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  1. Article ; Online: Pseudoleukocoria.

    Kawashima, Yuri / Adachi, Akihiko

    Pediatrics international : official journal of the Japan Pediatric Society

    2023  Volume 65, Issue 1, Page(s) e15600

    Language English
    Publishing date 2023-07-28
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15600
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    Zs.A 848: Show issues Location:
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  2. Article ; Online: Black hairy tongue due to antibiotics.

    Okumura, Hisatoshi / Kawashima, Atsushi

    BMJ case reports

    2023  Volume 16, Issue 7

    MeSH term(s) Humans ; Anti-Bacterial Agents/adverse effects ; Tongue, Hairy/chemically induced ; Tongue ; Tongue Diseases
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-255112
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  3. Article ; Online: Needs-based triggers for timely referral to palliative care for older adults severely affected by noncancer conditions: a systematic review and narrative synthesis.

    Kawashima, Arisa / Evans, Catherine J

    BMC palliative care

    2023  Volume 22, Issue 1, Page(s) 20

    Abstract: Background: Older people with noncancer conditions are less likely to be referred to palliative care services due to the inherent uncertain disease trajectory and a lack of standardised referral criteria. For older adults with noncancer conditions where ...

    Abstract Background: Older people with noncancer conditions are less likely to be referred to palliative care services due to the inherent uncertain disease trajectory and a lack of standardised referral criteria. For older adults with noncancer conditions where prognostic estimation is unpredictable, needs-based criteria are likely more suitable. Eligibility criteria for participation in clinical trials on palliative care could inform a needs-based criteria. This review aimed to identify and synthesise eligibility criteria for trials in palliative care to construct a needs-based set of triggers for timely referral to palliative care for older adults severely affected by noncancer conditions.
    Methods: A systematic narrative review of published trials of palliative care service level interventions for older adults with noncancer conditions. Electronic databases Medline, Embase, CINAHL, PsycINFO, CENTRAL, and ClinicalTrials.gov. were searched from inception to June 2022. We included all types of randomised controlled trials. We selected trials that reported eligibility criteria for palliative care involvement for older adults with noncancer conditions, where > 50% of the population was aged ≥ 65 years. The methodological quality of the included studies was assessed using a revised Cochrane risk-of-bias tool for randomized trials. Descriptive analysis and narrative synthesis provided descriptions of the patterns and appraised the applicability of included trial eligibility criteria to identify patients likely to benefit from receiving palliative care.
    Results: 27 randomised controlled trials met eligibility out of 9,584 papers. We identified six major domains of trial eligibility criteria in three categories, needs-based, time-based and medical history-based criteria. Needs-based criteria were composed of symptoms, functional status, and quality of life criteria. The major trial eligibility criteria were diagnostic criteria (n = 26, 96%), followed by medical history-based criteria (n = 15, 56%), and physical and psychological symptom criteria (n = 14, 52%).
    Conclusion: For older adults severely affected by noncancer conditions, decisions about providing palliative care should be based on the present needs related to symptoms, functional status, and quality of life. Further research is needed to examine how the needs-based triggers can be operationalized as referral criteria in clinical settings and develop international consensus on referral criteria for older adults with noncancer conditions.
    MeSH term(s) Humans ; Aged ; Palliative Care ; Quality of Life ; Hospice and Palliative Care Nursing ; Uncertainty
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 2091556-1
    ISSN 1472-684X ; 1472-684X
    ISSN (online) 1472-684X
    ISSN 1472-684X
    DOI 10.1186/s12904-023-01131-6
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  4. Article ; Online: Approaches to Alpha-Gal Syndrome in Japan.

    Okumura, Hisatoshi / Inaba, Satoshi / Kawashima, Atsushi

    Annals of emergency medicine

    2024  Volume 83, Issue 4, Page(s) 419

    MeSH term(s) Humans ; Japan/epidemiology ; Food Hypersensitivity
    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Letter
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2023.10.018
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    Zs.A 1344: Show issues Location:
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  5. Article ; Online: Contributions of Non-Neuronal Cholinergic Systems to the Regulation of Immune Cell Function, Highlighting the Role of α7 Nicotinic Acetylcholine Receptors.

    Kawashima, Koichiro / Mashimo, Masato / Nomura, Atsuo / Fujii, Takeshi

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Loewi's discovery of acetylcholine (ACh) release from the frog vagus nerve and the discovery by Dale and Dudley of ACh in ox spleen led to the demonstration of chemical transmission of nerve impulses. ACh is now well-known to function as a ... ...

    Abstract Loewi's discovery of acetylcholine (ACh) release from the frog vagus nerve and the discovery by Dale and Dudley of ACh in ox spleen led to the demonstration of chemical transmission of nerve impulses. ACh is now well-known to function as a neurotransmitter. However, advances in the techniques for ACh detection have led to its discovery in many lifeforms lacking a nervous system, including eubacteria, archaea, fungi, and plants. Notably, mRNAs encoding choline acetyltransferase and muscarinic and nicotinic ACh receptors (nAChRs) have been found in uninnervated mammalian cells, including immune cells, keratinocytes, vascular endothelial cells, cardiac myocytes, respiratory, and digestive epithelial cells. It thus appears that non-neuronal cholinergic systems are expressed in a variety of mammalian cells, and that ACh should now be recognized not only as a neurotransmitter, but also as a local regulator of non-neuronal cholinergic systems. Here, we discuss the role of non-neuronal cholinergic systems, with a focus on immune cells. A current focus of much research on non-neuronal cholinergic systems in immune cells is α7 nAChRs, as these receptors expressed on macrophages and T cells are involved in regulating inflammatory and immune responses. This makes α7 nAChRs an attractive potential therapeutic target.
    MeSH term(s) alpha7 Nicotinic Acetylcholine Receptor/metabolism ; Animals ; Humans ; Non-Neuronal Cholinergic System ; Acetylcholine/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Macrophages/metabolism ; Macrophages/immunology
    Chemical Substances alpha7 Nicotinic Acetylcholine Receptor ; Acetylcholine (N9YNS0M02X)
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084564
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  6. Article ; Online: Nigrospora oryzae causing human corneal keratitis: A case report.

    Takayama, Takuya / Inoda, Satoru / Watanabe, Akira / Kawashima, Hidetoshi

    American journal of ophthalmology case reports

    2024  Volume 34, Page(s) 102062

    Abstract: Purpose: We report a rare case of microbial keratitis caused by : Observations: A 72-year-old Japanese woman was injured by plant debris and developed oval corneal ulcers and hypopyon in the anterior chamber. After 5 days, she complained of pain, ... ...

    Abstract Purpose: We report a rare case of microbial keratitis caused by
    Observations: A 72-year-old Japanese woman was injured by plant debris and developed oval corneal ulcers and hypopyon in the anterior chamber. After 5 days, she complained of pain, redness, and vision loss in her left eye and was treated with antibacterial eye drops and an ointment (1.5 % levofloxacin hydrate, cefmenoxime hydrochloride, and sterilization and disinfection eye drops; SAN-IODE and ofloxacin ophthalmic ointment). Examination revealed a worsening oval corneal ulcer with Descemet's folds and a faint hypopyon. Considering the infection from soil or plants and the poor response to intensive antibacterial eye drops, topical antifungal eye drops, i.e., 1 % voriconazole eye drops, and 1 % natamycin ointment were applied. Direct microscopy of the corneal scraping with Gram staining was performed and the result was negative. Cultures from corneal scrapings showed the growth of dark colonies after several days. The colony was identified as
    Conclusions and importance: Here, we report a case of fungal keratitis caused by
    Language English
    Publishing date 2024-04-14
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2024.102062
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  7. Article ; Online: Live Cell Synthetic Histone Acetylation by Chemical Catalyst.

    Kawashima, Shigehiro A / Kanai, Motomu

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2519, Page(s) 155–161

    Abstract: Posttranslational modifications (PTMs) of histones, such as lysine acetylation and ubiquitination, regulate chromatin structure and gene expression. In living organisms, histone PTMs are catalyzed by histone-modifying enzymes. Here, we describe an ... ...

    Abstract Posttranslational modifications (PTMs) of histones, such as lysine acetylation and ubiquitination, regulate chromatin structure and gene expression. In living organisms, histone PTMs are catalyzed by histone-modifying enzymes. Here, we describe an entirely chemical method to introduce histone modifications in living cells without genetic manipulation. The chemical catalyst PEG-LANA-DSSMe activates a thioester acetyl donor, N,S-diacetylcysteamine (NAC-Ac), and promotes regioselective, synthetic histone acetylation at H2BK120 in living cells.
    MeSH term(s) Acetylation ; Catalysis ; Histones/metabolism ; Lysine/metabolism ; Protein Processing, Post-Translational
    Chemical Substances Histones ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2433-3_17
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  8. Article ; Online: Improved monitor view of a new AceScope™ video laryngoscope.

    Kobayashi, Atsushi / Kinoshita, Hiroyuki / Ohashi, Masahiko / Kawashima, Shingo / Kimura, Tetsuro

    Minerva anestesiologica

    2024  

    Language English
    Publishing date 2024-01-25
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.23.17881-3
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    Zs.A 516: Show issues Location:
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    Zs.MO 192: Show issues

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  9. Article ; Online: An indwelling Teflon vascular catheter used for modified intercostal nerve neurolysis under combination of fluoroscopy and ultrasound guidance.

    Kimura, Tetsuro / Kobayashi, Atsushi / Anezaki, Hiroki / Kawashima, Shingo / Kinoshita, Hiroyuki

    Minerva anestesiologica

    2024  

    Language English
    Publishing date 2024-02-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.24.17936-9
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    Zs.MO 192: Show issues

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  10. Article ; Online: Idiopathic Mesenteric Phlebosclerosis Secondary to Chinese Herbal Medicine Intake in an Older Adult.

    Kawashima, Akira / Shimomura, Akira / Inagaki, Takeshi

    The American journal of tropical medicine and hygiene

    2023  Volume 109, Issue 4, Page(s) 715–716

    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.22-0772
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