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  1. Article ; Online: Reply to "Caution Regarding Conclusions about COVID-19 Vaccine and Encephalitis".

    Zuhorn, Frédéric / Graf, Tilmann / Klingebiel, Randolf / Schäbitz, Wolf-Rüdiger / Rogalewski, Andreas

    Annals of neurology

    2022  Volume 91, Issue 4, Page(s) 578–580

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Encephalitis ; Humans ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.26314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 478: Show issues

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  2. Article ; Online: Seltene Enzephalitis nach Impfung gegen SARS-CoV-2.

    Zuhorn, Frédéric / Graf, Tilmann / Klingebiel, Randolf / Schäbitz, Wolf-Rüdiger / Rogalewski, Andreas

    Der Nervenarzt

    2021  Volume 93, Issue 6, Page(s) 620–623

    Title translation Rare encephalitis after vaccination against SARS-CoV-2.
    MeSH term(s) COVID-19/prevention & control ; Encephalitis ; Humans ; SARS-CoV-2 ; Vaccination
    Language German
    Publishing date 2021-10-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123291-5
    ISSN 1433-0407 ; 0028-2804
    ISSN (online) 1433-0407
    ISSN 0028-2804
    DOI 10.1007/s00115-021-01205-x
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    Zs.MO 446: Show issues

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  3. Article ; Online: Immediate high-dose intravenous immunoglobulins followed by direct thrombin-inhibitor treatment is crucial for survival in Sars-Covid-19-adenoviral vector vaccine-induced immune thrombotic thrombocytopenia VITT with cerebral sinus venous and portal vein thrombosis.

    Graf, Tilmann / Thiele, Thomas / Klingebiel, Randolf / Greinacher, Andreas / Schäbitz, Wolf-Rüdiger / Greeve, Isabell

    Journal of neurology

    2021  Volume 268, Issue 12, Page(s) 4483–4485

    MeSH term(s) Adult ; Antithrombins/therapeutic use ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; ChAdOx1 nCoV-19 ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Male ; Portal Vein ; Thrombin/antagonists & inhibitors ; Thrombocytopenia/chemically induced ; Thrombocytopenia/drug therapy ; Thrombosis/chemically induced ; Thrombosis/drug therapy
    Chemical Substances Antithrombins ; COVID-19 Vaccines ; Immunoglobulins, Intravenous ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2021-05-22
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-021-10599-2
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  4. Article ; Online: Postvaccinal Encephalitis after ChAdOx1 nCov-19.

    Zuhorn, Frédéric / Graf, Tilmann / Klingebiel, Randolf / Schäbitz, Wolf-Rüdiger / Rogalewski, Andreas

    Annals of neurology

    2021  Volume 90, Issue 3, Page(s) 506–511

    Abstract: The global SARS-CoV-2 pandemic has contributed to more than 163 million confirmed infections and 3.3 million deaths worldwide. The severity of the pandemic has led to an unprecedented effort to develop multiple effective vaccines. Due to excellent safety ...

    Abstract The global SARS-CoV-2 pandemic has contributed to more than 163 million confirmed infections and 3.3 million deaths worldwide. The severity of the pandemic has led to an unprecedented effort to develop multiple effective vaccines. Due to excellent safety and efficacy data from clinical trials, several vaccines were approved. We report a case series of postvaccinal encephalitis in temporal correlation to vaccination with ChAdOx1 nCov-19. The diagnostic criteria for possible autoimmune encephalitis were fulfilled. Our patients responded well to immunosuppressive therapy with corticosteroids. The incidence has been estimated to be approximately 8 per 10 million vaccine doses. Complication of postvaccinal encephalitis after ChAdOx1 nCoV-19 vaccination still appear to be very rare, but need to be diagnosed and treated adequately. Large pooled data from observational epidemiologic studies are necessary to verify causality. ANN NEUROL 2021;90:506-511.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; ChAdOx1 nCoV-19 ; Encephalomyelitis, Acute Disseminated/chemically induced ; Encephalomyelitis, Acute Disseminated/diagnostic imaging ; Encephalomyelitis, Acute Disseminated/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Young Adult
    Chemical Substances COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.26182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 478: Show issues

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  5. Article: Evidenzbasierte Straftäterbehandlung in Deutschland

    Wagner, Tilmann / Graf, Sarah F.

    Praxis der Rechtspsychologie

    2018  Volume 28, Issue 1, Page(s) 123–142

    Abstract: Die aktuelle Praxis der Straftäterbehandlung in Deutschland wird analysiert und kritisch reflektiert. Zunächst wird ausgeführt, dass trotz eines gestiegenen Behandlungsangebotes im Straf- und Maßregelvollzug bisher keine fundierte Wirksamkeitsprüfung zu ... ...

    Title translation Evidence-based treatment of criminals in Germany
    Abstract Die aktuelle Praxis der Straftäterbehandlung in Deutschland wird analysiert und kritisch reflektiert. Zunächst wird ausgeführt, dass trotz eines gestiegenen Behandlungsangebotes im Straf- und Maßregelvollzug bisher keine fundierte Wirksamkeitsprüfung zu klinisch-psychologischen Maßnahmen in diesem Anwendungsbereich vorliegt. Daher sei für die Behandlungsplanung meist ein Rückgriff auf Studien aus dem angloamerikanischen Raum sowie auf nicht-forensische Patientenpopulationen nötig. Eine Evaluation von bestehenden Interventionen wird der Analyse folgend durch eine uneinheitlichen Verwendung des Begriffes "Straftäterbehandlung" sowie durch eine fehlende Systematisierung der Programme erschwert. Verschiedene kriminaltherapeutische Prinzipien werden skizziert. Zuletzt werden offene Fragen für die weitere Forschung zu Behandlungsprogrammen thematisiert, die sich auf die Bereiche Manualisierung, Einzel- vs. Gruppentherapie, Motivationsförderung und Deliktorientierung beziehen.
    Keywords Adaptive Behandlung ; Behandlungsplanung ; Berufliche Standards ; Client Treatment Matching ; Criminal Rehabilitation ; Einzelpsychotherapie ; Evidence Based Practice ; Evidenzbasierte Praxis ; Forensic Psychiatry ; Forensische Psychiatrie ; Group Psychotherapy ; Gruppenpsychotherapie ; Incarceration ; Individual Psychotherapy ; Motivation ; Professional Standards ; Psychological Terminology ; Psychologische Terminologie ; Psychotherapeutic Outcomes ; Psychotherapeutic Processes ; Psychotherapeutic Techniques ; Psychotherapeutische Prozesse ; Psychotherapeutische Techniken ; Psychotherapieergebnisse ; Resozialisierung ; Strafvollzug ; Therapieerfolgskontrolle ; Treatment Effectiveness Evaluation ; Treatment Planning
    Language German
    Document type Article
    ZDB-ID 1173568-5
    ISSN 0939-9062
    ISSN 0939-9062
    Database PSYNDEX

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  6. Book ; Online: Review of state‐of‐the‐art AI tools and methods for screening, extracting and evaluating NAMs literature in the context of chemical risk assessment

    Blümmel, Tilmann / Rehn, Johannes / Mereu, Carla / Graf, Ferdinand / Kneuer, Carsten / Wittkowski, Paul / Sonnenburg, Anna / Moore, Anthony / Bech, Karsten / van der Lugt, Benthe / Bouwmeester, Hans / Kramer, Nynke / Dobrikov, Todor

    2023  

    Keywords Text ; ddc:610
    Language English
    Publisher Wiley
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online ; Thesis: Differentielle Effekte einer PPARg-Aktivierung [PPAR-gamma-Aktivierung] mit Pioglitazon in der Barrettadenokarzinomzelllinie OE33 in vitro und in vivo

    Graf, Tilmann

    2007  

    Author's details vorgelegt von Tilmann Graf
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Würzburg, 2007
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: SIGLEC1 enables straightforward assessment of type I interferon activity in idiopathic inflammatory myopathies

    Werner Stenzel / Udo Schneider / Robert Biesen / Gerd R Burmester / Falk Hiepe / Tilmann Kallinich / Martin Krusche / Christian Meisel / Nadine Unterwalder / Jens Klotsche / Thomas Rose / Akinori Uruha / Manuel Graf / Sae Lim von Stuckrad / Lydia Zorn-Pauly / Thomas Buttgereit

    RMD Open, Vol 8, Iss

    2022  Volume 1

    Keywords Medicine ; R
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Sudden coma from acute bilateral m1 occlusion: successful treatment with mechanical thrombectomy.

    Dietrich, Uwe / Graf, Tilmann / Schäbitz, Wolf-Rüdiger

    Case reports in neurology

    2014  Volume 6, Issue 2, Page(s) 144–148

    Abstract: We report a case with acute small infarct of the left middle cerebral artery in a 72-year-old man with atrial fibrillation documented by MRI and MR angiography. One hour later, he lost consciousness and CT with CT angiography revealed bilateral ... ...

    Abstract We report a case with acute small infarct of the left middle cerebral artery in a 72-year-old man with atrial fibrillation documented by MRI and MR angiography. One hour later, he lost consciousness and CT with CT angiography revealed bilateral hyperdense middle cerebral arteries due to occlusion of the M1 segments. Mechanical thrombectomy of the right middle cerebral artery was successfully performed. During that time, thrombosis on the left side had progressed to carotid T occlusion, which was recanalized as well. The patient had a good outcome with slight aphasia and mild paresis of the left hand and could be transferred to rehabilitation 2 weeks later.
    Language English
    Publishing date 2014-05-09
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2505302-4
    ISSN 1662-680X
    ISSN 1662-680X
    DOI 10.1159/000362160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SIGLEC1 enables straightforward assessment of type I interferon activity in idiopathic inflammatory myopathies.

    Graf, Manuel / von Stuckrad, Sae Lim / Uruha, Akinori / Klotsche, Jens / Zorn-Pauly, Lydia / Unterwalder, Nadine / Buttgereit, Thomas / Krusche, Martin / Meisel, Christian / Burmester, Gerd R / Hiepe, Falk / Biesen, Robert / Kallinich, Tilmann / Stenzel, Werner / Schneider, Udo / Rose, Thomas

    RMD open

    2022  Volume 8, Issue 1

    Abstract: Objective: To evaluate sialic acid binding Ig-like lectin 1 (SIGLEC1) expression on monocytes by flow cytometry as a type I interferon biomarker in idiopathic inflammatory myopathies (IIM).: Methods: We performed a retrospective analysis of adult and ...

    Abstract Objective: To evaluate sialic acid binding Ig-like lectin 1 (SIGLEC1) expression on monocytes by flow cytometry as a type I interferon biomarker in idiopathic inflammatory myopathies (IIM).
    Methods: We performed a retrospective analysis of adult and paediatric patients with the diagnosis of IIM. SIGLEC1 expression was assessed by flow cytometry and was compared with Physician Global Assessment or Childhood Myositis Assessment Scale disease activity scores. Mann Whitney U test and receiver operating characteristic curves were used for cross-sectional data analysis (n=96), two-level mixed-effects linear regression model for longitudinal analyses (n=26, 110 visits). Response to treatment was analysed in 14 patients within 12 months, using Wilcoxon test. SIGLEC1 was compared with interferon-stimulated gene 15/MxA status by immunohistochemical staining of muscle biopsies (n=17).
    Results: 96 patients with adult (a) and juvenile (j) dermatomyositis (DM, n=38), antisynthetase syndrome (AS, n=19), immune-mediated necrotising myopathy (IMNM, n=8), inclusion body myositis (IBM, n=9) and overlap myositis (n=22) were included. SIGLEC1 distinguished significantly between active and inactive disease with an area under the curve of 0.92 (95% CI 0.83 to 1) in DM and correlated with disease activity longitudinally (aDM: standardised beta=0.54, p<0.001; jDM: standardised beta=-0.70, p<0.001). Response to treatment in DM was associated with a decreasing SIGLEC1 (p<0.01, Wilcoxon test). SIGLEC1 was found upregulated in 8 of 19 patients with AS, 2 of 9 patients with IBM but not in IMNM.
    Conclusion: SIGLEC1 is a candidate biomarker to assess type I interferon activity in IIM and proved useful for monitoring disease activity and response to treatment in juvenile and adult DM.
    MeSH term(s) Adult ; Child ; Cross-Sectional Studies ; Dermatomyositis/diagnosis ; Dermatomyositis/pathology ; Humans ; Interferon Type I ; Myositis/diagnosis ; Retrospective Studies ; Sialic Acid Binding Ig-like Lectin 1/genetics
    Chemical Substances Interferon Type I ; SIGLEC1 protein, human ; Sialic Acid Binding Ig-like Lectin 1
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2021-001934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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