LIVIVO - Search results -

Search results

Result 1 - 10 of total 21118

Search options

Article: Corrigendum: Yin-Chen-Hao Tang Attenuates Severe Acute Pancreatitis in Rat: An Experimental Verification of

Xiang, Hong / Wang, Guijun / Qu, Jialin / Xia, Shilin / Tao, Xufeng / Qi, Bing / Zhang, Qingkai / Shang, Dong

2018 Volume 9, Page(s) 1203

Abstract: This corrects the article DOI: 10.3389/fphar.2016.00378.]. ...

Abstract	[This corrects the article DOI: 10.3389/fphar.2016.00378.].
Language	English
Publishing date	2018-10-17
Publishing country	Switzerland
Document type	Journal Article ; Published Erratum
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.01203
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Modelling bank erosion dependence on natural and anthropogenic factors — case study of Ganh Hao estuary, Bac Lieu - Ca Mau, Vietnam

Bui, Linh Hong Nhat / Bui, Long Ta

Environmental technology & innovation. 2020 Aug., v. 19

2020

Abstract: Vietnam’s Mekong Delta is formed up with alluvial sediments and accretion over the centuries. The mixed interaction of the river — the sea have formed fertile alluvial soil, with very diverse ecosystems. During more than 300 years of exploitation, we ... ...

Abstract	Vietnam’s Mekong Delta is formed up with alluvial sediments and accretion over the centuries. The mixed interaction of the river — the sea have formed fertile alluvial soil, with very diverse ecosystems. During more than 300 years of exploitation, we have never had to deal with the fierce impacts of weather, climate change, along with changes from upstream leading to erosion in both estuarines and coastal areas. In recent years, there have been many tropical depressions in the area, storms create strong waves phenomena, storm surges, and changes in the upstream areas, leading to the risk of erosion tends to increase. A numerical modelling and simulation experiment is carried out to assess the impact of anthropogenic such as discharge, sediment load and natural factors such as wave, tide, sea level rise due to climate change or storms to bank erosion on estuaries and coastlines. Erosion and deposition modelling was carried out in the study area under different scenarios, pay attention to storm surges, flowrate in the estuary. The modelling results are controlled and compared with reality, allowing the evaluation of the reliability of the modelling and serving to improve the design quality of the estuarine and coastal areas protection construction.
Keywords	alluvial soils ; bank erosion ; case studies ; climate change ; environmental technology ; estuaries ; risk ; river deltas ; rivers ; sea level ; sediment contamination ; Vietnam
Language	English
Dates of publication	2020-08
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ISSN	2352-1864
DOI	10.1016/j.eti.2020.100975
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Yin-Chen-Hao Tang Attenuates Severe Acute Pancreatitis in Rat: An Experimental Verification of

Xiang, Hong / Wang, Guijun / Qu, Jialin / Xia, Shilin / Tao, Xufeng / Qi, Bing / Zhang, Qingkai / Shang, Dong

Frontiers in pharmacology

2016 Volume 7, Page(s) 378

Abstract: Yin-Chen-Hao Tang (YCHT) is a classical Chinese medicine compound that has a long history ...

Abstract	Yin-Chen-Hao Tang (YCHT) is a classical Chinese medicine compound that has a long history of clinical use in China for the treatment of inflammatory diseases. However, the efficacy and mechanisms of YCHT for the treatment of severe acute pancreatitis (SAP) are not known. The current study investigated the pharmacological properties of YCHT against SAP and its underlying mechanisms. A computational prediction of potential targets of YCHT was initially established based on a network pharmacology simulation. The model suggested that YCHT attenuated SAP progress by apoptosis inducement, anti-inflammation, anti-oxidation and blood lipid regulation. These effects were validated in SAP rats. YCHT administration produced the following results: (1) significantly inhibited the secretion of pancreatic enzymes and protected pancreatic tissue; (2) obviously increased the number of
Language	English
Publishing date	2016-10-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2016.00378
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Yin-Chen-Hao-Tang alleviates biliary obstructive cirrhosis in rats by inhibiting biliary epithelial cell proliferation and activation.

Wang, Bing / Sun, Ming-Yu / Long, Ai-Hua / Cao, Hong-Yan / Ren, Shuang / Bian, Yan-Qin / Lu, Xiong / Gu, Hong-Tu / Liu, Cheng-Hai / Liu, Ping

Pharmacognosy magazine

2015 Volume 11, Issue 42, Page(s) 417–425

Abstract: Background: Yin-Chen-Hao-Tang (YCHT) consists of three aqueous extracts from Artemisia capillaris ...

Abstract	Background: Yin-Chen-Hao-Tang (YCHT) consists of three aqueous extracts from Artemisia capillaris, Gardenia sp., and prepared Rheum rhabarbarum (rhubarb) (3:2:1). YCHT is characterized by its anti-inflammatory properties in liver regulation and relief of jaundice. We aimed to study the effects and mechanisms of action of YCHT on biliary obstructive cirrhosis. Materials and methods: Secondary biliary fibrosis was induced in rats by bile duct ligation (BDL) and scission. One week after BDL, rats were randomly divided into a saline-treated BDL or YCHT-treated BDL group for 4 weeks. Liver function and hepatic hydroxyproline (Hyp) content were assessed. Types I and IV collagen (Col-IV), laminin, fibronectin, alpha smooth muscle actin (α-SMA), and proliferating cell nuclear antigen protein and messenger ribonucleic acid (mRNA) expression were assessed with immunohistochemistry and real-time polymerase chain reaction. Results: In the YCHT-treated BDL group, serum total bilirubin, total bile acids, aspartate aminotransferase, alanine aminotransferase, and γ-glutamyl transferase were lower than those in the sham-operated BDL group. The proliferation of bile ducts in hepatic tissues and the Hyp content and Col deposition were also significantly lower than those in control rats. In addition, α-SMA and Col-IV staining was less obvious, and mRNA expression of Procol-α1 (IV), platelet derived growth factor subunit B (PDGF)-B, connective tissue growth factor, and transforming growth factor-beta in proliferative biliary epithelial cells (BECs) in the YCHT-treated BDL group was significantly lower than those in controls. Conclusions: YCHT effectively reduces the formation of biliary obstructive cirrhosis mainly via inhibition of BEC proliferation by down-regulation of PDGF-B mRNA expression, inhibition of BEC profibrogenic paracrines, and the epithelial-mesenchymal transition pathological process.
Language	English
Publishing date	2015-01-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2274976-7
ISSN	0976-4062 ; 0973-1296
ISSN (online)	0976-4062
ISSN	0973-1296
DOI	10.4103/0973-1296.153098
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Yin-Chen-Hao-Tang ameliorates obstruction-induced hepatic apoptosis in rats.

Lee, Tzung-Yan / Chang, Hen-Hong / Wu, Mei-Yao / Lin, Han-Chieh

The Journal of pharmacy and pharmacology

2007 Volume 59, Issue 4, Page(s) 583–590

Abstract: ... to modulate liver fibrosis. Yin-Chen-Hao-Tang (YCHT) decoctions have been recognised as a hepatoprotective ...

Abstract	The accumulation of hydrophobic bile acids in the liver is considered to play a pivotal role in the induction of apoptosis of hepatocytes during cholestasis. Thus, factors that affect apoptosis may be used to modulate liver fibrosis. Yin-Chen-Hao-Tang (YCHT) decoctions have been recognised as a hepatoprotective agent for jaundice and various types of liver diseases. We used an experimental rat model of bile-duct ligation (BDL) to test whether YCHT plays a regulatory role in the pathogenesis of hepatic apoptosis. BDL-plus-YCHT groups received 250 or 500 mg kg (-1) YCHT by gavage once daily for 27 days. YCHT significantly ameliorated the portal hypertensive state and serum TNF-alpha compared with the vehicle-treated control group. In BDL-plus-YCHT-treated rats, hepatic glutathione contents were significantly higher than than in BDL-only rats. BDL caused a prominent liver apoptosis that was supported by an increase in Bax and cytochrome c protein and increased expression of Bax and Bcl-2 messenger RNA. The normalising effect of YCHT on expression of Bax and Bcl-2 mRNA was dependent on the dose of YCHT, 500 mg kg (-1) having the greater effect on both Bax and Bcl-2 of mRNA levels. Additionally, YCHT treatment down-regulated both hepatic caspase-3 and -8 activities of BDL rats. This study demonstrates the anti-apoptotic properties of YCHT and suggests a potential application of YCHT in the clinical management of hepatic disease resulting from biliary obstruction.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Artemisia/chemistry ; Bile Ducts/surgery ; Caspase 3/drug effects ; Caspase 3/metabolism ; Caspase 8/drug effects ; Caspase 8/metabolism ; Cholestasis, Extrahepatic/drug therapy ; Cholestasis, Extrahepatic/physiopathology ; Cytochromes c/chemistry ; Cytochromes c/drug effects ; Disease Models, Animal ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Gardenia/chemistry ; Gene Expression/drug effects ; Glutathione/chemistry ; Glutathione/drug effects ; Hepatocytes/drug effects ; Hepatocytes/pathology ; Hypertension, Portal/drug therapy ; Ligation ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Male ; Medicine, Chinese Traditional ; Phytotherapy ; RNA, Messenger/drug effects ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Rheum/chemistry ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/drug effects ; bcl-2-Associated X Protein/chemistry ; bcl-2-Associated X Protein/drug effects
Chemical Substances	Drugs, Chinese Herbal ; RNA, Messenger ; Tumor Necrosis Factor-alpha ; bcl-2-Associated X Protein ; Cytochromes c (9007-43-6) ; Caspase 3 (EC 3.4.22.-) ; Caspase 8 (EC 3.4.22.-) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2007-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1211/jpp.59.4.0014
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uf I Zs.149: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Alleviation of hepatic oxidative stress by Chinese herbal medicine Yin-Chen-Hao-Tang in obese mice with steatosis.

Lee, Tzung-Yan / Chang, Hen-Hong / Lo, Wen-Chai / Lin, Han-Chieh

International journal of molecular medicine

2010 Volume 25, Issue 6, Page(s) 837–844

Abstract: ... in the development of hepatic steatosis. This study was to test the efficacy of Yin-Chen-Hao-Tang (YCHT), an agent ...

Abstract	Obesity is associated with a complex systemic inflammatory state that has been implicated in the development of hepatic steatosis. This study was to test the efficacy of Yin-Chen-Hao-Tang (YCHT), an agent that improves hepatic triglyceride metabolism in its ability to modulate pathways implicated in hepatic steatosis. Mice were fed with high-fat diet for fifteen weeks. The therapeutic mechanism of YCHT likely enhanced adiponectin and endothelial progenitor cells, and up-regulation of peroxisome proliferator-activated receptor gamma might be responsible for fatty liver diseases. In addition, YCHT anti-oxidative stress effect might be associated with inhibition of hepatic free fatty acid concentrations and elevation of the glutathione levels in hepatic tissues. Furthermore, YCHT action mechanisms might promote senescence marker protein-30 metabolism that increase resistance to hepatic oxidative stress. These findings suggest a novel therapeutic approach for fatty liver progression in obesity mice.
MeSH term(s)	Animals ; Chromatography, Liquid ; Cytokines/blood ; Cytokines/genetics ; Dietary Fats/administration & dosage ; Dietary Fats/pharmacology ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Electrophoresis, Gel, Two-Dimensional ; Fatty Liver/drug therapy ; Fatty Liver/pathology ; Gene Expression Regulation/drug effects ; Liver/drug effects ; Liver/pathology ; Mass Spectrometry ; Medicine, Chinese Traditional ; Mice ; Mice, Obese ; Oxidative Stress/drug effects ; Phytotherapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	Cytokines ; Dietary Fats ; Drugs, Chinese Herbal ; Plant Extracts ; Protective Agents ; RNA, Messenger ; yin-chen-hao-tang
Language	English
Publishing date	2010-04-23
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm_00000412
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4942: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: [Effects of rice straw on the diversity of nitrifying genes (amoA and hao) in paddy soil].

Chen, Chun-Lan / Chen, Zhe / Zhu, Yi-Jun / Wu, Min-Na / Qin, Hong-Ling / Wei, Wen-Xue

Huan jing ke xue= Huanjing kexue

2010 Volume 31, Issue 6, Page(s) 1624–1632

Abstract: ... ammonia-oxidizing gene (amoA) and hydroxylamine-oxidizing gene (hao) in paddy soil were evaluated using ... hao in SR treatment was lower than that in CK, and LUBSHUFF statistical analyses demonstrated ... while no Nitrosomonas species were detected. As to hao, the strains from Silicibacter and Methylococcus ...

Abstract	The effects of long-term (16 years) fertilization on the diversity and community structure of soil ammonia-oxidizing gene (amoA) and hydroxylamine-oxidizing gene (hao) in paddy soil were evaluated using the methods of polymerase chain reaction, cloning and sequencing. The soil samples were collected from the treatments of NPK (CK) and NPK plus rice straw (SR) of the long-term field fertilization experiment in Taoyuan Agro-ecological Experimental Station. The Shannon Indices showed that the diversity of amoA and hao in SR treatment was lower than that in CK, and LUBSHUFF statistical analyses demonstrated that the sequence compositions of both amoA and huo libraries were significantly different between CK and SR. The phylogenetic trees indicated that some clusters appeared in SR treatment but were not detected in CK treatment. As to amoA, only Nitrosospira besides the uncultured amoA sequences were cloned from the two treatments, while no Nitrosomonas species were detected. As to hao, the strains from Silicibacter and Methylococcus were dominant in CK, while in SR the strains from Nitrosospira and Nitrosomonas were dominant. Sum up, the long-term rice straw application has caused a remarkable impact on the diversity and community structure on Nitrosobacteria.
MeSH term(s)	Fertilizers ; Genes, Bacterial/genetics ; Genetic Variation ; Nitrosomonas/classification ; Nitrosomonas/genetics ; Nitrosomonas/growth & development ; Oryza/growth & development ; Phylogeny ; Plant Stems/chemistry ; Refuse Disposal/methods ; Soil Microbiology ; Time Factors
Chemical Substances	Fertilizers
Language	Chinese
Publishing date	2010-06
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0250-3301
ISSN	0250-3301
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Changes of hepatic proteome in bile duct ligated rats with hepatic fibrosis following treatment with Yin-Chen-Hao-Tang.

Lee, Tzung-Yan / Chang, Hen-Hong / Kuo, Jong-Jen / Shen, Jiann-Jong

International journal of molecular medicine

2009 Volume 23, Issue 4, Page(s) 477–484

Abstract: Yin-Chen-Hao-Tang (YCHT) is recognized as a hepatoprotective agent for various types ...

Abstract	Yin-Chen-Hao-Tang (YCHT) is recognized as a hepatoprotective agent for various types of liver diseases. Proteomics approaches were used to study hepatic and serum protein expression changes in bile duct ligated (BDL) rats following YCHT treatment for 27 days. Two-dimensional gel electrophoresis was used to analyze proteome changes. Of the proteins that exhibited changes, 17 were identified by means of matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF) mass spectrometry. The major effect of YCHT was evident in cytoskeleton related protein, plectin-1. In addition, proteins involved in metabolism of lipids were also shown to be affected, including low-density lipoprotein receptor-related protein 2 precursor (glycoprotein 330) and apolipoprotein A-I precursor (ApoA-I). Significant up-regulation of keratin 8 and 19 was found in liver tissue of BDL rats. Supplementation with YCHT also triggered alterations in the above proteins. Interestingly, YCHT treatment caused a statistically significant down-regulation in the secretion of monocyte chemoattractant protein-1 (MCP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in BDL rats with fibrosis. Our results suggested that YCHT may be useful for treatment of liver fibrosis because of its possible antiapoptotic properties, and the therapeutic effects of YCHT on liver diseases might be associated with its lipid biosynthesis regulation.
MeSH term(s)	Animals ; Artemisia/chemistry ; Bile Ducts/surgery ; Blood Proteins/analysis ; Drug Combinations ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Electrophoresis, Gel, Two-Dimensional ; Gardenia/chemistry ; Gene Expression/drug effects ; Ligation/adverse effects ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis/blood ; Liver Cirrhosis/etiology ; Liver Cirrhosis/prevention & control ; Matrix Metalloproteinase 2/genetics ; Proteome/analysis ; Proteomics/methods ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; Rheum/chemistry ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Tissue Inhibitor of Metalloproteinase-1/genetics ; Tissue Inhibitor of Metalloproteinase-2/genetics
Chemical Substances	Blood Proteins ; Drug Combinations ; Drugs, Chinese Herbal ; Proteome ; RNA, Messenger ; Tissue Inhibitor of Metalloproteinase-1 ; yin-chen-hao-tang ; Tissue Inhibitor of Metalloproteinase-2 (127497-59-0) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2009-03-12
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1444428-8
ISSN	1107-3756
ISSN	1107-3756
DOI	10.3892/ijmm_00000154
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4942: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Antiapoptotic mechanisms of Chinese medicine formula, Guan-Xin-Er-Hao, in the rat ischemic heart.

Zhao, Hong-Wei / Qin, Feng / Liu, Yi-Xia / Huang, Xi / Ren, Ping

The Tohoku journal of experimental medicine

2008 Volume 216, Issue 4, Page(s) 309–316

Abstract: ... We have previously shown that Guan-Xin-Er-Hao (GXEH), a Chinese medicine formula, attenuates postischemia ...

Abstract	Considerable evidence indicates that apoptosis plays a critical role in acute myocardial infarction. We have previously shown that Guan-Xin-Er-Hao (GXEH), a Chinese medicine formula, attenuates postischemia myocardial apoptosis. The present study was designed to determine the mechanisms by which GXEH exerts its antiapoptotic effect. Adult male Sprague-Dawley rats were randomized to receive vehicle or GXEH (5 or 15 g/kg) orally 30 min before ischemia and subjected to myocardial ischemia of 3 h (apoptosis peak) or 24 h (necrosis peak) for determination of infarct size. Compared with rats receiving vehicle, those rats treated with GXEH (15 g/kg) showed significantly reduced infarct size, the reduced myocardial apoptosis, as judged by the decreases in TUNEL-positive staining (22.40 +/- 5.68% vs. 40.31 +/- 10.58%, p < 0.01), and the decrease in the degree of caspase-3 activation (82.97 +/- 10.54 vs. 159.95 +/- 9.16 mumol cleaved acetyl-Asp-Glu-Val-Asp-p-nitroanilide/mg protein, p < 0.01). Treatment with GXEH (15 g/kg) significantly reduced the release of mitochondrial cytochrome c, a primary mediator of apoptosis, the degree of caspase-9 activation, and the Bax/Bcl-2 ratio. Caspase-9 cleaves and activates caspase-3. Bax promotes apoptosis, while Bcl-2 inhibits apoptosis. Thus, the antiapoptotic mechanisms of GXEH may involve the mitochondrial cytochrome c-mediated caspase-3 activation in cardiomyocytes after acute myocardial infarction. Taken together, GXEH tilted the balance between Bax and Bcl-2 toward an antiapoptotic state, decreased mitochondrial cytochrome c release, reduced caspase-9 activation, and attenuated subsequent caspase-3 activation and postischemic myocardial apoptosis in rats. GXEH may be used as a promising agent for future treatment of cardiovascular diseases.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase 9/metabolism ; Cell Death/drug effects ; Cytochromes c/metabolism ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Enzyme Activation/drug effects ; Male ; Medicine, Chinese Traditional ; Mitochondria, Heart/drug effects ; Mitochondria, Heart/metabolism ; Myocardial Infarction/drug therapy ; Myocardial Infarction/pathology ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/pathology ; Myocardial Ischemia/prevention & control ; Random Allocation ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Drugs, Chinese Herbal ; guan xin II ; Cytochromes c (9007-43-6) ; Casp9 protein, rat (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-)
Language	English
Publishing date	2008-10-31
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123477-8
ISSN	1349-3329 ; 0040-8727
ISSN (online)	1349-3329
ISSN	0040-8727
DOI	10.1620/tjem.216.309
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.155: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Herb medicine Yin-Chen-Hao-Tang ameliorates hepatic fibrosis in bile duct ligation rats.

Lee, Tzung-Yan / Chang, Hen-Hong / Chen, Jenn-Han / Hsueh, Ming-Lung / Kuo, Jong-Jen

Journal of ethnopharmacology

2007 Volume 109, Issue 2, Page(s) 318–324

Abstract: ... in the induction of hepatic injury. Yin-Chen-Hao-Tang (YCHT) decoction is an aqueous extract from three different ...

Abstract	The accumulation of hydrophilic bile acids in the liver is considered to play a pivotal role in the induction of hepatic injury. Yin-Chen-Hao-Tang (YCHT) decoction is an aqueous extract from three different herbs: Artemisia capillaries Thunb (Compositae), Gardenia jasminoides Ellis (Rubiaceae), Rheum officinale Baill (Polygonaceae), which has been recognized as a hepatoprotective agent for various types of liver diseases. Therefore, we used an experimental of biliary atresia model to test that YCHT plays a regulatory role in the pathogenesis of hepatic fibrosis. Hepatic damage with fibrosis was produced by common bile duct ligation (BDL) for 27 days in experimental cholestasis animal model. After surgery, YCHT (250 and 500mg/kg BW) oral administration once a day continued for 27 days. BDL caused a prominent liver collagen deposition that was supported by the increased alpha-SMA protein and mRNA expression of procollagen I. YCHT significantly decreased hepatic alpha-SMA protein levels and decreased in hydroxyproline and thiobarbituric acid reactive substances (TBARS) levels of BDL rats. On the other hand, the normalizing effect of YCHT (250mg/kg) on the TGF-beta1mRNA expression was independent on the dose of YCHT, 500mg/kg was not effectively changed the quantitative composition of mRNA levels. The study shows that hepatic hydroxyproline accumulation caused by hydrophilic bile acids accompanied by elevated hepatic lipid peroxidation, and hepatic collagen levels can be decreased in the presence of YCHT. In conclusion, long-term administration of YCHT in rats ameliorated the hydropholic bile acids induced hepatic injury that probably related to a reduced oxidant stress and degree of hepatic fibrosis.
MeSH term(s)	Actins/drug effects ; Actins/metabolism ; Animals ; Asteraceae/chemistry ; Bile Ducts/surgery ; Body Weight/drug effects ; Collagen Type I/drug effects ; Collagen Type I/metabolism ; Drugs, Chinese Herbal/pharmacology ; Gardenia/chemistry ; Hydroxyproline/metabolism ; Ligation ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/etiology ; Liver Cirrhosis/pathology ; Male ; Medicine, Chinese Traditional ; Organ Size/drug effects ; Oxidative Stress/drug effects ; Phytotherapy/methods ; Plant Extracts/pharmacology ; Rats ; Rats, Sprague-Dawley ; Rheum/chemistry ; Thiobarbituric Acid Reactive Substances/metabolism ; Transaminases/blood ; Transaminases/drug effects ; Transforming Growth Factor beta1/drug effects ; Transforming Growth Factor beta1/metabolism
Chemical Substances	Actins ; Collagen Type I ; Drugs, Chinese Herbal ; Plant Extracts ; Thiobarbituric Acid Reactive Substances ; Transforming Growth Factor beta1 ; smooth muscle actin, rat ; Transaminases (EC 2.6.1.-) ; Hydroxyproline (RMB44WO89X)
Language	English
Publishing date	2007-01-19
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2006.07.042
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1494: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito