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Article: N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.

Schuff, Norbert / Meyerhoff, Dieter J / Mueller, Susanne / Chao, Linda / Sacrey, Diana Truran / Laxer, Kenneth / Weiner, Michael W

Advances in experimental medicine and biology

2006 Volume 576, Page(s) 241–62; discussion 361–3

MeSH term(s)	Aging/physiology ; Alcoholism/metabolism ; Alcoholism/pathology ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Biomarkers/metabolism ; Brain/metabolism ; Brain/pathology ; Brain Injuries/metabolism ; Brain Injuries/pathology ; Choline/metabolism ; Cocaine/metabolism ; Creatine/metabolism ; Epilepsy/metabolism ; Ethanol/metabolism ; HIV Infections/metabolism ; HIV Infections/pathology ; Humans ; Magnetic Resonance Imaging ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neurons/pathology ; Stress Disorders, Post-Traumatic/metabolism ; Stress Disorders, Post-Traumatic/pathology
Chemical Substances	Biomarkers ; Aspartic Acid (30KYC7MIAI) ; Ethanol (3K9958V90M) ; N-acetylaspartate (997-55-7) ; Cocaine (I5Y540LHVR) ; Creatine (MU72812GK0) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2006-06-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	410187-X
ISSN	0065-2598
ISSN	0065-2598
DOI	10.1007/0-387-30172-0_17
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Article: Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder.

Schuff, Norbert / Neylan, Thomas C / Fox-Bosetti, Sabrina / Lenoci, Maryanne / Samuelson, Kristin W / Studholme, Colin / Kornak, John / Marmar, Charles R / Weiner, Michael W

Psychiatry research

2008 Volume 162, Issue 2, Page(s) 147–157

Abstract: ... PTSD patients with (n=28) and without (n=27) alcohol abuse and subjects negative for PTSD with (n=23 ... and without (n=26) alcohol abuse, were enrolled in this observational MRI and MRSI study of structural ... and metabolic brain abnormalities in PTSD. PTSD was associated with reduced N-acetylaspartate (NAA ...

Abstract	Magnetic resonance spectroscopic imaging (MRSI) studies suggest hippocampal abnormalities in posttraumatic stress disorder (PTSD), whereas findings of volume deficits in the hippocampus, as revealed with magnetic resonance imaging (MRI), have been inconsistent. Co-morbidities of PTSD, notably alcohol abuse, may have contributed to the inconsistency. The objective was to determine whether volumetric and metabolic abnormalities in the hippocampus and other brain regions are present in PTSD, independent of alcohol abuse. Four groups of subjects, PTSD patients with (n=28) and without (n=27) alcohol abuse and subjects negative for PTSD with (n=23) and without (n=26) alcohol abuse, were enrolled in this observational MRI and MRSI study of structural and metabolic brain abnormalities in PTSD. PTSD was associated with reduced N-acetylaspartate (NAA) in both the left and right hippocampus, though only when normalized to creatine levels in the absence of significant hippocampal volume reduction. Furthermore, PTSD was associated with reduced NAA in the right anterior cingulate cortex regardless of creatine. NAA appears to be a more sensitive marker for neuronal abnormality in PTSD than brain volume. The alteration in the anterior cingulate cortex in PTSD has implications for fear conditioning and extinction.
MeSH term(s)	Adult ; Alcoholism/pathology ; Alcoholism/physiopathology ; Algorithms ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Atrophy ; Combat Disorders/diagnosis ; Combat Disorders/physiopathology ; Comorbidity ; Conditioning, Classical/physiology ; Creatine/metabolism ; Depressive Disorder, Major/pathology ; Depressive Disorder, Major/physiopathology ; Dominance, Cerebral/physiology ; Energy Metabolism/physiology ; Extinction, Psychological/physiology ; Fear/physiology ; Female ; Frontal Lobe/pathology ; Frontal Lobe/physiopathology ; Gyrus Cinguli/physiopathology ; Hippocampus/pathology ; Hippocampus/physiopathology ; Humans ; Image Processing, Computer-Assisted ; Life Change Events ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Neurons/pathology ; Neurons/physiology ; Software ; Stress Disorders, Post-Traumatic/diagnosis ; Stress Disorders, Post-Traumatic/physiopathology ; Veterans
Chemical Substances	Aspartic Acid (30KYC7MIAI) ; N-acetylaspartate (997-55-7) ; Creatine (MU72812GK0)
Language	English
Publishing date	2008-01-16
Publishing country	Ireland
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0165-1781 ; 0925-4927
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0165-1781 ; 0925-4927
DOI	10.1016/j.pscychresns.2007.04.011
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Article ; Online: Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients.

Chao, L L / Schuff, N / Kramer, J H / Du, A T / Capizzano, A A / O'Neill, J / Wolkowitz, O M / Jagust, W J / Chui, H C / Miller, B L / Yaffe, K / Weiner, M W

Neurology

2005 Volume 64, Issue 2, Page(s) 282–289

Abstract: Background: N-acetylaspartate (NAA) in the medial temporal lobe (MTL) and parietal lobe gray ... significantly with impaired memory performance.: Conclusion: Reduced medial temporal lobe N-acetylaspartate ...

Abstract	Background: N-acetylaspartate (NAA) in the medial temporal lobe (MTL) and parietal lobe gray matter (GM) is diminished in Alzheimer disease (AD). Because NAA is considered a marker of neuronal integrity, reduced medial temporal and parietal lobe NAA could be an early indication of dementia-related pathology in elderly individuals. Objectives: 1) To determine whether cognitively impaired but nondemented (CIND) elderly individuals exhibit a similar pattern of reduced medial temporal and parietal lobe NAA as AD patients. 2) To compare regional NAA patterns, hippocampal and neocortical gray matter (GM) volumes in CIND patients who remained cognitively stable and those who became demented over 3.6 years of follow-up. 3) To examine the relationship between memory performance, medial temporal lobe NAA, and hippocampal volume. Methods: Seventeen CIND, 24 AD, and 24 cognitively normal subjects were studied using MRSI and MRI. Results: Relative to controls, CIND patients had reduced MTL NAA (19 to 21%, p = 0.005), hippocampal (11 to 14%, p < or = 0.04), and neocortical GM (5%, p = 0.05) volumes. CIND patients who later became demented had less MTL NAA (26%, p = 0.01), hippocampal (17 to 23%, p < or = 0.05), and neocortical GM (13%, p = 0.02) volumes than controls, but there were no significant differences between stable CIND patients and controls. MTL NAA in combination with hippocampal volume improved discrimination of CIND and controls over hippocampal volume alone. In AD and CIND patients, decreased MTL NAA correlated significantly with impaired memory performance. Conclusion: Reduced medial temporal lobe N-acetylaspartate, together with reduced hippocampal and neocortical gray matter volumes, may be early indications of dementia-related pathology in subjects at high risk for developing dementia.
MeSH term(s)	Aged ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/analysis ; Atrophy ; Cognition Disorders/metabolism ; Cognition Disorders/pathology ; Dementia/epidemiology ; Female ; Hippocampus/chemistry ; Hippocampus/pathology ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Parietal Lobe/metabolism ; Parietal Lobe/pathology ; Risk Factors ; Temporal Lobe/chemistry ; Temporal Lobe/pathology
Chemical Substances	Aspartic Acid (30KYC7MIAI) ; N-acetylaspartate (997-55-7)
Language	English
Publishing date	2005-01-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/01.WNL.0000149638.45635.FF
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Article: Cortisol levels are positively correlated with hippocampal N-acetylaspartate.

Neylan, Thomas C / Schuff, Norbert / Lenoci, Maryanne / Yehuda, Rachel / Weiner, Michael W / Marmar, Charles R

Biological psychiatry

2003 Volume 54, Issue 10, Page(s) 1118–1121

Abstract: ... hippocampal N-acetylaspartate (NAA) in posttraumatic stress disorder (PTSD) patients and control subjects ... cortisol levels (n = 22, r =.53, p =.013) and post-dexamethasone cortisol levels (n = 22, r =.63, p =.002 ...

Abstract	Background: This study examined the relationship of hypothalamic-pituitary-adrenal measures and hippocampal N-acetylaspartate (NAA) in posttraumatic stress disorder (PTSD) patients and control subjects. Methods: Eleven patients with combat-related PTSD and 11 control subjects were evaluated with magnetic resonance spectroscopy as well as by morning salivary cortisol samples before and after administration of low-dose dexamethasone (.5 mg). Results: Left hippocampal NAA was strongly associated with both pre-dexamethasone cortisol levels (n = 22, r =.53, p =.013) and post-dexamethasone cortisol levels (n = 22, r =.63, p =.002). After accounting for clinical symptom severity and hippocampal volume, cortisol levels accounted for 21.9% of the variance (F = 5.6, p =.004) in left hippocampal NAA and 12.6% of the variance (F = 3.2, p =.035) in right hippocampal NAA. Conclusions: This study shows a positive relationship between cortisol levels and hippocampal NAA in subjects without hypercortisolemia. Within the range of values seen in our subjects, cortisol may have a trophic effect on the hippocampus.
MeSH term(s)	Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Case-Control Studies ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Dexamethasone/administration & dosage ; Glucocorticoids/administration & dosage ; Hippocampus/drug effects ; Hippocampus/metabolism ; Humans ; Hydrocortisone/metabolism ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy/methods ; Male ; Middle Aged ; Radioimmunoassay/methods ; Regression Analysis ; Saliva/metabolism ; Statistics as Topic ; Stress Disorders, Post-Traumatic/metabolism ; Veterans
Chemical Substances	Glucocorticoids ; Aspartic Acid (30KYC7MIAI) ; Dexamethasone (7S5I7G3JQL) ; N-acetylaspartate (997-55-7) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2003-11-15
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
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Article: Reduced concentrations of thalamic N-acetylaspartate in male patients with schizophrenia.

Deicken, R F / Johnson, C / Eliaz, Y / Schuff, N

The American journal of psychiatry

2000 Volume 157, Issue 4, Page(s) 644–647

Abstract: Objective: The authors measured N-acetylaspartate (a putative neuronal marker) in the right and ... with schizophrenia and 10 male comparison subjects. Concentrations of N-acetylaspartate, creatine, and choline were ... significantly lower concentrations of N-acetylaspartate than the comparison subjects in both the right and left ...

Abstract	Objective: The authors measured N-acetylaspartate (a putative neuronal marker) in the right and left thalamus of 17 male patients with schizophrenia using in vivo proton magnetic resonance spectroscopic imaging ((1)H MRSI). Method: (1)H MRSI was performed on 17 medicated male patients with schizophrenia and 10 male comparison subjects. Concentrations of N-acetylaspartate, creatine, and choline were determined in the thalamic regions bilaterally. Results: The patients with schizophrenia demonstrated significantly lower concentrations of N-acetylaspartate than the comparison subjects in both the right and left thalamic regions. Right thalamic N-acetylaspartate and left thalamic N-acetylaspartate were significantly correlated in the patients but not in the comparison subjects. There was no association between N-acetylaspartate and duration of illness or medication dose. No group differences or lateralized asymmetries in choline or creatine were noted. Conclusions: The finding of reduced concentrations of N-acetylaspartate bilaterally suggests neuronal dysfunction and/or loss in both the right and left thalamic regions in male patients with schizophrenia.
MeSH term(s)	Adult ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/analysis ; Cell Count ; Choline/analysis ; Creatine/analysis ; Functional Laterality ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Neurons/cytology ; Schizophrenia/diagnosis ; Schizophrenia/drug therapy ; Schizophrenia/metabolism ; Sex Factors ; Thalamus/chemistry ; Thalamus/cytology ; Thalamus/metabolism
Chemical Substances	Aspartic Acid (30KYC7MIAI) ; N-acetylaspartate (997-55-7) ; Creatine (MU72812GK0) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2000-04
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	280045-7
ISSN	1535-7228 ; 0002-953X
ISSN (online)	1535-7228
ISSN	0002-953X
DOI	10.1176/appi.ajp.157.4.644
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Article: Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder.

Deicken, R F / Eliaz, Y / Feiwell, R / Schuff, N

Psychiatry research

2000 Volume 106, Issue 1, Page(s) 35–45

Abstract: N-Acetylaspartate (NAA) in the anterior and mediodorsal thalamic regions was measured using proton ...

Abstract	N-Acetylaspartate (NAA) in the anterior and mediodorsal thalamic regions was measured using proton magnetic resonance spectroscopic imaging (1H-MRSI) in 15 euthymic male patients with familial bipolar I disorder and compared to values in 15 male control subjects to determine if there was evidence for altered neuronal/axonal integrity. MRI tissue segmentation methods were also utilized to obtain tissue-contribution estimates for each MRSI voxel. Relative to the comparison group, the patients with bipolar I disorder demonstrated significantly higher NAA and creatine in both the right and left thalamus. NAA was also significantly higher in the left thalamus compared to the right in both bipolar I patients and controls. There were no group or lateralized differences in the percentages of different tissue types within the MRSI voxels, suggesting that the thalamic NAA and creatine alterations were not an artifact of variations in tissue type percentages in the MRSI voxels. There was also no significant association between NAA or creatine and illness duration. The findings of increased thalamic NAA bilaterally may represent neuronal hypertrophy or hyperplasia, reduced glial cell density, or abnormal synaptic and dendritic pruning. Increased thalamic creatine bilaterally may represent altered cellular energy metabolism and is consistent with prior studies demonstrating changes in thalamic metabolism in mood disorders.
MeSH term(s)	Adult ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Bipolar Disorder/genetics ; Bipolar Disorder/metabolism ; Choline/metabolism ; Creatine/metabolism ; Humans ; Hypertrophy/pathology ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Neuroglia/pathology ; Thalamus/metabolism ; Thalamus/pathology
Chemical Substances	Aspartic Acid (30KYC7MIAI) ; N-acetylaspartate (997-55-7) ; Creatine (MU72812GK0) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2000-12-14
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0165-1781 ; 0925-4927
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0165-1781 ; 0925-4927
DOI	10.1016/s0925-4927(00)00083-4
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Article: Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder.

Schuff, N / Neylan, T C / Lenoci, M A / Du, A T / Weiss, D S / Marmar, C R / Weiner, M W

Biological psychiatry

2001 Volume 50, Issue 12, Page(s) 952–959

Abstract: ... atrophy and posttraumatic stress disorder in the absence of alcohol abuse, and 2) to test if loss of N ... to volume, N-acetylaspartate was significantly reduced by about 23% bilaterally in the hippocampus ... in the right hippocampus of posttraumatic stress disorder.: Conclusions: N-acetyl asparate and creatine ...

Abstract	Background: Previous magnetic resonance imaging studies of posttraumatic stress disorder reported hippocampal volume loss. The goals of this study were 1) to determine the relationship between hippocampal atrophy and posttraumatic stress disorder in the absence of alcohol abuse, and 2) to test if loss of N-acetylaspartate (a neuron marker) in the hippocampus of posttraumatic stress disorder occurs separate from atrophy. In addition, volume changes in the entorhinal cortex were also explored. Methods: Eighteen male patients with combat-related posttraumatic stress disorder (mean age 51.2 +/- 2.5 years) and 19 male control subjects (mean age 51.8 +/- 3.2 years) were studied using magnetic resonance imaging and Proton magnetic resonance spectroscopic imaging. Both groups had no alcohol and drug abuse during the past 5 years. Results: Posttraumatic stress disorder and control subjects had similar volumes of hippocampus and entorhinal cortex. In contrast to volume, N-acetylaspartate was significantly reduced by about 23% bilaterally in the hippocampus of posttraumatic stress disorder when compared with control subjects, and creatine-containing compounds were reduced by 26% in the right hippocampus of posttraumatic stress disorder. Conclusions: N-acetyl asparate and creatine reductions imply that there are hippocampal abnormalities in posttraumatic stress disorder. Furthermore, these metabolite changes seem to be better indicators of posttraumatic stress disorder pathology than volume losses.
MeSH term(s)	Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Atrophy ; Brain/metabolism ; Case-Control Studies ; Creatine/metabolism ; Hippocampus/metabolism ; Hippocampus/pathology ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Severity of Illness Index ; Stress Disorders, Post-Traumatic/metabolism ; Stress Disorders, Post-Traumatic/pathology
Chemical Substances	Aspartic Acid (30KYC7MIAI) ; N-acetylaspartate (997-55-7) ; Creatine (MU72812GK0)
Language	English
Publishing date	2001-12-15
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/s0006-3223(01)01245-8
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Article: Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD.

Schuff, N / Capizzano, A A / Du, A T / Amend, D L / O'Neill, J / Norman, D / Kramer, J / Jagust, W / Miller, B / Wolkowitz, O M / Yaffe, K / Weiner, M W

Neurology

2002 Volume 58, Issue 6, Page(s) 928–935

Abstract: ... to distinguish between AD and age-related brain tissue loss. MRS imaging (MRSI) measures the neuronal marker N ...

Abstract	Background: Both AD and normal aging cause brain atrophy, limiting the ability of MRI to distinguish between AD and age-related brain tissue loss. MRS imaging (MRSI) measures the neuronal marker N-acetylaspartate (NAA), which could help assess brain change in AD and aging. Objectives: To determine the effects of AD on concentrations of NAA, and choline- and creatine-containing compounds in different brain regions and to assess the extent NAA in combination with volume measurements by MRI improves discrimination between AD patients and cognitively normal subjects. Methods: Fifty-six patients with AD (mean age: 75.6 +/- 8.0 years) and 54 cognitively normal subjects (mean age: 74.3 +/- 8.1 years) were studied using MRSI and MRI. Results: NAA concentration was less in patients with AD compared with healthy subjects by 21% (p < 0.0001) in the medial temporal lobe and by 13% to 18% (p < 0.003) in parietal lobe gray matter (GM), but was not changed significantly in white matter and frontal lobe GM. In addition to lower NAA, AD patients had 29% smaller hippocampi and 11% less cortical GM than healthy subjects. Classification of AD and healthy subjects increased significantly from 89% accuracy using hippocampal volume alone to 95% accuracy using hippocampal volume and NAA together. Conclusion: In addition to brain atrophy, NAA reductions occur in regions that are predominantly impacted by AD pathology.
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Analysis of Variance ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Atrophy ; Female ; Humans ; Magnetic Resonance Spectroscopy/methods ; Magnetic Resonance Spectroscopy/statistics & numerical data ; Male ; Middle Aged ; Parietal Lobe/metabolism ; Parietal Lobe/pathology ; Temporal Lobe/metabolism ; Temporal Lobe/pathology
Chemical Substances	Aspartic Acid (30KYC7MIAI) ; N-acetylaspartate (997-55-7)
Language	English
Publishing date	2002-01-30
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/wnl.58.6.928
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Book ; Online ; Thesis: Isolierung und Charakterisierung von Forkhead-Transkriptionsfaktoren der Subklasse N in Xenopus laevis

Schuff, Maximilian François [Verfasser]

2007

Author's details	vorgelegt von Maximilian François Schuff
Keywords	Biowissenschaften, Biologie ; Life Science, Biology
Subject code	sg570
Language	German
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Decreased N-acetylaspartate in motor cortex and corticospinal tract in ALS.

Rooney, W D / Miller, R G / Gelinas, D / Schuff, N / Maudsley, A A / Weiner, M W

Neurology

1998 Volume 50, Issue 6, Page(s) 1800–1805

Abstract: The primary objectives of this study were to test whether 1) N-acetylaspartate (NAA), a neuronal ...

Abstract	The primary objectives of this study were to test whether 1) N-acetylaspartate (NAA), a neuronal marker, is reduced in motor cortex and corticospinal-tract (CST) brain regions of ALS patients; and 2) motor cortex NAA correlates to a clinical measurement of upper motor neuron function in ALS patients. Ten probable or definite ALS patients and nine neurologically normal control subjects were studied. Three axial planes of two-dimensional 1H MRSI data were collected, using a single spin-echo multislice sequence (TE140/TR2000). Two of the 1H MRSI planes were positioned superior to the lateral ventricles, and one plane was positioned at the level of the internal capsule. Spectroscopy voxels were selected from motor cortex, frontal cortex, parietal cortex, medial gray matter, centrum semiovale white matter, anterior internal capsule, and posterior internal capsule. Peak integrals were obtained for the three major 1H MRSI singlet resonances, NAA, creatine and phosphocreatine (Cr), and cholines (Cho). Maximum finger-tap rate was used as a clinical measurement of upper motor neuron function. In ALS, brain NAA/(Cho+Cr) was reduced 19% (p=0.024) in the motor cortex and 16% (p=0.021) in the CST (centrum semiovale and posterior internal capsule) regions. NAA/ (Cho+Cr) was not reduced in frontal cortex, parietal cortex, medial gray matter, or anterior internal capsule. There was a significant relation between ALS motor cortex NAA/(Cho+Cr) and maximum finger-tap rate (r=0.80; p=0.014). NAA/(Cho+Cr) was reduced in motor cortex and CST regions and unchanged in other brain regions of ALS patients when compared with controls. These findings are consistent with the known distribution of neuronal loss in ALS. The positive correlation between motor cortex NAA/(Cho+Cr) and maximum finger-tap rate suggests that reduced NAA/(Cho+Cr) is a surrogate marker of motor cortex neuron loss in ALS. These findings support the study of 1H MRSI NAA measurement as an objective and quantitative measurement of upper motor neuron dysfunction in ALS.
MeSH term(s)	Adult ; Aged ; Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/metabolism ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Female ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Motor Cortex/metabolism ; Pyramidal Tracts/metabolism ; Reference Values ; Tissue Distribution
Chemical Substances	Aspartic Acid (30KYC7MIAI) ; N-acetylaspartate (997-55-7)
Language	English
Publishing date	1998-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/wnl.50.6.1800
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