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  1. Article ; Online: Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft.

    Kiselevskiy, Mikhail V / Gromova, Elena G / Kozlov, Nikolay A / Bezhanova, Svetlana D / Shubina, Irina Zh

    Exploration of targeted anti-tumor therapy

    2023  Volume 4, Issue 3, Page(s) 511–518

    Abstract: Transmission of a malignancy from a donor's organ to the recipient of the graft is a rare event, though it is a severe complication that can result in a poor outcome. Usually, immunosuppressive therapy is discontinued and the allograft is removed. ... ...

    Abstract Transmission of a malignancy from a donor's organ to the recipient of the graft is a rare event, though it is a severe complication that can result in a poor outcome. Usually, immunosuppressive therapy is discontinued and the allograft is removed. However, treatment of patients with the disseminated cancers implies that after the graft removal and cessation of the immunosuppression, radiotherapy, chemotherapy, or immunotherapy with alpha-interferon (INF-α) or interleukin-2 (IL-2) are required. The case report presents a clinical case of a transmitted kidney graft with multiple metastases (MTS) in a 31-year-old woman with the spontaneous regression of the metastatic cancer after transplantectomy and cancellation of the immunosuppressive therapy. Obviously, the determining factor is the recognition of the tumor by the effectors of the antitumor immunity due to the human leukocyte antigen (HLA) mismatch between the donor and the recipient. Therefore, cancellation of the immunosuppressive therapy in cases of transferal of a malignancy with a transplanted organ allows the effectors of the immune system to distinguish the tumor as a foreign tissue and effectively eliminate this neoplasm.
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Case Reports
    ISSN 2692-3114
    ISSN (online) 2692-3114
    DOI 10.37349/etat.2023.00148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development of Bioactive Scaffolds for Orthopedic Applications by Designing Additively Manufactured Titanium Porous Structures: A Critical Review.

    Kiselevskiy, Mikhail V / Anisimova, Natalia Yu / Kapustin, Alexei V / Ryzhkin, Alexander A / Kuznetsova, Daria N / Polyakova, Veronika V / Enikeev, Nariman A

    Biomimetics (Basel, Switzerland)

    2023  Volume 8, Issue 7

    Abstract: We overview recent findings achieved in the field of model-driven development of additively manufactured porous materials for the development of a new generation of bioactive implants for orthopedic applications. Porous structures produced from ... ...

    Abstract We overview recent findings achieved in the field of model-driven development of additively manufactured porous materials for the development of a new generation of bioactive implants for orthopedic applications. Porous structures produced from biocompatible titanium alloys using selective laser melting can present a promising material to design scaffolds with regulated mechanical properties and with the capacity to be loaded with pharmaceutical products. Adjusting pore geometry, one could control elastic modulus and strength/fatigue properties of the engineered structures to be compatible with bone tissues, thus preventing the stress shield effect when replacing a diseased bone fragment. Adsorption of medicals by internal spaces would make it possible to emit the antibiotic and anti-tumor agents into surrounding tissues. The developed internal porosity and surface roughness can provide the desired vascularization and osteointegration. We critically analyze the recent advances in the field featuring model design approaches, virtual testing of the designed structures, capabilities of additive printing of porous structures, biomedical issues of the engineered scaffolds, and so on. Special attention is paid to highlighting the actual problems in the field and the ways of their solutions.
    Language English
    Publishing date 2023-11-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics8070546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Depolymerization of a fucosylated chondroitin sulfate from Cucumaria japonica: Structure and activity of the product.

    Ustyuzhanina, Nadezhda E / Bilan, Maria I / Anisimova, Natalia Yu / Dmitrenok, Andrey S / Tsvetkova, Evgenia A / Kiselevskiy, Mikhail V / Nifantiev, Nikolay E / Usov, Anatolii I

    Carbohydrate polymers

    2022  Volume 281, Page(s) 119072

    Abstract: Fucosylated chondroitin sulfate CJ from the body wall of sea cucumber Cucumaria japonica was depolymerized by the treatment with ... ...

    Abstract Fucosylated chondroitin sulfate CJ from the body wall of sea cucumber Cucumaria japonica was depolymerized by the treatment with H
    MeSH term(s) Animals ; Anticoagulants/chemistry ; Chondroitin Sulfates/chemistry ; Chondroitin Sulfates/pharmacology ; Cucumaria/chemistry ; Hydrogen Peroxide ; Sea Cucumbers/chemistry
    Chemical Substances Anticoagulants ; fucosylated chondroitin sulfate ; Chondroitin Sulfates (9007-28-7) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2021.119072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft

    Mikhail V. Kiselevskiy / Elena G. Gromova / Nikolay A. Kozlov / Svetlana D. Bezhanova / Irina Zh. Shubina

    Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 3, Pp 511-

    2023  Volume 518

    Abstract: Transmission of a malignancy from a donor’s organ to the recipient of the graft is a rare event, though it is a severe complication that can result in a poor outcome. Usually, immunosuppressive therapy is discontinued and the allograft is removed. ... ...

    Abstract Transmission of a malignancy from a donor’s organ to the recipient of the graft is a rare event, though it is a severe complication that can result in a poor outcome. Usually, immunosuppressive therapy is discontinued and the allograft is removed. However, treatment of patients with the disseminated cancers implies that after the graft removal and cessation of the immunosuppression, radiotherapy, chemotherapy, or immunotherapy with alpha-interferon (INF-α) or interleukin-2 (IL-2) are required. The case report presents a clinical case of a transmitted kidney graft with multiple metastases (MTS) in a 31-year-old woman with the spontaneous regression of the metastatic cancer after transplantectomy and cancellation of the immunosuppressive therapy. Obviously, the determining factor is the recognition of the tumor by the effectors of the antitumor immunity due to the human leukocyte antigen (HLA) mismatch between the donor and the recipient. Therefore, cancellation of the immunosuppressive therapy in cases of transferal of a malignancy with a transplanted organ allows the effectors of the immune system to distinguish the tumor as a foreign tissue and effectively eliminate this neoplasm.
    Keywords cancer ; spontaneous regressions ; kidney graft ; immunosuppressive therapy ; Internal medicine ; RC31-1245
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Open Exploration Publishing Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Glycosaminoglycans from the Starfish

    Bilan, Maria I / Anisimova, Natalia Yu / Tokatly, Alexandra I / Nikogosova, Sofya P / Vinnitskiy, Dmitriy Z / Ustyuzhanina, Nadezhda E / Dmitrenok, Andrey S / Tsvetkova, Evgenia A / Kiselevskiy, Mikhail V / Nifantiev, Nikolay E / Usov, Anatolii I

    Marine drugs

    2023  Volume 21, Issue 4

    Abstract: Crude anionic polysaccharides extracted from the Pacific ... ...

    Abstract Crude anionic polysaccharides extracted from the Pacific starfish
    MeSH term(s) Animals ; Glycosaminoglycans/pharmacology ; Dermatan Sulfate/chemistry ; Iduronic Acid ; Starfish ; Polysaccharides ; Sulfates/chemistry
    Chemical Substances Glycosaminoglycans ; Dermatan Sulfate (24967-94-0) ; Iduronic Acid (3402-98-0) ; Polysaccharides ; Sulfates
    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21040205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Antiviral Cell Products against COVID-19: Learning Lessons from Previous Research in Anti-Infective Cell-Based Agents.

    Chikileva, Irina / Shubina, Irina / Burtseva, Anzhelika-Mariia / Kirgizov, Kirill / Stepanyan, Nara / Varfolomeeva, Svetlana / Kiselevskiy, Mikhail

    Biomedicines

    2022  Volume 10, Issue 4

    Abstract: COVID-19 is a real challenge for the protective immunity. Some people do not respond to vaccination by acquiring an appropriate immunological memory. The risk groups for this particular infection such as the elderly and people with compromised immunity ( ... ...

    Abstract COVID-19 is a real challenge for the protective immunity. Some people do not respond to vaccination by acquiring an appropriate immunological memory. The risk groups for this particular infection such as the elderly and people with compromised immunity (cancer patients, pregnant women, etc.) have the most serious problems in developing an adequate immune response. Therefore, dendritic cell (DC) vaccines that are loaded ex vivo with SARS-CoV-2 antigens in the optimal conditions are promising for immunization. Lymphocyte effector cells with chimeric antigen receptor (CAR lymphocytes) are currently used mainly as anti-tumor treatment. Before 2020, few studies on the antiviral CAR lymphocytes were reported, but since the outbreak of SARS-CoV-2 the number of such studies has increased. The basis for CARs against SARS-CoV-2 were several virus-specific neutralizing monoclonal antibodies. We propose a similar, but basically novel and more universal approach. The extracellular domain of the immunoglobulin G receptors will be used as the CAR receptor domain. The specificity of the CAR will be determined by the antibodies, which it has bound. Therefore, such CAR lymphocytes are highly universal and have functional activity against any infectious agents that have protective antibodies binding to a foreign surface antigen on the infected cells.
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10040868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Influence of the Phase Composition of Titanium Alloys on Cell Adhesion and Surface Colonization.

    Straumal, Boris B / Anisimova, Natalia Yu / Kiselevskiy, Mikhail V / Novruzov, Keryam M / Korneva, Anna / Gornakova, Alena S / Kilmametov, Askar R / Sommadossi, Silvana / Davdian, Gregory

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 22

    Abstract: The pivotal role of metal implants within the host's body following reconstructive surgery hinges primarily on the initial phase of the process: the adhesion of host cells to the implant's surface and the subsequent colonization by these cells. Notably, ... ...

    Abstract The pivotal role of metal implants within the host's body following reconstructive surgery hinges primarily on the initial phase of the process: the adhesion of host cells to the implant's surface and the subsequent colonization by these cells. Notably, titanium alloys represent a significant class of materials used for crafting metal implants. This study, however, marks the first investigation into how the phase composition of titanium alloys, encompassing the volume fractions of the α, β, and ω phases, influences cell adhesion to the implant's surface. Moreover, the research delves into the examination of induced hemolysis and cytotoxicity. To manipulate the phase composition of titanium alloys, various parameters were altered, including the chemical composition of titanium alloys with iron and niobium, annealing temperature, and high-pressure torsion parameters. By systematically adjusting these experimental parameters, we were able to discern the distinct impact of phase composition. As a result, the study unveiled that the colonization of the surfaces of the examined Ti-Nb and Ti-Fe alloys by human multipotent mesenchymal stromal cells exhibits an upward trend with the increasing proportion of the ω phase, concurrently accompanied by a decrease in the α and β phases. These findings signify a new avenue for advancing Ti-based alloys for both permanent implants and temporary fixtures, capitalizing on the ability to regulate the volume fractions of the α, β, and ω phases. Furthermore, the promising characteristics of the ω phase suggest the potential emergence of a third generation of biocompatible Ti alloys, the ω-based materials, following the first-generation α-Ti alloys and second-generation β alloys.
    Language English
    Publishing date 2023-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16227130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bioactivity Features of a Zn-1%Mg-0.1%Dy Alloy Strengthened by Equal-Channel Angular Pressing.

    Martynenko, Natalia / Anisimova, Natalia / Shinkareva, Maria / Rybalchenko, Olga / Rybalchenko, Georgy / Zheleznyi, Mark / Lukyanova, Elena / Temralieva, Diana / Gorbenko, Artem / Raab, Arseny / Pashintseva, Natalia / Babayeva, Gulalek / Kiselevskiy, Mikhail / Dobatkin, Sergey

    Biomimetics (Basel, Switzerland)

    2023  Volume 8, Issue 5

    Abstract: The structure, phase composition, corrosion and mechanical properties, as well as aspects of biocompatibility in vitro and in vivo, of a Zn-1%Mg-0.1%Dy alloy after equal-channel angular pressing (ECAP) were studied. The structure refinement after ECAP ... ...

    Abstract The structure, phase composition, corrosion and mechanical properties, as well as aspects of biocompatibility in vitro and in vivo, of a Zn-1%Mg-0.1%Dy alloy after equal-channel angular pressing (ECAP) were studied. The structure refinement after ECAP leads to the formation of elongated α-Zn grains with a width of ~10 µm and of Mg- and Dy-containing phases. In addition, X-ray diffraction analysis demonstrated that ECAP resulted in the formation of the basal texture in the alloy. These changes in the microstructure and texture lead to an increase in ultimate tensile strength up to 262 ± 7 MPa and ductility up to 5.7 ± 0.2%. ECAP slows down the degradation process, apparently due to the formation of a more homogeneous microstructure. It was found that the alloy degradation rate in vivo after subcutaneous implantation in mice is significantly lower than in vitro ones. ECAP does not impair biocompatibility in vitro and in vivo of the Zn-1%Mg-0.1%Dy alloy. No signs of suppuration, allergic reactions, the formation of visible seals or skin ulcerations were observed after implantation of the alloy. This may indicate the absence of an acute reaction of the animal body to the Zn-1%Mg-0.1%Dy alloy in both states.
    Language English
    Publishing date 2023-09-03
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics8050408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Fucosylated Chondroitin Sulfates with Rare Disaccharide Branches from the Sea Cucumbers

    Ustyuzhanina, Nadezhda E / Bilan, Maria I / Anisimova, Natalia Yu / Nikogosova, Sofya P / Dmitrenok, Andrey S / Tsvetkova, Evgenia A / Panina, Elena G / Sanamyan, Nadezhda P / Avilov, Sergey A / Stonik, Valentin A / Kiselevskiy, Mikhail V / Usov, Anatolii I / Nifantiev, Nikolay E

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 12

    Abstract: Two fucosylated chondroitin sulfates were isolated from the sea ... ...

    Abstract Two fucosylated chondroitin sulfates were isolated from the sea cucumbers
    Language English
    Publishing date 2023-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16121673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A New Approach Based on Glued Multi-Ultra High Molecular Weight Polyethylene Forms to Fabricate Bone Replacement Products.

    Dayyoub, Tarek / Maksimkin, Aleksey / Senatov, Fedor / Kaloshkin, Sergey / Anisimova, Natalia / Kiselevskiy, Mikhail

    Polymers

    2020  Volume 12, Issue 11

    Abstract: Three types of glue based on thiol-ene reaction, polyvinyl alcohol (PVA)/cellulose, and phenol formaldehyde were prepared and applied on modified ultra-high molecular weight polyethylene (UHMWPE) samples grafted by cellulose. In comparison with ... ...

    Abstract Three types of glue based on thiol-ene reaction, polyvinyl alcohol (PVA)/cellulose, and phenol formaldehyde were prepared and applied on modified ultra-high molecular weight polyethylene (UHMWPE) samples grafted by cellulose. In comparison with unmodified UHMWPE samples, T-peel tests on the modified and grafted UHMWPE films showed an increase in the peel strength values for the glues based on thiol-ene reaction, PVA/cellulose, and phenol formaldehyde by 40, 29, and 41 times, respectively. The maximum peel strength value of 0.62 Kg/cm was obtained for the glue based on phenol formaldehyde. Mechanical tests for the cylindrical multi-UHMWPE forms samples, made of porous UHMWPE as a trabecular layer and an armored layer (cortical layer) that consists of bulk and UHMWPE films, indicated an improvement in the mechanical properties of these samples for all glue types, as a result of the UHMWPE films existence and the increase in the number of their layers. The maximum compressive yield strength and compressive modulus values for the armored layer (bulk and six layers of the UHMWPE films using the glue based on thiol-ene reaction) were 44.1 MPa (an increase of 17%) and 1130 MPa (an increase of 36%), respectively, in comparison with one armored layer of bulk UHMWPE. A hemocompatibility test carried out on these glues clarified that the modified UHMWPE grafted by cellulose with glues based on PVA/cellulose and thiol-ene reaction were classified as biocompatible materials. These multi-UHMWPE forms composites can be considered a promising development for joint reconstruction.
    Language English
    Publishing date 2020-10-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym12112545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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