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Article ; Online: Chronic orbital inflammatory disease and optic neuropathy associated with long-term intranasal cocaine abuse: 2 cases and literature review.

Siemerink, Martin J / Freling, Nicole J M / Saeed, Peerooz

2017 Volume 36, Issue 5, Page(s) 350–355

Abstract: Orbital inflammatory disease and secondary optic neuropathy is a rare but devastating complication of long-term intranasal cocaine abuse. We describe 2 patients with a history of intranasal cocaine consumption who presented with subacute onset of ... ...

Abstract	Orbital inflammatory disease and secondary optic neuropathy is a rare but devastating complication of long-term intranasal cocaine abuse. We describe 2 patients with a history of intranasal cocaine consumption who presented with subacute onset of unilateral vision loss from optic neuropathy and limitation of abduction in the affected eye. Magnetic resonance imaging findings included an orbital mass in combination with absent nasal septum and partial destruction of the paranasal sinuses. Biopsies and histopathologic examination of the nasal cavity and the orbital mass revealed chronic inflammation. Both patients were treated with oral corticosteroids, ocular movements completely normalized but no improvement of visual acuity was noted. Intranasal cocaine abuse can cause orbital complications from chronic sinonasal inflammatory disease and these patients are at risk to develop optic neuropathy. Optic neuropathy may be caused by compression, infiltration, or ischaemia.
Language	English
Publishing date	2017-10
Publishing country	England
Document type	Journal Article
ZDB-ID	603157-2
ISSN	1744-5108 ; 0167-6830
ISSN (online)	1744-5108
ISSN	0167-6830
DOI	10.1080/01676830.2017.1337178
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Zs.A 1735: Show issues

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Article: Patterns of Hearing Loss in Irradiated Survivors of Head and Neck Rhabdomyosarcoma.

Diepstraten, Franciscus A / Wiersma, Jan / Schoot, Reineke A / Knops, Rutger R G / Zuur, Charlotte L / Meijer, Annelot J M / Dávila Fajardo, Raquel / Pieters, Bradley R / Balgobind, Brian V / Westerveld, Henrike / Freling, Nicole / van Tinteren, Harm / Smeele, Ludwig E / Bel, Arjan / van den Heuvel-Eibrink, Marry M / Stokroos, Robert J / Merks, Johannes H M / Hoetink, Alexander E / Hol, Marinka L F

Cancers

2022 Volume 14, Issue 23

Abstract: Purpose: The frequency and patterns of HL in a HNRMS survivor cohort were investigated. A dose-effect relationship between the dose to the cochlea and HL was explored.: Methods: Dutch survivors treated for HNRMS between 1993 and 2017 with no relapse ... ...

Abstract	Purpose: The frequency and patterns of HL in a HNRMS survivor cohort were investigated. A dose-effect relationship between the dose to the cochlea and HL was explored. Methods: Dutch survivors treated for HNRMS between 1993 and 2017 with no relapse and at least two years after the end of treatment were eligible for inclusion. The survivors were evaluated for HL with pure-tone audiometry. HL was graded according to the Muenster, Common Terminology Criteria for Adverse Events (CTCAE) v4.03 and International Society for Paediatric Oncology (SIOP) classification. We defined deleterious HL as Muenster ≥ 2b, CTCAE ≥ 2, and SIOP ≥ 2. Mixed-effects logistic regression was used to search for the dose-effect relationship between the irradiation dose to the cochlea and the occurrence of HL. Results: Forty-two HNRMS survivors underwent pure-tone audiometry. The Muenster, CTCAE and SIOP classification showed that 19.0% ( Conclusion: HL occurred in up to 19% of survivors of HNRMS. More research is needed on HL patterns in HNRMS survivors and on radiotherapy dose-effect relationships.
Language	English
Publishing date	2022-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14235749
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Article ; Online: Prevalence of chronic rhinosinusitis in the general population based on sinus radiology and symptomatology.

Dietz de Loos, Dirk / Lourijsen, Evelijn S / Wildeman, Maarten A M / Freling, Nicole J M / Wolvers, Marije D J / Reitsma, Sietze / Fokkens, Wytske J

The Journal of allergy and clinical immunology

2018 Volume 143, Issue 3, Page(s) 1207–1214

Abstract: Background: The prevalence of chronic rhinosinusitis (CRS) measured in epidemiologic studies is 5% to 12%. This might be an overestimation because of overlap with other diseases, such as allergic rhinitis.: Objective: We aimed to calculate the ... ...

Abstract	Background: The prevalence of chronic rhinosinusitis (CRS) measured in epidemiologic studies is 5% to 12%. This might be an overestimation because of overlap with other diseases, such as allergic rhinitis. Objective: We aimed to calculate the prevalence of CRS using a combination of epidemiologically based CRS according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) together with sinonasal opacification on imaging. Methods: Subjects who underwent a computed tomographic or magnetic resonance imaging scan of the head for any nonrhinologic indication were asked to fill in the Global Allergy and Asthma European Network survey containing EPOS symptom criteria. The scans were evaluated according to the Lund-Mackay (LM) scoring system. Epidemiologically based CRS is based on nasal symptoms according to EPOS; clinically based CRS also encompasses endoscopy and/or CT scanning. Results: Eight hundred thirty-four subjects were included. One hundred seven (12.8%) had epidemiologically based CRS according to EPOS. Of these subjects, 50% had an LM score of 0, 26% had an LM score of 1 to 3, and 23% had an LM score of 4 or greater. Twenty-five (3.0%) subjects had clinically based CRS (based on LM score ≥4), and 53 (6.4%) subjects had clinically based CRS (based on LM score >0). Allergic rhinitis was reported by 167 (20%) subjects. In subjects who did not report upper airway symptoms, 57% had an LM score of 0, 30% had an LM score of 1 to 3, and 12% had an LM score of 4 or greater. Conclusion: We found a prevalence of 3.0% to 6.4% of clinically based CRS (depending on an LM cutoff point; ie, LM ≥ 4 or LM > 0, respectively) in a relatively randomly selected group of subjects.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Chronic Disease ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Paranasal Sinuses/diagnostic imaging ; Prevalence ; Rhinitis/diagnostic imaging ; Rhinitis/epidemiology ; Sinusitis/diagnostic imaging ; Sinusitis/epidemiology ; Tomography, X-Ray Computed ; Young Adult
Language	English
Publishing date	2018-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2018.12.986
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Article ; Online: Local Resection and Brachytherapy for Primary Orbital Rhabdomyosarcoma: Outcome and Failure Pattern Analysis.

Schoot, Reineke A / Saeed, Peerooz / Freling, Nicole J / Blank, Leo E C M / Pieters, Bradley R / van der Grient, Johan N B / Strackee, Simon D / Bras, Johannes / Caron, Huib N / Merks, Johannes H M

Ophthalmic plastic and reconstructive surgery

2016 Volume 32, Issue 5, Page(s) 354–360

Abstract: Purpose: Survival in patients with orbital rhabdomyosarcoma (RMS) is excellent. Therefore, new local treatment modalities, such as brachytherapy, have been developed to minimize adverse events. Since 1990, patients with orbital RMS and a residual tumor ... ...

Abstract	Purpose: Survival in patients with orbital rhabdomyosarcoma (RMS) is excellent. Therefore, new local treatment modalities, such as brachytherapy, have been developed to minimize adverse events. Since 1990, patients with orbital RMS and a residual tumor after induction chemotherapy were eligible for resection and brachytherapy. Otherwise patients received external beam radiotherapy. In this study, the authors describe the outcome for 20 patients with primary orbital RMS. The aim was to assess risk factors for treatment failure in this single center cohort. Methods: In this retrospective cohort study, the authors reviewed imaging studies, surgery reports, histology reports, and radiotherapy plans in a multidisciplinary setting. The authors included 20 consecutive patients with orbital RMS, treated between 1990 and 2007, (median age: 7.4 years, range: 0.7-16.1; median follow up: 11.5 years). Results: After induction chemotherapy, 12 patients were treated with surgery and brachytherapy, 2 with external beam radiotherapy, and in 5 patients who achieved complete remission, local treatment was withheld. In 1 patient, brachytherapy was incorrectly withheld after delayed surgery. Seven patients relapsed (no local treatment, N = 2; surgery and brachytherapy, N = 2; external beam radiotherapy, N = 2; surgery only, N = 1). The authors found no patient, tumor, or treatment characteristics that predisposed for treatment failure. Ten-year-overall survival and event-free survival were 89% and 65%, respectively. Conclusions: Overall survival in this cohort of orbital RMS patients was good, including surgery and brachytherapy as treatment modality for orbital RMS resulted in an effective local treatment approach with fewer adverse events than external beam radiotherapy. The authors could not identify factors predisposing for treatment failure.
MeSH term(s)	Adolescent ; Brachytherapy/methods ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Forecasting ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Netherlands/epidemiology ; Ophthalmologic Surgical Procedures/methods ; Orbit/diagnostic imaging ; Orbit/surgery ; Orbital Neoplasms/diagnosis ; Orbital Neoplasms/mortality ; Orbital Neoplasms/therapy ; Retrospective Studies ; Rhabdomyosarcoma/diagnosis ; Rhabdomyosarcoma/mortality ; Rhabdomyosarcoma/therapy ; Survival Rate/trends ; Tomography, X-Ray Computed
Language	English
Publishing date	2016-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	632830-1
ISSN	1537-2677 ; 0740-9303
ISSN (online)	1537-2677
ISSN	0740-9303
DOI	10.1097/IOP.0000000000000562
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Zs.A 2159: Show issues

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Article ; Online: Endoscopic management of Ewing's sarcoma of ethmoid sinus within the AMORE framework: a new paradigm.

Meccariello, Giuseppe / Merks, Johannes H M / Pieters, Bradley R / van Furth, Wouter R / Saeed, Peerooz / Schoot, Reineke A / Freling, Nicole J M / Bras, Johannes / Strackee, Simon D / Balm, Alfons J M / Georgalas, Christos

International journal of pediatric otorhinolaryngology

2013 Volume 77, Issue 1, Page(s) 139–143

Abstract: The Ablative surgery, MOulage brachytherapy and REconstruction) (AMORE) protocol developed in the Academic Medical Center of Amsterdam has been used successfully to treat sarcomas. The use of endoscopic surgery fits well within this framework. A 6-year- ... ...

Abstract	The Ablative surgery, MOulage brachytherapy and REconstruction) (AMORE) protocol developed in the Academic Medical Center of Amsterdam has been used successfully to treat sarcomas. The use of endoscopic surgery fits well within this framework. A 6-year-old boy presented with Ewing Sarcoma of left ethmoid sinus closest to orbit. The patient underwent neoadjuvant chemotherapy followed by complete endoscopic resection, brachytherapy and reconstruction. Brachytherapy was administered by iridium catheters through limited Lynch-Howarth incision. Skull base defect was reconstructed with a galea flap. The use of endoscopic surgery complemented by neoadjuvant chemotherapy and brachytherapy might maximize tumor control while reducing morbidity.
MeSH term(s)	Bone Neoplasms/diagnosis ; Bone Neoplasms/therapy ; Brachytherapy/methods ; Chemoradiotherapy/methods ; Child ; Combined Modality Therapy ; Endoscopy/methods ; Ethmoid Sinus ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Neoadjuvant Therapy/methods ; Reconstructive Surgical Procedures/methods ; Sarcoma, Ewing/diagnosis ; Sarcoma, Ewing/therapy ; Treatment Outcome
Language	English
Publishing date	2013-01
Publishing country	Ireland
Document type	Case Reports ; Journal Article
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2012.09.023
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Zs.A 1507: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Computed tomography pulmonary angiography in acute pulmonary embolism: the effect of a computer-assisted detection prototype used as a concurrent reader.

Wittenberg, Rianne / Peters, Joost F / van den Berk, Inge A H / Freling, Nicole J M / Lely, Rutger / de Hoop, Bartjan / Horsthuis, Karin / Ravesloot, Cécile J / Weber, Michael / Prokop, W Mathias / Schaefer-Prokop, Cornelia M

Journal of thoracic imaging

2013 Volume 28, Issue 5, Page(s) 315–321

Abstract: Purpose: To assess the effect of computer-assisted detection (CAD) on diagnostic accuracy, reader confidence, and reading time when used as a concurrent reader for the detection of acute pulmonary embolism in computed tomography pulmonary angiography.!## ...

Abstract	Purpose: To assess the effect of computer-assisted detection (CAD) on diagnostic accuracy, reader confidence, and reading time when used as a concurrent reader for the detection of acute pulmonary embolism in computed tomography pulmonary angiography. Materials and methods: In this institutional review board-approved retrospective study, 6 observers with varying experience evaluated 158 negative and 38 positive consecutive computed tomography pulmonary angiographies (mean patient age 60 y; 115 women) without and with CAD as a concurrent reader. Readers were asked to determine the presence of pulmonary embolism, assess their diagnostic confidence using a 5-point scale, and document their reading time. Results were compared with an independent standard established by 2 readers, and a third chest radiologist was consulted in case of discordant findings. Results: Using logistic regression for repeated measurements, we found a significant increase in readers' sensitivity (P<0.001) without loss of specificity (P=0.855) with the effects being reader dependent (P<0.001). Sensitivities varied from 68% to 100% without CAD and from 76% to 100% with CAD. A 2-way analysis of variance showed a small but significant decrease in reading time (P<0.001), with the duration varying between 24 and 208 seconds without CAD and between 17 and 196 seconds with CAD, and a significant increase in readers' confidence scores using CAD as a concurrent reader (P<0.001). Conclusions: CAD as a concurrent reader has the potential to increase readers' sensitivity and confidence with a decrease in reading time without loss of specificity. The differences between readers, however, require further evaluation of CAD as a concurrent reader in a larger trial before stronger conclusions can be drawn.
MeSH term(s)	Acute Disease ; Angiography ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Pulmonary Embolism/diagnostic imaging ; Radiographic Image Interpretation, Computer-Assisted/methods ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2013-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632900-7
ISSN	1536-0237 ; 0883-5993
ISSN (online)	1536-0237
ISSN	0883-5993
DOI	10.1097/RTI.0b013e3182870b97
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Zs.A 2187: Show issues

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Article ; Online: Observer training for computer-aided detection of pulmonary nodules in chest radiography.

De Boo, Diederick W / van Hoorn, François / van Schuppen, Joost / Schijf, Laura / Scheerder, Maeke J / Freling, Nicole J / Mets, Onno / Weber, Michael / Schaefer-Prokop, Cornelia M

European radiology

2012 Volume 22, Issue 8, Page(s) 1659–1664

Abstract: Objectives: To assess whether short-term feedback helps readers to increase their performance using computer-aided detection (CAD) for nodule detection in chest radiography.: Methods: The 140 CXRs (56 with a solitary CT-proven nodules and 84 negative ...

Abstract	Objectives: To assess whether short-term feedback helps readers to increase their performance using computer-aided detection (CAD) for nodule detection in chest radiography. Methods: The 140 CXRs (56 with a solitary CT-proven nodules and 84 negative controls) were divided into four subsets of 35; each were read in a different order by six readers. Lesion presence, location and diagnostic confidence were scored without and with CAD (IQQA-Chest, EDDA Technology) as second reader. Readers received individual feedback after each subset. Sensitivity, specificity and area under the receiver-operating characteristics curve (AUC) were calculated for readings with and without CAD with respect to change over time and impact of CAD. Results: CAD stand-alone sensitivity was 59 % with 1.9 false-positives per image. Mean AUC slightly increased over time with and without CAD (0.78 vs. 0.84 with and 0.76 vs. 0.82 without CAD) but differences did not reach significance. The sensitivity increased (65 % vs. 70 % and 66 % vs. 70 %) and specificity decreased over time (79 % vs. 74 % and 80 % vs. 77 %) but no significant impact of CAD was found. Conclusion: Short-term feedback does not increase the ability of readers to differentiate true- from false-positive candidate lesions and to use CAD more effectively. Key points: • Computer-aided detection (CAD) is increasingly used as an adjunct for many radiological techniques. • Short-term feedback does not improve reader performance with CAD in chest radiography. • Differentiation between true- and false-positive CAD for low conspicious possible lesions proves difficult. • CAD can potentially increase reader performance for nodule detection in chest radiography.
MeSH term(s)	Area Under Curve ; Case-Control Studies ; Diagnosis, Computer-Assisted ; False Positive Reactions ; Humans ; Lung/diagnostic imaging ; Middle Aged ; Observer Variation ; Radiographic Image Interpretation, Computer-Assisted/methods ; Radiography, Thoracic/methods ; Radiology/education ; Radiology/methods ; Retrospective Studies ; Sensitivity and Specificity ; Solitary Pulmonary Nodule/diagnosis ; Solitary Pulmonary Nodule/diagnostic imaging
Language	English
Publishing date	2012-03-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-012-2412-7
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Article ; Online: Imaging findings in craniofacial childhood rhabdomyosarcoma.

Freling, Nicole J M / Merks, Johannes H M / Saeed, Peerooz / Balm, Alfons J M / Bras, Johannes / Pieters, Bradley R / Adam, Judit A / van Rijn, Rick R

Pediatric radiology

2010 Volume 40, Issue 11, Page(s) 1723–38; quiz 1855

Abstract: Rhabdomyosarcoma (RMS) is the commonest paediatric soft-tissue sarcoma constituting 3-5% of all malignancies in childhood. RMS has a predilection for the head and neck area and tumours in this location account for 40% of all childhood RMS cases. In this ... ...

Abstract	Rhabdomyosarcoma (RMS) is the commonest paediatric soft-tissue sarcoma constituting 3-5% of all malignancies in childhood. RMS has a predilection for the head and neck area and tumours in this location account for 40% of all childhood RMS cases. In this review we address the clinical and imaging presentations of craniofacial RMS, discuss the most appropriate imaging techniques, present characteristic imaging features and offer an overview of differential diagnostic considerations. Post-treatment changes will be briefly addressed.
MeSH term(s)	Child ; Child, Preschool ; Diagnostic Imaging/methods ; Face/pathology ; Female ; Head and Neck Neoplasms/diagnosis ; Humans ; Male ; Rhabdomyosarcoma/diagnosis ; Skull/pathology
Language	English
Publishing date	2010-08-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124459-0
ISSN	1432-1998 ; 0301-0449
ISSN (online)	1432-1998
ISSN	0301-0449
DOI	10.1007/s00247-010-1787-3
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Article ; Online: Computer-aided detection of small pulmonary nodules in chest radiographs: an observer study.

De Boo, Diederick W / Uffmann, Martin / Weber, Michael / Bipat, Shandra / Boorsma, Eelco F / Scheerder, Maeke J / Freling, Nicole J / Schaefer-Prokop, Cornelia M

Academic radiology

2011 Volume 18, Issue 12, Page(s) 1507–1514

Abstract: Rationale and objectives: To evaluate the impact of computer-aided detection (CAD, IQQA-Chest; EDDA Technology, Princeton Junction, NJ) used as second reader on the detection of small pulmonary nodules in chest radiography (CXR).: Materials and ... ...

Abstract	Rationale and objectives: To evaluate the impact of computer-aided detection (CAD, IQQA-Chest; EDDA Technology, Princeton Junction, NJ) used as second reader on the detection of small pulmonary nodules in chest radiography (CXR). Materials and methods: A total of 113 patients (mean age 62 years) with CT and CXR within 6 weeks were selected. Fifty-nine patients showed 101 pulmonary nodules (diameter 5-15mm); the remaining 54 patients served as negative controls. Six readers of varying experience individually evaluated the CXR without and with CAD as second reader in two separate reading sessions. The sensitivity per lesion, figure of merit (FOM), and mean false positive per image (mFP) were calculated. Institutional review board approval was waived. Results: With CAD, the sensitivity increased for inexperienced readers (39% vs. 45%, P < .05) and remained unchanged for experienced readers (50% vs. 51%). The mFP nonsignificantly increased for both inexperienced and experienced readers (0.27 vs. 0.34 and 0.16 vs. 0.21). The mean FOM did not significantly differ for readings without and with CAD irrespective of reader experience (0.71 vs. 0.71 and 0.84 vs. 0.87). All readers together dismissed 33% of true-positive CAD candidates. False-positive candidates by CAD provoked 40% of all false-positive marks made by the readers. Conclusion: CAD improves the sensitivity of inexperienced readers for the detection of small nodules at the expense of loss of specificity. Overall performance by means of FOM was therefore not affected. To use CAD more beneficial, readers need to improve their ability to differentiate true from false-positive CAD candidates.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Clinical Competence ; Diagnosis, Computer-Assisted ; False Positive Reactions ; Female ; Humans ; Male ; Middle Aged ; Multiple Pulmonary Nodules/diagnostic imaging ; Observer Variation ; Radiography, Thoracic ; Sensitivity and Specificity ; Young Adult
Language	English
Publishing date	2011-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2011.08.008
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Article ; Online: Predictors of endoscopic transsphenoidal surgery outcome in acromegaly: patient and tumor characteristics evaluated by magnetic resonance imaging.

van Bunderen, Christa C / van Varsseveld, Nadège C / Baayen, Johannes C / van Furth, Wouter R / Aliaga, Esther Sanchez / Hazewinkel, Marieke J / Majoie, Charles B L M / Freling, Nicole J M / Lips, Paul / Fliers, Eric / Bisschop, Peter H / Drent, Madeleine L

Pituitary

2012 Volume 16, Issue 2, Page(s) 158–167

Abstract: The availability of various first-line treatment modalities for acromegaly and evolving surgical techniques emphasize the need for accurately defined predictors of surgical outcome. We retrospectively analysed the outcome of 30 patients with acromegaly ... ...

Abstract	The availability of various first-line treatment modalities for acromegaly and evolving surgical techniques emphasize the need for accurately defined predictors of surgical outcome. We retrospectively analysed the outcome of 30 patients with acromegaly after initial endoscopic transsphenoidal surgery in two university hospitals from 2001 until 2009, and reviewed comparable literature investigating predictive tumor characteristics. Medical records were monitored for patient characteristics. Each pituitary magnetic resonance imaging (MRI) scan was revised independently by two neuroradiologists using a standardised analysis form to record distinctive predefined tumor characteristics. All characteristics were independently analysed as predictors for persistent disease, and a multivariable predictive model was created. Literature from 2000 onwards was searched for studies describing tumor characteristics predictive for surgical outcome. The cohort consisted of 27 macroadenomas with 90 % demonstrating signs of parasellar extension. The surgical cure rate overall was 30 %. Independently, next to male sex and increasing tumor size, infrasellar and parasellar extension based on MRI staging tended to increase the risk of persistent disease. In a multivariable analysis, sex and parasellar extension of the tumor were demonstrated to be the variables allowing for the best fitted predictive model for persistent disease. Earlier studies on preoperative tumor characteristics showed comparable results, although these were based on several different tumor classification systems. This retrospective study demonstrates that accurately defined tumor characteristics based on imaging, especially for cavernous sinus invasion, can be helpful in predicting surgical outcome. Comparative studies on different treatment modalities are essential for clinical practice within the scope of re-evaluation of the role of surgery in GH-secreting adenomas.
MeSH term(s)	Acromegaly/surgery ; Adult ; Aged ; Endoscopy ; Female ; Growth Hormone-Secreting Pituitary Adenoma/surgery ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2012-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1385151-2
ISSN	1573-7403 ; 1386-341X
ISSN (online)	1573-7403
ISSN	1386-341X
DOI	10.1007/s11102-012-0395-7
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