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Article ; Online: Improving pulmonary infection diagnosis with metagenomic next-generation sequencing of bronchoalveolar lavage fluid.

Long, Ying / Xia, Xianzhu / Feng, Hao / Zhao, Pingsen

2024 Volume 73, Issue 2

Abstract: Introduction. ...

Abstract	Introduction.
MeSH term(s)	Humans ; Bronchoalveolar Lavage Fluid ; Coinfection ; Prospective Studies ; Retrospective Studies ; High-Throughput Nucleotide Sequencing ; Bacteriophages ; Metagenomics ; Pneumonia ; Sensitivity and Specificity
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	218356-0
ISSN	1473-5644 ; 0022-2615
ISSN (online)	1473-5644
ISSN	0022-2615
DOI	10.1099/jmm.0.001808
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Zs.A 634: Show issues

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Article ; Online: The antibacterial and hemostatic curdlan hydrogel-loading epigallocatechin gallate for facilitating the infected wound healing.

Ding, Qiang / Mo, Zhendong / Wang, Xinyue / Chen, Meiling / Zhou, Fan / Liu, Zhengquan / Long, Ying / Xia, Xianzhu / Zhao, Pingsen

International journal of biological macromolecules

2024 Volume 266, Issue Pt 1, Page(s) 131257

Abstract: The infected wounds pose one of the major threats to human health today. To address this issue, it is necessary to develop innovative wound dressings with superior antibacterial activity and other properties. Due to its potent antibacterial, antioxidant, ...

Abstract	The infected wounds pose one of the major threats to human health today. To address this issue, it is necessary to develop innovative wound dressings with superior antibacterial activity and other properties. Due to its potent antibacterial, antioxidant, and immune-boosting properties, epigallocatechin gallate (EGCG) has been widely utilized. In this study, a multifunctional curdlan hydrogel loading EGCG (Cur-EGCGH3) was designed. Cur-EGCGH3 exhibited excellent physicochemical properties, good biocompatibility, hemostatic, antibacterial, and antioxidant activities. Also, ELISA data showed that Cur-EGCGH3 stimulated macrophages to secrete pro-inflammatory and pro-regenerative cytokines. Cell scratch results indicated that Cur-EGCGH3 promoted the migration of NIH3T3 and HUVECs. In vivo experiments confirmed that Cur-EGCGH3 could inhibit bacterial infection of the infected wounds, accelerate hemostasis, and promote epithelial regeneration and collagen deposition. These results demonstrated that Cur-EGCGH3 holds promise for promoting healing of the infected wounds.
MeSH term(s)	Catechin/analogs & derivatives ; Catechin/pharmacology ; Catechin/chemistry ; Animals ; Wound Healing/drug effects ; Mice ; beta-Glucans/chemistry ; beta-Glucans/pharmacology ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Humans ; NIH 3T3 Cells ; Hemostatics/pharmacology ; Hemostatics/chemistry ; Wound Infection/drug therapy ; Wound Infection/microbiology ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Human Umbilical Vein Endothelial Cells/drug effects
Chemical Substances	Catechin (8R1V1STN48) ; epigallocatechin gallate (BQM438CTEL) ; beta-Glucans ; Hydrogels ; Anti-Bacterial Agents ; Hemostatics ; curdlan (6930DL209R) ; Antioxidants
Language	English
Publishing date	2024-03-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131257
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Zs.B 2374: Show issues

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Article ; Online: Quantitative characterization of the B cell receptor repertoires of human immunized with commercial rabies virus vaccine.

Zhao, Pingsen / Guo, Sharula / Zhong, Zhixiong / Yang, Songtao / Xia, Xianzhu

Human vaccines & immunotherapeutics

2021 Volume 17, Issue 8, Page(s) 2538–2546

Abstract: Humoral immunity is crucial for an efficient host immune response against rabies virus (RABV) infection. But the B cell receptor (BCR) repertoire in human after RABV vaccine immunization remained unclear. To study the BCR repertoires in peripheral blood ... ...

Abstract	Humoral immunity is crucial for an efficient host immune response against rabies virus (RABV) infection. But the B cell receptor (BCR) repertoire in human after RABV vaccine immunization remained unclear. To study the BCR repertoires in peripheral blood mononuclear cells (PBMCs) of human immunized with rabies virus vaccine. In this study, we conducted BCR complementarity determining region 3 (CDR3) repertoires in 4 healthy volunteers before and after immunization with RABV vaccine by high-throughput sequencing. The bioinformatics analysis process was performed. The results showed that RABV vaccination changed the BCR diversity and the usage of V/J gene segments, as well as V-J pairing. B cell clone expansion was induced by the vaccination and sequences of high expand CDR3 aa clones were identified. To the best of our knowledge, we firstly quantitative characterized B cell receptor repertoire of human immunized with c rabies virus vaccine. It might provide us with new insights into B cell receptor condition after RABV vaccination.
MeSH term(s)	Humans ; Leukocytes, Mononuclear ; Rabies/prevention & control ; Rabies Vaccines ; Rabies virus/genetics ; Receptors, Antigen, B-Cell/genetics
Chemical Substances	Rabies Vaccines ; Receptors, Antigen, B-Cell
Language	English
Publishing date	2021-09-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2021.1893576
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Zs.A 6967: Show issues

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Article ; Online: Characterization of small metabolites alteration in mice brain tissues after infected by rabies virus.

Zhao, Pingsen / Hou, Kaijian / Yang, Songtao / Xia, Xianzhu

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2020 Volume 85, Page(s) 104571

Abstract: Rabies, caused by rabies virus (RABV), is still one of the deadliest infectious diseases. Host metabolomic changes against RABV infection has not yet been fully understood. We performed untargeted metabolomics to discover the metabolites associated with ... ...

Abstract	Rabies, caused by rabies virus (RABV), is still one of the deadliest infectious diseases. Host metabolomic changes against RABV infection has not yet been fully understood. We performed untargeted metabolomics to discover the metabolites associated with RABV infection. The brain tissues from 20 RABV infected mice and 10 mock infected mice were used for this method. A total of 1352 differential metabolites were identified after the first-run screen, and the number reduced to 75 after second-run screen. Multivariate analysis using PLS-DA and OPLS-DA clearly discriminated the RABV infected samples from controls. Pathways enrichment analysis revealed that most differential metabolites were associated with metabolism of nucleotide and amino acid, and aminoacyl - tRNA biosynthesis and purine metabolism were the most active pathways. The findings presented in our study would promote the understanding of metabolomics changes in brains of mice after RABV infection as well as a new perspective to study the relationship between RABV and host.
MeSH term(s)	Animals ; Biomarkers ; Brain/metabolism ; Brain/virology ; Disease Susceptibility ; Energy Metabolism ; Metabolome ; Metabolomics/methods ; Mice ; Rabies/metabolism ; Rabies/virology ; Rabies virus/physiology
Chemical Substances	Biomarkers
Language	English
Publishing date	2020-09-25
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2020.104571
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Zs.A 5645: Show issues

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Article ; Online: Prognostic and immune regulating roles of YIF1B in Pan-Cancer: a potential target for both survival and therapy response evaluation.

Liu, Jun / Chen, Zheng / Zhao, Pingsen / Li, Wenli

Bioscience reports

2020 Volume 40, Issue 7

Abstract: The neurotransmitter, serotonin has emerged as a tumor growth factor and immune response regulator through complex signaling pathways. Yip1 Interacting Factor Homolog B (YIF1B) is a membrane protein involved in serotonin receptor (HTR) membrane ... ...

Abstract	The neurotransmitter, serotonin has emerged as a tumor growth factor and immune response regulator through complex signaling pathways. Yip1 Interacting Factor Homolog B (YIF1B) is a membrane protein involved in serotonin receptor (HTR) membrane trafficking and signal transmission in neuropathy. Participation of YIF1B in serotonin-induced tumor growth and immune regulation has not been previously investigated. Data for analysis of YIF1B mRNA expression were downloaded from the website portals: The Cancer Genome Atlas (TCGA), GTEx, Cancer Cell Line Encyclopedia (CCLE) and International Cancer Genome Consortium (ICGC), including clinical and mutational information. Survival analysis included the Kaplan-Meier method for calculation of the cumulative incidence of the survival event and the log rank method for comparison of survival curves between groups. Infiltration levels of immune cells were calculated and correlated with YIF1B expression using the Spearman correlation test to evaluate significance. Further correlation analyses between YIF1B expression and mutation indicators such as tumor mutation burden (TMB), microsatellite instability (MSI), and mismatch repair (MMR) were also examined by the Spearman test. YIF1B expression was elevated in most cancer types and this high expression was indicative of poor overall survival (OS) and death-specific survival. In breast invasive carcinoma (BRCA) and liver hepatocellular carcinoma (LIHC), high YIF1B expression correlated with a poor disease-free interval (DFI), indicating a role in malignancy progression. There was a positive relationship between YIF1B expression and immune cell infiltration in several cancer types, and YIF1B also positively correlated with TMB, MSI, and methylation in some cancer types, linking its expression to possible evaluation of therapy response. The bioinformatics analyses have, therefore, established YIF1B as a good biomarker for prognostic and therapeutic evaluation.
MeSH term(s)	Antineoplastic Agents, Immunological/therapeutic use ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/metabolism ; Computational Biology ; Datasets as Topic ; Humans ; Kaplan-Meier Estimate ; Mutation ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/mortality ; Neoplasms/pathology ; Prognosis ; Receptors, Serotonin/metabolism ; Risk Assessment/methods ; Serotonin/metabolism ; Treatment Outcome ; Vesicular Transport Proteins/analysis ; Vesicular Transport Proteins/metabolism
Chemical Substances	Antineoplastic Agents, Immunological ; Biomarkers, Tumor ; Receptors, Serotonin ; Vesicular Transport Proteins ; YIF1B protein, human ; Serotonin (333DO1RDJY)
Language	English
Publishing date	2020-07-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20201384
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Zs.A 1676: Show issues

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Article ; Online: Immune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing.

Zhao, Pingsen / Zou, Jiahua / Zhou, Fan / Zhu, Yanyan / Song, Qibin / Yu, Dongdong / Li, Xiangpan

International immunopharmacology

2022 Volume 108, Page(s) 108767

Abstract: It remains unclear whether immune responses following natural infection can be sustained or potentially prove critical for long-term immune protection against SARS-CoV-2 reinfection. Here, we systematically mapped the phenotypic landscape of SARS-CoV-2- ... ...

Abstract	It remains unclear whether immune responses following natural infection can be sustained or potentially prove critical for long-term immune protection against SARS-CoV-2 reinfection. Here, we systematically mapped the phenotypic landscape of SARS-CoV-2-specific immune responses in peripheral blood samples of convalescent patients with COVID-19 by single-cell RNA sequencing. The relative percentage of the CD8 + effector memory subset was increased in both convalescent moderate and severe cases, but NKT-CD160 and marginal zone B clusters were decreased. Innate immune responses were attenuated reflected by decreased expression of genes involved in interferon-gamma, leukocyte migration and neutrophil mediated immune response in convalescent COVID-19 patients. Functions of T cell were strengthened in convalescent COVID-19 patients by clear endorsement of increased expression of genes involved in biological processes of regulation of T cell activation, differentiation and cell-cell adhesion. In addition, T cell mediated immune responses were enhanced with remarkable clonal expansions of TCR and increased transition of CD4 + effector memory and CD8 + effector-GNLY in severe subjects. B cell immune responses displayed complicated and dualfunctions during convalescence of COVID-19, providing a novel mechanism that B cell activation was observed especially in moderate while humoral immune response was weakened. Interestingly, HLA class I genes displayed downregulation while HLA class II genes upregulation in both T and B cell subsets in convalescent individuals. Our results showed that innate immunity was declined but SARS-CoV-2-specific T cell responses were retained even strengthened whereas complicated and dualfunctions of B cells, including declined humoral immunity were presented at several months following infections.
MeSH term(s)	Antibodies, Viral ; COVID-19 ; Convalescence ; Humans ; Immunity, Humoral ; SARS-CoV-2 ; Sequence Analysis, RNA
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2022-04-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2022.108767
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Zs.A 5408: Show issues

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Article: Characterization of small metabolites alteration in mice brain tissues after infected by rabies virus

Zhao, Pingsen / Hou, Kaijian / Yang, Songtao / Xia, Xianzhu

Infection, genetics, and evolution. 2020 Nov., v. 85

2020

Abstract	Rabies, caused by rabies virus (RABV), is still one of the deadliest infectious diseases. Host metabolomic changes against RABV infection has not yet been fully understood. We performed untargeted metabolomics to discover the metabolites associated with RABV infection. The brain tissues from 20 RABV infected mice and 10 mock infected mice were used for this method. A total of 1352 differential metabolites were identified after the first-run screen, and the number reduced to 75 after second-run screen. Multivariate analysis using PLS-DA and OPLS-DA clearly discriminated the RABV infected samples from controls. Pathways enrichment analysis revealed that most differential metabolites were associated with metabolism of nucleotide and amino acid, and aminoacyl - tRNA biosynthesis and purine metabolism were the most active pathways. The findings presented in our study would promote the understanding of metabolomics changes in brains of mice after RABV infection as well as a new perspective to study the relationship between RABV and host.
Keywords	Rabies lyssavirus ; amino acids ; biosynthesis ; brain ; evolution ; infection ; metabolites ; metabolomics ; multivariate analysis ; rabies
Language	English
Dates of publication	2020-11
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2037068-4
ISSN	1567-1348
ISSN	1567-1348
DOI	10.1016/j.meegid.2020.104571
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 5645: Show issues

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Article ; Online: Quantitative characterization of the T cell receptor repertoires of human immunized by rabies virus vaccine.

Zhao, Pingsen / Hou, Kaijian / Zhong, Zhixiong / Guo, Sharula / Yang, Songtao / Xia, Xianzhu

Human vaccines & immunotherapeutics

2021 Volume 17, Issue 8, Page(s) 2530–2537

Abstract: Cellular immunity is crucial for an efficient host immune response against rabies virus (RABV) infection. But the T cell receptor (TCR) repertoire in human after RABV vaccine immunization remained unclear. In this study, we conducted high-throughput ... ...

Abstract	Cellular immunity is crucial for an efficient host immune response against rabies virus (RABV) infection. But the T cell receptor (TCR) repertoire in human after RABV vaccine immunization remained unclear. In this study, we conducted high-throughput sequencing of TCR β chain complementarity determining region 3(CDR3) repertoires in 4 healthy volunteers before and after immunization with RABV vaccine. Our data showed that RABV vaccination changed the TCR diversity and the usage of V/J gene segments, as well as V-J pairing. The high-frequency clonotypes that altered after vaccination were identified. These results may provide us with new insights into T cell receptor condition after RABV vaccination.
MeSH term(s)	Complementarity Determining Regions ; Humans ; Rabies Vaccines ; Rabies virus/genetics ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell, alpha-beta
Chemical Substances	Complementarity Determining Regions ; Rabies Vaccines ; Receptors, Antigen, T-Cell ; Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2021.1893575
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Zs.A 6967: Show issues

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Article ; Online: Molecular and cytogenetic analysis of infertile Hakka men with azoospermia and severe oligozoospermia in southern China.

Zhao, Pingsen / Gu, Xiaodong / Wu, Heming / Deng, Xunwei

The Journal of international medical research

2019 Volume 47, Issue 3, Page(s) 1114–1123

Abstract: Objective: To determine the prevalence of chromosome abnormalities and azoospermia factor (AZF) microdeletions in Hakka men with infertility in southern China.: Methods: Hakka male patients, who received clinical counselling for infertility between ... ...

Abstract	Objective: To determine the prevalence of chromosome abnormalities and azoospermia factor (AZF) microdeletions in Hakka men with infertility in southern China. Methods: Hakka male patients, who received clinical counselling for infertility between August 2016 and October 2017, and fertile male controls, were enrolled into this retrospective study. Patients diagnosed with infertility and controls underwent cytogenetic analysis by standard G-banding; AZF microdeletions were examined by multiplex polymerase chain reaction and capillary electrophoresis. Results: Out of 918 male patients who received fertility counselling, 57 were diagnosed with infertility due to azoospermia or severe oligozoospermia. Of these infertile patients, 22.81% (13/57) carried chromosome abnormalities, with 47, XXY being the most common abnormal karyotype. In addition, 36.84% (21/57) presented with Y chromosome microdeletions, most frequently in the complete AZFc and partial AZFc region. Duplication of the AZFc region was found in three patients. No AZF microdeletions were found in 60 fertile male controls. Conclusion: The high AZF microdeletion frequency in the current Hakka population suggests that AZF microdeletion analysis is essential in fertility screening, and combined with cytogenetic analysis, may influence the choice of assisted reproductive techniques and reduce the risk of inherited genetic disease.
MeSH term(s)	Adult ; Azoospermia/epidemiology ; Azoospermia/genetics ; Azoospermia/pathology ; Case-Control Studies ; China/epidemiology ; Chromosome Aberrations ; Cytogenetic Analysis/methods ; Follow-Up Studies ; Humans ; Male ; Oligospermia/epidemiology ; Oligospermia/genetics ; Oligospermia/pathology ; Polymerase Chain Reaction/methods ; Prevalence ; Prognosis ; Retrospective Studies
Language	English
Publishing date	2019-01-07
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/0300060518816253
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Zs.A 925: Show issues

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Article ; Online: Molecular Spectrum of α- and β-Thalassemia Mutations in a Large Ethnic Hakka Population in Southern China.

Zhao, Pingsen / Weng, Ruiqiang / Wu, Heming

Hemoglobin

2018 Volume 42, Issue 2, Page(s) 117–121

Abstract: Thalassemia is one of the most prevalent inherited disorders in southern China. However, there have been few reports on molecular characterization of α- and β-thalassemia (α- and β-thal) in the large Hakka population living in Meizhou, a city with high ... ...

Abstract	Thalassemia is one of the most prevalent inherited disorders in southern China. However, there have been few reports on molecular characterization of α- and β-thalassemia (α- and β-thal) in the large Hakka population living in Meizhou, a city with high incidence of thalassemia in China. A total of 11,631 in- and outpatients in the Hakka area were analyzed by DNA-based α- and β-thal testing. Of all the samples, 4280 mutant chromosomes were detected, accounting in a total of 35.98%, of which 2864 (24.82%) α-thal mutants were detected, 1268 (10.09%) β-thal mutants were detected, 148 (1.27%) α- and β-thal mutants were detected. The following mutations - -
MeSH term(s)	China/epidemiology ; Genotype ; Humans ; Molecular Epidemiology ; Mutation ; Population Surveillance ; Prevalence ; alpha-Thalassemia/epidemiology ; alpha-Thalassemia/genetics ; beta-Thalassemia/epidemiology ; beta-Thalassemia/genetics
Language	English
Publishing date	2018-07-23
Publishing country	England
Document type	Journal Article
ZDB-ID	750615-6
ISSN	1532-432X ; 0363-0269
ISSN (online)	1532-432X
ISSN	0363-0269
DOI	10.1080/03630269.2018.1470094
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