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  1. Article ; Online: Reply to: HER2-Low Breast Cancer Can Be Visualized by HER2 PET.

    Seban, Romain-David

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2023  Volume 64, Issue 11, Page(s) 1841–1842

    MeSH term(s) Humans ; Female ; Breast Neoplasms/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Receptor, ErbB-2 ; Fluorodeoxyglucose F18
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1) ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.123.266490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  2. Article: Advances in PET/CT Imaging for Breast Cancer Patients and Beyond.

    Khalil, David / Lotfalla, Andrew / Girard, Antoine / Ha, Richard / Dercle, Laurent / Seban, Romain-David

    Journal of clinical medicine

    2023  Volume 12, Issue 2

    Abstract: Breast cancer is the most common cancer in women around the world and the fifth leading cause of cancer-related death [ ... ]. ...

    Abstract Breast cancer is the most common cancer in women around the world and the fifth leading cause of cancer-related death [...].
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical Potential of HER2 PET as a Predictive Biomarker to Guide the Use of Trastuzumab Deruxtecan in Breast Cancer Patients.

    Seban, Romain-David / Champion, Laurence / Bellesoeur, Audrey / Vincent-Salomon, Anne / Bidard, Francois-Clement

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2023  Volume 64, Issue 7, Page(s) 1164–1165

    MeSH term(s) Humans ; Female ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Trastuzumab/therapeutic use ; Camptothecin ; Immunoconjugates ; Biomarkers ; Positron-Emission Tomography ; Receptor, ErbB-2
    Chemical Substances trastuzumab deruxtecan (5384HK7574) ; Trastuzumab (P188ANX8CK) ; Camptothecin (XT3Z54Z28A) ; Immunoconjugates ; Biomarkers ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.123.265434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: 68 Ga-DOTATOC PET/CT Imaging of a Muscular Solitary Fibrous Tumor.

    Richard, Capucine / Cros, Jérôme / Seban, Romain-David / Champion, Laurence / Hescot, Ségolène

    Clinical nuclear medicine

    2023  Volume 48, Issue 5, Page(s) e228–e229

    Abstract: Abstract: A 73-year-old woman was referred for 68 Ga-DOTATOC PET/CT staging of a grade 2 pancreatic neuroendocrine tumor, which showed the primary pancreatic tumor, liver metastases, one left pleural metastasis, and high uptake in a mass of the right ... ...

    Abstract Abstract: A 73-year-old woman was referred for 68 Ga-DOTATOC PET/CT staging of a grade 2 pancreatic neuroendocrine tumor, which showed the primary pancreatic tumor, liver metastases, one left pleural metastasis, and high uptake in a mass of the right triceps brachii muscle. Two years before, she underwent 18 F-FDG PET/CT and 111 In-pentetreotide scan, respectively, with low and high uptake of each radiotracer in the triceps mass. Histopathological analysis revealed a solitary fibrous tumor. Immunohistochemistry showed no staining for SSTR-2 and SSTR-5, suggesting tumor overexpression of another somatostatin receptor. This case highlighted a potential pitfall on 68 Ga-DOTATOC PET/CT.
    MeSH term(s) Female ; Humans ; Aged ; Positron Emission Tomography Computed Tomography/methods ; Octreotide ; Positron-Emission Tomography/methods ; Pancreatic Neoplasms/pathology ; Receptors, Somatostatin ; Hemangiopericytoma ; Solitary Fibrous Tumors ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/pathology ; Organometallic Compounds
    Chemical Substances Edotreotide (U194AS08HZ) ; Octreotide (RWM8CCW8GP) ; Receptors, Somatostatin ; Gallium-68 (98B30EPP5S) ; Organometallic Compounds
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1276: Show issues Location:
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  5. Article ; Online: Spleen glucose metabolism on [

    Seban, Romain-David / Champion, Laurence / Schwartz, Lawrence H / Dercle, Laurent

    European journal of nuclear medicine and molecular imaging

    2021  Volume 48, Issue 8, Page(s) 2309–2311

    MeSH term(s) Biomarkers ; Fluorodeoxyglucose F18 ; Glucose ; Humans ; Neoplasms/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Spleen
    Chemical Substances Biomarkers ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-01-09
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-020-05126-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1227: Show issues Location:
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  6. Article ; Online: Clinical Implications of 18F-FDG PET/CT in Malignant Glomus Tumors of the Esophagus.

    Seban, Romain-David / Bozec, Laurence / Champion, Laurence

    Clinical nuclear medicine

    2020  Volume 45, Issue 6, Page(s) e301–e302

    Abstract: The majority of glomus tumors are localized to cutaneous sites and are benign. However, extracutaneous malignant glomus tumors have been reported and are aggressive. Here, we report a case of a 45-year-old man who presented severe dysphagia, diagnosed ... ...

    Abstract The majority of glomus tumors are localized to cutaneous sites and are benign. However, extracutaneous malignant glomus tumors have been reported and are aggressive. Here, we report a case of a 45-year-old man who presented severe dysphagia, diagnosed with malignant glomus tumor of the esophagus. F-FDG PET/CT played a decisive role in several phases of the patient management offering previously unknown accuracy. It was first performed in the initial staging of local tumor extent before surgery. A year and a half after, F-FDG PET/CT helped to detect recurrence and, finally, was performed for response evaluation of several systemic therapies.
    MeSH term(s) Esophageal Neoplasms/diagnostic imaging ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Fluorodeoxyglucose F18 ; Glomus Tumor/diagnostic imaging ; Glomus Tumor/pathology ; Glomus Tumor/surgery ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fibroblast heterogeneity in solid tumors: From single cell analysis to whole-body imaging.

    Peltier, Agathe / Seban, Romain-David / Buvat, Irène / Bidard, François-Clément / Mechta-Grigoriou, Fatima

    Seminars in cancer biology

    2022  Volume 86, Issue Pt 3, Page(s) 262–272

    Abstract: Cancer-Associated Fibroblasts (CAFs) represent the most prominent component of the tumor microenvironment (TME). Recent studies demonstrated that CAF are heterogeneous and composed of different subpopulations exerting distinct functions in cancer. CAF ... ...

    Abstract Cancer-Associated Fibroblasts (CAFs) represent the most prominent component of the tumor microenvironment (TME). Recent studies demonstrated that CAF are heterogeneous and composed of different subpopulations exerting distinct functions in cancer. CAF populations differentially modulate various aspects of tumor growth, including cancer cell proliferation, extra-cellular matrix remodeling, metastatic dissemination, immunosuppression and resistance to treatment. Among other markers, the Fibroblast Activation Protein (FAP) led to the identification of a specific CAF subpopulation involved in metastatic spread and immunosuppression. Expression of FAP at the surface of CAF is detected in many different cancer types of poor prognosis. Thus, FAP recently appears as an appealing target for therapeutic and molecular imaging applications. In that context,
    MeSH term(s) Humans ; Gelatinases/metabolism ; Positron Emission Tomography Computed Tomography/methods ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Single-Cell Analysis ; Whole Body Imaging ; Membrane Proteins/metabolism ; Neoplasms/diagnostic imaging ; Neoplasms/metabolism ; Fibroblasts/metabolism ; Tumor Microenvironment
    Chemical Substances Gelatinases (EC 3.4.24.-) ; Serine Endopeptidases (EC 3.4.21.-) ; Membrane Proteins
    Language English
    Publishing date 2022-04-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2022.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2922: Show issues Location:
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  8. Article: Clinical Utility of Pre-Therapeutic [18F]FDG PET/CT Imaging for Predicting Outcomes in Breast Cancer.

    Najid, Sophia / Seban, Romain-David / Champion, Laurence / De Moura, Alexandre / Sebbag, Clara / Salaün, Hélène / Cabel, Luc / Bonneau, Claire

    Journal of clinical medicine

    2023  Volume 12, Issue 17

    Abstract: Background: [18F]FDG PET/CT is used for staging and could also provide information associated with clinical outcomes. The objective of this study was to determine the clinical utility of biomarkers measured using [18F]FDG PET/CT to predict the absence ... ...

    Abstract Background: [18F]FDG PET/CT is used for staging and could also provide information associated with clinical outcomes. The objective of this study was to determine the clinical utility of biomarkers measured using [18F]FDG PET/CT to predict the absence of pathological complete response (no-pCR) and recurrence.
    Methods: In this retrospective study, we included patients with non-special-type breast carcinoma who underwent [18F]FDG PET/CT before neoadjuvant chemotherapy between 2011 and 2019. Clinicopathological data were collected. Tumor SUVmax and total metabolic tumor volume (TMTV) were measured from PET images. The association between biomarkers and no-pCR was studied using logistic regression. The cut-off value was determined using the area under the ROC Curve. To predict 3-year recurrence-free survival (RFS), we used a multivariable Cox model, and the cut-off value was determined using time-dependent ROC and predictiveness curves.
    Results: Two hundred and eighty-six patients were included in the analysis. One hundred and twelve patients had a pCR (39.2%). The pCR rate was significantly higher in patients with a high nuclear grade (
    Conclusion: High TMTV in pre-therapeutic imaging is associated with no-pCR and recurrence. It can help in identifying high-risk patients and be considered as an intensified or alternative adjuvant therapy for closely monitoring patients.
    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12175487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Potential Theranostic Role of Bone Marrow Glucose Metabolism on Baseline

    Seban, Romain-David / Champion, Laurence / Muneer, Izza / Synn, Shwe / Schwartz, Lawrence H / Dercle, Laurent

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2021  Volume 63, Issue 1, Page(s) 166

    MeSH term(s) Positron Emission Tomography Computed Tomography
    Language English
    Publishing date 2021-05-28
    Publishing country United States
    Document type Letter
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.121.262361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Diagnosis of Hyperprogressive Disease in Patients Treated with Checkpoint Inhibitors Using

    Seban, Romain-David / Schwartz, Lawrence H / Bonardel, Gerald / Dercle, Laurent

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2020  Volume 61, Issue 9, Page(s) 1404–1405

    MeSH term(s) Carcinoma, Non-Small-Cell Lung ; Fluorodeoxyglucose F18 ; Humans ; Lung Neoplasms ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radiopharmaceuticals
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2020-02-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.242768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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