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Article: Crosstalk between Apoptosis and Cytotoxic Lymphocytes (CTLs) in the Course of

Niedźwiedzka-Rystwej, Paulina / Deptuła, Wiesław

2023 Volume 67, Issue 1, Page(s) 41–47

Abstract: Introduction: Lagovirus europaeus: Material and methods: Sixty rabbits of Polish hybrid breed comprising both sexes and weighing 3.2-4.2 kg were the experimental group, and an identical group was the control. Each of the six GI.1a : Results: The ... ...

Abstract	Introduction: Lagovirus europaeus Material and methods: Sixty rabbits of Polish hybrid breed comprising both sexes and weighing 3.2-4.2 kg were the experimental group, and an identical group was the control. Each of the six GI.1a Results: The activation of apoptosis in peripheral blood lymphocytes was recorded from 4 h post inoculation (p.i.) up to 36 h p.i. The percentage of CTLs in the total blood pool decreased from 8 to 36 h p.i. A negative correlation between apoptosis of lymphocytes and the number of CTLs was proven. Conclusion: This may be the first evidence of virus-induced CTL apoptosis in
Language	English
Publishing date	2023-02-28
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2855010-9
ISSN	2450-8608 ; 2450-7393
ISSN (online)	2450-8608
ISSN	2450-7393
DOI	10.2478/jvetres-2023-0008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Phenomenon of Antibiotic Resistance in the Polar Regions: An Overview of the Global Problem.

Depta, Julia / Niedźwiedzka-Rystwej, Paulina

Infection and drug resistance

2023 Volume 16, Page(s) 1979–1995

Abstract: The increasing prevalence of antibiotic resistance is a global problem in human and animal health. This leads to a reduction in the therapeutic effectiveness of the measures used so far and to the limitation of treatment options, which may pose a threat ... ...

Abstract	The increasing prevalence of antibiotic resistance is a global problem in human and animal health. This leads to a reduction in the therapeutic effectiveness of the measures used so far and to the limitation of treatment options, which may pose a threat to human health and life. The problem of phenomenon of antibiotic resistance affects more and more the polar regions. This is due to the increase in tourist traffic and the number of people staying at research stations, unmodernised sewage systems in inhabited areas, as well as the migration of animals or the movement of microplastics, which may contain resistant bacteria. Research shows that the presence of antibiotic resistance genes is more dominant in zones of human and wildlife influence than in remote areas. In a polluted environment, there is evidence of a direct correlation between human activity and the spread and survival of antibiotic-resistant bacteria. Attention should be paid to the presence of resistance to synthetic and semi-synthetic antibiotics in the polar regions, which is likely to be correlated with human presence and activity, and possible steps to be taken. We need to understand many more aspects of this, such as bacterial epigenetics and environmental stress, in order to develop effective strategies for minimizing the spread of antibiotic resistance genes. Studying the diversity and abundance of antibiotic resistance genes in regions with less anthropogenic activity could provide insight into the diversity of primary genes and explain the historical evolution of antibiotic resistance.
Language	English
Publishing date	2023-04-03
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S369023
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Article ; Online: Etiology of viral induced acute liver failure and defensins as potential therapeutic agents in ALF treatment.

Hrynkiewicz, Rafał / Niedźwiedzka-Rystwej, Paulina

Frontiers in immunology

2023 Volume 14, Page(s) 1153528

Abstract: Acute liver failure (ALF) is a rare and severe disease, which, despite continuous advances in medicine, is still characterized by high mortality (65-85%). Very often, a liver transplant is the only effective treatment for ALF. Despite the implementation ... ...

Abstract	Acute liver failure (ALF) is a rare and severe disease, which, despite continuous advances in medicine, is still characterized by high mortality (65-85%). Very often, a liver transplant is the only effective treatment for ALF. Despite the implementation of prophylactic vaccinations in the world, the viral background of ALF is still a problem and leads to many deaths. Depending on the cause of ALF, it is sometimes possible to reverse this condition with appropriate therapies, which is why the search for effective antiviral agents seems to be a very desirable direction of research. Defensins, which are our natural antimicrobial peptides, have a very high potential to be used as therapeutic agents for infectious liver diseases. Previous studies on the expression of human defensins have shown that increased expression of human α and β-defensins in HCV and HBV infections is associated with a better response to treatment. Unfortunately, conducting clinical trials for ALF is very difficult due to the severity of the disease and the low incidence, therefore animal models are important for the development of new therapeutic strategies. One of the best animal models that has real reference to research on acute liver failure (ALF) is rabbit hemorrhagic disease in rabbits caused by the
MeSH term(s)	Liver Failure, Acute/therapy ; Liver Failure, Acute/virology ; Defensins/therapeutic use ; Animals ; Rabbits ; Disease Models, Animal ; Hemorrhagic Disease Virus, Rabbit ; Caliciviridae Infections/therapy
Chemical Substances	Defensins
Language	English
Publishing date	2023-04-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1153528
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Article ; Online: Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers.

Małkowska, Paulina / Niedźwiedzka-Rystwej, Paulina

Frontiers in immunology

2022 Volume 13, Page(s) 1010635

Abstract: Viral hemorrhagic fever (VHF) is a term referring to a group of life-threatening infections caused by several virus families ( ...

Abstract	Viral hemorrhagic fever (VHF) is a term referring to a group of life-threatening infections caused by several virus families (
MeSH term(s)	Animals ; Antiviral Agents ; Arenaviridae ; DEAD-box RNA Helicases/metabolism ; Hemorrhagic Fevers, Viral ; Humans ; Interferons ; Nucleic Acids
Chemical Substances	Antiviral Agents ; Nucleic Acids ; Interferons (9008-11-1) ; DEAD-box RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2022-09-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1010635
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Article ; Online: The Interplay between Autophagy and Virus Pathogenesis-The Significance of Autophagy in Viral Hepatitis and Viral Hemorrhagic Fevers.

Bębnowska, Dominika / Niedźwiedzka-Rystwej, Paulina

Cells

2022 Volume 11, Issue 5

Abstract: Autophagy is a process focused on maintaining the homeostasis of organisms; nevertheless, the role of this process has also been widely documented in viral infections. Thus, xenophagy is a selective form of autophagy targeting viruses. However, the ... ...

Abstract	Autophagy is a process focused on maintaining the homeostasis of organisms; nevertheless, the role of this process has also been widely documented in viral infections. Thus, xenophagy is a selective form of autophagy targeting viruses. However, the relation between autophagy and viruses is ambiguous-this process may be used as a strategy to fight with a virus, but is also in favor of the virus's replication. In this paper, we have gathered data on autophagy in viral hepatitis and viral hemorrhagic fevers and the relations impacting its viral pathogenesis. Thus, autophagy is a potential therapeutic target, but research is needed to fully understand the mechanisms by which the virus interacts with the autophagic machinery. These studies must be performed in specific research models other than the natural host for many reasons. In this paper, we also indicate
MeSH term(s)	Autophagy ; Hemorrhagic Fevers, Viral ; Hepatitis, Viral, Human ; Humans ; Lagovirus ; Viruses
Language	English
Publishing date	2022-03-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11050871
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Article ; Online: Adipokines as potential biomarkers for type 2 diabetes mellitus in cats.

Sierawska, Olga / Niedźwiedzka-Rystwej, Paulina

Frontiers in immunology

2022 Volume 13, Page(s) 950049

Abstract: Type 2 diabetes mellitus (T2DM) is no longer only a disease of humans, but also of domestic animals, and it particularly affects cats. It is increasingly thought that because of its unique characteristics, T2DM may belong not only to the group of ... ...

Abstract	Type 2 diabetes mellitus (T2DM) is no longer only a disease of humans, but also of domestic animals, and it particularly affects cats. It is increasingly thought that because of its unique characteristics, T2DM may belong not only to the group of metabolic diseases but also to the group of autoimmune diseases. This is due to the involvement of the immune system in the inflammation that occurs with T2DM. Various pro- and anti-inflammatory substances are secreted, especially cytokines in patients with T2DM. Cytokines secreted by adipose tissue are called adipokines, and leptin, adiponectin, resistin, omentin, TNF-α, and IL-6 have been implicated in T2DM. In cats, approximately 90% of diabetic cases are T2DM. Risk factors include older age, male sex, Burmese breed, presence of obesity, and insulin resistance. Diagnosis of a cat requires repeated testing and is complicated compared to human diagnosis. Based on similarities in the pathogenesis of T2DM between humans and cats, adipokines previously proposed as biomarkers for human T2DM may also serve in the diagnosis of this disease in cats.
MeSH term(s)	Adipokines ; Adiponectin/metabolism ; Animals ; Biomarkers/metabolism ; Cats ; Cytokines ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Interleukin-6 ; Leptin/metabolism ; Male ; Resistin ; Tumor Necrosis Factor-alpha
Chemical Substances	Adipokines ; Adiponectin ; Biomarkers ; Cytokines ; Interleukin-6 ; Leptin ; Resistin ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2022-09-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.950049
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Article ; Online: Crosstalk between apoptosis and cytotoxic lymphocytes (CTLs) in the course of Lagovirus europaeus GI.1a infection in rabbits

Niedźwiedzka-Rystwej Paulina / Deptuła Wiesław

Journal of Veterinary Research, Vol 67, Iss 1, Pp 41-

2023 Volume 47

Abstract: Lagovirus europaeus is a single-stranded RNA virus causing an acute fatal disease in wild and domestic rabbits around the world. Studies have shown that the pivotal process impacting the immune response against the disease is apoptosis, registered mainly ...

Abstract	Lagovirus europaeus is a single-stranded RNA virus causing an acute fatal disease in wild and domestic rabbits around the world. Studies have shown that the pivotal process impacting the immune response against the disease is apoptosis, registered mainly in hepatocytes and in peripheral blood, together with an increased number of cytotoxic lymphocytes (CTLs). It is known that cytotoxic lymphocytes can induce target cells to undergo apoptosis on the pseudoreceptor pathway, such apoptosis having been found in several acute and chronic viral infections. The study aimed to assess the crosstalk between the apoptosis of peripheral blood lymphocytes and CD8+ T lymphocytes (as CTLs) in rabbits infected with 6 Lagovirus europaeus GI.1a viruses.
Keywords	lagovirus europaeus ; rhdv ; rabbit ; apoptosis ; cytotoxic lymphocytes ; Veterinary medicine ; SF600-1100
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment.

Moeini, Pedram / Niedźwiedzka-Rystwej, Paulina

International journal of molecular sciences

2021 Volume 22, Issue 13

Abstract: Macrophages are one of the most important cells of the innate immune system and are known for their ability to engulf and digest foreign substances, including cellular debris and tumor cells. They can convert into tumor-associated macrophages (TAMs) when ...

Abstract	Macrophages are one of the most important cells of the innate immune system and are known for their ability to engulf and digest foreign substances, including cellular debris and tumor cells. They can convert into tumor-associated macrophages (TAMs) when mature macrophages are recruited into the tumor microenvironment. Their role in cancer progression, metastasis, and therapy failure is of special note. The aim of this review is to understand how the presence of TAMs are both advantageous and disadvantageous in the immune system.
MeSH term(s)	Animals ; Combined Modality Therapy ; Female ; Humans ; Immunity, Innate ; Immunotherapy/methods ; Male ; Models, Immunological ; Neoplasms/immunology ; Neoplasms/therapy ; Tumor Microenvironment/immunology ; Tumor-Associated Macrophages/classification ; Tumor-Associated Macrophages/immunology
Language	English
Publishing date	2021-07-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22137239
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Article ; Online: Apoptotic Cell Death in an Animal Model of Virus-Induced Acute Liver Failure-Observations during

Bębnowska, Dominika / Hrynkiewicz, Rafał / Rzeszotek, Sylwia / Freus, Marika / Poniewierska-Baran, Agata / Niedźwiedzka-Rystwej, Paulina

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Lagovirus ... ...

Abstract	Lagovirus europaeus
MeSH term(s)	Humans ; Animals ; Caspase 3 ; bcl-2-Associated X Protein ; Liver Failure, Acute/etiology ; Communicable Diseases ; Apoptosis ; Models, Animal ; Gastrointestinal Diseases ; Hemorrhagic Disorders ; Lagomorpha ; Lagovirus ; Proto-Oncogene Proteins c-bcl-2
Chemical Substances	Caspase 3 (EC 3.4.22.-) ; bcl-2-Associated X Protein ; Proto-Oncogene Proteins c-bcl-2
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25020798
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Article ; Online: The Interplay between Autophagy and Virus Pathogenesis—The Significance of Autophagy in Viral Hepatitis and Viral Hemorrhagic Fevers

Dominika Bębnowska / Paulina Niedźwiedzka-Rystwej

Cells, Vol 11, Iss 871, p

2022 Volume 871

Abstract	Autophagy is a process focused on maintaining the homeostasis of organisms; nevertheless, the role of this process has also been widely documented in viral infections. Thus, xenophagy is a selective form of autophagy targeting viruses. However, the relation between autophagy and viruses is ambiguous—this process may be used as a strategy to fight with a virus, but is also in favor of the virus’s replication. In this paper, we have gathered data on autophagy in viral hepatitis and viral hemorrhagic fevers and the relations impacting its viral pathogenesis. Thus, autophagy is a potential therapeutic target, but research is needed to fully understand the mechanisms by which the virus interacts with the autophagic machinery. These studies must be performed in specific research models other than the natural host for many reasons. In this paper, we also indicate Lagovirus europaeus virus as a potentially good research model for acute liver failure and viral hemorrhagic disease.
Keywords	autophagy ; viral hepatitis ; viral hemorrhagic fever (VHF) ; animal model ; Lagovirus europaeus ; rabbit hemorrhagic disease ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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