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  1. Article: Zum 200sten Todestag des Frankfurter Großherzoglichen Obermedizinalrats JOHANN PHILIPP ACHILLES LEISLER (1772 - 1813) in Hanau/Main

    Hinkel, A. / Kolb, A.

    Nyctalus

    2013  Volume 18, Issue 2, Page(s) 160

    Language German
    Document type Article
    ZDB-ID 405504-4
    ISSN 0138-2276
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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  2. Article: The anti-tumorigenic activity of A2M—A lesson from the naked mole-rat

    Groth, Marco / Pieroh, Philipp / Kolb, Marlen / Huse, Klaus / Platzer, Matthias / Hoffmann, Ralf / Birkenmeier, Gerd

    PLOS ONE, 12(12):e0189514

    2017  

    Abstract: Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which ... ...

    Institution Leibniz-Institut für Alternsforschung
    Abstract Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute to the naked mole-rat’s cancer resistance. Notably, A2M is known to dramatically decrease with age in humans. We hypothesize that this might facilitate tumour development. Here we found that A2M modulates tumour cell adhesion, migration and growth by inhibition of tumour promoting signalling pathways, e.g. PI3K / AKT, SMAD and up-regulated PTEN via down-regulation of miR-21, in vitro and in tumour xenografts. A2M increases the expression of CD29 and CD44 but did not evoke EMT. Transcriptome analysis of A2M-treated tumour cells, xenografts and mouse liver demonstrated a multifaceted regulation of tumour promoting signalling pathways indicating a less tumorigenic environment mediated by A2M. By virtue of these multiple actions the naturally occurring A2M has strong potential as a novel therapeutic agent.
    Keywords Cancer treatment ; Apoptosis ; Blood ; Gene expression ; Gene regulation ; HT29 cells ; Immunoprecipitation ; Transcriptome analysis
    Language English
    Document type Article
    Database Repository for Life Sciences

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  3. Article ; Online: Isolation, Identification and Structural Verification of a Methylene-Bridged Naloxone "Dimer" Formed by Formaldehyde.

    Schmidt, Philipp / Kolb, Christine / Reiser, Andreas / Philipp, Markus / Müller, Hans-Christian / Karaghiosoff, Konstantin

    Journal of pharmaceutical sciences

    2021  Volume 111, Issue 6, Page(s) 1682–1689

    Abstract: We report the isolation and characterization of a methylene bridged "dimer" of the opioid antagonist Naloxone, previously detected in experimental Buprenorphine-Naloxone oral films. This compound was found to form via an aldol addition followed by a ... ...

    Abstract We report the isolation and characterization of a methylene bridged "dimer" of the opioid antagonist Naloxone, previously detected in experimental Buprenorphine-Naloxone oral films. This compound was found to form via an aldol addition followed by a condensation reaction under acidic conditions between two units of Naloxone and one unit of formaldehyde. HPLC-UV-HRMS analysis revealed the formation of three individual stereoisomers during this reaction, which were separately isolated using solid-phase extraction. These isomers were shown to freely react into one another in solvent, forming an equilibrium. The structure of the unknown compound was determined via HRMS spectrometry and 1D and 2D NMR spectroscopy.
    MeSH term(s) Chromatography, High Pressure Liquid/methods ; Formaldehyde ; Magnetic Resonance Spectroscopy/methods ; Naloxone ; Polymers ; Solid Phase Extraction
    Chemical Substances Polymers ; Formaldehyde (1HG84L3525) ; Naloxone (36B82AMQ7N)
    Language English
    Publishing date 2021-11-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2021.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Separation and identification of a complex flurbiprofen-polyethylene glycol mono- and diester mixture via a hyphenated HPLC-DAD-HRMS/SPE NMR system.

    Schmidt, Philipp / Kolb, Christine / Godejohann, Markus / Reiser, Andreas / Philipp, Markus / Müller, Hans-Christian / Karaghiosoff, Konstantin

    Journal of pharmaceutical and biomedical analysis

    2022  Volume 222, Page(s) 115068

    Abstract: We report the use of a hyphenated HPLC-DAD(diode array detector)-HRMS/SPE NMR system for the separation and isolation of a complex mixture of esters, containing substances with very similar LC retention times. The literature known mono- and diesters of ... ...

    Abstract We report the use of a hyphenated HPLC-DAD(diode array detector)-HRMS/SPE NMR system for the separation and isolation of a complex mixture of esters, containing substances with very similar LC retention times. The literature known mono- and diesters of the drug Flurbiprofen and polyethylene glycol, which form a large number of substances with varying chain lengths, were chosen for this study. We demonstrate the use of this hyphenated system to quickly and effectively isolate sixteen of these highly similar individual esters in an automated fashion, demonstrating its applicability in standard pharmaceutical analysis and quality control of drugs. Both, synthetic solutions of these esters and extracts from Flurbiprofen lozenges were used for this purpose. By the sole use of this system, the individual compounds were isolated and UV, HRMS and 1D and
    MeSH term(s) Chromatography, High Pressure Liquid ; Flurbiprofen ; Polyethylene Glycols ; Magnetic Resonance Spectroscopy ; Magnetic Resonance Imaging
    Chemical Substances Flurbiprofen (5GRO578KLP) ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2022-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2022.115068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Immune complexes as culprits of immunopathology in severe COVID-19.

    Kolb, Philipp / Giese, Sebastian / Voll, Reinhard Edmund / Hengel, Hartmut / Falcone, Valeria

    Medical microbiology and immunology

    2022  Volume 212, Issue 2, Page(s) 185–191

    Abstract: Infection with the pandemic human coronavirus SARS-CoV-2 elicits a respiratory tract disease, termed Coronavirus disease 2019 (COVID-19). While a variable degree of disease-associated symptoms may emerge, severe COVID-19 is commonly associated with ... ...

    Abstract Infection with the pandemic human coronavirus SARS-CoV-2 elicits a respiratory tract disease, termed Coronavirus disease 2019 (COVID-19). While a variable degree of disease-associated symptoms may emerge, severe COVID-19 is commonly associated with respiratory complications such as acute respiratory distress syndrome (ARDS), the necessity for mechanical ventilation or even extracorporeal membrane oxygenation (ECMO). Amongst others, disease outcome depends on age and pre-existing conditions like cardiovascular diseases, metabolic disorders but also age and biological sex. Intriguingly, increasing experimental and clinical evidence suggests that an exacerbated inflammatory response and in particular IgG immune complexes (ICs), significantly contribute to severe and prolonged COVID-19 disease progression. Vast amounts of deposited, unresolved ICs in tissue are capable to initiate an exaggerated Fc gamma receptor (FcγR) mediated signalling cascade which eventually results in common IC-associated organ diseases such as vasculitis, glomerulonephritis and arthritis, comorbidities that have been frequently reported for COVID-19. Moreover and independent of deposited ICs, very recent work identified soluble ICs (sIC) to be also present in the circulation of a majority of severely ill patients, where their systemic abundance correlated with disease severity. Thus, detection of circulating sICs in patients represents a potential marker for critical COVID-19 disease progression. Their detection early after clinical deterioration might become an indicator for the requirement of prompt anti-inflammatory treatment. Here, we review the role of ICs in COVID-19 progression, their possible origins and potential intervention strategies.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Antigen-Antibody Complex ; Respiratory Distress Syndrome ; Disease Progression
    Chemical Substances Antigen-Antibody Complex
    Language English
    Publishing date 2022-07-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 120933-4
    ISSN 1432-1831 ; 0300-8584
    ISSN (online) 1432-1831
    ISSN 0300-8584
    DOI 10.1007/s00430-022-00743-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Four-wave mixing seeded by a rapid wavelength-sweeping FDML laser for nonlinear imaging at 900 nm and 1300 nm.

    Lamminger, Philipp / Hakert, Hubertus / Lotz, Simon / Kolb, Jan Philip / Kutscher, Tonio / Karpf, Sebastian / Huber, Robert

    Optics letters

    2023  Volume 48, Issue 14, Page(s) 3713–3716

    Abstract: Four-wave mixing (FWM) enables the generation and amplification of light in spectral regions where suitable fiber gain media are unavailable. The 1300 nm and 900 nm regions are of especially high interest for time-encoded (TICO) stimulated Raman ... ...

    Abstract Four-wave mixing (FWM) enables the generation and amplification of light in spectral regions where suitable fiber gain media are unavailable. The 1300 nm and 900 nm regions are of especially high interest for time-encoded (TICO) stimulated Raman scattering microscopy and spectro-temporal laser imaging by diffracted excitation (SLIDE) two-photon microscopy. We present a new, to the best of our knowledge, FWM setup where we shift the power of a home-built fully fiber-based master oscillator power amplifier (MOPA) at 1064 nm to the 1300-nm region of a rapidly wavelength-sweeping Fourier domain mode-locked (FDML) laser in a photonic crystal fiber (PCF) creating pulses in the 900-nm region. The resulting 900-nm light can be wavelength swept over 54 nm and has up to 2.5 kW (0.2 µJ) peak power and a narrow instantaneous spectral linewidth of 70 pm. The arbitrary pulse patterns of the MOPA and the fast wavelength tuning of the FDML laser (419 kHz) allow it to rapidly tune the FWM light enabling new and faster TICO-Raman microscopy, SLIDE imaging, and other applications.
    MeSH term(s) Equipment Design ; Fiber Optic Technology ; Lasers ; Microscopy, Confocal
    Chemical Substances alpha-methoxy-alpha-phenylacetic acid (MAT0P17A95)
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.488181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluation of Spectral X-Ray Imaging for Panoramic Dental Images Based on a Simulation Framework.

    Berthe, Daniel / Kolb, Anna / Rabi, Abdulrahman / Sellerer, Thorsten / Somerkivi, Villseveri / Feuerriegel, Georg Constantin / Sauter, Andreas Philipp / Meurer, Felix / Hämisch, York / Pantsar, Tuomas / Lohman, Henrik / Pfeiffer, Daniela / Pfeiffer, Franz

    Journal of imaging informatics in medicine

    2024  Volume 37, Issue 2, Page(s) 892–898

    Abstract: Modern photon counting detectors allow the calculation of virtual monoenergetic or material decomposed X-ray images but are not yet used for dental panoramic radiography systems. To assess the diagnostic potential and image quality of photon counting ... ...

    Abstract Modern photon counting detectors allow the calculation of virtual monoenergetic or material decomposed X-ray images but are not yet used for dental panoramic radiography systems. To assess the diagnostic potential and image quality of photon counting detectors in dental panoramic radiography, ethics approval from the local ethics committee was obtained for this retrospective study. Conventional CT scans of the head and neck region were segmented into bone and soft tissue. The resulting datasets were used to calculate panoramic equivalent thickness bone and soft tissue images by forward projection, using a geometry like that of conventional panoramic radiographic systems. The panoramic equivalent thickness images were utilized to generate synthetic conventional panoramic radiographs and panoramic virtual monoenergetic radiographs at various energies. The conventional, two virtual monoenergetic images at 40 keV and 60 keV, and material-separated bone and soft tissue panoramic equivalent thickness X-ray images simulated from 17 head CTs were evaluated in a reader study involving three experienced radiologists regarding their diagnostic value and image quality. Compared to conventional panoramic radiographs, the material-separated bone panoramic equivalent thickness image exhibits a higher image quality and diagnostic value in assessing the bone structure
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2948-2933
    ISSN (online) 2948-2933
    DOI 10.1007/s10278-023-00940-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Formation of a Thiol-Ene Addition Product of Asthma Medication Montelukast Caused by a Widespread Tin-Based Thermal Stabilizer.

    Schmidt, Philipp / Kolb, Christine / Reiser, Andreas / Philipp, Markus / Godejohann, Markus / Helmboldt, Hannes / Müller, Hans-Christian / Karaghiosoff, Konstantin

    Chemical research in toxicology

    2020  Volume 33, Issue 12, Page(s) 2963–2971

    Abstract: We report the formation and characterization of two diastereomeric thiol-ene addition products of the asthma medication Montelukast within chewing tablets. Widespread tin-based thermal stabilizers dioctyltin bis(2-ethylhexyl thioglycolate) and ... ...

    Abstract We report the formation and characterization of two diastereomeric thiol-ene addition products of the asthma medication Montelukast within chewing tablets. Widespread tin-based thermal stabilizers dioctyltin bis(2-ethylhexyl thioglycolate) and monooctyltin tris(2-ethylhexyl thioglycolate), used in the manufacturing process of the medication's forming foil, were identified as the source of the thiol reactant, showing that these stabilizers may play a part in the degradation of Montelukast and APIs with functionalities similar to those of Montelukast, which should be considered during development of medication. The isolation and analysis of these impurities was performed by HPLC and UV-vis spectroscopy. HRMS and NMR data were collected to characterize and determine the structures of these compounds.
    MeSH term(s) Acetates/analysis ; Acetates/therapeutic use ; Asthma/drug therapy ; Cyclopropanes/analysis ; Cyclopropanes/therapeutic use ; Humans ; Molecular Structure ; Organotin Compounds/chemistry ; Quinolines/analysis ; Quinolines/therapeutic use ; Sulfhydryl Compounds/analysis ; Sulfhydryl Compounds/therapeutic use ; Sulfides/analysis ; Sulfides/therapeutic use ; Temperature
    Chemical Substances Acetates ; Cyclopropanes ; Organotin Compounds ; Quinolines ; Sulfhydryl Compounds ; Sulfides ; montelukast (MHM278SD3E)
    Language English
    Publishing date 2020-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639353-6
    ISSN 1520-5010 ; 0893-228X
    ISSN (online) 1520-5010
    ISSN 0893-228X
    DOI 10.1021/acs.chemrestox.0c00261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Thesis: Schwindungskompensation bei der Kunststoffreplikation dickwandiger LED-Beleuchtungsoptiken

    Kolb, Philipp Rüdiger

    (Edition Wissenschaft - Apprimus ; Ergebnisse aus der Produktionstechnik ; 2014,32 ; Produktionsmaschinen)

    2014  

    Author's details Philipp Rüdiger Kolb
    Series title Edition Wissenschaft - Apprimus
    Ergebnisse aus der Produktionstechnik ; 2014,32
    Produktionsmaschinen
    Keywords Dickwandiges Bauelement ; Optisches Bauelement ; Lumineszenzdiode ; Kunststoffformteil ; Leuchtenherstellung ; Spritzprägen
    Language German
    Size VIII, 143 S., Ill., graph. Darst., 21 cm, 250 g
    Edition 1. Aufl.
    Publisher Apprimus-Verl
    Publishing place Aachen
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Techn. Hochsch., Diss.--Aachen, 2014
    Note Mit dt. u. engl. Zsfassung. - Literaturverz. S. 133 - 143
    ISBN 9783863592356 ; 3863592352
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article ; Online: Third-generation CD19.CAR-T cell-containing combination therapy in Scl70+ systemic sclerosis.

    Merkt, Wolfgang / Freitag, Merle / Claus, Maren / Kolb, Philipp / Falcone, Valeria / Röhrich, Manuel / Rodon, Lea / Deicher, Franca / Andreeva, Ivana / Tretter, Theresa / Tykocinski, Lars-Oliver / Blank, Norbert / Watzl, Carsten / Schmitt, Anita / Sauer, Tim / Müller-Tidow, Carsten / Polke, Markus / Heußel, Claus Peter / Dreger, Peter /
    Lorenz, Hanns-Martin / Schmitt, Michael

    Annals of the rheumatic diseases

    2024  Volume 83, Issue 4, Page(s) 543–546

    MeSH term(s) Humans ; Scleroderma, Systemic ; Antigens, CD19 ; Immunotherapy, Adoptive ; T-Lymphocytes
    Chemical Substances Antigens, CD19
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2023-225174
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