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  1. Article ; Online: Towards Early Diagnosis of Axial Psoriatic Arthritis.

    Watad, Abdulla / McGonagle, Dennis

    Rheumatology (Oxford, England)

    2024  

    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keae002
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    Zs.B 240: Show issues Location:
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  2. Article ; Online: Health-care workers recovered from natural SARS-CoV-2 infection should be exempt from mandatory vaccination edicts.

    McGonagle, Dennis G

    The Lancet. Rheumatology

    2022  Volume 4, Issue 3, Page(s) e170

    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(22)00038-8
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  3. Article ; Online: Immune and non-immune mechanisms that determine vasculitis and coronary artery aneurysm topography in Kawasaki disease and MIS-C.

    Giryes, Sami / McGonagle, Dennis

    Autoimmunity reviews

    2022  Volume 22, Issue 2, Page(s) 103240

    Abstract: The overlap between multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) including coronary artery aneurysms (CAA) and broadly shared gastrointestinal and mucocutaneous disease is poorly defined. In this perspective, we ... ...

    Abstract The overlap between multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) including coronary artery aneurysms (CAA) and broadly shared gastrointestinal and mucocutaneous disease is poorly defined. In this perspective, we highlight common age-related extravascular epicardial microanatomical and immunological factors that might culminate in CAA expression in both MIS-C and KD. Specifically, the coronary vasa vasorum originates outside the major coronary arteries. Widespread inflammation in the epicardial interstitial compartment in shared between KD and MIS-C. Age-related changes in the neonatal and immature coronary vasculature including the impact of coronary artery biomechanical factors including coronary vessel calibre, age-related vessel distensibility, flow, and vessel neurovascular innervation may explain the decreasing CAA frequency from neonates to older children and the virtual absence of CAA in young adults with the MIS-C phenotype. Other KD and MIS-C features including mucocutaneous disease with keratinocyte-related immunopathology corroborate that disease phenotypes are centrally influenced by inflammation originating outside vessel walls but a potential role for primary coronary artery vascular wall inflammation cannot be excluded. Hence, common extravascular originating tissue-specific responses to aetiologically diverse triggers including superantigens may lead to widespread interstitial tissue inflammation characteristically manifesting as CAA development, especially in younger subjects. Given that CAA is virtually absent in adults, further studies are needed to ascertain whether epicardial interstitial inflammation may impact on both coronary artery physiology and cardiac conduction tissue and contribute to cardiovascular disease- a hitherto unappreciated consideration.
    MeSH term(s) Humans ; Mucocutaneous Lymph Node Syndrome/complications ; Coronary Vessels/pathology ; Coronary Aneurysm/complications ; Coronary Aneurysm/pathology ; Inflammation/pathology
    Language English
    Publishing date 2022-12-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2022.103240
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    Zs.A 5913: Show issues Location:
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  4. Article ; Online: Role of neutrophil interleukin-23 in spondyloarthropathy spectrum disorders.

    Macleod, Tom / Bridgewood, Charles / McGonagle, Dennis

    The Lancet. Rheumatology

    2023  Volume 5, Issue 1, Page(s) e47–e57

    Abstract: Neutrophilic inflammation is a pervasive characteristic common to spondyloarthropathies and related disorders. This inflammation manifests as Munro's microabscesses of the skin and osteoarticular neutrophilic inflammation in patients with psoriatic ... ...

    Abstract Neutrophilic inflammation is a pervasive characteristic common to spondyloarthropathies and related disorders. This inflammation manifests as Munro's microabscesses of the skin and osteoarticular neutrophilic inflammation in patients with psoriatic arthritis, intestinal crypt abscesses in patients with inflammatory bowel disease, ocular hypopyon in anterior uveitis, and neutrophilic macroscopic and microscopic inflammation in patients with Behçet's disease. Strong MHC class I associations are seen in these diseases, which represent so-called MHC-I-opathies, and these associations indicate an involvement of CD8 T-cell immunopathology that is not yet well understood. In this Personal View, we highlight emerging data suggesting that the T-cell-neutrophil axis involves both a T-cell-mediated and interleukin (IL)-17-mediated (type 17) recruitment and activation of neutrophils, and also a sequestration of activated neutrophils at disease sites that might directly amplify type 17 T-cell responses. This amplification likely involves neutrophilic production of IL-23 and proteases as well as other feedback mechanisms that could be regulated by local microbiota, pathogens, or tissue damage. This crosstalk between innate and adaptive immunity offers a novel explanation for how bacterial and fungal microbes at barrier sites could innately control type 17 T-cell development, with the aim of restoring tissue homoeostasis, and could potentially explain features of clinical disease and treatment response, such as the fast-onset action of the IL-23 pathway blockade in certain patients. This axis could be crucial to understanding non-response to IL-23 inhibitors among patients with ankylosing spondylitis, as the axial skeleton is a site rich in neutrophils and a site of haematopoiesis with myelopoiesis in adults.
    MeSH term(s) Adult ; Humans ; Interleukin-23 ; Neutrophils ; Spondylarthropathies ; Arthritis, Psoriatic ; Abscess
    Chemical Substances Interleukin-23
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(22)00334-4
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  5. Article ; Online: Severe COVID-19 as a virus-independent immunothrombotic process - Authors' reply.

    McGonagle, Dennis / Watad, Abdulla / Bridgewood, Charles

    The Lancet. Rheumatology

    2022  Volume 4, Issue 3, Page(s) e173

    Language English
    Publishing date 2022-02-24
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(22)00031-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Toward Cannabinoid Use for Refractory Cutaneous Dermatomyositis.

    Wittmann, Miriam / Staubach, Petra / McGonagle, Dennis

    The Journal of investigative dermatology

    2022  Volume 142, Issue 10, Page(s) 2556–2557

    MeSH term(s) Administration, Cutaneous ; Cannabinoids/therapeutic use ; Dermatomyositis/drug therapy ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Skin
    Chemical Substances Cannabinoids ; Immunoglobulins, Intravenous
    Language English
    Publishing date 2022-09-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.07.017
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    Ui VI Zs.124: Show issues Location:
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  7. Article ; Online: Recent advances and evolving concepts in Still's disease.

    Ruscitti, Piero / Cantarini, Luca / Nigrovic, Peter A / McGonagle, Dennis / Giacomelli, Roberto

    Nature reviews. Rheumatology

    2024  Volume 20, Issue 2, Page(s) 116–132

    Abstract: Still's disease is a rare inflammatory syndrome that encompasses systemic juvenile idiopathic arthritis and adult-onset Still's disease, both of which can exhibit life-threatening complications, including macrophage activation syndrome (MAS), a secondary ...

    Abstract Still's disease is a rare inflammatory syndrome that encompasses systemic juvenile idiopathic arthritis and adult-onset Still's disease, both of which can exhibit life-threatening complications, including macrophage activation syndrome (MAS), a secondary form of haemophagocytic lymphohistiocytosis. Genetic insights into Still's disease involve both HLA and non-HLA susceptibility genes, suggesting the involvement of adaptive immune cell-mediated immunity. At the same time, phenotypic evidence indicates the involvement of autoinflammatory processes. Evidence also implicates the type I interferon signature, mechanistic target of rapamycin complex 1 signalling and ferritin in the pathogenesis of Still's disease and MAS. Pathological entities associated with Still's disease include lung disease that could be associated with biologic DMARDs and with the occurrence of MAS. Historically, monophasic, recurrent and persistent Still's disease courses were recognized. Newer proposals of alternative Still's disease clusters could enable better dissection of clinical heterogeneity on the basis of immune cell profiles that could represent diverse endotypes or phases of disease activity. Therapeutically, data on IL-1 and IL-6 antagonism and Janus kinase inhibition suggest the importance of early administration in Still's disease. Furthermore, there is evidence that patients who develop MAS can be treated with IFNγ antagonism. Despite these developments, unmet needs remain that can form the basis for the design of future studies leading to improvement of disease management.
    MeSH term(s) Adult ; Humans ; Arthritis, Juvenile/drug therapy ; Antirheumatic Agents/therapeutic use ; Macrophage Activation Syndrome/drug therapy ; Macrophage Activation Syndrome/etiology ; Still's Disease, Adult-Onset/complications ; Still's Disease, Adult-Onset/drug therapy ; Lymphohistiocytosis, Hemophagocytic/drug therapy
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-023-01065-6
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    Zs.A 6338: Show issues Location:
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  8. Book ; Conference proceedings: New views on nail anatomy and psoriasis

    Girolomoni, Giampiero / McGonagle, Dennis / Reich, Kristian

    a Satellite Symposium ["New Views on Nail Anatomy and Psoriasis"] from the Congress "Psoriasis: From Gene to Clinic" held in London, UK on 4 - 6 December 2008

    (Journal of the European Academy of Dermatology and Venereology ; 23, Suppl. 1)

    2009  

    Event/congress Satellite Symposium New Views on Nail Anatomy and Psoriasis (2008, London) ; Congress Psoriasis From Gene to Clinic (2008, London)
    Author's details faculty Giampiero Girolomoni ; Dennis McGonagle ; Kristian Reich
    Series title Journal of the European Academy of Dermatology and Venereology ; 23, Suppl. 1
    Collection
    Language English
    Size 21 S. : Ill.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT016050944
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 3492 -23,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  9. Article ; Online: Predominant ligament-centric soft-tissue involvement differentiates axial psoriatic arthritis from ankylosing spondylitis.

    McGonagle, Dennis / David, Paula / Macleod, Tom / Watad, Abdulla

    Nature reviews. Rheumatology

    2023  Volume 19, Issue 12, Page(s) 818–827

    Abstract: Since the original description of spondyloarthritis 50 years ago, results have demonstrated similarities and differences between ankylosing spondylitis (AS) and axial psoriatic arthritis (PsA). HLA-B27 gene carriage in axial inflammation is linked to ... ...

    Abstract Since the original description of spondyloarthritis 50 years ago, results have demonstrated similarities and differences between ankylosing spondylitis (AS) and axial psoriatic arthritis (PsA). HLA-B27 gene carriage in axial inflammation is linked to peri-fibrocartilaginous sacroiliac joint osteitis, as well as to spinal peri-entheseal osteitis, which is often extensive and which provides a crucial anatomical and immunological differentiation between the AS and PsA phenotypes. Specifically, HLA-B27-related diffuse bone marrow oedema (histologically an osteitis) and bone marrow fatty corners detected via magnetic resonance imaging, as well as radiographic changes such as sacroiliitis, vertebral squaring, corner erosions and Romanus lesions, all indicate initial bone phenotypes in HLA-B27
    MeSH term(s) Humans ; Arthritis, Psoriatic ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/genetics ; Osteitis ; HLA-B27 Antigen/genetics ; Ligaments/pathology
    Chemical Substances HLA-B27 Antigen
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-023-01038-9
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    Zs.A 6338: Show issues Location:
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  10. Article ; Online: Reply.

    Rosine, Nicolas / Rogge, Lars / McGonagle, Dennis / Miceli-Richard, Corinne

    Arthritis & rheumatology (Hoboken, N.J.)

    2022  Volume 74, Issue 12, Page(s) 2046–2047

    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42277
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