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  1. Article ; Online: Concomitant medications and circulating tumor cells: friends or foes?

    Di Cosimo, Serena / Cappelletti, Vera

    Cancer drug resistance (Alhambra, Calif.)

    2023  Volume 6, Issue 1, Page(s) 30–34

    Abstract: The use of concomitant medications by patients with cancer is observed almost globally; however, little attention has been paid to this topic in the medical literature. Most clinical studies do not describe the type and duration of drugs used at the time ...

    Abstract The use of concomitant medications by patients with cancer is observed almost globally; however, little attention has been paid to this topic in the medical literature. Most clinical studies do not describe the type and duration of drugs used at the time of inclusion and during treatment or how these drugs may affect the experimental and/or standard therapy. Even less information has been published on the potential interaction between concomitant medications and tumor biomarkers. However, we do know that concomitant drugs can complicate cancer clinical trials and biomarker development, thus contributing to their interaction, leading to side effects, and resulting in suboptimal adherence to anticancer treatment. On the basis of these premises and moving from the study by Jurisova
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 2578-532X
    ISSN (online) 2578-532X
    DOI 10.20517/cdr.2022.68
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: DESTINY-Breast03 trial: some questions remain.

    Di Cosimo, Serena / Apolone, Giovanni / Cappelletti, Vera / Torri, Valter

    Lancet (London, England)

    2023  Volume 401, Issue 10389, Page(s) 1653

    Language English
    Publishing date 2023-05-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00685-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Advancing immunotherapy for early-stage triple-negative breast cancer.

    Di Cosimo, Serena

    Lancet (London, England)

    2020  Volume 396, Issue 10257, Page(s) 1046–1048

    MeSH term(s) Albumins ; Anthracyclines ; Antibodies, Monoclonal, Humanized ; Breast Neoplasms ; Double-Blind Method ; Humans ; Immunotherapy ; Neoadjuvant Therapy ; Paclitaxel
    Chemical Substances 130-nm albumin-bound paclitaxel ; Albumins ; Anthracyclines ; Antibodies, Monoclonal, Humanized ; atezolizumab (52CMI0WC3Y) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2020-09-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31962-0
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  4. Article ; Online: Association of Hormone Receptors With Clinical Outcomes in Patients With ERBB2-Low Breast Cancer.

    Cappelletti, Vera / Di Cosimo, Serena / Pruneri, Giancarlo

    JAMA oncology

    2022  Volume 9, Issue 1, Page(s) 146–147

    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Receptor, ErbB-2 ; Hormones
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1) ; Hormones ; ERBB2 protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2022-11-03
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2022.5091
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  5. Article ; Online: Assessing HER2 status in breast cancer through next-generation sequencing of circulating tumor cells.

    Di Cosimo, Serena / Silvestri, Marco / De Marco, Cinzia / Reduzzi, Carolina / Folli, Secondo / De Santis, Maria Carmen / Cappelletti, Vera

    The International journal of biological markers

    2024  , Page(s) 3936155241246542

    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Letter
    ZDB-ID 645113-5
    ISSN 1724-6008 ; 0393-6155
    ISSN (online) 1724-6008
    ISSN 0393-6155
    DOI 10.1177/03936155241246542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2491: Show issues Location:
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  6. Article ; Online: Advancing Circulating Tumor DNA for Recurrent Breast Cancer.

    Di Cosimo, Serena / Cappelletti, Vera / Pruneri, Giancarlo

    JCO precision oncology

    2020  Volume 7, Page(s) e2200596

    MeSH term(s) Humans ; Female ; Circulating Tumor DNA/genetics ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/genetics ; Neoplastic Cells, Circulating ; DNA, Neoplasm/genetics
    Chemical Substances Circulating Tumor DNA ; DNA, Neoplasm
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.22.00596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Can we define breast cancer HER2 status by liquid biopsy?

    Di Cosimo, Serena / De Marco, Cinzia / Silvestri, Marco / Busico, Adele / Vingiani, Andrea / Pruneri, Giancarlo / Cappelletti, Vera

    International review of cell and molecular biology

    2023  Volume 381, Page(s) 23–56

    Abstract: Human Epidermal growth factor Receptor 2 (HER2) assessment is crucial for breast cancer treatment. Therapeutic decisions for recurrent cases often rely on primary tumor status. However, mounting evidence suggests that tumors show dynamic changes and up ... ...

    Abstract Human Epidermal growth factor Receptor 2 (HER2) assessment is crucial for breast cancer treatment. Therapeutic decisions for recurrent cases often rely on primary tumor status. However, mounting evidence suggests that tumors show dynamic changes and up to 10% of breast cancer modify their initial status during progression. It is still debated whether these changes reflect a biological evolution of the disease or are secondary to primary tumor heterogeneity. Certainly, repeating HER2 assessment during breast cancer trajectory is important for the increasing availability of effective anti-HER2 drugs. In response to this need, circulating biomarkers such as circulating tumor cells (CTCs) and cell-free circulating tumor DNA (ctDNA) offer the potential to safely and repeatedly assess HER2 status over time. This chapter outlines current methods for testing HER2 in CTCs and ctDNA, and reviews clinical trials evaluating its prognostic and predictive value in patients with breast cancer, as well as recent advances in the field.
    MeSH term(s) Female ; Humans ; Biological Evolution ; Breast Neoplasms/drug therapy ; Liquid Biopsy
    Language English
    Publishing date 2023-09-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2427220-6
    ISSN 1937-6448 ; 0074-7696
    ISSN 1937-6448 ; 0074-7696
    DOI 10.1016/bs.ircmb.2023.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Uc I Zs.317: Show issues Location:
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  8. Article ; Online: CDK 4/6 inhibitors mired in uncertainty in HR positive and HER2 negative early breast cancer.

    Di Cosimo, Serena / Porcu, Luca / Cardoso, Fatima

    Breast (Edinburgh, Scotland)

    2020  Volume 55, Page(s) 75–78

    Abstract: Cell-cycle abnormalities are common in estrogen receptor- and/or progesterone receptor-positive, and HER2-non-overexpressing (HR+/HER2-) breast cancer, and have long been considered potential therapeutic targets. Cyclin-dependent kinase (CDK) 4/6 ... ...

    Abstract Cell-cycle abnormalities are common in estrogen receptor- and/or progesterone receptor-positive, and HER2-non-overexpressing (HR+/HER2-) breast cancer, and have long been considered potential therapeutic targets. Cyclin-dependent kinase (CDK) 4/6 inhibitors have dramatically changed the therapeutic management of HR+/HER2-advanced breast cancer by prolonging progression-free and overall survival when given in combination with endocrine therapy. In this article, available data from PALLAS and monarchE trials regarding the efficacy and toxicity of adjuvant combined therapy with CDK 4/6 inhibitors and endocine therapy in HR+/HER2-early breast cancer are reviewed, and relevant issues including study hypothesis, patient selection, and duration of follow-up are discussed.
    MeSH term(s) Aminopyridines/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/drug therapy ; Cyclin-Dependent Kinase 4 ; Cyclin-Dependent Kinase 6 ; Female ; Humans ; Piperazines/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Purines/therapeutic use ; Pyridines/therapeutic use ; Receptor, ErbB-2 ; Uncertainty
    Chemical Substances Aminopyridines ; Piperazines ; Protein Kinase Inhibitors ; Purines ; Pyridines ; Receptor, ErbB-2 (EC 2.7.10.1) ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; Cyclin-Dependent Kinase 6 (EC 2.7.11.22)
    Language English
    Publishing date 2020-12-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1143210-x
    ISSN 1532-3080 ; 0960-9776
    ISSN (online) 1532-3080
    ISSN 0960-9776
    DOI 10.1016/j.breast.2020.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3620: Show issues Location:
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    Zs.MO 588: Show issues

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  9. Article: The worldwide impact of COVID-19 on cancer care: A meta-analysis of surveys published after the first wave of the pandemic.

    Di Cosimo, Serena / Susca, Nicola / Apolone, Giovanni / Silvestris, Nicola / Racanelli, Vito

    Frontiers in oncology

    2022  Volume 12, Page(s) 961380

    Abstract: Background: The rapid and global spread of COVID-19 posed a massive challenge to healthcare systems, which came across the need to provide high-intensity assistance to thousands of patients suffering from SARS-CoV-2 infection while assuring continuous ... ...

    Abstract Background: The rapid and global spread of COVID-19 posed a massive challenge to healthcare systems, which came across the need to provide high-intensity assistance to thousands of patients suffering from SARS-CoV-2 infection while assuring continuous care for all other diseases. This has been of particular importance in the oncology field. This study explores how oncology centers responded to the pandemic at a single center level by assessing surveys addressing different aspects of cancer care after the pandemic outbreak.
    Methods: We performed a systematic review and meta-analysis of the cancer care surveys published until December 11th, 2020. Data were analyzed according to three main areas of interest, namely health care organization, including cancellation/delay and/or modification of scheduled treatments, cancellation/delay of outpatient visits, and reduction of overall cancer care activities; routine use of preventive measures, such as personal protective equipment (PPE) by both patients and health care workers, and systematic SARS-CoV-2 screening by nasopharyngeal swabs; and implementation of telemedicine through remote consultations.
    Findings: Fifty surveys reporting data on 9150 providers from 121 countries on 5 continents were included. Cancellation/delay of treatment occurred in 58% of centers; delay of outpatient visits in 75%; changes in treatment plans in 65%; and a general reduction in clinical activity in 58%. Routine use of PPE by patients and healthcare personnel was reported by 81% and 80% of centers, respectively; systematic SARS-CoV-2 screening by nasopharyngeal swabs was reported by only 41% of centers. Virtual visits were implemented by the majority (72%) of centers.
    Interpretation: These results describe the negative impact of COVID-19 on cancer care, the rapid response of cancer centers in terms of preventive measures and alternative treatment approaches such as telemedicine, and confirm that surveys can provide the valuable, low-cost and immediate information that critical situations require.
    Language English
    Publishing date 2022-09-29
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.961380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Psychosocial factors associated with workability after surgery in cancer survivors: An explorative study.

    Silvaggi, Fabiola / Mariniello, Arianna / Leonardi, Matilde / Silvani, Antonio / Lamperti, Elena / Di Cosimo, Serena / Folli, Secondo / Trapani, Anna / Schiavolin, Silvia

    Journal of health psychology

    2023  Volume 28, Issue 11, Page(s) 999–1010

    Abstract: This study aimed to evaluate the work ability and its associated factors in patients with glioma (II, III) and breast cancer after 6 (T0) and 12 (T1) months from surgery. A total of 99 patients were evaluated with self-reported questionnaires at T0 and ... ...

    Abstract This study aimed to evaluate the work ability and its associated factors in patients with glioma (II, III) and breast cancer after 6 (T0) and 12 (T1) months from surgery. A total of 99 patients were evaluated with self-reported questionnaires at T0 and T1. Correlation and Mann-Whitney tests were used to investigate the association between work ability and sociodemographic, clinical, and psychosocial factors. The Wilcoxon test was used to investigate the longitudinal change in work ability. Our sample showed a decrease in work ability level between T0 and T1. Work ability was associated with emotional distress, disability, resilience, and social support in glioma III patients at T0, and with fatigue, disability, and clinical treatments in patients with breast cancer at T0 and T1. Work ability levels decreased in patients with glioma and breast cancer and were associated with different psychosocial factors after surgery. Their investigation is suggested to facilitate the return to work.
    MeSH term(s) Humans ; Female ; Cancer Survivors ; Breast Neoplasms/surgery ; Surveys and Questionnaires ; Self Report ; Glioma
    Language English
    Publishing date 2023-02-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2021897-7
    ISSN 1461-7277 ; 1359-1053
    ISSN (online) 1461-7277
    ISSN 1359-1053
    DOI 10.1177/13591053231151286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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