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  1. Book: NERVOUS SYSTEM AND HYPERTENSION. EDITED BY PHILIPPE MEYER, HENRI SCHMITT

    Meyer, Philippe

    (PERSPECTIVES IN NEPHROLOGY AND HYPERTENSION)

    1979  

    Title variant NERVOUS SYSTEM AND HYPERTENSION
    Series title PERSPECTIVES IN NEPHROLOGY AND HYPERTENSION
    Keywords HYPERTENSION / CONGRESSES ; NEUROTRANSMITTERS / CONGRESSES ; NEUROPHYSIOLOGY / CONGRESSES
    Size 14,383 S.
    Publisher FLAMMARION MEDECINE-SCIENCES
    Publishing place PARIS
    Document type Book
    Note 'PAPERS PRESENTED AT THE WORKSHOP ON NERVOUS SYSTEM AND HYPERTENSION, HELD IN PARIS ON JUNE 8-9, 1978 ...' - P.375
    HBZ-ID HT002805922
    ISBN 0-471-04718-X ; 978-0-471-04718-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1980 A 1293 order for loan Magazin
    1980 A 1293A order for loan Magazin

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  2. Article ; Online: Reply to Jérôme Verine, Christophe Leboeuf and Philippe Ratajczak's letter to the editor re: Jimsgene Sanjmyatav, Sven Hauke, Mieczyslaw Gajda, et al. Establishment of a multicolour fluorescence in situ hybridisation-based assay for subtyping of renal cell tumours. Eur Urol 2013;64:689-91.

    Sanjmyatav, Jimsgene / Hartmann, Arndt / Moch, Holger / Hauke, Sven / Gajda, Mieczyslaw / Meyer, Britta / Pryalukhin, Alexey / Grimm, Marc-Oliver / Junker, Kerstin

    European urology

    2014  Volume 65, Issue 5, Page(s) e71–2

    MeSH term(s) Adenoma, Oxyphilic/genetics ; Biomarkers, Tumor/genetics ; Carcinoma, Papillary/genetics ; Carcinoma, Renal Cell/genetics ; Genetic Testing/methods ; Humans ; In Situ Hybridization, Fluorescence ; Kidney Neoplasms/genetics
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2014-05
    Publishing country Switzerland
    Document type Comment ; Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2013.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  3. Article: PHILIPPE BELLOCQ 1888-1962.

    MEYER, P

    Strasbourg medical

    1963  Volume 14, Page(s) 1001–1003

    Title translation PHILIPPE BELLOCQ 1888-1962.
    MeSH term(s) History, 19th Century ; History, 20th Century ; Humans
    Language French
    Publishing date 1963-12
    Publishing country France
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 205171-0
    ISSN 0491-1377
    ISSN 0491-1377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Erlebte Geschichte - Möglichkeiten ihrer Darstellung am Beispiel der Memoiren von Philippe de Commynes

    Meyer, Wolfgang J

    ein Beitrag zum Thema "Die Historie und ihr Diskurs"

    1977  

    Author's details Wolfgang J. Meyer
    Keywords Geschichtsschreibung ; Geschichtsdarstellung ; Erzählung ; Autobiographie
    Language German
    Size 244 S
    Publisher Fink
    Publishing place München
    Document type Book
    Note Zugl.: @Konstanz, Univ., Diss., 1973
    ISBN 3770514513 ; 9783770514519
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article: [No title information]

    Meyer, Philippe

    Revue medicale suisse

    2019  Volume 15, Issue 666, Page(s) 1832

    Title translation Insuffisance cardiaque : approche médicamenteuse.
    MeSH term(s) Heart Failure/drug therapy ; Humans
    Language French
    Publishing date 2019-10-10
    Publishing country Switzerland
    Document type News
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5998: Show issues Location:
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  6. Article ; Online: Germinal centers are permissive to subdominant antibody responses.

    Robert, Philippe A / Arulraj, Theinmozhi / Meyer-Hermann, Michael

    Frontiers in immunology

    2024  Volume 14, Page(s) 1238046

    Abstract: Introduction: A protective humoral response to pathogens requires the development of high affinity antibodies in germinal centers (GC). The combination of antigens available during immunization has a strong impact on the strength and breadth of the ... ...

    Abstract Introduction: A protective humoral response to pathogens requires the development of high affinity antibodies in germinal centers (GC). The combination of antigens available during immunization has a strong impact on the strength and breadth of the antibody response. Antigens can display various levels of immunogenicity, and a hierarchy of immunodominance arises when the GC response to an antigen dampens the response to other antigens. Immunodominance is a challenge for the development of vaccines to mutating viruses, and for the development of broadly neutralizing antibodies. The extent by which antigens with different levels of immunogenicity compete for the induction of high affinity antibodies and therefore contribute to immunodominance is not known.
    Methods: Here, we perform
    Results: We found that GC dynamics were driven by the most immunogenic domain and immunodominance arose as affinity maturation to less immunogenic domain was inhibited. However, this inhibition was moderate since the less immunogenic domain exhibited a weak GC response in the absence of the most immunogenic domain. Less immunogenic domains reduced the dominance of GC responses to more immunogenic domains, albeit at a later time point.
    Discussion: The simulations suggest that increased vaccine valency may decrease immunodominance of the GC response to strongly immunogenic domains and therefore, act as a potential strategy for the natural induction of broadly neutralizing antibodies in GC reactions.
    MeSH term(s) Antibody Formation ; Broadly Neutralizing Antibodies ; Germinal Center ; Immunization ; Antigens
    Chemical Substances Broadly Neutralizing Antibodies ; Antigens
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1238046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Cross-Neutralization between Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2 after Vaccination with a BVDV-1a Modified-Live-Vaccine.

    Grange, Geromine / Mindeguia, Marie / Gisbert, Philippe / Meyer, Gilles

    Vaccines

    2023  Volume 11, Issue 7

    Abstract: Control of Bovine Viral Diarrhea Virus types 1 and 2 (BVDV-1 and BVDV-2) involves removing persistently infected animals from the herd, ensuring the biosecurity level of the farms and vaccination for the prevention of fetal infection. Given pestiviruses ... ...

    Abstract Control of Bovine Viral Diarrhea Virus types 1 and 2 (BVDV-1 and BVDV-2) involves removing persistently infected animals from the herd, ensuring the biosecurity level of the farms and vaccination for the prevention of fetal infection. Given pestiviruses high genetic and antigenic diversities, one challenge for a BVDV vaccine is to provide the broadest possible heterologous protection against most genotypes and sub-genotypes. The Modified-Live Mucosiffa
    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11071204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Image Processing Pitfalls in Vendor Adaptive Radiotherapy Software with Tomotherapy-like Systems: Feedback from Clinical Case Reports.

    Niederst, Claudine / Dehaynin, Nicolas / Lallement, Alex / Meyer, Philippe

    Current medical imaging

    2023  Volume 19, Issue 10, Page(s) 1156–1166

    Abstract: Background: Adaptive radiotherapy (ART) has the potential to reduce the toxicities of radiotherapy and improve overall survival by considering variations in the patient's anatomy during the course of treatment. ART's first commercial solutions are now ... ...

    Abstract Background: Adaptive radiotherapy (ART) has the potential to reduce the toxicities of radiotherapy and improve overall survival by considering variations in the patient's anatomy during the course of treatment. ART's first commercial solutions are now implemented in clinical radiotherapy departments. However, before they can be used safely with real patients, these solutions must be rigorously evaluated to precisely determine the limits of their use.
    Methods: In this paper, we evaluated an offline ART vendor system in 50 patients treated on tomotherapy- like systems for six months. Illustrated by numerous examples of head and neck, thoracic and abdominopelvic localizations, two limitations of image processing used in the ART workflow have been highlighted: deformable image registration (DIR) accuracy and the way the limited field of view (FOV) is compensated. This feedback from clinical experience makes it possible to identify topics of image processing research with strong clinical interest.
    Results: Current DIR method accuracy may be too weak for some clinical ART applications, and their improvement remains highly important, especially for multimodality registration. Improvements in contour propagation methods also remain crucial today. We showed that there is a need for the development of automatic DIR accuracy quantification methods to help streamline the ART process. Finally, the limited FOV of the onboard images may induce dose calculation errors, highlighting the need to develop new FOV extension methods.
    Conclusion: We have evaluated a vendor ART system, but some image processing pitfalls, such as DIR accuracy and the limited FOV of the onboard images, make its implementation into clinical practice difficult for the moment.
    MeSH term(s) Humans ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/radiotherapy ; Feedback ; Radiotherapy Planning, Computer-Assisted/methods ; Algorithms ; Software
    Language English
    Publishing date 2023-01-11
    Publishing country United Arab Emirates
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1573-4056
    ISSN (online) 1573-4056
    DOI 10.2174/1573405619666230111114244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Detecting and quantifying spatial misalignment between longitudinal kilovoltage computed tomography (kVCT) scans of the head and neck by using convolutional neural networks (CNNs).

    Lallement, Alex / Noblet, Vincent / Antoni, Delphine / Meyer, Philippe

    Technology and health care : official journal of the European Society for Engineering and Medicine

    2023  Volume 31, Issue 4, Page(s) 1253–1266

    Abstract: Background: Adaptive radiotherapy (ART) aims to address anatomical modifications appearing during the treatment of patients by modifying the planning treatment according to the daily positioning image. Clinical implementation of ART relies on the ... ...

    Abstract Background: Adaptive radiotherapy (ART) aims to address anatomical modifications appearing during the treatment of patients by modifying the planning treatment according to the daily positioning image. Clinical implementation of ART relies on the quality of the deformable image registration (DIR) algorithms included in the ART workflow. To translate ART into clinical practice, automatic DIR assessment is needed.
    Objective: This article aims to estimate spatial misalignment between two head and neck kilovoltage computed tomography (kVCT) images by using two convolutional neural networks (CNNs).
    Methods: The first CNN quantifies misalignments between 0 mm and 15 mm and the second CNN detects and classifies misalignments into two classes (poor alignment and good alignment). Both networks take pairs of patches of 33x33x33 mm3 as inputs and use only the image intensity information. The training dataset was built by deforming kVCT images with basis splines (B-splines) to simulate DIR error maps. The test dataset was built using 2500 landmarks, consisting of hard and soft landmark tissues annotated by 6 clinicians at 10 locations.
    Results: The quantification CNN reaches a mean error of 1.26 mm (± 1.75 mm) on the landmark set which, depending on the location, has annotation errors between 1 mm and 2 mm. The errors obtained for the quantification network fit the computed interoperator error. The classification network achieves an overall accuracy of 79.32%, and although the classification network overdetects poor alignments, it performs well (i.e., it achieves a rate of 90.4%) in detecting poor alignments when given one.
    Conclusion: The performances of the networks indicate the feasibility of using CNNs for an agnostic and generic approach to misalignment quantification and detection.
    MeSH term(s) Humans ; Algorithms ; Head ; Image Processing, Computer-Assisted/methods ; Neural Networks, Computer ; Radiotherapy Planning, Computer-Assisted ; Tomography, X-Ray Computed ; Deep Learning
    Language English
    Publishing date 2023-02-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1159961-3
    ISSN 1878-7401 ; 0928-7329
    ISSN (online) 1878-7401
    ISSN 0928-7329
    DOI 10.3233/THC-220519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3846: Show issues Location:
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  10. Article ; Online: Surgical valve replacement in a case of idiopathic dilated cardiomyopathy with massive left atrial dilatation and secondary mitral regurgitation.

    Noble, Stephane / Mauler-Wittwer, Sarah / Meyer, Philippe / Giannakopoulos, Georgios

    Cardiology journal

    2023  Volume 30, Issue 2, Page(s) 333–334

    MeSH term(s) Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/etiology ; Cardiomyopathy, Dilated/complications ; Cardiomyopathy, Dilated/diagnosis ; Cardiomyopathy, Dilated/surgery ; Atrial Fibrillation/complications ; Dilatation ; Surgical Instruments
    Language English
    Publishing date 2023-05-03
    Publishing country Poland
    Document type Case Reports ; Journal Article
    ZDB-ID 2488680-4
    ISSN 1898-018X ; 1897-5593
    ISSN (online) 1898-018X
    ISSN 1897-5593
    DOI 10.5603/CJ.2023.0023
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