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Article ; Online: ACP Journal Club. Review: computed tomography angiography is highly accurate for diagnosing significant stenosis in peripheral arterial disease.

Niinuma, Hiroyuki

2009 Volume 150, Issue 10, Page(s) JC5–12

Language	English
Publishing date	2009-05-19
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/0003-4819-150-10-200905190-02012
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Ua VI Zs.178/2: Show issues

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Article ; Online: Coronary artery disease grading by cardiac CT for predicting outcome in patients with stable angina.

Oeing, Christian U / Matheson, Matthew B / Ostovaneh, Mohammad R / Rochitte, Carlos E / Chen, Marcus Y / Pieske, Burkert / Kofoed, Klaus F / Schuijf, Joanne D / Niinuma, Hiroyuki / Dewey, Marc / di Carli, Marcelo F / Cox, Christopher / Lima, João A C / Arbab-Zadeh, Armin

Journal of cardiovascular computed tomography

2023 Volume 17, Issue 5, Page(s) 310–317

Abstract: Background: The coronary atheroma burden drives major adverse cardiovascular events (MACE) in patients with suspected coronary heart disease (CHD). However, a consensus on how to grade disease burden for effective risk stratification is lacking. The ... ...

Abstract	Background: The coronary atheroma burden drives major adverse cardiovascular events (MACE) in patients with suspected coronary heart disease (CHD). However, a consensus on how to grade disease burden for effective risk stratification is lacking. The purpose of this study was to compare the effectiveness of common CHD grading tools to risk stratify symptomatic patients. Methods: We analyzed the 5-year outcome of 381 prospectively enrolled patients in the CORE320 international, multicenter study using baseline clinical and cardiac computer-tomography (CT) imaging characteristics, including coronary artery calcium score (CACS), percent atheroma volume, "high-risk" plaque, disease severity grading using the CAD-RADS, and two simplified CAD staging systems. We applied Cox proportional hazard models and area under the curve (AUC) analysis to predict MACE or hard MACE, defined as death, myocardial infarction, or stroke. Analyses were stratified by a history of CHD. Additional forward selection analysis was performed to evaluate incremental value of metrics. Results: Clinical characteristics were the strongest predictors of MACE in the overall cohort. In patients without history of CHD, CACS remained the only independent predictor of MACE yielding an AUC of 73 (CI 67-79) vs. 64 (CI 57-70) for clinical characteristics. Noncalcified plaque volume did not add prognostic value. Simple CHD grading schemes yielded similar risk stratification as the CAD-RADS classification. Forward selection analysis confirmed prominent role of CACS and revealed usefulness of functional testing in subgroup with known CHD. Conclusion: In patients referred for invasive angiography, a history of CHD was the strongest predictor of MACE. In patients without history of CHD, a coronary calcium score yielded at least equal risk stratification vs. more complex CHD grading.
MeSH term(s)	Humans ; Angina, Stable/diagnostic imaging ; Angina, Stable/therapy ; Calcium ; Computed Tomography Angiography/methods ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Multidetector Computed Tomography ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Prognosis ; Risk Assessment ; Risk Factors
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2023.07.004
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Zs.A 6761: Show issues

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Article: Pulmonary thromboembolism and deep vein thrombosis in beta-thalassemia minor.

Tanigawa, Tomoyuki / Yamazoe, Masahiro / Koyamada, Ryosuke / Niinuma, Hiroyuki / Nishi, Yutaro / Higuchi, Takakazu / Okada, Sadamu

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

2017 Volume 104, Issue 11, Page(s) 2400–2404

MeSH term(s)	Humans ; Pulmonary Embolism/complications ; Venous Thrombosis/complications ; beta-Thalassemia/complications
Language	Japanese
Publishing date	2017-04-25
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	952816-7
ISSN	1883-2083 ; 0021-5384
ISSN (online)	1883-2083
ISSN	0021-5384
DOI	10.2169/naika.104.2400
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Zs.B 594: Show issues

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Article ; Online: Quantification of coronary atherosclerosis with coronary computed tomography: impact on clinical risk assessment?

Schoenhagen, Paul / Niinuma, Hiroyuki

Journal of cardiovascular computed tomography

2009 Volume 3, Issue 6, Page(s) 383–385

MeSH term(s)	Algorithms ; Calcinosis/diagnostic imaging ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Humans ; Imaging, Three-Dimensional ; Predictive Value of Tests ; Prognosis ; Radiographic Image Interpretation, Computer-Assisted ; Risk Assessment ; Severity of Illness Index ; Software ; Tomography, X-Ray Computed
Language	English
Publishing date	2009-11
Publishing country	United States
Document type	Editorial
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2009.09.005
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Zs.A 6761: Show issues

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Article ; Online: Changes in left ventricular twist after mitral valve repair.

Kazui, Toshinobu / Niinuma, Hiroyuki / Tsuboi, Junichi / Okabayashi, Hitoshi

The Journal of thoracic and cardiovascular surgery

2011 Volume 141, Issue 3, Page(s) 716–724

Abstract: Objective: We performed echocardiographic tissue tracking to investigate whether mitral valve repair preserves left ventricular function.: Methods: We studied 16 subjects without heart disease (11 male; mean age, 54.6 ± 15.1 years) and 18 patients in ...

Abstract	Objective: We performed echocardiographic tissue tracking to investigate whether mitral valve repair preserves left ventricular function. Methods: We studied 16 subjects without heart disease (11 male; mean age, 54.6 ± 15.1 years) and 18 patients in normal sinus rhythm undergoing solitary mitral valve repair (12 male; mean age, 53.6 ± 16.6 years). Transthoracic echocardiography was performed before and after surgery, and left ventricular apical and basal short-axis images were recorded. Left ventricular rotation angle was measured with off-line Vector Velocity Imaging (Siemens Medical Solutions USA Inc, Mountain View, Calif) at each slice level. Results: Left ventricular ejection fraction was significantly higher in the control (68.4% ± 3.6%) and preoperative groups (70.9% ± 6.5%) than the postoperative group (59.4% ± 11.4%, P < .05). Left ventricular end-diastolic and end-systolic volumes were significantly greater in the preoperative group than the control group (130.0 ± 41.5 mL and 41.6 ± 16.6 mL vs 80.0 ± 16.7 mL and 26.6 ± 9.2 mL, respectively, P < .05). Left ventricular end-diastolic volume normalized postoperatively. Left ventricular twist was significantly greater in the preoperative group than the other groups (11.7° ± 4.1° versus 7.1° ± 3.8° and 8.2° ± 5.7°, P < .05). Left ventricular twist did not differ significantly between control and postoperative groups. New York Heart Association functional class improved from 1.6 ± 0.5 to 1.0 ± 0.0 after surgery (P < .05). Conclusions: Although preoperative left ventricular ejection fraction seemed normal, left ventricular twist was greater. Left ventricular twist normalized after surgery, suggesting that it preserves left ventricular function.
MeSH term(s)	Adult ; Aged ; Case-Control Studies ; Chronic Disease ; Female ; Humans ; Japan ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve/physiopathology ; Mitral Valve/surgery ; Mitral Valve Annuloplasty ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/surgery ; Severity of Illness Index ; Stroke Volume ; Torsion, Mechanical ; Treatment Outcome ; Ultrasonography ; Ventricular Function, Left
Language	English
Publishing date	2011-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2010.05.004
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Uk I Zs.104: Show issues

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Article: [Surgical treatment of ischemic mitral regurgitation].

Niinuma, Hiroyuki / Kawazoe, Kohei

Nihon Geka Gakkai zasshi

2006 Volume 107, Issue 1, Page(s) 21–26

Abstract: Ischemic mitral regurgitation (IMR) is a serious problem, which conveys adverse prognosis, doubling mortality after myocardial infarction. It is common and increases mortality even when mild. IMR is often associated with the occlusion of left circumflex ... ...

Abstract	Ischemic mitral regurgitation (IMR) is a serious problem, which conveys adverse prognosis, doubling mortality after myocardial infarction. It is common and increases mortality even when mild. IMR is often associated with the occlusion of left circumflex coronary artery, such as second or third obtuse marginal branches by experimental model. However, cause of IMR still remains unclear in many respects. Several study using echocardiography and magnetic resonance imaging show some probable reasons left ventricular structure and deformity of left ventricle may cause mitral leaflet restriction and mitral annulus deformity, lead to tethering. The aim of surgical treatment of IMR is to reduce the grade of mitral regurgitation and left ventricular remodeling. Recent study clarified the advantage of valve repair in IMR opposed to valve replacement that may affect the patient poor quality of life. Some new technique of saddle shaped ring repair, second chordal cutting, edge-to-edge repair are available but these long-term outcome remain unclear. It may be effective combined left ventricular revascularization and mitral valve repair. Understanding mechanism of IMR will improve therapies for targeted primary causes with new therapeutic options provided a more flexible approach for surgical repair of IMR.
MeSH term(s)	Cardiac Surgical Procedures ; Heart Ventricles/surgery ; Humans ; Mitral Valve/surgery ; Mitral Valve Insufficiency/etiology ; Mitral Valve Insufficiency/pathology ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/surgery ; Myocardial Infarction/complications ; Prognosis ; Severity of Illness Index ; Ventricular Remodeling/physiology
Language	Japanese
Publishing date	2006-01
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	412544-7
ISSN	1880-1129 ; 0301-4894
ISSN (online)	1880-1129
ISSN	0301-4894
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Zs.B 1737: Show issues

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Article ; Online: Carotid intima-media thickness is a useful screening tool to detect coronary artery plaque in type 2 diabetic patients with zero calcium score.

Inohara, Taku / Niinuma, Hiroyuki / Nishihara, Shuzo / Makita, Zenji / Sanoyama, Kyou / Niwa, Koichiro

International journal of cardiology

2014 Volume 172, Issue 1, Page(s) e132–4

MeSH term(s)	Aged ; Calcium ; Carotid Intima-Media Thickness ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/epidemiology ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2014
Publishing country	Netherlands
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2013.12.110
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Zs.A 1673: Show issues

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Article ; Online: Feeding artery of giant left atrial myxoma visualized on computed tomography.

Kin, Hajime / Koizumi, Junichi / Yoshioka, Kunihiro / Niinuma, Hiroyuki

Asian cardiovascular & thoracic annals

2007 Volume 15, Issue 6, Page(s) 541

MeSH term(s)	Arteries/pathology ; Cardiac Surgical Procedures ; Echocardiography, Transesophageal ; Female ; Heart Atria/diagnostic imaging ; Heart Neoplasms/blood supply ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/surgery ; Humans ; Middle Aged ; Myxoma/blood supply ; Myxoma/diagnostic imaging ; Myxoma/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2007-12
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1400468-9
ISSN	1816-5370 ; 0218-4923
ISSN (online)	1816-5370
ISSN	0218-4923
DOI	10.1177/021849230701500624
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Article: [Report from the 6th Tohoku Chapter Educational Seminar; a case of elevated serum IgA levels complicated with heart failure].

Miyazaki, Mariko / Niinuma, Hiroyuki / Fusazaki, Tetsuya / Satoh, Mamoru / Oikawa, Minako / Noji, Hideyoshi / Osawa, Hiroshi

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

2011 Volume 100, Issue 2, Page(s) 513–521

MeSH term(s)	Amyloidosis/complications ; Cardiomyopathies/complications ; Heart Failure/etiology ; Humans ; Immunoglobulin A/blood ; Male ; Middle Aged ; Multiple Myeloma/diagnosis
Chemical Substances	Immunoglobulin A
Language	Japanese
Publishing date	2011-02-22
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	952816-7
ISSN	1883-2083 ; 0021-5384
ISSN (online)	1883-2083
ISSN	0021-5384
DOI	10.2169/naika.100.513
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Zs.B 594: Show issues

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Article ; Online: Contemporary Discrepancies of Stenosis Assessment by Computed Tomography and Invasive Coronary Angiography.

Song, Young Bin / Arbab-Zadeh, Armin / Matheson, Matthew B / Ostovaneh, Mohammad R / Vavere, Andrea L / Dewey, Marc / Rochitte, Carlos / Niinuma, Hiroyuki / Laham, Roger / Schuijf, Joanne D / Cox, Christopher / Brinker, Jeffrey / di Carli, Marcelo / Lima, João A C / Miller, Julie M

Circulation. Cardiovascular imaging

2019 Volume 12, Issue 2, Page(s) e007720

Abstract: Background Ongoing advancements of coronary computed tomographic angiography (CTA) continue to challenge the role of invasive coronary angiography (ICA) as the gold standard for the evaluation of coronary artery disease (CAD). We sought to investigate ... ...

Abstract	Background Ongoing advancements of coronary computed tomographic angiography (CTA) continue to challenge the role of invasive coronary angiography (ICA) as the gold standard for the evaluation of coronary artery disease (CAD). We sought to investigate the diagnostic accuracy of 320-slice CTA for detecting obstructive CAD in reference to ICA and nuclear myocardial perfusion imaging using single-photon emission computed tomography. Methods For the CORE320 study (Coronary Artery Evaluation Using 320-Row Multidetector Computed Tomography Angiography and Myocardial Perfusion), 381 patients at 16 centers underwent CTA, nuclear myocardial perfusion imaging by single-photon emission computed tomography, and ICA for the evaluation of CAD. Imaging studies were analyzed in blinded core laboratories, and a stenosis of ≥50% by quantitative coronary angiography was considered obstructive, whereas a stress difference score of ≥1 indicated inducible myocardial ischemia. The area under the receiver operating characteristic curve was used to evaluate diagnostic accuracy. Results Of 381 patients, 229 (60%) had obstructive CAD by quantitative coronary angiography. Diagnostic accuracy of CTA on a per-patient analysis revealed an area under the receiver operating characteristic curve of 0.90 (95% CI, 0.87-0.93). Per-vessel and per-segment analysis revealed lower area under the receiver operating characteristic curve of 0.87 (0.84-0.90) and 0.81 (0.78-0.83), respectively. Median radiation dose was lower for CTA versus ICA: 3.16 (interquartile range, 2.82-3.59) versus 11.97 (interquartile range, 7.60-17.8) mSv ( P<0.001). Accuracy for identifying patients with inducible myocardial ischemia by SPECT-MPI was similar for CTA and ICA (area under the receiver operating characteristic curve, 0.68 versus 0.71 by quantitative coronary angiography and 0.68 by visual angiographic assessment; P>0.05). Furthermore, accuracy for identifying patients who subsequently underwent clinically driven coronary revascularization also was similar for CTA (0.76 [0.71-0.81]) and ICA (0.78 [0.74-0.83]; P=0.20). Conclusions Contemporary CTA accurately identifies patients with obstructive CAD by ICA at lower radiation exposure; however, agreement is lower in vessel- and segment-level analyses. Both CTA and ICA perform similarly for predicting clinically driven revascularization and for detecting myocardial ischemia by myocardial perfusion imaging using single-photon emission computed tomography, suggesting that limitations by both CTA and ICA contribute to variability of stenosis quantification. Clinical Trial Registration URL: https://www.clinicaltrials.gov . Unique identifier: NCT00934037.
MeSH term(s)	Aged ; Computed Tomography Angiography ; Coronary Angiography/methods ; Coronary Circulation ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography ; Myocardial Perfusion Imaging/methods ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results ; Severity of Illness Index ; Tomography, Emission-Computed, Single-Photon
Language	English
Publishing date	2019-02-15
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2435045-X
ISSN	1942-0080 ; 1941-9651
ISSN (online)	1942-0080
ISSN	1941-9651
DOI	10.1161/CIRCIMAGING.118.007720
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