photophobia and blurred vision in the left eye. On examination, the most striking retinal finding was of bilateral well-demarcated, anterior circumferential chorioretinal atrophy with scattered pigment clumping from the mid periphery to the ora. In addition, she had posterior pole RPE hypopigmentation, peripapillary chorioretinal atrophy, left macular choroidal folds and retinal vasculature tortuosity with atypical branching. Her retinal electrophysiology was consistent with a cone rod photoreceptor dystrophy and left macular dysfunction. Ten years later, her BCVA, the anterior circumferential chorioretinal atrophy and her visual field constriction all remained stable. Her retinal electrophysiology demonstrated deterioration of left rod function, while cone dysfunction remained stable. Macular function deteriorated in both eyes. During follow-up, she was also noted to have progressive aortic root dilatation, posterior embryotoxon and an x ray diagnosis of butterfly vertebrae. Whole-exome sequencing revealed a novel c.2412C > A p.(Tyr804Ter) truncating mutation in JAG1 that was predicted to be pathogenic and suggested a diagnosis of Alagille syndrome. Conclusion: This is the first report of the long-term detailed follow-up of a patient with Alagille syndrome whose most striking ophthalmic finding was bilateral well-demarcated, anterior circumferential chorioretinal atrophy. During follow-up, this finding remained stable, suggesting that this may be developmental in origin. This is in contrast with the progressive deterioration in the posterior pole retinal and macular function.
MeSH term(s)	Adult ; Electroretinography ; Female ; Fluorescein Angiography ; Follow-Up Studies ; Humans ; Jagged-1 Protein ; Retina ; Retinal Dystrophies ; Tomography, Optical Coherence
Chemical Substances	JAG1 protein, human ; Jagged-1 Protein
Language	English
Publishing date	2021-04-20
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	212594-8
ISSN	1573-2622 ; 0012-4486
ISSN (online)	1573-2622
ISSN	0012-4486
DOI	10.1007/s10633-021-09836-w
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Article ; Online: Description and Evaluation of an Emission‐Driven and Fully Coupled Methane Cycle in UKESM1

G. A. Folberth / Z. Staniaszek / A. T. Archibald / N. Gedney / P. T. Griffiths / C. D. Jones / F. M. O’Connor / R. J. Parker / A. A. Sellar / A. Wiltshire

Journal of Advances in Modeling Earth Systems, Vol 14, Iss 7, Pp n/a-n/a (2022)

2022

Abstract: Abstract Methane (CH4) is one of the most important trace gases in the atmosphere owing to its role as an exceedingly effective greenhouse gas and atmospheric pollutant. Better understanding of the global methane cycle and its interactions with the Earth ...

Abstract	Abstract Methane (CH4) is one of the most important trace gases in the atmosphere owing to its role as an exceedingly effective greenhouse gas and atmospheric pollutant. Better understanding of the global methane cycle and its interactions with the Earth system is therefore necessary for robust future projections of anthropogenic climate change and assessments of multi‐gas mitigation strategies. Here we present a newly developed methane emission‐driven Earth system model to simulate the global methane cycle fully interactively. We provide an evaluation of methane sources and sinks and a full‐cycle methane budget and its change over the historic period. We further evaluate the methane atmospheric abundance and lifetime against available observations. The new methane emission‐driven model simulates all the components of the methane cycle within observational uncertainty. We calculate a total present‐day (2000–2009 decadal average) methane source of 591 Tg(CH4) yr−1 with 197 Tg(CH4) yr−1 coming from wetlands. These sources are nearly balanced by the global methane sinks amounting to 580 Tg (CH4) yr−1; reaction of methane with the hydroxyl radical in the troposphere alone removes 525 Tg(CH4) yr−1. The imbalance between sources and sinks of 11 Tg(CH4) yr−1 represents the atmospheric methane growth rate and is in fairly good agreement with current best estimates of 5.8 Tg(CH4) yr−1 with a range of 4.9–6.6 Tg(CH4) yr−1. At present‐day the model shows a maximum systematic negative‐bias of approximately 200 ppb in the methane surface mole fraction.
Keywords	Earth system model ; fully coupled methane cycle ; wetland emissions ; methane earth system feedbacks ; emission‐driven simulation ; Physical geography ; GB3-5030 ; Oceanography ; GC1-1581
Subject code	500
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	American Geophysical Union (AGU)
Document type	Article ; Online
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Article ; Online: The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis.

Mollison, Daisy / Sellar, Robin / Bastin, Mark / Mollison, Denis / Chandran, Siddharthan / Wardlaw, Joanna / Connick, Peter

PloS one

2017 Volume 12, Issue 5, Page(s) e0177727

Abstract: ... was r = -0.30 (95% confidence interval: -0.34, -0.26). Wide methodological variability was seen ...

Abstract	Background: Moderate correlation exists between the imaging quantification of brain white matter lesions and cognitive performance in people with multiple sclerosis (MS). This may reflect the greater importance of other features, including subvisible pathology, or methodological limitations of the primary literature. Objectives: To summarise the cognitive clinico-radiological paradox and explore the potential methodological factors that could influence the assessment of this relationship. Methods: Systematic review and meta-analysis of primary research relating cognitive function to white matter lesion burden. Results: Fifty papers met eligibility criteria for review, and meta-analysis of overall results was possible in thirty-two (2050 participants). Aggregate correlation between cognition and T2 lesion burden was r = -0.30 (95% confidence interval: -0.34, -0.26). Wide methodological variability was seen, particularly related to key factors in the cognitive data capture and image analysis techniques. Conclusions: Resolving the persistent clinico-radiological paradox will likely require simultaneous evaluation of multiple components of the complex pathology using optimum measurement techniques for both cognitive and MRI feature quantification. We recommend a consensus initiative to support common standards for image analysis in MS, enabling benchmarking while also supporting ongoing innovation.
MeSH term(s)	Brain/diagnostic imaging ; Brain/pathology ; Cognition ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/psychology ; Neuropsychological Tests ; Publication Bias ; White Matter/diagnostic imaging ; White Matter/pathology
Language	English
Publishing date	2017-05-15
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0177727
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Article ; Online: Relapse in teenage and young adult patients treated on a paediatric minimal residual disease stratified ALL treatment protocol is associated with a poor outcome: results from UKALL2003.

Sellar, Rob S / Rowntree, Clare / Vora, Ajay J / Furness, Caroline L / Goulden, Nicholas / Mitchell, Chris / Moorman, Anthony V / Hough, Rachael

British journal of haematology

2018 Volume 181, Issue 4, Page(s) 515–522

Abstract: Outcomes for teenage and young adult (TYA) patients with acute lymphoblastic leukaemia (ALL) who relapse on contemporary risk-adapted paediatric protocols are largely unknown and there is no consensus on optimal salvage strategies. We assessed the ... ...

Abstract	Outcomes for teenage and young adult (TYA) patients with acute lymphoblastic leukaemia (ALL) who relapse on contemporary risk-adapted paediatric protocols are largely unknown and there is no consensus on optimal salvage strategies. We assessed the treatment and outcome of TYA patients (aged 16-24 years) recruited to the UKALL2003 trial, who relapsed following attainment of complete morphological remission. Forty-two of 223 patients (18·8%) relapsed, the majority (n = 26, 62%) on treatment. Thirty-eight (90%) patients received salvage treatment, with 22 (58%) achieving second remission (CR2) and 21 patients receiving an allogeneic haematopoietic cell transplant (alloHSCT). Post-relapse outcomes were poor with a 5-year overall survival (OS) of 23% (95% confidence interval; 11-37%). Outcomes for patients relapsing on active treatment were inferior to those relapsing after completing treatment (5-year OS 9% vs. 52%, log-rank P = 0·001). No patient with B cell ALL relapsing on treatment was alive at the end of the study period. TYA patients with ALL who relapse on the UK paediatric protocol, UKALL2003, are largely unsalvageable with conventional approaches aimed at achieving CR2 followed by alloHSCT. Future efforts should be aimed at identifying those patients who are destined to relapse and exploring novel treatment approaches for this high-risk group and for those who do relapse.
MeSH term(s)	Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Disease-Free Survival ; Female ; Humans ; Male ; Neoplasm, Residual ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/blood ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/mortality ; Recurrence ; Salvage Therapy ; Survival Rate ; United Kingdom/epidemiology ; Young Adult
Language	English
Publishing date	2018-04-24
Publishing country	England
Document type	Clinical Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.15208
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