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Article ; Online: Targeting KRAS G12C mutation in lung adenocarcinoma.

Rohatgi, Anjali / Govindan, Ramaswamy

2021 Volume 165, Page(s) 28–33

Abstract: Lung cancer continues to be a major cause of cancer related death globally. Therapies targeting driver mutations have significantly extended the survival of patients whose lung cancer cells harbor these mutations. Patients with KRAS mutations, however, ... ...

Abstract	Lung cancer continues to be a major cause of cancer related death globally. Therapies targeting driver mutations have significantly extended the survival of patients whose lung cancer cells harbor these mutations. Patients with KRAS mutations, however, lacked specific targeted therapy until the recent FDA approval of sotorasib, a specific inhibitor of KRAS G12C mutant protein. We will discuss the efficacy and toxicities of the novel KRAS G12C inhibitors as well as other indirect strategies for targeting oncogenic KRAS mutations. We will review the limited literature on acquired resistance to these inhibitors and the novel combinatorial treatment strategies that are being tested currently in clinical trials.
Language	English
Publishing date	2021-12-31
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2021.12.021
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Zs.A 2135: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 423: Show issues

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Article ; Online: Rare variant of atypical Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome with breast malformation: case report and review of literature.

Mahey, Reeta / Ramaswamy, Anjali / Cheluvaraju, Rohitha / Manchanda, Smita / Bhatla, Neerja

Clinical dysmorphology

2022 Volume 31, Issue 3, Page(s) 141–144

MeSH term(s)	46, XX Disorders of Sex Development/diagnosis ; 46, XX Disorders of Sex Development/genetics ; Congenital Abnormalities/diagnosis ; Congenital Abnormalities/genetics ; Humans ; Mullerian Ducts/abnormalities
Language	English
Publishing date	2022-02-13
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1121482-x
ISSN	1473-5717 ; 0962-8827
ISSN (online)	1473-5717
ISSN	0962-8827
DOI	10.1097/MCD.0000000000000414
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Zs.A 3528: Show issues

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Article ; Online: Maximizing insights from monogenic immune disorders.

Barmada, Anis / Ramaswamy, Anjali / Lucas, Carrie L

Current opinion in immunology

2021 Volume 73, Page(s) 50–57

Abstract: Monogenic immune disorders provide unprecedented insights into the consequences of disrupting single genes in humans, thereby informing our understanding of fundamental immune function and disease. Genomics has accelerated monogenic disease discovery ... ...

Abstract	Monogenic immune disorders provide unprecedented insights into the consequences of disrupting single genes in humans, thereby informing our understanding of fundamental immune function and disease. Genomics has accelerated monogenic disease discovery while also revealing the complexity of human disease, where several factors beyond the genome can govern pathogenesis. At this juncture, the optimal path forward will focus on maximizing basic and translational immunology insights from these disorders. This pursuit will be most direct and impactful if human disease gene discovery is paired with mechanistic studies employing integrative omics and mouse modeling to leverage their unique strengths.
MeSH term(s)	Animals ; Disease Models, Animal ; Genetic Testing ; Genomics ; Humans ; Immune System Diseases/genetics ; Mice ; Proteomics ; Translational Research, Biomedical
Language	English
Publishing date	2021-10-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2021.09.008
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Article ; Online: The Mystery of MIS-C Post-SARS-CoV-2 Infection.

Brodsky, Nina N / Ramaswamy, Anjali / Lucas, Carrie L

Trends in microbiology

2020 Volume 28, Issue 12, Page(s) 956–958

Abstract: Following emergence of the coronavirus disease 2019 (COVID-19) pandemic, a surge in the life-threatening illness now termed 'multisystem inflammatory syndrome in children' (MIS-C) has raised questions about the unique effects of severe acute respiratory ... ...

Abstract	Following emergence of the coronavirus disease 2019 (COVID-19) pandemic, a surge in the life-threatening illness now termed 'multisystem inflammatory syndrome in children' (MIS-C) has raised questions about the unique effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children and adolescents. Two important new studies by Consiglio et al. and Gruber et al. have begun to shine light on the immune drivers of this enigmatic disease.
MeSH term(s)	Adolescent ; Betacoronavirus ; COVID-19 ; Child ; Coronavirus ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome ; Systemic Inflammatory Response Syndrome
Keywords	covid19
Language	English
Publishing date	2020-10-14
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1158963-2
ISSN	1878-4380 ; 0966-842X
ISSN (online)	1878-4380
ISSN	0966-842X
DOI	10.1016/j.tim.2020.10.004
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Zs.A 3738: Show issues

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Article ; Online: The Mystery of MIS-C Post-SARS-CoV-2 Infection

Brodsky, Nina N. / Ramaswamy, Anjali / Lucas, Carrie L.

Trends in Microbiology

2020 Volume 28, Issue 12, Page(s) 956–958

Keywords	Microbiology (medical) ; Microbiology ; Virology ; Infectious Diseases ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1158963-2
ISSN	1878-4380 ; 0966-842X
ISSN (online)	1878-4380
ISSN	0966-842X
DOI	10.1016/j.tim.2020.10.004
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Article ; Online: It's the data, stupid: Inflection point for Artificial Intelligence in Indian healthcare.

Ramaswamy, Anjali / R Gowda, Naveen / Vikas, H / Prabhu, Meghana / Sharma, D K / Gowda, Praveen R / Mohan, Deepak / Kumar, Atul

Artificial intelligence in medicine

2022 Volume 128, Page(s) 102300

Abstract: Indian healthcare is fast growing and with significant chunk of it being in small, fragmented, informal sector; Artificial Intelligence (AI) is pegged as a magical tool for a better healthcare system. There is an inclination to merely mimic the US ... ...

Abstract	Indian healthcare is fast growing and with significant chunk of it being in small, fragmented, informal sector; Artificial Intelligence (AI) is pegged as a magical tool for a better healthcare system. There is an inclination to merely mimic the US approach in the on-going policy making and legislative exercises, which can have serious fallouts for Indian healthcare. India needs a different approach to suite her unique requirements. In this regard, each of the five stages in AI development lifecycle has been analyzed in the light of current on-ground realities. These boil down to three fold challenges of how to increase adoption of digital health, prevent data silos and create maximum value from data. Availability of quality data for value addition without barriers and restrictions is the common denominator for leveraging the full potential of AI. This requires liberal policies enabling secondary use of data in developing countries with rapidly growing healthcare sector akin to India. This has to be carefully balanced with data privacy and security. Restrictive healthcare data policies and laws can slow down adoption of digitization, perpetuate status-quo, be biased towards the incumbent players, cause Industry stagnation and thus will do more harm than good. It is therefore the data policies that will make or break AI in Indian healthcare.
MeSH term(s)	Artificial Intelligence ; Delivery of Health Care ; India
Language	English
Publishing date	2022-04-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	645179-2
ISSN	1873-2860 ; 0933-3657
ISSN (online)	1873-2860
ISSN	0933-3657
DOI	10.1016/j.artmed.2022.102300
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Zs.A 2547: Show issues

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Article: The Mystery of MIS-C Post-SARS-CoV-2 Infection

Brodsky, Nina N / Ramaswamy, Anjali / Lucas, Carrie L

Trends Microbiol

Abstract	Following emergence of the coronavirus disease 2019 (COVID-19) pandemic, a surge in the life-threatening illness now termed 'multisystem inflammatory syndrome in children' (MIS-C) has raised questions about the unique effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children and adolescents. Two important new studies by Consiglio et al. and Gruber et al. have begun to shine light on the immune drivers of this enigmatic disease.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #857205
Database	COVID19

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Article ; Online: Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine-associated myocarditis.

Science immunology

2023 Volume 8, Issue 83, Page(s) eadh3455

Abstract: Rare immune-mediated cardiac tissue inflammation can occur after vaccination, including after SARS-CoV-2 mRNA vaccines. However, the underlying immune cellular and molecular mechanisms driving this pathology remain poorly understood. Here, we ... ...

Abstract	Rare immune-mediated cardiac tissue inflammation can occur after vaccination, including after SARS-CoV-2 mRNA vaccines. However, the underlying immune cellular and molecular mechanisms driving this pathology remain poorly understood. Here, we investigated a cohort of patients who developed myocarditis and/or pericarditis with elevated troponin, B-type natriuretic peptide, and C-reactive protein levels as well as cardiac imaging abnormalities shortly after SARS-CoV-2 mRNA vaccination. Contrary to early hypotheses, patients did not demonstrate features of hypersensitivity myocarditis, nor did they have exaggerated SARS-CoV-2-specific or neutralizing antibody responses consistent with a hyperimmune humoral mechanism. We additionally found no evidence of cardiac-targeted autoantibodies. Instead, unbiased systematic immune serum profiling revealed elevations in circulating interleukins (IL-1β, IL-1RA, and IL-15), chemokines (CCL4, CXCL1, and CXCL10), and matrix metalloproteases (MMP1, MMP8, MMP9, and TIMP1). Subsequent deep immune profiling using single-cell RNA and repertoire sequencing of peripheral blood mononuclear cells during acute disease revealed expansion of activated CXCR3
MeSH term(s)	Humans ; Myocarditis/etiology ; SARS-CoV-2 ; Leukocytes, Mononuclear ; COVID-19 Vaccines/adverse effects ; Contrast Media ; COVID-19/prevention & control ; Gadolinium ; Antineoplastic Agents ; Killer Cells, Natural ; Cytokines
Chemical Substances	COVID-19 Vaccines ; Contrast Media ; Gadolinium (AU0V1LM3JT) ; Antineoplastic Agents ; Cytokines
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.adh3455
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Article ; Online: Trends in Stage I Lung Cancer.

Singareddy, Aashray / Flanagan, Mary Ellen / Samson, Pamela P / Waqar, Saiama N / Devarakonda, Siddhartha / Ward, Jeffrey P / Herzog, Brett H / Rohatgi, Anjali / Robinson, Clifford G / Gao, Feng / Govindan, Ramaswamy / Puri, Varun / Morgensztern, Daniel

Clinical lung cancer

2022 Volume 24, Issue 2, Page(s) 114–119

Abstract: Introduction: The American Cancer Society has recently reported an increase in the percentage of patients with localized lung cancer from 2004 to 2018, coinciding with the initial lung cancer screening guidelines issued in 2013. We conducted a National ... ...

Abstract	Introduction: The American Cancer Society has recently reported an increase in the percentage of patients with localized lung cancer from 2004 to 2018, coinciding with the initial lung cancer screening guidelines issued in 2013. We conducted a National Cancer Database (NCDB) study to further evaluate the trends in stage I according to patient and tumor characteristics. Methods: We selected patients with lung cancer from the NCDB Public Benchmark Report diagnosed between 2010 and 2017. Patients with stages I to IV according to the AJCC seventh edition were evaluated according to the year of diagnosis, histology, age, sex, race, and insurance. Results: Among the 1,447,470 patients identified in the database, 56,382 (3.9%) were excluded due to stage 0 or unknown, or incorrect histology, leaving 1,391,088 patients eligible. The percentage of patients with stage I increased from 23.5% in 2010 to 29.1% in 2017 for all lung cancers, from 25.9% to 31.8% in non-small-cell lung cancer (NSCLC), and from 5.0% to 5.4% in small-cell lung cancer (SCLC). Patients younger than 70 years, males and blacks had lower percentages of stage I compared to older patients, females, and nonblacks respectively. Patients with no insurance had the lowest percentage of stage I. Conclusions: There has been a significant increase in the percentage of stage I lung cancer at diagnosis from 2010 to 2017, which occurred mostly in NSCLC. Although the staging shift was observed in all subsets of patients, there were noticeable imbalances according to demographic factors.
MeSH term(s)	Male ; Female ; United States/epidemiology ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/epidemiology ; Lung Neoplasms/pathology ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/epidemiology ; Carcinoma, Non-Small-Cell Lung/pathology ; Early Detection of Cancer ; Neoplasm Staging ; Small Cell Lung Carcinoma/diagnosis ; Small Cell Lung Carcinoma/epidemiology ; Small Cell Lung Carcinoma/pathology
Language	English
Publishing date	2022-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2022.11.005
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Zs.MO 440: Show issues

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Article: Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity.

Ramaswamy, Anjali / Brodsky, Nina N / Sumida, Tomokazu S / Comi, Michela / Asashima, Hiromitsu / Hoehn, Kenneth B / Li, Ningshan / Liu, Yunqing / Shah, Aagam / Ravindra, Neal G / Bishai, Jason / Khan, Alamzeb / Lau, William / Sellers, Brian / Bansal, Neha / Guerrerio, Pamela / Unterman, Avraham / Habet, Victoria / Rice, Andrew J /

Catanzaro, Jason / Chandnani, Harsha / Lopez, Merrick / Kaminski, Naftali / Dela Cruz, Charles S / Tsang, John S / Wang, Zuoheng / Yan, Xiting / Kleinstein, Steven H / van Dijk, David / Pierce, Richard W / Hafler, David A / Lucas, Carrie L

medRxiv : the preprint server for health sciences

2021

Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV2 infection in otherwise healthy children. Here, we define immune abnormalities in ... ...

Abstract	Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV2 infection in otherwise healthy children. Here, we define immune abnormalities in MIS-C compared to adult COVID-19 and pediatric/adult healthy controls using single-cell RNA sequencing, antigen receptor repertoire analysis, unbiased serum proteomics, and
Language	English
Publishing date	2021-04-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2020.12.01.20241364
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