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  1. Book: Primer of diagnostic imaging

    Weissleder, Ralph

    (Expert consult)

    2012  

    Title variant Diagnostic imaging
    Author's details Ralph Weissleder
    Series title Expert consult
    Keywords Diagnostic Imaging ; Diagnostic imaging
    Subject code 616.0754
    Language English
    Size XXIII, 792 S. : Ill., graph. Darst.
    Edition 5. ed.
    Publisher Mosby Elsevier
    Publishing place St. Louis
    Publishing country United States
    Document type Book
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT016984664
    ISBN 978-0-323-06538-2 ; 0-323-06538-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 3920 order for loan Magazin
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Article ; Online: Leveraging technology to address current and future world issues.

    Weissleder, Ralph

    Science translational medicine

    2022  Volume 14, Issue 666, Page(s) eabq0606

    Abstract: Biotechnology is essential to advance modern medicine and alleviate global health crises, yet commercialization is often wrought by competing forces. ...

    Abstract Biotechnology is essential to advance modern medicine and alleviate global health crises, yet commercialization is often wrought by competing forces.
    MeSH term(s) Biotechnology ; Global Health
    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abq0606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6941: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Book: Molecular imaging

    Weissleder, Ralph

    principles and practice

    2010  

    Author's details Ralph Weissleder
    Keywords Molecular Imaging / methods
    Language English
    Size XXII, 1357 S. : Ill., graph. Darst.
    Publisher People's Med. Publ. House
    Publishing place Shelton, Conn
    Publishing country United States
    Document type Book
    HBZ-ID HT016480844
    ISBN 978-1-60795-005-9 ; 1-60795-005-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 4317 order for loan Magazin

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  4. Book: Primer of diagnostic imaging

    Weissleder, Ralph

    2007  

    Title variant Diagnostic imaging ; MRI physics
    Author's details Ralph Weissleder
    Keywords Diagnostic Imaging ; Diagnostic imaging
    Subject code 616.0754
    Language English
    Size XXVII, 1112 S. : Ill.
    Edition 4. ed.
    Publisher Mosby Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    Note CD-ROM u.d.T.: MRI physics. - Systemvoraussetzungen: Windows: Windows 2000, Windows XP with Service Pack 1,2; Pentium Processor; 233 MHz or higher; 64 MB of a available hard-disk space; 8x or faster CD-ROM drive; VGA monitor supporting 256 colors; 800 x 600 screen resolution. - Macintosh: Apple Power PC 166 MHz or higher; Mac OS version 10.2 or higher; 64 MB of available RAM; 2 MB of available hard-disk space; 8x or faster CD-ROM drive; VGA monitor supporting 256 colors; 800 x 600 screen resolution
    Accompanying material 1 CD-ROM (12 cm)
    Old title 3. Aufl. u.d.T. Weissleder, Ralph: Primer of diagnostic imaging
    HBZ-ID HT014959300
    ISBN 0-323-04068-3 ; 978-0-323-04068-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 6029 order for loan Magazin
    2007 MO 709 <<[Begleitmaterial]>> order for loan Magazin

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  5. Article: The Magical World of Circulating Vesicles.

    Weissleder, Ralph

    Advanced biosystems

    2020  Volume 4, Issue 12, Page(s) e2000475

    MeSH term(s) Biomedical Research ; Extracellular Vesicles ; Humans ; Models, Biological
    Language English
    Publishing date 2020-12-21
    Publishing country Germany
    Document type Editorial
    ISSN 2366-7478
    ISSN 2366-7478
    DOI 10.1002/adbi.202000475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Light-Deactivated Fluorescent Probes (FLASH-Off) for Multiplexed Imaging.

    Halabi, Elias A / Weissleder, Ralph

    Journal of the American Chemical Society

    2023  

    Abstract: Highly multiplexed, cyclic fluorescence imaging has advanced our understanding of the biology, evolution, and complexity of human diseases. Currently available cyclic methods still have considerable limitations including the need for long quenching times ...

    Abstract Highly multiplexed, cyclic fluorescence imaging has advanced our understanding of the biology, evolution, and complexity of human diseases. Currently available cyclic methods still have considerable limitations including the need for long quenching times and extensive wash steps. Here, we report a new series of fluorochromes that can be efficiently inactivated by a single light pulse (∼405 nm) by means of a photo-immolating triazene linker. Upon UV-light irradiation, the rhodamines are cleaved off from the antibody conjugates and undergo a fast intramolecular spirocyclization that inherently switches off their fluorescence emission without the need to wash or add exogenous chemicals. We show that these switch-off probes are fast, highly controllable, biocompatible, and allow spatiotemporal quenching control of live and fixed samples.
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c00170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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  7. Article: Deep Learning Pipeline for Automated Cell Profiling from Cyclic Imaging.

    Landeros, Christian / Oh, Juhyun / Weissleder, Ralph / Lee, Hakho

    Research square

    2023  

    Abstract: Recent advances in microscopy allow scientists to generate vast amounts of biological data from a single biopsy sample. Cyclic fluorescence microscopy, in particular, enables multiple targets to be detected simultaneously. This, in turn, has deepened our ...

    Abstract Recent advances in microscopy allow scientists to generate vast amounts of biological data from a single biopsy sample. Cyclic fluorescence microscopy, in particular, enables multiple targets to be detected simultaneously. This, in turn, has deepened our understanding of tissue composition, cell-to-cell interactions, and cell signaling. Unfortunately, analysis of these datasets can be time-prohibitive due to the sheer volume of data. In this paper, we present CycloNET, a computational pipeline tailored for analyzing raw fluorescent images obtained through cyclic immunofluorescence. The automated pipeline pre-processes raw image files, quickly corrects for translation errors between imaging cycles, and leverages a pre-trained neural network to segment individual cells and generate single-cell molecular profiles. We applied CycloNET to a dataset of 22 human samples from head and neck squamous cell carcinoma patients and trained a neural network to segment immune cells. CycloNET efficiently processed a large-scale dataset (17 fields of view per cycle and 13 staining cycles per specimen) in 10 minutes, delivering insights at the single-cell resolution and facilitating the identification of rare immune cell clusters. We expect that this rapid pipeline will serve as a powerful tool to understand complex biological systems at the cellular level, with the potential to facilitate breakthroughs in areas such as developmental biology, disease pathology, and personalized medicine.
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3745061/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: PARP trapping is governed by the PARP inhibitor dissociation rate constant.

    Gopal, Angelica A / Fernandez, Bianca / Delano, Justin / Weissleder, Ralph / Dubach, J Matthew

    Cell chemical biology

    2024  

    Abstract: Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) are a class of cancer drugs that enzymatically inhibit PARP activity at sites of DNA damage. Yet, PARPi function mainly by trapping PARP1 onto DNA with a wide range of potency among the clinically ... ...

    Abstract Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) are a class of cancer drugs that enzymatically inhibit PARP activity at sites of DNA damage. Yet, PARPi function mainly by trapping PARP1 onto DNA with a wide range of potency among the clinically relevant inhibitors. How PARPi trap and why some are better trappers remain unknown. Here, we show trapping occurs primarily through a kinetic phenomenon at sites of DNA damage that correlates with PARPi k
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2023.12.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype.

    Sarkar, Biplab / Arlauckas, Sean P / Cuccarese, Michael F / Garris, Christopher S / Weissleder, Ralph / Rodell, Christopher B

    Frontiers in immunology

    2024  Volume 15, Page(s) 1331480

    Abstract: Macrophages are critical regulators of the tumor microenvironment and often present an immuno-suppressive phenotype, supporting tumor growth and immune evasion. Promoting a robust pro-inflammatory macrophage phenotype has emerged as a therapeutic ... ...

    Abstract Macrophages are critical regulators of the tumor microenvironment and often present an immuno-suppressive phenotype, supporting tumor growth and immune evasion. Promoting a robust pro-inflammatory macrophage phenotype has emerged as a therapeutic modality that supports tumor clearance, including through synergy with immune checkpoint therapies. Polyglucose nanoparticles (macrins), which possess high macrophage affinity, are useful vehicles for delivering drugs to macrophages, potentially altering their phenotype. Here, we examine the potential of functionalized macrins, synthesized by crosslinking carboxymethyl dextran with
    MeSH term(s) Animals ; Mice ; Pharmaceutical Preparations ; Tumor-Associated Macrophages ; Neoplasms ; Nanoparticles/chemistry ; beta-Cyclodextrins ; Phenotype ; Tumor Microenvironment
    Chemical Substances Pharmaceutical Preparations ; beta-Cyclodextrins
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1331480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Publisher Correction: The expanding landscape of inflammatory cells affecting cancer therapy.

    Weissleder, Ralph / Pittet, Mikael J

    Nature biomedical engineering

    2020  Volume 4, Issue 5, Page(s) 573

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2020-04-05
    Publishing country England
    Document type Journal Article ; Published Erratum
    ISSN 2157-846X
    ISSN (online) 2157-846X
    DOI 10.1038/s41551-020-0554-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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