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Article ; Online: Unpredictable Chemical Diversity of Essential Oils in

Xie, Peiwu / Yang, Qiyi / Chen, Jielian / Tu, Tieyao / Lian, Huiming / He, Boxiang / Cai, Yanling

2024 Volume 29, Issue 6

Abstract: ... The ... ...

Abstract	The genus
MeSH term(s)	Humans ; Oils, Volatile/chemistry ; Cinnamomum/genetics ; Lauraceae ; Phylogeny ; Maternal Inheritance ; Camphanes
Chemical Substances	Oils, Volatile ; isoborneol (L88RA8N5EG) ; Camphanes
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29061206
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Article ; Online: Management strategies for acute cholecystitis in late pregnancy: a multicenter retrospective study.

Zhang, Wei / Yi, Huiming / Cai, Ming / Zhang, Jian

BMC surgery

2023 Volume 23, Issue 1, Page(s) 340

Abstract: Objective: This study aims to investigate the management strategies for acute cholecystitis in the third trimester of pregnancy by comparing the effectiveness of three different treatments.: Methods: Clinical data of 102 patients with acute ... ...

Abstract	Objective: This study aims to investigate the management strategies for acute cholecystitis in the third trimester of pregnancy by comparing the effectiveness of three different treatments. Methods: Clinical data of 102 patients with acute cholecystitis in third trimester of pregnancy admitted to three Tertiary Hospitals from January 2010 to June 2020 were collected and divided into 3 groups according to the primary treatment during their first hospitalization: Group A (surgical group; n = 11), Group B (percutaneous transhepatic gallbladder drainage (PTGD) group, n = 29) and Group C (conservative treatment group, n = 62). The length of stay, readmission rate, and preterm delivery rate of each group were analyzed retrospectively. Results: The average age of patients included in this study was 29 ± 2.16 years with an average gestational cycle of 35.26 ± 1.02 weeks. The readmission rates of patients in groups A, B, and C were 9.09%, 24.14%, and 58.06%; the preterm delivery rates were 9.09%, 3.45%, and 12.90%; and the length of stay was 4.02 ± 1.02 days, 12.53 ± 2.21 days, and 11.22 ± 2.09 days, respectively. The readmission rate was lower in group A than in groups B and C, the preterm delivery rate was lower in group B than in groups A and C, and the length of stay was shorter in group A than in groups B and C (all with statistically significant differences, P < 0.05). Conclusion: Patients with acute cholecystitis in late pregnancy need to be appropriately graded for severity and offered a sound treatment strategy after a thorough assessment of the condition while taking into account the willingness of the patients. For patients with mild severity, conservative treatment can be adopted; for patients with moderate or severe inflammation, PTGD can be performed first for symptom control, and wait till after delivery for surgery to be considered; and in some cases of critical condition and poor symptom control, surgical intervention should be promptly performed.
MeSH term(s)	Female ; Infant, Newborn ; Humans ; Pregnancy ; Adult ; Retrospective Studies ; Cholecystectomy, Laparoscopic/adverse effects ; Premature Birth/etiology ; Premature Birth/surgery ; Drainage/adverse effects ; Treatment Outcome ; Cholecystitis, Acute/surgery
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-023-02257-3
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Article: Combined indocyanine green and medical glue enables stable and precise position in animal studies: promising for fluorescence-guided pulmonary ground glass nodule resection.

Wang, Ziyang / Li, Yunlong / Yu, Jianghong / Cai, Huiming / Wang, Yiqing

Translational lung cancer research

2023 Volume 12, Issue 9, Page(s) 1923–1934

Abstract: Background: Accurate preoperative localization of pulmonary nodules is crucial for surgical treatment. The use of indocyanine green (ICG) for localization is prone to thoracic contamination and spread, resulting in the eventual failure of localization. ... ...

Abstract	Background: Accurate preoperative localization of pulmonary nodules is crucial for surgical treatment. The use of indocyanine green (ICG) for localization is prone to thoracic contamination and spread, resulting in the eventual failure of localization. By using medical glue combined with ICG, we can accurately and permanently locate various tissues in animal study, which can provide evidences for clinical translations. Methods: A series of medical glue and ICG volume ratios of 2:3, 3:3, 4:3, 6:3, and 9:3 were mixed and injected immediately into subcutaneous tissues of BALB/c nude mice; either medical glue or ICG was injected singly in the control group. Fluorescence intensity over time and boundary sharpness were investigated to determine the optimal ratio. Then, fluorescence guided resection of tissue was performed Results: The localization agents with a volume ratio of 4:3 showed the best boundary sharpness and the strongest photostability. With the guidance of fluorescence navigation, the marked tissues were accurately separated and removed from the surrounding tissue both on mice and on pig intestines. In the organs of living mice, the localization agents (ratio 4:3) realized accurate positioning of marked tissues. Additionally, the medical glue limited the diffusion of ICG, promising to enable more stable and precise positioning of the nodules during surgery. Conclusions: The combination of ICG and medical glue presents a superior approach when compared to the individual use of either ICG or medical glue. This technique offers enhanced precision and durability and sealed the wound, thereby mitigating the risk of pneumothorax following puncture procedures. This innovative technique optimizes the properties of medical adhesive to augment tissue density while harnessing the real-time fluorescent endoscopic marking capabilities of ICG during surgical interventions. By employing this innovative technique, it holds significant promise for augmenting the accuracy of pulmonary nodule localization in thoracoscopic surgery within future clinical applications.
Language	English
Publishing date	2023-09-25
Publishing country	China
Document type	Journal Article
ZDB-ID	2754335-3
ISSN	2226-4477 ; 2218-6751
ISSN (online)	2226-4477
ISSN	2218-6751
DOI	10.21037/tlcr-23-553
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Article ; Online: Experimental Analysis of the Discharge Valve Movement of the Oil-Free Linear Compressor in the Refrigeration System

Chengzhan Li / Jian Sun / Huiming Zou / Jinghui Cai / Tingting Zhu

Sustainability, Vol 15, Iss 5853, p

2023 Volume 5853

Abstract: In a linear compressor, the valve motion significantly affects the thermodynamic efficiency and the compressor’s reliability, especially in oil-free conditions. To better understand the dynamic behavior of the discharge valve, a real-time test bench was ... ...

Abstract	In a linear compressor, the valve motion significantly affects the thermodynamic efficiency and the compressor’s reliability, especially in oil-free conditions. To better understand the dynamic behavior of the discharge valve, a real-time test bench was built. The piston movements and dynamic pressure in the cylinder were also observed to obtain the synchronizing characteristics among the reed valve motion, cylinder pressure, and piston motion. Observing the motion of the discharge valve visually, the discharge valve flutters due to the change in the form of the cylinder pressure, the delayed opening of the valve is caused by the inertia of the valve itself, and additional displacement fluctuations are present. This paper presents the dynamic behavior of the discharge valve under different discharge pressure/operating frequency/piston stroke/clearance length conditions. The results show that the valve flutters increase, the mean displacement of the valve increases, and the duration of the discharge increases when the discharge pressure decreases. When the operating frequency increases, the duration of the discharge decreases, while the mean displacement of the valve increases. For a high stroke or a low clearance length case, the duration of the discharge increases, while the valve flutters increase due to the pressure fluctuations in the cylinder. Through analyzing the synchronizing characteristic among the valve movements, piston movements, and cylinder pressure, it is shown that the phenomenon of the delayed opening valve is much worse for a low stroke or a high operating frequency case. In addition, the delayed closing of the valve appears for a high operating frequency case (75 Hz).
Keywords	oil-free linear compressor ; refrigeration system ; discharge valve ; dynamic behavior ; synchronizing characteristic ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	621
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A human serum albumin-indocyanine green complex offers improved tumor identification in fluorescence-guided surgery.

Li, Yunlong / Dai, Chun / Hua, Zhaolai / Xia, Lin / Ding, Yongbin / Wang, Qiang / Gié, Marie-Laure Matthey / Bouvet, Michael / Cai, Huiming

Translational cancer research

2024 Volume 13, Issue 1, Page(s) 437–452

Abstract: Background: Complete tumor removal is critical for achieving a good prognosis in patients but remains challenging for surgeons. Near-infrared fluorescence-guided surgery (NIRFGS) enables surgeons to accurately localize tumors in real time and ... ...

Abstract	Background: Complete tumor removal is critical for achieving a good prognosis in patients but remains challenging for surgeons. Near-infrared fluorescence-guided surgery (NIRFGS) enables surgeons to accurately localize tumors in real time and facilitates accurate resection. Indocyanine green (ICG) has been approved by the U.S. Food and Drug Administration and the National Medical Products Administration for many years. Although the application of ICG has progressed for a variety of surgeries, there are inherent limitations to ICG, including poor water solubility and photostability, short blood half-life, and aggregation in blood, resulting in poor imaging performance. We found that mixing ICG with human serum albumin (HSA) preoperatively and then injecting it can improve the imaging performance. Methods: We prepared fluorescent probes by combining ICG with HSA and identified their optimal ratio via Results: Through Conclusions: This study suggests that ICG-HSA can achieve higher tumor-to-background contrast with shorter time and can provide an overall superior imaging performance compared to ICG alone, thus exhibiting considerable potential for clinical application.
Language	English
Publishing date	2024-01-29
Publishing country	China
Document type	Journal Article
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr-23-2338
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Full-length transcriptome sequencing reveals the molecular mechanism of monoterpene and sesquiterpene biosynthesis in

Hou, Chen / Zhang, Qian / Xie, Peiwu / Lian, Huiming / Wang, Yingli / Liang, Dongcheng / Cai, Yanling / He, Boxiang

Frontiers in genetics

2023 Volume 13, Page(s) 1087495

Abstract: Essential oil ... ...

Abstract	Essential oil of
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.1087495
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Article: Assessment of liver injury using indocyanine green fluorescence imaging.

Chen, Yan / Liu, Ge / Wu, Yulin / Cai, Huiming

Annals of translational medicine

2021 Volume 9, Issue 14, Page(s) 1167

Abstract: Background: To investigate whether indocyanine green (ICG) fluorescence imaging can be used to evaluate chronic and acute liver injury induced by either a high-fat (HF) diet or carbon tetrachloride (CCl: Methods: Sprague-Dawley (SD) rats were ... ...

Abstract	Background: To investigate whether indocyanine green (ICG) fluorescence imaging can be used to evaluate chronic and acute liver injury induced by either a high-fat (HF) diet or carbon tetrachloride (CCl Methods: Sprague-Dawley (SD) rats were randomly divided into three groups: control group, HF diet-induced model group, and CCl Results: After HF feeding, the liver index and levels of serum ALT and AST were significantly increased, and the livers of the rats showed severe histopathological changes. Compared with the control group, the hepatic lobes of the model rats exhibited incomplete green fluorescence, and the corresponding spectral value was markedly reduced. Conclusions: ICG fluorescence imaging can be used to evaluate liver injury induced by either a HF diet or CCl
Language	English
Publishing date	2021-07-30
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-21-3049
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Article ; Online: Functional testing is a complementary tool for the diagnosis of vaginitis.

Feng, Danqin / Zhang, Fuhui / Cai, Jianguo / Zhang, Yansheng / Yan, Honghong / Yang, Yichi / Zhong, Hongxiu / Ye, Huiming

BMC women's health

2024 Volume 24, Issue 1, Page(s) 224

Abstract: Objective: Vaginal microbiota evaluation is a methodology widely used in China to diagnose various vaginal inflammatory diseases. Although vaginal microbiota evaluation has many advantages, it is time-consuming and requires highly skilled and ... ...

Abstract	Objective: Vaginal microbiota evaluation is a methodology widely used in China to diagnose various vaginal inflammatory diseases. Although vaginal microbiota evaluation has many advantages, it is time-consuming and requires highly skilled and experienced operators. Here, we investigated a six-index functional test that analyzed pH, hydrogen peroxide (H Materials and methods: The research was conducted using data extracted from the Laboratory Information System of Women and Children's Hospital. A total of 4902 subjects, ranging in age from 35.4 ± 9.7 years, were analyzed. During the consultation, a minimum of two vaginal swab specimens per patient were collected for both functional and morphological testing. Fisher's exact was used to analyze data using SPSS. Results: Of the 4,902 patients, 2,454 were considered to have normal Lactobacillus morphotypes and 3,334 were considered to have normal dominant microbiota. The sensitivity and specificity of H Conclusion: Functional tests (pH, SNA, H
MeSH term(s)	Child ; Humans ; Female ; Adult ; Middle Aged ; Hydrogen Peroxide ; Vaginosis, Bacterial/diagnosis ; Candidiasis, Vulvovaginal/diagnosis ; Candidiasis, Vulvovaginal/microbiology ; Vagina/microbiology ; Sensitivity and Specificity
Chemical Substances	Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2024-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2050444-5
ISSN	1472-6874 ; 1472-6874
ISSN (online)	1472-6874
ISSN	1472-6874
DOI	10.1186/s12905-024-03035-w
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Article: Application of an indocyanine green-mediated fluorescence imaging navigation system in detecting mice tumors.

Zhao, Xueyan / Wang, Ziyu / Wu, Yulin / Cai, Huiming

Annals of translational medicine

2021 Volume 9, Issue 15, Page(s) 1238

Abstract: Background: Surgical operation plays an important role in the treatment of cancer. The success of the operation lies in the complete removal of the primary and disseminated tumor tissue while preserving the normal tissue. The development of optical ... ...

Abstract	Background: Surgical operation plays an important role in the treatment of cancer. The success of the operation lies in the complete removal of the primary and disseminated tumor tissue while preserving the normal tissue. The development of optical molecular image navigation technology has provided a new option for intraoperative tumor visualization. In this study, a fluorescence imaging navigation system was used to detect the diameter of mice tumors and provide experimental evidence for the further development of digital diagnosis and treatment equipment. Methods: The minimum detection concentration in vitro of the fluorescence imaging navigation system for indocyanine green (ICG) was first detected, then 120 female Institute of Cancer Research (ICR) mice and 120 female BALB/c nude mice were randomly divided into three groups by weight, high-dose (H, 4 mg/kg), middle-dose (M, 2 mg/kg), and low-dose (L, 1 mg/kg) groups of ICG solution. After inoculating solid tumors, high, medium, and low doses of ICG were injected via the tail vein, and the tumor diameter was measured by a fluorescence imaging navigation system and vernier caliper within 24 hours of injection. Results: The minimum detectable diameter of the system could reach 0.2 mm compared with the vernier caliper, and the actual measurement error was within 0.2 mm. Conclusions: A fluorescence imaging navigation system has high accuracy and sensitivity in the application of tumor detection, which may assist the clinical diagnosis and treatment of tumors.
Language	English
Publishing date	2021-09-16
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-21-3050
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Article: Role of Tetraspanins in Hepatocellular Carcinoma.

Cai, Sicheng / Deng, Yue / Peng, Huiming / Shen, Jian

Frontiers in oncology

2021 Volume 11, Page(s) 723341

Abstract: Hepatocellular carcinoma (HCC) is characterized by high prevalence, morbidity, and mortality. Liver cancer is the sixth most common cancer worldwide; and its subtype, HCC, accounts for nearly 80% of cases. HCC progresses rapidly, and to date, there is no ...

Abstract	Hepatocellular carcinoma (HCC) is characterized by high prevalence, morbidity, and mortality. Liver cancer is the sixth most common cancer worldwide; and its subtype, HCC, accounts for nearly 80% of cases. HCC progresses rapidly, and to date, there is no efficacious treatment for advanced HCC. Tetraspanins belong to a protein family characterized by four transmembrane domains. Thirty-three known tetraspanins are widely expressed on the surface of most nucleated cells and play important roles in different biological processes. In our review, we summarize the functions of tetraspanins and their underlying mechanism in the life cycle of HCC, from its initiation, progression, and finally to treatment. CD9, TSPAN15, and TSPAN31 can promote HCC cell proliferation or suppress apoptosis. CD63, CD151, and TSPAN8 can also facilitate HCC metastasis, while CD82 serves as a suppressor of metastasis. TSPAN1, TSPAN8, and CD151 act as prognosis indicators and are inversely correlated to the overall survival rate of HCC patients. In addition, we discuss the potential of role of the tetraspanin family proteins as novel therapeutic targets and as an approach to overcome drug resistance, and also provide suggestions for further research.
Language	English
Publishing date	2021-09-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.723341
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