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  1. Article ; Online: NASCI case of the month: extensive ascending aortic graft infection with underlying chronic sternal osteomyelitis-a rare and high-risk complication.

    Wieseler, Carissa / Young, Phillip M

    The international journal of cardiovascular imaging

    2024  

    Abstract: Thoracic aortic graft infections are infrequent yet grave complications of cardiovascular surgery. Risk factors include prolonged operative time, postoperative wound infections, and patient-specific risk factors like diabetes or malnutrition (Van ... ...

    Abstract Thoracic aortic graft infections are infrequent yet grave complications of cardiovascular surgery. Risk factors include prolonged operative time, postoperative wound infections, and patient-specific risk factors like diabetes or malnutrition (Van Hemelrijck et al., Vessel Plus 6:47, 2022). In postoperative vascular scenarios, it is critical to utilize cross-sectional imaging to detect the presence of a complication, followed by describing the morphology, extent, and ancillary features. FDG-PET/CT can help differentiate between expected postoperative changes and worrisome infection by metabolic activity (FDG uptake). We present an extensive case of ascending aortic graft infection in the setting of ongoing sternal osteomyelitis. CT and PET/CT reveal chronic sternal osteomyelitic changes spreading into the retrosternal soft tissues, and a large intraluminal thrombus in the ascending aortic graft. Small mobile strands propagate toward the right brachiocephalic origin, posing a significant stroke risk. PET/CT confirmed postoperative infection by demonstrating increased FDG uptake.
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2055311-0
    ISSN 1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1875-8312 ; 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-024-03117-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2104: Show issues Location:
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  2. Article ; Online: Performing chest computed tomography on pediatric patients on extracorporeal membrane oxygenation (ECMO): a stepwise approach.

    Hull, Nathan C / Young, Phillip M / Thacker, Paul G

    Pediatric radiology

    2022  Volume 52, Issue 10, Page(s) 1877–1887

    Abstract: Chest CT in pediatric patients on extracorporeal membrane oxygenation (ECMO) can be done safely and provide valuable high-quality diagnostic images to help guide patient management. An understanding of the basics of the ECMO circuit, cannula locations, ... ...

    Abstract Chest CT in pediatric patients on extracorporeal membrane oxygenation (ECMO) can be done safely and provide valuable high-quality diagnostic images to help guide patient management. An understanding of the basics of the ECMO circuit, cannula locations, where and how to inject contrast media, and how to time image acquisition is vital for the radiologist. Additionally, understanding the precautions associated with performing these exams is essential to ensure the safety of the child. This article provides a brief review of pediatric ECMO and its challenges and considerations, as well as a stepwise approach to perform and optimize these exams safely.
    MeSH term(s) Child ; Contrast Media ; Extracorporeal Membrane Oxygenation ; Humans ; Tomography, X-Ray Computed/methods
    Chemical Substances Contrast Media
    Language English
    Publishing date 2022-04-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-022-05336-4
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    Zs.A 927: Show issues Location:
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  3. Article ; Online: CT Fractional Flow Reserve: A Practical Guide to Application, Interpretation, and Problem Solving.

    Rajiah, Prabhakar / Cummings, Kristopher W / Williamson, Eric / Young, Phillip M

    Radiographics : a review publication of the Radiological Society of North America, Inc

    2022  Volume 42, Issue 2, Page(s) 340–358

    Abstract: CT fractional flow reserve ( ... ...

    Abstract CT fractional flow reserve (FFR
    MeSH term(s) Computed Tomography Angiography/methods ; Coronary Angiography/methods ; Coronary Artery Disease ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/therapy ; Fractional Flow Reserve, Myocardial/physiology ; Humans ; Predictive Value of Tests ; Problem Solving ; Severity of Illness Index ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603172-9
    ISSN 1527-1323 ; 0271-5333
    ISSN (online) 1527-1323
    ISSN 0271-5333
    DOI 10.1148/rg.210097
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    Zs.A 1751: Show issues Location:
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  4. Article ; Online: Selective Glycan Labeling of Mannose-Containing Glycolipids in Mycobacteria.

    Lee, So Young / Marando, Victoria M / Smelyansky, Stephanie R / Kim, Daria E / Calabretta, Phillip J / Warner, Theodore C / Bryson, Bryan D / Kiessling, Laura L

    Journal of the American Chemical Society

    2023  Volume 146, Issue 1, Page(s) 377–385

    Abstract: Mycobacterium ... ...

    Abstract Mycobacterium tuberculosis
    MeSH term(s) Humans ; Glycolipids/chemistry ; Mannose/metabolism ; Lipopolysaccharides/metabolism ; Polysaccharides/chemistry ; Mycobacterium tuberculosis/metabolism
    Chemical Substances Glycolipids ; Mannose (PHA4727WTP) ; Lipopolysaccharides ; Polysaccharides
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c09495
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  5. Article ; Online: Shining a LAMP on the applications of isothermal amplification for monitoring environmental biosecurity

    Nathan Deliveyne / Jennifer M. Young / Jeremy J. Austin / Phillip Cassey

    NeoBiota, Vol 82, Iss , Pp 119-

    2023  Volume 144

    Abstract: Environmental biosecurity risks associated with the transnational wildlife trade include the loss of biodiversity, threats to public health, and the proliferation of invasive alien species. To assist enforcement agencies in identifying species either ... ...

    Abstract Environmental biosecurity risks associated with the transnational wildlife trade include the loss of biodiversity, threats to public health, and the proliferation of invasive alien species. To assist enforcement agencies in identifying species either intentionally (trafficked) or unintentionally (stowaway) entrained in the trade-chain pathway, rapid forensic techniques are needed to enable their detection from DNA samples when physical identification is not possible. Loop Mediated Isothermal Amplification (LAMP) is an emerging technique, with recent applications in biosecurity and forensic sciences, which has potential to function as a field-based detection tool. Here we provide an overview of current research that applies LAMP to environmental biosecurity, including identification of ornamental wildlife parts, consumer products, and invasive species monitoring and biosecurity detection. We discuss the current scope of LAMP as applied to various wildlife trade scenarios and biosecurity checkpoint monitoring, highlight the specificity, sensitivity, and robustness for these applications, and review the potential utility of LAMP for rapid field-based detection at biosecurity checkpoints. Based on our assessment of the literature we recommend broader interest, research uptake, and investment in LAMP as an appropriate field-based species detection method for a wide range of environmental biosecurity scenarios.
    Keywords Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Pensoft Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Lumbopelvic fixation in the treatment of spinopelvic dissociation: union, complications, and neurologic outcomes of a multicenter case series.

    Moo Young, Justin P / Savakus, Jonathan C / Obey, Mitchel R / Morris, Cade A / Pereira, Daniel E / Hills, Jeffrey M / McKane, Ava / Babcock, Sharon N / Miller, Anna N / Mitchell, Phillip M / Stephens, Byron F

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

    2024  

    Abstract: Purpose: To review outcomes of spinopelvic dissociation treated with open lumbopelvic fixation.: Methods: We reviewed all cases of spinopelvic dissociation treated at three Level-I trauma centers with open lumbopelvic fixation, including those with ... ...

    Abstract Purpose: To review outcomes of spinopelvic dissociation treated with open lumbopelvic fixation.
    Methods: We reviewed all cases of spinopelvic dissociation treated at three Level-I trauma centers with open lumbopelvic fixation, including those with adjunctive percutaneous fixation. We collected demographic data, associated injuries, pre- and postoperative neurologic status, pre- and postoperative kyphosis, and Roy-Camille classification. Outcomes included presence of union, reoperation rates, and complications involving hardware or wound.
    Results: From an initial cohort of 260 patients with spinopelvic dissociation, forty patients fulfilled inclusion criteria with a median follow-up of 351 days. Ten patients (25%) had a combination of percutaneous iliosacral and open lumbopelvic repair. Average pre- and postoperative kyphosis was 30 degrees and 26 degrees, respectively. Twenty patients (50%) had neurologic deficit preoperatively, and eight (20%) were unknown or unable to be assessed. All patients presenting with bowel or bladder dysfunction (n = 12) underwent laminectomy at time of surgery, with 3 patients (25%) having continued dysfunction at final follow-up. Surgical site infection occurred in four cases (10%) and wound complications in two (5%). All cases (100%) went on to union and five patients (13%) required hardware removal.
    Conclusion: Open lumbopelvic fixation resulted in a high union rate in the treatment of spinopelvic dissociation. Approximately 1 in 6 patients had a wound complication, the majority of which were surgical site infections. Bowel and bladder dysfunction at presentation were common with the majority of cases resolving by final follow-up when spinopelvic dissociation had been treated with decompression and stable fixation.
    Language English
    Publishing date 2024-04-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 1231084-0
    ISSN 1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
    ISSN (online) 1432-1068
    ISSN 1633-8065 ; 0948-4817 ; 0940-3264
    DOI 10.1007/s00590-024-03928-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3479: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Urgent Need for Studies of the Late Effects of SARS-CoV-2 on the Cardiovascular System.

    Maleszewski, Joseph J / Young, Phillip M / Ackerman, Michael J / Halushka, Marc K

    Circulation

    2020  Volume 143, Issue 13, Page(s) 1271–1273

    MeSH term(s) Autopsy ; COVID-19/complications ; COVID-19/pathology ; COVID-19/virology ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/pathology ; Cardiovascular System/diagnostic imaging ; Humans ; Magnetic Resonance Imaging, Cine ; SARS-CoV-2/isolation & purification ; Troponin T/blood
    Chemical Substances Troponin T
    Keywords covid19
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.051362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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  8. Article ; Online: Shining a LAMP on the applications of isothermal amplification for monitoring environmental biosecurity

    Deliveyne, Nathan / Young, Jennifer M. / Austin, Jeremy J. / Cassey, Phillip

    NeoBiota. 2023 Feb. 24, v. 82 p.119-144

    2023  

    Abstract: AbstractEnvironmental biosecurity risks associated with the transnational wildlife trade include the loss of biodiversity, threats to public health, and the proliferation of invasive alien species. To assist enforcement agencies in identifying species ... ...

    Abstract AbstractEnvironmental biosecurity risks associated with the transnational wildlife trade include the loss of biodiversity, threats to public health, and the proliferation of invasive alien species. To assist enforcement agencies in identifying species either intentionally (trafficked) or unintentionally (stowaway) entrained in the trade-chain pathway, rapid forensic techniques are needed to enable their detection from DNA samples when physical identification is not possible. Loop Mediated Isothermal Amplification (LAMP) is an emerging technique, with recent applications in biosecurity and forensic sciences, which has potential to function as a field-based detection tool. Here we provide an overview of current research that applies LAMP to environmental biosecurity, including identification of ornamental wildlife parts, consumer products, and invasive species monitoring and biosecurity detection. We discuss the current scope of LAMP as applied to various wildlife trade scenarios and biosecurity checkpoint monitoring, highlight the specificity, sensitivity, and robustness for these applications, and review the potential utility of LAMP for rapid field-based detection at biosecurity checkpoints. Based on our assessment of the literature we recommend broader interest, research uptake, and investment in LAMP as an appropriate field-based species detection method for a wide range of environmental biosecurity scenarios.
    Keywords DNA ; biodiversity ; biosecurity ; forensic sciences ; invasive species ; public health ; trade ; wildlife ; Environmental biosecurity ; loop mediated isothermal amplification (LAMP) ; wildlife forensics
    Language English
    Dates of publication 2023-0224
    Size p. 119-144.
    Publishing place Pensoft Publishers
    Document type Article ; Online
    ZDB-ID 2628537-X
    ISSN 1314-2488 ; 1619-0033
    ISSN (online) 1314-2488
    ISSN 1619-0033
    DOI 10.3897/neobiota.82.97998
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models.

    Odell, Luke R / Jones, Nigel C / Chau, Ngoc / Robertson, Mark J / Ambrus, Joseph I / Deane, Fiona M / Young, Kelly A / Whiting, Ainslie / Xue, Jing / Prichard, Kate / Daniel, James A / Gorgani, Nick N / O'Brien, Terence J / Robinson, Phillip J / McCluskey, Adam

    RSC medicinal chemistry

    2023  Volume 14, Issue 8, Page(s) 1492–1511

    Abstract: We show that dansylcadaverine (1) a known in-cell inhibitor of clathrin mediated endocytosis (CME), moderately inhibits dynamin I (dynI) GTPase activity ( ... ...

    Abstract We show that dansylcadaverine (1) a known in-cell inhibitor of clathrin mediated endocytosis (CME), moderately inhibits dynamin I (dynI) GTPase activity (IC
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d2md00371f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Mating Type Idiomorphs, Heterothallism, and High Genetic Diversity in

    Bock, Clive H / Young, Carolyn A / Zhang, Minling / Chen, Chunxian / Brannen, Phillip M / Adaskaveg, Jim / Charlton, Nikki D

    Phytopathology

    2021  Volume 111, Issue 2, Page(s) 408–424

    Abstract: Scab (caused ... ...

    Abstract Scab (caused by
    MeSH term(s) Fungal Genus Venturia ; Genes, Mating Type, Fungal/genetics ; Genetic Variation ; Plant Diseases ; Prunus persica ; Sequence Analysis, DNA
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208889-7
    ISSN 1943-7684 ; 0031-949X
    ISSN (online) 1943-7684
    ISSN 0031-949X
    DOI 10.1094/PHYTO-12-19-0485-R
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    Zs.B 698: Show issues Location:
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