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  1. Article ; Online: Paying the brain's energy bill.

    Padamsey, Zahid / Rochefort, Nathalie L

    Current opinion in neurobiology

    2022  Volume 78, Page(s) 102668

    Abstract: How have animals managed to maintain metabolically expensive brains given the volatile and fleeting availability of calories in the natural world? Here we review studies in support of three strategies that involve: 1) a reallocation of energy from ... ...

    Abstract How have animals managed to maintain metabolically expensive brains given the volatile and fleeting availability of calories in the natural world? Here we review studies in support of three strategies that involve: 1) a reallocation of energy from peripheral tissues and functions to cover the costs of the brain, 2) an implementation of energy-efficient neural coding, enabling the brain to operate at reduced energy costs, and 3) efficient use of costly neural resources during food scarcity. Collectively, these studies reveal a heterogeneous set of energy-saving mechanisms that make energy-costly brains fit for survival.
    MeSH term(s) Animals ; Brain ; Head
    Language English
    Publishing date 2022-12-24
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2022.102668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Defying Expectations: How Neurons Compute Prediction Errors in Visual Cortex.

    Padamsey, Zahid / Rochefort, Nathalie L

    Neuron

    2020  Volume 108, Issue 6, Page(s) 1016–1019

    Abstract: In this issue of Neuron, Jordan and Keller (2020) explore subthreshold computations underlying predictive coding using whole-cell recordings in mouse visual cortex. Their findings suggest that layer 2/3, but not layer 5/6, neurons compute prediction ... ...

    Abstract In this issue of Neuron, Jordan and Keller (2020) explore subthreshold computations underlying predictive coding using whole-cell recordings in mouse visual cortex. Their findings suggest that layer 2/3, but not layer 5/6, neurons compute prediction errors by subtracting predicted and actual visual flow inputs generated by locomotion.
    MeSH term(s) Animals ; Locomotion ; Mice ; Motivation ; Neurons ; Patch-Clamp Techniques ; Visual Cortex
    Language English
    Publishing date 2020-12-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2020.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Show issues

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  3. Article ; Online: A two-compartment model of synaptic computation and plasticity.

    Tong, Rudi / Emptage, Nigel J / Padamsey, Zahid

    Molecular brain

    2020  Volume 13, Issue 1, Page(s) 79

    Abstract: The synapse is typically viewed as a single compartment, which acts as a linear gain controller on incoming input. Traditional plasticity rules enable this gain control to be dynamically optimized by Hebbian activity. Whilst this view nicely captures ... ...

    Abstract The synapse is typically viewed as a single compartment, which acts as a linear gain controller on incoming input. Traditional plasticity rules enable this gain control to be dynamically optimized by Hebbian activity. Whilst this view nicely captures postsynaptic function, it neglects the non-linear dynamics of presynaptic function. Here we present a two-compartment model of the synapse in which the presynaptic terminal first acts to filter presynaptic input before the postsynaptic terminal, acting as a gain controller, amplifies or depresses transmission. We argue that both compartments are equipped with distinct plasticity rules to enable them to optimally adapt synaptic transmission to the statistics of pre- and postsynaptic activity. Specifically, we focus on how presynaptic plasticity enables presynaptic filtering to be optimally tuned to only transmit information relevant for postsynaptic firing. We end by discussing the advantages of having a presynaptic filter and propose future work to explore presynaptic function and plasticity in vivo.
    MeSH term(s) Animals ; Humans ; Models, Neurological ; Nerve Net/physiology ; Neuronal Plasticity/physiology ; Neurons/physiology ; Synapses/physiology ; Synaptic Transmission/physiology
    Language English
    Publishing date 2020-05-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2436057-0
    ISSN 1756-6606 ; 1756-6606
    ISSN (online) 1756-6606
    ISSN 1756-6606
    DOI 10.1186/s13041-020-00617-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Optical Quantal Analysis Using Ca

    Padamsey, Zahid / Tong, Rudi / Emptage, Nigel

    Frontiers in synaptic neuroscience

    2019  Volume 11, Page(s) 5

    Abstract: Despite evidence that presynaptic efficacy and plasticity influence circuit function and ... ...

    Abstract Despite evidence that presynaptic efficacy and plasticity influence circuit function and behavior
    Language English
    Publishing date 2019-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592086-8
    ISSN 1663-3563
    ISSN 1663-3563
    DOI 10.3389/fnsyn.2019.00005
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  5. Article ; Online: Neocortex saves energy by reducing coding precision during food scarcity.

    Padamsey, Zahid / Katsanevaki, Danai / Dupuy, Nathalie / Rochefort, Nathalie L

    Neuron

    2021  Volume 110, Issue 2, Page(s) 280–296.e10

    Abstract: Information processing is energetically expensive. In the mammalian brain, it is unclear how information coding and energy use are regulated during food scarcity. Using whole-cell recordings and two-photon imaging in layer 2/3 mouse visual cortex, we ... ...

    Abstract Information processing is energetically expensive. In the mammalian brain, it is unclear how information coding and energy use are regulated during food scarcity. Using whole-cell recordings and two-photon imaging in layer 2/3 mouse visual cortex, we found that food restriction reduced AMPA receptor conductance, reducing synaptic ATP use by 29%. Neuronal excitability was nonetheless preserved by a compensatory increase in input resistance and a depolarized resting potential. Consequently, neurons spiked at similar rates as controls but spent less ATP on underlying excitatory currents. This energy-saving strategy had a cost because it amplified the variability of visually-evoked subthreshold responses, leading to a 32% broadening of orientation tuning and impaired fine visual discrimination. This reduction in coding precision was associated with reduced levels of the fat mass-regulated hormone leptin and was restored by exogenous leptin supplementation. Our findings reveal that metabolic state dynamically regulates the energy spent on coding precision in neocortex.
    MeSH term(s) Animals ; Mammals ; Mice ; Neocortex/physiology ; Neurons/physiology ; Patch-Clamp Techniques ; Receptors, AMPA ; Visual Cortex/physiology
    Chemical Substances Receptors, AMPA
    Language English
    Publishing date 2021-11-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2021.10.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Show issues

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  6. Article ; Online: High and asymmetric somato-dendritic coupling of V1 layer 5 neurons independent of visual stimulation and locomotion.

    Francioni, Valerio / Padamsey, Zahid / Rochefort, Nathalie L

    eLife

    2019  Volume 8

    Abstract: Active dendrites impact sensory processing and behaviour. However, it remains unclear how active dendritic integration relates to somatic output in vivo. We imaged semi-simultaneously GCaMP6s signals in the soma, trunk and distal tuft dendrites of layer ... ...

    Abstract Active dendrites impact sensory processing and behaviour. However, it remains unclear how active dendritic integration relates to somatic output in vivo. We imaged semi-simultaneously GCaMP6s signals in the soma, trunk and distal tuft dendrites of layer 5 pyramidal neurons in the awake mouse primary visual cortex. We found that apical tuft signals were dominated by widespread, highly correlated calcium transients throughout the tuft. While these signals were highly coupled to trunk and somatic transients, the frequency of calcium transients was found to decrease in a distance-dependent manner from soma to tuft. Ex vivo recordings suggest that low-frequency back-propagating action potentials underlie the distance-dependent loss of signals, while coupled somato-dendritic signals can be triggered by high-frequency somatic bursts or strong apical tuft depolarization. Visual stimulation and locomotion increased neuronal activity without affecting somato-dendritic coupling. High, asymmetric somato-dendritic coupling is therefore a widespread feature of layer 5 neurons activity in vivo.
    MeSH term(s) Action Potentials/physiology ; Animals ; Calcium/metabolism ; Dendrites/physiology ; Locomotion/physiology ; Mice ; Photic Stimulation ; Pyramidal Cells/metabolism ; Pyramidal Cells/physiology ; Synapses/physiology ; Visual Cortex/physiology
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-12-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.49145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intracellular Ca

    Padamsey, Zahid / Foster, William J / Emptage, Nigel J

    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

    2018  Volume 25, Issue 3, Page(s) 208–226

    Abstract: ... ...

    Abstract Ca
    MeSH term(s) Animals ; Calcium Signaling ; Dendritic Spines/metabolism ; Endoplasmic Reticulum/metabolism ; Humans ; Lysosomes/metabolism ; Mitochondria/metabolism ; Neuronal Plasticity ; Neurons/metabolism ; Presynaptic Terminals/metabolism ; Synapses/metabolism
    Language English
    Publishing date 2018-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1233753-5
    ISSN 1089-4098 ; 1073-8584
    ISSN (online) 1089-4098
    ISSN 1073-8584
    DOI 10.1177/1073858418785334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4315: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Inhibition of lysosomal Ca

    Padamsey, Zahid / McGuinness, Lindsay / Emptage, Nigel J

    Communicative & integrative biology

    2017  Volume 10, Issue 5-6, Page(s) e1344802

    Abstract: A growing body of evidence suggests that lysosomes, which have traditionally been regarded as degradative organelles, can function as ... ...

    Abstract A growing body of evidence suggests that lysosomes, which have traditionally been regarded as degradative organelles, can function as Ca
    Language English
    Publishing date 2017-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2451097-X
    ISSN 1942-0889
    ISSN 1942-0889
    DOI 10.1080/19420889.2017.1344802
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  9. Article ; Online: High and asymmetric somato-dendritic coupling of V1 layer 5 neurons independent of visual stimulation and locomotion

    Valerio Francioni / Zahid Padamsey / Nathalie L Rochefort

    eLife, Vol

    2019  Volume 8

    Abstract: Active dendrites impact sensory processing and behaviour. However, it remains unclear how active dendritic integration relates to somatic output in vivo. We imaged semi-simultaneously GCaMP6s signals in the soma, trunk and distal tuft dendrites of layer ... ...

    Abstract Active dendrites impact sensory processing and behaviour. However, it remains unclear how active dendritic integration relates to somatic output in vivo. We imaged semi-simultaneously GCaMP6s signals in the soma, trunk and distal tuft dendrites of layer 5 pyramidal neurons in the awake mouse primary visual cortex. We found that apical tuft signals were dominated by widespread, highly correlated calcium transients throughout the tuft. While these signals were highly coupled to trunk and somatic transients, the frequency of calcium transients was found to decrease in a distance-dependent manner from soma to tuft. Ex vivo recordings suggest that low-frequency back-propagating action potentials underlie the distance-dependent loss of signals, while coupled somato-dendritic signals can be triggered by high-frequency somatic bursts or strong apical tuft depolarization. Visual stimulation and locomotion increased neuronal activity without affecting somato-dendritic coupling. High, asymmetric somato-dendritic coupling is therefore a widespread feature of layer 5 neurons activity in vivo.
    Keywords dendrites ; visual cortex ; awake behaving mice ; apical tuft ; calcium imaging ; layer 5 neurons ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 590
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Glutamate is required for depression but not potentiation of long-term presynaptic function.

    Padamsey, Zahid / Tong, Rudi / Emptage, Nigel

    eLife

    2017  Volume 6

    Abstract: Hebbian plasticity is thought to require glutamate signalling. We show this is not the case for hippocampal presynaptic long-term potentiation ( ... ...

    Abstract Hebbian plasticity is thought to require glutamate signalling. We show this is not the case for hippocampal presynaptic long-term potentiation (LTP
    MeSH term(s) Animals ; Glutamic Acid/metabolism ; Hippocampus/physiology ; Long-Term Synaptic Depression ; Microscopy, Confocal ; Neurotransmitter Agents/metabolism ; Patch-Clamp Techniques ; Presynaptic Terminals/drug effects ; Presynaptic Terminals/physiology ; Rats, Wistar
    Chemical Substances Neurotransmitter Agents ; Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2017-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.29688
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