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  1. Article ; Online: A roadmap for gut microbiome-derived aromatic amino acids for improved cardiovascular risk stratification.

    Stähli, Barbara E / Scharl, Michael / Matter, Christian M

    European heart journal

    2023  Volume 44, Issue 32, Page(s) 3097–3099

    MeSH term(s) Humans ; Risk Factors ; Cardiovascular Diseases/prevention & control ; Gastrointestinal Microbiome ; Amino Acids, Aromatic/metabolism ; Heart Disease Risk Factors ; Disease Progression
    Chemical Substances Amino Acids, Aromatic
    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad367
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  2. Article ; Online: Inflammation in acute myocardial infarction: the good, the bad and the ugly.

    Matter, Michael A / Paneni, Francesco / Libby, Peter / Frantz, Stefan / Stähli, Barbara E / Templin, Christian / Mengozzi, Alessandro / Wang, Yu-Jen / Kündig, Thomas M / Räber, Lorenz / Ruschitzka, Frank / Matter, Christian M

    European heart journal

    2023  Volume 45, Issue 2, Page(s) 89–103

    Abstract: Convergent experimental and clinical evidence have established the pathophysiological importance of pro-inflammatory pathways in coronary artery disease. Notably, the interest in treating inflammation in patients suffering acute myocardial infarction ( ... ...

    Abstract Convergent experimental and clinical evidence have established the pathophysiological importance of pro-inflammatory pathways in coronary artery disease. Notably, the interest in treating inflammation in patients suffering acute myocardial infarction (AMI) is now expanding from its chronic aspects to the acute setting. Few large outcome trials have proven the benefits of anti-inflammatory therapies on cardiovascular outcomes by targeting the residual inflammatory risk (RIR), i.e. the smouldering ember of low-grade inflammation persisting in the late phase after AMI. However, these studies have also taught us about potential risks of anti-inflammatory therapy after AMI, particularly related to impaired host defence. Recently, numerous smaller-scale trials have addressed the concept of targeting a deleterious flare of excessive inflammation in the early phase after AMI. Targeting different pathways and implementing various treatment regimens, those trials have met with varied degrees of success. Promising results have come from those studies intervening early on the interleukin-1 and -6 pathways. Taking lessons from such past research may inform an optimized approach to target post-AMI inflammation, tailored to spare 'The Good' (repair and defence) while treating 'The Bad' (smouldering RIR) and capturing 'The Ugly' (flaming early burst of excess inflammation in the acute phase). Key constituents of such a strategy may read as follows: select patients with large pro-inflammatory burden (i.e. large AMI); initiate treatment early (e.g. ≤12 h post-AMI); implement a precisely targeted anti-inflammatory agent; follow through with a tapering treatment regimen. This approach warrants testing in rigorous clinical trials.
    MeSH term(s) Humans ; Myocardial Infarction/therapy ; Inflammation/metabolism ; Coronary Artery Disease/drug therapy ; Anti-Inflammatory Agents/therapeutic use
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2023-08-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad486
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  3. Article ; Online: Is the amount of glow predicting the fire? Residual inflammatory risk after percutaneous coronary intervention.

    Candreva, Alessandro / Matter, Christian M

    European heart journal

    2018  Volume 43, Issue 7, Page(s) e10–e13

    Language English
    Publishing date 2018-11-16
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehy729
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  4. Article ; Online: Higher 1-year mortality on rest days in patients with acute coronary syndromes and decompensated heart failure-A SPUM-ACS sub-study.

    Matter, Michael A / Candreva, Alessandro / Stähli, Barbara E / Heg, Dik / Klingenberg, Roland / Räber, Lorenz / Windecker, Stephan / Rodondi, Nicolas / Nanchen, David / Mach, François / Gencer, Baris / Ruschitzka, Frank / Matter, Christian M / Templin, Christian

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2023  Volume 103, Issue 2, Page(s) 286–294

    Abstract: Background: Acute coronary syndromes (ACS) occurring on rest days have been associated with higher mortality, but the current literature remains inconsistent in this regard. This study included ACS patients presenting with acute decompensated heart ... ...

    Abstract Background: Acute coronary syndromes (ACS) occurring on rest days have been associated with higher mortality, but the current literature remains inconsistent in this regard. This study included ACS patients presenting with acute decompensated heart failure (ADHF) investigating the relationship between time of coronary catheterization and outcomes.
    Methods: Analyses were performed from the prospective, multicentric Special Program University Medicine Acute Coronary Syndromes and Inflammation (SPUM-ACS) Cohort. Patients were divided into two groups according to time of coronary catheterization on either workdays (Monday, 00:00 to Friday, 23:59) or rest days (Saturday, 00:00 to Sunday, 23:59 and public holidays). ADHF was defined by Killip Class III or IV upon presentation. Patients were followed over 1 year.
    Results: Out of 4787 ACS patients enrolled in the SPUM-ACS Cohort, 207 (4.3%) presented with ADHF. 52 (25.1%) and 155 (74.9%) patients underwent coronary angiography on rest days or workdays, respectively. Baseline characteristics were similar among these groups. ACS patients with ADHF showed increased 1-year mortality on rest days (34.6% vs. 17.4%, p-value = 0.009). After correction for baseline characteristics, including the GRACE 2.0 Score, rest day presentation remained a significant predictor for 1-year mortality (adjusted hazard ratio = 2.42 [95% confidence interval: 1.14-5.17], p-value = 0.022).
    Conclusions: One-year all-cause mortality was high in ACS patients with ADHF and doubled for patients admitted on rest days. The present data support the association of a rest day effect and long-term patient survival and indicate a need for further investigations.
    MeSH term(s) Humans ; Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/therapy ; Prospective Studies ; Treatment Outcome ; Heart Failure/diagnosis ; Heart Failure/therapy ; Proportional Hazards Models
    Language English
    Publishing date 2023-12-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.30938
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  5. Article: Modulating Sirtuin Biology and Nicotinamide Adenine Diphosphate Metabolism in Cardiovascular Disease-From Bench to Bedside.

    Wang, Yu-Jen / Paneni, Francesco / Stein, Sokrates / Matter, Christian M

    Frontiers in physiology

    2021  Volume 12, Page(s) 755060

    Abstract: Sirtuins (SIRT1-7) comprise a family of highly conserved deacetylases with distribution in different subcellular compartments. Sirtuins deacetylate target proteins depending on one common substrate, nicotinamide adenine diphosphate ( ... ...

    Abstract Sirtuins (SIRT1-7) comprise a family of highly conserved deacetylases with distribution in different subcellular compartments. Sirtuins deacetylate target proteins depending on one common substrate, nicotinamide adenine diphosphate (NAD
    Language English
    Publishing date 2021-10-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.755060
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  6. Article ; Online: Effect of Alirocumab on Carotid Inflammation by [

    Bang, Lia E / Jensen, Jacob Kildevang / Räber, Lorenz / Koskinas, Konstantinos C / Bär, Sarah / Losdat, Sylvain / Matter, Christian M / Lonborg, Jacob / Radu Juul Jensen, Maria D / Kjaer, Andreas / Engstrøm, Thomas / Ripa, Rasmus Sejersten

    JACC. Cardiovascular imaging

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Letter
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2024.04.001
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  7. Article: Ribociclib-induced liver injury: a case report.

    Schaeffer, Sofia / Lutz, Christian / Dobbie, Michael / Terracciano, Luigi M / Matter, Matthias / Vosbeck, Jürg / Heim, Markus H / Bernsmeier, Christine

    Frontiers in oncology

    2023  Volume 13, Page(s) 1256783

    Abstract: Background: Idiosyncratic drug-induced liver injury (DILI) is a rare, unpredictable hepatic adverse event and the most common cause of acute liver failure in Europe and the US. Ribociclib is a potent Cyclin-dependent kinase 4 and 6 (CDK4/6)-inhibitor ... ...

    Abstract Background: Idiosyncratic drug-induced liver injury (DILI) is a rare, unpredictable hepatic adverse event and the most common cause of acute liver failure in Europe and the US. Ribociclib is a potent Cyclin-dependent kinase 4 and 6 (CDK4/6)-inhibitor administered for advanced hormone-receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer. Previous reports have shown hepatotoxicity without liver necrosis related to ribociclib.
    Case presentation: A 41-year-old female patient with primary metastatic HR-positive, HER2-negative breast cancer developed liver enzyme elevation under treatment with ribociclib. Ribociclib was withdrawn 8 weeks after initiation due to liver enzyme elevation. A liver biopsy, performed due to further enzyme increase (peak ALT 2836 U/l), onset of jaundice (peak bilirubin 353 µmol/l) and coagulopathy (INR 1.8) two weeks later, revealed acute hepatitis with 30% parenchymal necrosis. Roussel Uclaf Causality Assessment Method (RUCAM) score was 7 points (probable). Under treatment with prednisone (60mg), initiated 2 weeks after drug withdrawal, and subsequently N-acetylcysteine (Prescott regimen) liver enzymes normalized within 8 weeks along with prednisone tapering.
    Conclusion: This case illustrates the development of a severe idiosyncratic hepatocellular pattern DILI grade 3 (International DILI Expert Working Group) induced by ribociclib. Routine liver enzyme testing during therapy, immediate hepatologic work-up and treatment interruption in case of liver enzyme elevation are highly recommended. Corticosteroid treatment should be considered in cases of severe necroinflammation.
    Language English
    Publishing date 2023-12-01
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1256783
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  8. Article ; Online: Protective role of the co-stimulator CD27 receptor and regulatory T cells in early atherogenesis.

    Stein, Sokrates / Matter, Christian M

    European heart journal

    2017  Volume 38, Issue 48, Page(s) 3600–3602

    MeSH term(s) Animals ; Atherosclerosis ; CD4-Positive T-Lymphocytes/immunology ; Lymphocyte Activation ; Mice ; T-Lymphocytes, Regulatory/immunology
    Language English
    Publishing date 2017-11-28
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehx630
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  9. Article ; Online: Value of troponin T versus I in the diagnosis of immune checkpoint inhibitor-related myocarditis and myositis: rechallenge?

    Rossi, Valentina A / Gawinecka, Joanna / Dimitriou, Florentia / von Eckardstein, Arnold / Dummer, Reinhard / Ruschitzka, Frank / Matter, Christian M

    ESC heart failure

    2023  Volume 10, Issue 4, Page(s) 2680–2685

    Abstract: A 54-year old patient with metastatic melanoma presented with asymptomatic myositis and myocarditis after combined immune checkpoint inhibitors (ICI) therapy (anti-programmed cell death receptor-1, anti-lymphocyte activating gene-3, and anti-indoleamine ... ...

    Abstract A 54-year old patient with metastatic melanoma presented with asymptomatic myositis and myocarditis after combined immune checkpoint inhibitors (ICI) therapy (anti-programmed cell death receptor-1, anti-lymphocyte activating gene-3, and anti-indoleamine 2,3-dioxygenase-1). The diagnosis was based on the typical time window after ICI, recurrence upon re-challenge, elevations of CK, high-sensitive troponin T (hs-TnT) and I (hs-TnI), mild NT-proBNP increase, and positive magnetic resonance imaging criteria. Notably, hsTnI was found to more rapidly increase and fall and to be more heart-specific than TnT in the context of ICI-related myocarditis. This led to ICI therapy withdrawal and switch to a less effective systemic therapy. This case report highlights the differential value of hs-TnT and hs-TnI for diagnosis and monitoring of ICI-related myositis and myocarditis.
    MeSH term(s) Humans ; Middle Aged ; Myocarditis/chemically induced ; Myocarditis/diagnosis ; Immune Checkpoint Inhibitors ; Troponin T ; Myositis/chemically induced ; Myositis/diagnosis ; Heart
    Chemical Substances Immune Checkpoint Inhibitors ; Troponin T
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14360
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  10. Article ; Online: CardioPulse: Translational research in cardiovascular disease.

    Stein, Sokrates / Matter, Christian M

    European heart journal

    2016  Volume 37, Issue 14, Page(s) 1091–1092

    MeSH term(s) Animals ; Biomarkers/analysis ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Cells, Cultured ; Disease Models, Animal ; Humans ; Mice ; Pluripotent Stem Cells ; Translational Research, Biomedical/methods
    Chemical Substances Biomarkers
    Language English
    Publishing date 2016-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
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