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Article ; Online: Investigating trade-offs between ovary activation and immune protein expression in bumble bee (

McAfee, Alison / Chapman, Abigail / Bao, Grace / Tarpy, David R / Foster, Leonard J

2024 Volume 291, Issue 2015, Page(s) 20232463

Abstract: Evidence for a trade-off between reproduction and immunity has manifested in many animal species, including social insects. However, investigations in social insect queens present a conundrum: new gynes of many social hymenopterans, such as bumble bees ... ...

Abstract	Evidence for a trade-off between reproduction and immunity has manifested in many animal species, including social insects. However, investigations in social insect queens present a conundrum: new gynes of many social hymenopterans, such as bumble bees and ants, must first mate, then transition from being solitary to social as they establish their nests, thus experiencing confounding shifts in environmental conditions. Worker bumble bees offer an opportunity to investigate patterns of immune protein expression associated with ovary activation while minimizing extraneous environmental factors and genetic differences. Here, we use proteomics to interrogate the patterns of immune protein expression of female bumble bees (
MeSH term(s)	Female ; Bees ; Animals ; Ovary ; Reproduction ; Ants ; Hemolymph ; Pelvis
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2023.2463
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Article ; Online: Metagenomic analysis of the honey bee queen microbiome reveals low bacterial diversity and Caudoviricetes phages.

Caesar, Lílian / Rice, Danny W / McAfee, Alison / Underwood, Robyn / Ganote, Carrie / Tarpy, David R / Foster, Leonard J / Newton, Irene L G

mSystems

2024 Volume 9, Issue 2, Page(s) e0118223

Abstract: In eusocial insects, the health of the queens-the colony founders and sole reproductive females-is a primary determinant for colony success. Queen failure in the honey ... ...

Abstract	In eusocial insects, the health of the queens-the colony founders and sole reproductive females-is a primary determinant for colony success. Queen failure in the honey bee
MeSH term(s)	Bees ; Female ; Animals ; Bacteriophages/genetics ; Microbiota/genetics ; Reproduction ; Metagenome
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ISSN	2379-5077
ISSN (online)	2379-5077
DOI	10.1128/msystems.01182-23
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Article ; Online: Using expletives to enhance therapeutic outcomes: A case report.

Washmuth, Nicholas B / Stephens, Richard / McAfee, Blake / McAfee, Abby D / Bise, Christopher G / Durham, Jerry

Health psychology research

2023 Volume 11, Page(s) 89726

Abstract: Background: Swearing deserves attention in the physical therapy setting due to its potential positive effects on pain, physical performance, and therapeutic alliance. The purpose of this case report is to describe the strategic use of swearing in the ... ...

Abstract	Background: Swearing deserves attention in the physical therapy setting due to its potential positive effects on pain, physical performance, and therapeutic alliance. The purpose of this case report is to describe the strategic use of swearing in the clinical setting. Case presentation: A 44-year-old female completed an episode of physical therapy after undergoing patellofemoral arthroplasty. Swearing was formally included into the plan of care, and the patient swore out loud during the most challenging and painful interventions. Results: The patient reported that repeating a swear word was funny, distracted the patient, and made the patient feel more confident. The patient and physical therapist self-reported a strong therapeutic alliance. Conclusion: There is evidence repeating a swear word out loud can strengthen the therapeutic alliance, improve physical performance, and decrease pain. This is, to our knowledge, the first report of a patient swearing during an episode of physical therapy care.
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2709692-0
ISSN	2420-8124 ; 2420-8124
ISSN (online)	2420-8124
ISSN	2420-8124
DOI	10.52965/001c.89726
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Article ; Online: Knowledge, Perceptions, and Use of Psychedelics among Individuals with Fibromyalgia.

Glynos, Nicolas G / Pierce, Jennifer / Davis, Alan K / McAfee, Jenna / Boehnke, Kevin F

Journal of psychoactive drugs

2022 Volume 55, Issue 1, Page(s) 73–84

Abstract: ... in alternative treatments. There is growing interest in the potential of psychedelic substances (e.g., psilocybin ...

Abstract	Fibromyalgia (FM) is a difficult to treat chronic pain condition for which there is strong interest in alternative treatments. There is growing interest in the potential of psychedelic substances (e.g., psilocybin) in conjunction with psychotherapy to treat chronic pain. Via a cross-sectional, anonymous, online survey, we aimed to characterize knowledge, perceptions, and past use of serotonergic ("classic") and non-serotonergic psychedelics among a population of individuals with FM, and to investigate interest in psychedelic-based FM treatments. Among a North American population of 354 participants with FM, 29.9% reported past use of a psychedelic, with lysergic acid diethylamide (LSD) and psilocybin mushrooms being most commonly used. Perceptions of benefit from psychedelic use were generally neutral (59.4%) or positive (36.8%), with <3% reporting negative impacts on overall health or pain symptoms. Among 12 participants who used psychedelics with intentions of treating chronic pain, 11 reported improved symptoms. Regardless of past use, the majority of participants believed that psychedelics have potential for chronic pain treatments and would be willing to participate in a psychedelic-based clinical trial for their pain. These findings support the need for additional studies to understand the potential and effectiveness of psychedelic substances in managing FM symptoms.
MeSH term(s)	Humans ; Hallucinogens/therapeutic use ; Psilocybin/therapeutic use ; Fibromyalgia/drug therapy ; Chronic Pain/drug therapy ; Cross-Sectional Studies ; Lysergic Acid Diethylamide
Chemical Substances	Hallucinogens ; Psilocybin (2RV7212BP0) ; Lysergic Acid Diethylamide (8NA5SWF92O)
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	392405-1
ISSN	2159-9777 ; 0279-1072
ISSN (online)	2159-9777
ISSN	0279-1072
DOI	10.1080/02791072.2021.2022817
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Article ; Online: NIR-Based Intelligent Sensing of Product Yield Stress for High-Value Bioresorbable Polymer Processing.

Mulrennan, Konrad / Munir, Nimra / Creedon, Leo / Donovan, John / Lyons, John G / McAfee, Marion

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 8

Abstract: PLA (polylactide) is a bioresorbable polymer used in implantable medical and drug delivery devices. Like other bioresorbable polymers, PLA needs to be processed carefully to avoid degradation. In this work we combine in-process temperature, pressure, and ...

Abstract	PLA (polylactide) is a bioresorbable polymer used in implantable medical and drug delivery devices. Like other bioresorbable polymers, PLA needs to be processed carefully to avoid degradation. In this work we combine in-process temperature, pressure, and NIR spectroscopy measurements with multivariate regression methods for prediction of the mechanical strength of an extruded PLA product. The potential to use such a method as an intelligent sensor for real-time quality analysis is evaluated based on regulatory guidelines for the medical device industry. It is shown that for the predictions to be robust to processing at different times and to slight changes in the processing conditions, the fusion of both NIR and conventional process sensor data is required. Partial least squares (PLS), which is the established 'soft sensing' method in the industry, performs the best of the linear methods but demonstrates poor reliability over the full range of processing conditions. Conversely, both random forest (RF) and support vector regression (SVR) show excellent performance for all criteria when used with a prior principal component (PC) dimension reduction step. While linear methods currently dominate for soft sensing of mixture concentrations in highly conservative, regulated industries such as the medical device industry, this work indicates that nonlinear methods may outperform them in the prediction of mechanical properties from complex physicochemical sensor data. The nonlinear methods show the potential to meet industrial standards for robustness, despite the relatively small amount of training data typically available in high-value material processing.
MeSH term(s)	Absorbable Implants ; Least-Squares Analysis ; Polyesters ; Polymers/chemistry ; Reproducibility of Results
Chemical Substances	Polyesters ; Polymers
Language	English
Publishing date	2022-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22082835
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Article ; Online: Benefits of auditory-verbal intervention for adult cochlear implant users: perspectives of users and their coaches.

Fitzpatrick, Elizabeth M / Carrier, Valérie / Turgeon, Geneviève / Olmstead, Tina / McAfee, Arran / Whittingham, JoAnne / Schramm, David

International journal of audiology

2022 Volume 61, Issue 12, Page(s) 993–1002

Abstract: Objective: Post-implant rehabilitation is limited for adult cochlear implant (CI) recipients. The objective of this research was to capture the perspectives of CI users and their coaches regarding their experiences with auditory-verbal intervention as ... ...

Abstract	Objective: Post-implant rehabilitation is limited for adult cochlear implant (CI) recipients. The objective of this research was to capture the perspectives of CI users and their coaches regarding their experiences with auditory-verbal intervention as an example of post-implant rehabilitation and their views on perceived benefits and challenges related to the intervention. Design: This qualitative study involved semi-structured focus group interviews with adult CI users and their coaches who accompanied them in a 24-week auditory-verbal intervention program. Study sample: A total of 17 participants (eight CI users and nine coaches) contributed to the interviews. Results: Three key topic areas emerged from the interviews capturing CI users' and coaches' experiences related to the intervention program: (1) benefits of the intervention, (2) factors affecting experiences, and (3) challenges and barriers. Benefits included increased confidence in hearing, communication, social participation, and new knowledge about technology and hearing. Factors affecting the experience were participants' motivation and the therapist's skills. The primary challenge was the time commitment for weekly therapy. Conclusions: Both CI users and coaches perceived a focussed auditory-verbal intervention to be beneficial in improving speech understanding, confidence in using hearing, social interaction, and knowledge about technology. Participants recommended reducing the intensity of intervention to facilitate participation.
MeSH term(s)	Adult ; Humans ; Cochlear Implants ; Speech Perception ; Cochlear Implantation ; Speech ; Communication
Language	English
Publishing date	2022-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2073098-6
ISSN	1708-8186 ; 1499-2027
ISSN (online)	1708-8186
ISSN	1499-2027
DOI	10.1080/14992027.2021.1993361
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Article ; Online: Statistical Approaches for Establishing Appropriate Immunogenicity Assay Cut Points: Impact of Sample Distribution, Sample Size, and Outlier Removal.

Garlits, John / McAfee, Sean / Taylor, Jessica-Ann / Shum, Enoch / Yang, Qi / Nunez, Emily / Kameron, Kristina / Fenech, Keilah / Rodriguez, Jacqueline / Torri, Albert / Chen, Jihua / Sumner, Giane / Partridge, Michael A

The AAPS journal

2023 Volume 25, Issue 3, Page(s) 37

Abstract: The statistical assessments needed to establish anti-drug antibody (ADA) assay cut points (CPs) can be challenging for bioanalytical scientists. Poorly established CPs that are too high could potentially miss treatment emergent ADA or, when set too low, ... ...

Abstract	The statistical assessments needed to establish anti-drug antibody (ADA) assay cut points (CPs) can be challenging for bioanalytical scientists. Poorly established CPs that are too high could potentially miss treatment emergent ADA or, when set too low, result in detection of responses that may have no clinical relevance. We evaluated 16 validation CP datasets generated with ADA assays at Regeneron's bioanalytical laboratory and compared results obtained from different CP calculation tools. We systematically evaluated the impact of various factors on CP determination including biological and analytical variability, number of samples for capturing biological variability, outlier removal methods, and the use of parametric vs. non-parametric CP determination. In every study, biological factors were the major component of assay response variability, far outweighing the contribution from analytical variability. Non-parametric CP estimations resulted in screening positivity in drug-naïve samples closer to the targeted rate (5%) and were less impacted by skewness. Outlier removal using the boxplot method with an interquartile range (IQR) factor of 3.0 resulted in screening positivity close to the 5% targeted rate when applied to entire drug-naïve dataset. In silico analysis of CPs calculated using different sample sizes showed that using larger numbers of individuals resulted in CP estimates closer to the CP of the entire population, indicating a larger sample size (~ 150) for CP determination better represents the diversity of the study population. Finally, simpler CP calculations, such as the boxplot method performed in Excel, resulted in CPs similar to those determined using complex methods, such as random-effects ANOVA.
MeSH term(s)	Humans ; Sample Size ; Antibodies
Chemical Substances	Antibodies
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1550-7416
ISSN (online)	1550-7416
DOI	10.1208/s12248-023-00806-5
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Article: Evaluating multiple historical climate products in ecological models under current and projected temperatures.

Sadoti, Giancarlo / McAfee, Stephanie A / Nicklen, E Fleur / Sousanes, Pamela J / Roland, Carl A

Ecological applications : a publication of the Ecological Society of America

2020 Volume 31, Issue 2, Page(s) e02240

Abstract: Gridded historical climate products (GHCPs) are employed with increasing frequency when modeling ecological phenomena across large scales and predicting ecological responses to projected climate changes. Concurrently, there is an increasing ... ...

Abstract	Gridded historical climate products (GHCPs) are employed with increasing frequency when modeling ecological phenomena across large scales and predicting ecological responses to projected climate changes. Concurrently, there is an increasing acknowledgement of the need to account for uncertainty when employing climate projections from ensembles of global circulation models (GCMs) and emissions scenarios. Despite the growing usage and documented differences among GHCPs, uncertainty characterization has primarily focused on GCM and emissions scenario choice, while the consequences of using a single GHCP to make predictions over space and time have received less attention. Here we employ average July temperature data from observations and seven GHCPs to model plant canopy cover and tree basal area across central Alaska, USA. We first compare the fit of, and support for, models employing observed temperatures, GHCP temperatures, and GHCP temperatures with an elevation adjustment, finding (1) greater support for, and better fit using, elevation-adjusted vs. raw temperature models and (2) overall similar fits of elevation-adjusted models employing temperatures from observations or GHCPs. Focusing on basal area, we next compare predictions generated by elevation-adjusted models employing GHCP data under current conditions and a warming scenario of current temperatures plus 2°C, finding good agreement among GHCPs though with between-GHCP differences and variation primarily at middle elevations (~1,000 m). These differences were amplified under the warming scenario. Finally, using pooled indices of prediction variation and difference across GHCP models, we identify characteristics of areas most likely to exhibit prediction uncertainty under current and warming conditions. Despite (1) overall good performance of GHCP data relative to observations in models and (2) positive correlation among model predictions, variation in predictions across models, particularly in mid-elevation areas where the position of treeline may be changing, suggests researchers should exercise caution if selecting a single GHCP for use in models. We recommend the use of multiple GHCPs to provide additional uncertainty information beyond standard estimated prediction intervals, particularly when model predictions are employed in conservation planning.
MeSH term(s)	Alaska ; Climate Change ; Forecasting ; Models, Theoretical ; Temperature
Language	English
Publishing date	2020-11-22
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1074505-1
ISSN	1939-5582 ; 1051-0761
ISSN (online)	1939-5582
ISSN	1051-0761
DOI	10.1002/eap.2240
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Article: Source and transport controls on nutrient delivery to tile drains

Williams, Mark R. / Penn, Chad J. / McAfee, Scott J.

Journal of hydrology. 2022 Sept., v. 612

2022

Abstract: ... to 1.8 kg ha⁻¹ and 0–101 g ha⁻¹, respectively, while cumulative loads were 30.7 kg ha⁻¹ and 1,040 g ...

Abstract	Apportioning sources, assessing flow pathways, and quantifying the interaction between source and transport factors are critical for decreasing nutrient loss from agricultural catchments. In this study, water, nutrient, and tracer (δ¹⁸O, electrical conductivity) fluxes were measured over two years from a tile-drained field in Indiana, USA to quantify linkages among water flow pathways, management practices, and nutrient delivery to tile drains. Three-component hydrograph separation showed that tile discharge was, on average, sourced from groundwater (65 ± 31%), shallow soil water (10–20-cm deep; 29 ± 28%), and precipitation (6 ± 8%). Daily nitrate-N (NO₃-N) and dissolved reactive phosphorus (DRP) load ranged from 0.0 to 1.8 kg ha⁻¹ and 0–101 g ha⁻¹, respectively, while cumulative loads were 30.7 kg ha⁻¹ and 1,040 g ha⁻¹. Nutrient management practices (fertilizer rate, placement, timing) directly influenced the magnitude of incidental nutrient loss and proportion of load that was derived from a fertilizer source. It was estimated that 52% and 46% of cumulative NO₃-N and DRP load, respectively, was incidental loss that occurred within 30 d of fertilizer application. Continuous re-distribution of NO₃-N throughout the soil profile following fertilizer application resulted in a broad range of concentration across flow pathways and antecedent conditions. In contrast, dry conditions with tile water sourced from shallow soil water or precipitation resulted in greater, but more variable, DRP concentration compared to wetter conditions when tile water was largely comprised of groundwater. Findings suggest that groundwater table dynamics exerted a strong control over DRP concentration, as similar surface-tile hydrologic connectivity occurred during both dry and wet conditions but produced different water quality outcomes. Groundwater may therefore serve both as a chemical and hydrologic buffer of DRP concentration. Combined measurements of water, nutrient, and tracer fluxes revealed novel insights into processes controlling nutrient delivery to tile drains, with direct applicability for conservation practice implementation and improving process representation in models.
Keywords	conservation practices ; electrical conductivity ; fertilizer rates ; fertilizers ; groundwater ; hydrograph ; nitrate nitrogen ; nutrient management ; reactive phosphorus ; soil profiles ; soil water ; tile drainage ; water flow ; water quality ; water table ; Indiana
Language	English
Dates of publication	2022-09
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2022.128146
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Immunogenicity of Cemiplimab: Low Incidence of Antidrug Antibodies and Cut-Point Suitability Across Tumor Types.

Valentine, Jenny L / Dengler, Andrew / Zhao, An / Truong, Tiffany / McAfee, Sean / Hassanein, Mohamed / Irvin, Susan C / Chen, Jihua / Meng, Xiao / Yan, Hong / Torri, Albert / Sumner, Giane / Andisik, Matthew D / Paccaly, Anne / Partridge, Michael A

Journal of clinical pharmacology

2023 Volume 64, Issue 1, Page(s) 125–136

Abstract: The immunogenicity of cemiplimab, a fully human immunoglobulin G4 monoclonal antibody directed against programmed cell death 1, was assessed in patients across multiple tumor types. The development of antidrug antibodies (ADAs) against cemiplimab was ... ...

Abstract	The immunogenicity of cemiplimab, a fully human immunoglobulin G4 monoclonal antibody directed against programmed cell death 1, was assessed in patients across multiple tumor types. The development of antidrug antibodies (ADAs) against cemiplimab was monitored using a validated bridging immunoassay. To identify ADA-positive samples in the assay, statistically determined cut points were established by analyzing baseline clinical study samples from a mixed population of different tumor types, and this validation cut point was used to assess immunogenicity in all subsequent studies. Regulatory guidance requires that ADA assay cut points be verified for appropriateness in different patient populations. Thus, for the cemiplimab ADA assay, we evaluated whether each new oncology population was comparable with the validation population used to set the cut point. Assay responses from 2393 individual serum samples from 8 different tumor types were compared with the validation population, using established statistical methods for cut-point determination and comparison, with no significant differences observed. Across tumor types, the immunogenicity of cemiplimab was low, with an overall treatment-emergent ADA incidence rate of 1.9% and 2.5% at intravenous dose regimens of 3 mg/kg every 2 weeks and 350 mg every 3 weeks, respectively. Moreover, no neutralizing antibodies to cemiplimab were detected in patients with ADA-positive samples, and there was no observed impact of cemiplimab ADAs on pharmacokinetics. Study-specific cut points may be required in some diseases, such as immune and inflammatory diseases; however, based on this analysis, in-study cut points are not required for each new oncology disease indication for cemiplimab.
MeSH term(s)	Humans ; Incidence ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Neoplasms/drug therapy
Chemical Substances	cemiplimab (6QVL057INT) ; Antibodies, Monoclonal, Humanized ; Antibodies, Monoclonal
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188980-1
ISSN	1552-4604 ; 0091-2700 ; 0021-9754
ISSN (online)	1552-4604
ISSN	0091-2700 ; 0021-9754
DOI	10.1002/jcph.2340
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