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Article ; Online: Domestic Physical Activity: An Overlooked Risk-Modifier for Incident Hypertension?

Lui, Matthew / Mitchell, Joshua D

2022 Volume 135, Issue 11, Page(s) 1282–1283

MeSH term(s)	Humans ; Hypertension/epidemiology ; Exercise ; Risk Factors ; Incidence
Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2022.07.002
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Article ; Online: [No title information]

Schulte, Thomas E / Archie, Chinyere A / Sherrer, D Matthew / Franklin, Andrew D / Tsai, Mitchell H

Journal of clinical anesthesia

2024 Volume 96, Page(s) 111471

Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Letter
ZDB-ID	1011618-7
ISSN	1873-4529 ; 0952-8180
ISSN (online)	1873-4529
ISSN	0952-8180
DOI	10.1016/j.jclinane.2024.111471
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Article ; Online: Exercise Snacks and Other Forms of Intermittent Physical Activity for Improving Health in Adults and Older Adults: A Scoping Review of Epidemiological, Experimental and Qualitative Studies.

Jones, Matthew D / Clifford, Briana K / Stamatakis, Emmanuel / Gibbs, Mitchell T

Sports medicine (Auckland, N.Z.)

2024 Volume 54, Issue 4, Page(s) 813–835

Abstract: Exercise snacks, including other variants of brief intermittent bouts, are an emerging approach for increasing physical activity, although their operationalisation is unstandardised and their health benefits remain unclear. This scoping review aimed to ... ...

Abstract	Exercise snacks, including other variants of brief intermittent bouts, are an emerging approach for increasing physical activity, although their operationalisation is unstandardised and their health benefits remain unclear. This scoping review aimed to explore characterisations of exercise snacks and summarise their effects on health in adults and older adults. Clinical trial registers (clinicaltrials.gov and ANZCTR) and electronic databases (PubMed, CINAHL, CENTRAL, PsycINFO) were searched from inception to 1 June 2023, for ongoing and published studies of exercise snacks. Backwards and forwards citation tracking was also conducted to identify additional eligible studies. Studies were included if they investigated exercise snacks-brief intermittent bouts of physical activity spread across the day-in adults or older adults. We included epidemiological, experimental, quasi-experimental and qualitative studies that examined the effect of exercise snacks on any health outcomes or described barriers to and enablers of these approaches. Thirty-two studies were included (7 trial registers, 1 published protocol, 3 epidemiological studies and 20 trials reported across 21 studies). Three main terms were used to describe exercise snacks: exercise snack(ing), snacktivity and vigorous intermittent lifestyle physical activity (VILPA). Participants were predominantly physically inactive but otherwise healthy adults or older adults. Exercise snacks were feasible and appeared safe. Epidemiological studies showed steep, near-linear associations of VILPA with reduced all-cause, cardiovascular and cancer mortality as well as reduced incidence of major adverse cardiovascular events and cancer. The limited trial evidence showed exercise snacks had modest effects on improving cardiorespiratory fitness, whereas effects on physical function, mood, quality of life and other health outcomes were equivocal. In conclusion, exercise snacks appear feasible and safe for adults and older adults and may have promising health benefits, but this is mostly based on findings from a limited number of small quasi-experimental studies, small randomised trials or qualitative studies. More studies are needed in individuals with chronic disease. This emerging physical activity approach may have appeal for individuals who find structured exercise unfeasible.Registration https://osf.io/qhu24/.
MeSH term(s)	Humans ; Snacks ; Exercise ; Aged ; Adult
Language	English
Publishing date	2024-01-08
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	605911-9
ISSN	1179-2035 ; 0112-1642
ISSN (online)	1179-2035
ISSN	0112-1642
DOI	10.1007/s40279-023-01983-1
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Article ; Online: Response Letter.

Sherrer, D Matthew / Franklin, Andrew D / Kimatian, Stephen J / Black, Ian H / Tsai, Mitchell H

Anesthesia and analgesia

2023 Volume 137, Issue 3, Page(s) e25–e26

Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000006597
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Article ; Online: Complex Family Planning fellowship graduates' intended practice plans and barriers to practicing in areas of unmet need.

Pomerantz, Tali / Ponzini, Matthew D / Wilson, Machelle D / Creinin, Mitchell D

Contraception

2023 Volume 123, Page(s) 110005

Abstract: Objectives: To describe practice patterns and challenges encountered by Complex Family Planning (CFP) fellowship graduates.: Study design: We invited all 110 obstetrics and gynecology physicians who graduated from the CFP fellowship from 2017-2020 ... ...

Abstract	Objectives: To describe practice patterns and challenges encountered by Complex Family Planning (CFP) fellowship graduates. Study design: We invited all 110 obstetrics and gynecology physicians who graduated from the CFP fellowship from 2017-2020 via email to complete an anonymous online survey. We inquired about demographics, intended and obtained postfellowship positions, and successes and challenges in obtaining jobs. We used Fisher's exact test to assess if the proportion of graduates who grew up, attended residency, and completed fellowship in a US region (Northeast, Midwest, South, and West) and practiced in that same region differed. Results: Ninety-nine (90.0%) graduates completed the survey. When entering fellowship, most (n = 92 [92.9%]) expected to practice in an academic environment. About half (n = 49 [49.5%]) pursued fellowship with the intent to practice in a location with an unmet need for abortion providers, of which 22 (44.9%) did so. Forty-nine (49.5%) respondents did not practice after fellowship where they initially intended, citing common challenges of job availability, family-related concerns, safety concerns, and relationship status changes. We found associations between regions where graduates completed residency and currently practice (p = 0.004), driven primarily by higher associations in the South (76.9%) and West (70.6%) and a lower association in the Midwest (22.7%). We found no association between current practice region and where graduates grew up (p = 0.15) or completed fellowship (p = 0.23). Conclusions: CFP fellowship graduates from 2017-2020 primarily intended to practice in academic environments with half planning to practice in underserved locations. However, more than half of those who entered fellowship hoping to fill an unmet need for abortion providers did not do so. Implications: About half of CFP fellowship graduates from 2017-2020 intended to obtain positions in areas they defined as having an unmet need for abortion provision. Personal life and job barriers prevented many from serving in such positions after fellowship. Practice location intentions and outcomes may be different in a post-Dobbs environment.
MeSH term(s)	Pregnancy ; Female ; Humans ; Family Planning Services ; Fellowships and Scholarships ; Surveys and Questionnaires ; Internship and Residency ; Physicians
Language	English
Publishing date	2023-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	80106-9
ISSN	1879-0518 ; 0010-7824
ISSN (online)	1879-0518
ISSN	0010-7824
DOI	10.1016/j.contraception.2023.110005
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Article: Market segmentation strategies can be used to overcome COVID-19 vaccine hesitancy and other health crises.

Meng, Matthew D / Olsen, Mitchell C

The Journal of consumer affairs

2021 Volume 56, Issue 2, Page(s) 957–968

Abstract: As the COVID-19 pandemic continues to impact everyone to some degree, it has become clear that experts from many disparate fields must work together to overcome such public health crises. Even now, a significant portion of U.S. residents remain hesitant ... ...

Abstract	As the COVID-19 pandemic continues to impact everyone to some degree, it has become clear that experts from many disparate fields must work together to overcome such public health crises. Even now, a significant portion of U.S. residents remain hesitant to receive a vaccine. In the quest to safely return to a fully open economy, time is of the essence, as many lives and livelihoods can be saved by even marginal improvements in vaccination rates. To reach widespread immunization sooner, science stands to benefit by using market segmentation strategies with vaccine holdouts, much like brands do with customers. As evidence, we present results from a national survey segmented into four groups of COVID-19 vaccine holdouts. When viewed and considered as separate segments, important distinctions regarding the nature and strength of reasons behind COVID-19 vaccine aversion, and the solutions to which people are most open, become clearer.
Language	English
Publishing date	2021-11-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2066552-0
ISSN	1745-6606 ; 0022-0078
ISSN (online)	1745-6606
ISSN	0022-0078
DOI	10.1111/joca.12421
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Article ; Online: Generative β-hairpin design using a residue-based physicochemical property landscape.

Satalkar, Vardhan / Degaga, Gemechis D / Li, Wei / Pang, Yui Tik / McShan, Andrew C / Gumbart, James C / Mitchell, Julie C / Torres, Matthew P

Biophysical journal

2024

Abstract: De novo peptide design is a new frontier that has broad application potential in the biological and biomedical fields. Most existing models for de novo peptide design are largely based on sequence homology that can be restricted based on evolutionarily ... ...

Abstract	De novo peptide design is a new frontier that has broad application potential in the biological and biomedical fields. Most existing models for de novo peptide design are largely based on sequence homology that can be restricted based on evolutionarily derived protein sequences and lack the physicochemical context essential in protein folding. Generative machine learning for de novo peptide design is a promising way to synthesize theoretical data that are based on, but unique from, the observable universe. In this study, we created and tested a custom peptide generative adversarial network intended to design peptide sequences that can fold into the β-hairpin secondary structure. This deep neural network model is designed to establish a preliminary foundation of the generative approach based on physicochemical and conformational properties of 20 canonical amino acids, for example, hydrophobicity and residue volume, using extant structure-specific sequence data from the PDB. The beta generative adversarial network model robustly distinguishes secondary structures of β hairpin from α helix and intrinsically disordered peptides with an accuracy of up to 96% and generates artificial β-hairpin peptide sequences with minimum sequence identities around 31% and 50% when compared against the current NCBI PDB and nonredundant databases, respectively. These results highlight the potential of generative models specifically anchored by physicochemical and conformational property features of amino acids to expand the sequence-to-structure landscape of proteins beyond evolutionary limits.
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	218078-9
ISSN	1542-0086 ; 0006-3495
ISSN (online)	1542-0086
ISSN	0006-3495
DOI	10.1016/j.bpj.2024.01.029
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Zs.A 235: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 2: Show issues

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Article ; Online: The Icarus Paradox and the Future of Anesthesiology.

Sherrer, D Matthew / Franklin, Andrew D / Kimatian, Stephen J / Black, Ian H / Tsai, Mitchell H

Anesthesia and analgesia

2022 Volume 136, Issue 1, Page(s) 185–189

MeSH term(s)	Anesthesiology
Language	English
Publishing date	2022-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000006253
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Uk I Zs.78: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 149: Show issues

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Article ; Online: Are the attitudes and beliefs of Australian exercise-based practitioners associated with their use of, and confidence in, treatment modalities for people with chronic low back pain?

Gibbs, Mitchell T / Last, Theo / Marshall, Paul / Jones, Matthew D

Musculoskeletal care

2023

Abstract: Background: Practitioners' attitudes and beliefs towards chronic low back pain (CLBP) influence their clinical decision making, but few studies have investigated decision making outside the context of patient vignettes for a range of first- and second- ... ...

Abstract	Background: Practitioners' attitudes and beliefs towards chronic low back pain (CLBP) influence their clinical decision making, but few studies have investigated decision making outside the context of patient vignettes for a range of first- and second-line treatment options for CLBP, or in accredited exercise physiologists (AEPs). Methods: Using an online survey, Australian AEPs and physiotherapists rated their use of different treatments for CLBP (exercise, education, manual therapy, cognitive behavioural therapy) and their confidence in these treatments for reducing pain and disability. Their biomedical and biopsychosocial beliefs were also assessed using the Pain and Attitudes Beliefs Scale for Physiotherapists. Differences between disciplines in treatment use and confidence were analysed using Mann-Whitney U tests and independent t-tests, respectively. Multiple linear regression was used to explore factors associated with treatment choices. Results: Two-hundred thirty-three practitioners (n = 143 physiotherapists, n = 90 AEPs) completed the survey. Most practitioners were confident in treating CLBP, had a moderate-high level of confidence in the different treatments, and regularly used them in practice. Practitioners with higher biomedical beliefs had greater use of, and confidence in, specific exercise, manual therapy, and combined exercise and manual therapy. Practitioners with higher biopsychosocial beliefs were more confident in general exercise, cognitive behavioural therapy, pain education and combined exercise and pain education. Conclusion: Practitioner beliefs influence their use of, and confidence in different treatments for CLBP. These findings suggest a need for strategies to enhance biopsychosocial beliefs/reduce biomedical beliefs in Australian exercise-based practitioners.
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2171452-6
ISSN	1557-0681 ; 1478-2189
ISSN (online)	1557-0681
ISSN	1478-2189
DOI	10.1002/msc.1852
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Article ; Online: Advances in Screening for Radiation-Associated Cardiotoxicity in Cancer Patients.

Schiffer, Walter / Pedersen, Lauren N / Lui, Matthew / Bergom, Carmen / Mitchell, Joshua D

Current cardiology reports

2023 Volume 25, Issue 11, Page(s) 1589–1600

Abstract: Purpose of review: Radiation is foundational to the treatment of cancer and improves overall survival. Yet, it is important to recognize the potential cardiovascular effects of radiation therapy and how to best minimize or manage them. Screening-both ... ...

Abstract	Purpose of review: Radiation is foundational to the treatment of cancer and improves overall survival. Yet, it is important to recognize the potential cardiovascular effects of radiation therapy and how to best minimize or manage them. Screening-both through imaging and with biomarkers-can potentially identify cardiovascular effects early, allowing for prompt initiation of treatment to mitigate late effects. Recent findings: Cardiac echocardiography, magnetic resonance imaging (MRI), computed tomography, and measurements of troponin and natriuretic peptides serve as the initial screening tests of choice for RICD. Novel imaging applications, including positron emission tomography and specific MRI parameters, and biomarker testing, including myeloperoxidase, growth differentiation factor 15, galectin 3, micro-RNA, and metabolomics, hold promise for earlier detection and more specific characterization of RICD. Advances in imaging and novel applications of biomarkers have potential to identify subclinical RICD and may reveal opportunities for early intervention. Further research is needed to elucidate optimal imaging screening modalities, biomarkers, and surveillance strategies.
MeSH term(s)	Humans ; Cardiotoxicity/diagnostic imaging ; Cardiotoxicity/etiology ; Early Detection of Cancer ; Neoplasms/radiotherapy ; Neoplasms/drug therapy ; Biomarkers ; Echocardiography ; Antineoplastic Agents/therapeutic use
Chemical Substances	Biomarkers ; Antineoplastic Agents
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055373-0
ISSN	1534-3170 ; 1523-3782
ISSN (online)	1534-3170
ISSN	1523-3782
DOI	10.1007/s11886-023-01971-x
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